Changes of functions of polymorphonuclear leukocyte after surgery for carcinoma of GI tract.

Research Project

Project/Area Number	63570587
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	General surgery
Research Institution	Akita University (1989) Tohoku University (1988)
Principal Investigator	KITAMURA Michihiko Akita University 2nd Department of Surgery, Assistant Professor, 医学部, 助教授 (10153131)
Co-Investigator(Kenkyū-buntansha)	NISIHIRA Tetsuro Touhoku University 2nd Department of Surgery, Instructor, 医学部, 講師 (50101142) SIGA Kiyoto Touhoku University 2nd Department of Surgery, Coworker HASIMOTO Masaji Akita University 2nd Department of Surgery, Instructor TAKAYA Kiyoshi Touhoku University 2nd Department of Surgery, Coworker IZUMI Keiichi Akita University 2nd Department of Surgery, Instructor 神谷彰秋田大学, 医学部, 助手 (80204626) 泉啓一秋田大学, 医学部, 講師 (60176237) 橋本正治秋田大学, 医学部, 講師 (70175701) 志賀清人東北大学, 医学部, 助手 (10187338) 高屋潔東北大学, 医学部附属病院, 助手 (60188092)
Project Period (FY)	1988 – 1989
Project Status	Completed (Fiscal Year 1989)
Budget Amount *help	¥2,000,000 (Direct Cost: ¥2,000,000) Fiscal Year 1989: ¥500,000 (Direct Cost: ¥500,000) Fiscal Year 1988: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords	respiratory failure after surgery for carcinoma of GI tract / superoxide anion production of polymorphonuclear leukocyte(PMN) / content of lysozome of PMN / complement receptors of PMN / serum complement / serum PMN elastase / 消化器癌術後の呼吸不全 / 多核白血球の活性酸素産性能 / 多核白血球の活性酸素産生能 / 多核白血球のライソゾーム酸素含有量 / 多核白血球の補体レセプター活性
Research Abstract	Superoxide anion production of polymorphonuclear Ieukocyte(PMN) after surgery for carcinoma of the esophagus increased significantly and reached to a peak level on 3rd-postoperative-day. Values of serum PMN elastase also increased after surgery and contents of lysozomal enzyme decreased at the same phase. Serum complement values(C3a) increased and there was statistically significant relation between the change of values of superoxide anion production and that of serum C3a. PMN complement receptors also increased. Respiratory-M-index, calculated for estimation of hypoxemia,increased significantly after surgery and reached to a peak level on 3rd-postoperative-day. There was statistically significant relation between the change of values of respiratory-M-index and that of superoxide anion production of PMN. It is concluded that hypoxemia after surgery for carcinoma of GI tract can be caused by activation of functions of PMN such as superoxide anion production and lysozomal enzyme release.