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Experimental Research for Primary Non-Function in Liver Transplantation

Research Project

Project/Area Number 63570603
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionNara Medical University, School of Medicine

Principal Investigator

NAKAJIMA Yoshiyuki  Nara Med. Univ., 1st. Dept. of Surgery, Instructor, 医学部・第1外科, 講師 (00142381)

Co-Investigator(Kenkyū-buntansha) NAKANO Hiroshige  Nara Med. Univ., 1st. Dept. of Surgery, Professor, 医学部・第1外科, 教授 (20075071)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1990: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1989: ¥600,000 (Direct Cost: ¥600,000)
Keywordsliver transplantation / arterial ketone body ratio (AKBR) / plasma amino acids / calcium channel blocker / Diltiazem / hepatic ischemia / primary non-function / charcoal hemofiltration / primary non-function / カルシウムイオン / カルシウム拮抗剤 / 肝代謝機能 / pyruvate / Lactate比 / 総遊離血漿アミノ酸 / アラニン
Research Abstract

In order to estimate the initial hepatic allograft function, we investigated arterial ketone body ratio (AKBR) and plasma amino acid levels in canine orthotopic liver transplantation. In successful cases, AKBR and plasma amino acids, especially alanine and total free plasma amino acids restored to the preoperative levels 3 hours after arterial reperfusion. On the other hand, in cases which died due to hepatic insufficiency, they could not recover even after reperfusion. Accordingly, AKBR and plasma amino acids are the rapid indicators to estimate the viability of hepatic graft and that primary non-fnction can be detected with these parameters by 3 hours after reperfusion.
Next study was to investigate the protective effect of a calcium channel blocker, Diltiazem (DZ), on ischemic liver damage and whether or not DZ might prevent primary non-function in liver transplantation. AKBR and hepatic arterial blood flow recovered 1 hour after hepatic ischemia for 60 minutes, whereas they were not restored in untreated controls. Furthermore, although all untreated dogs transplanted with warm ischemically damaged livers for 20 minutes died due to liver failure, half number of dogs (50%) which were administered DZ could survive over 48 hours after grafting without hepatic isufficiency. These results showed that DZ has protective effects on liver ischemia and warm ischemic injury in preservation of liver transplantation.
As a treatment of primary non-function, charcoal hemofiltration could not normalize the hepatic function when that was started just after the diagnosis of primary non-function.

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 中島 祥介 他: "肝臓移植ー移植肝の早期機能評価に関する研究ー" 移植. 22. 39-47 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] YOSHIYUKI NAKAJIMA et al.: "An Experimental Evaluation of the Order of Revascularization after Interrupting Hepatic Afferent Blood Flow" JOURNAL OF SURGLCAL RESEARCH. 48. 111-115 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] YOAHIYUKI NAKAJIMA et al.: "A Canine Model for Orthotopic Combined Hepatopncreatic Transplantation" TRANSPLANTATION. 49. 996-997 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 久永 倫聖 他: "移植肝の早期機能評価に関する研究 ー特に血漿アミノ酸と動脈血中ケント体比の変動からー" 移植. 24. 477-485 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] MICHIYOSHI HISANAGA et al.: "Evaluation of Initial Hepatic Allograft Function with Changes of Free Plasma Amino Acids in Canine Orthotopic Liver Transplantation" JoURNAL OF SURGICAL RESEARCH. 50. 139-145 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 和田 隆昭 他: "肝虚血障害に対するCa拮抗剤塩酸diltiazemの効果" 日本消化器外科学会雑誌. 22. 2018-2024 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yoshiyuki Nakajima, et al.: "Liver Transplantation -Rapid Indicators of Assessing Initial Hepatic Allograft Function-" Japanese Journal of Transplantation.22. 39-47 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yoshiyuki Nakajima, et al.: "An Experimental Evaluation of the Order of Revascularization after Interrupting Hepatic Afferent Blood Flow" Journal of Surgical Research.48. 111-115 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yoshiyuki Nakajima, et al.: "A Canine Model for Orthotopic Combined Hepatopancreatic Transplantation" Transplantation.49. 996-997

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Michiyoshi Hisanaga, et al.: "Evaluation of Initial Hepatic Allograft Function -Changes of Arterial Ketone Body Ratio and Plasma Amino Acids-" Japanese Journal of Transplantation.24. 477-485 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Michiyoshi Hisanaga, et al.: "Evaluation of Initial Hepatic Allograft Function with Changes of Free Plasma Amino Acids in Canine Orthotopic Liver Transplantation" Journal of Surgical Research.50. 139-145 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takaaki Wada, et al.: "The effect of Diltiazem, a calcium channel blocker on liver ischemia" The Japanese Journal of Gastroenterological Surgery. 22. 2018-2024 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] YOSHIYUKI NAKAJIMA: "A Conlne model for orthotopic combined hepatopancreas transplantation" Transplantation. 49. 966-997 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] TOSHIYUKI HUKUOKA: "Effect of platelet activating factor antagonist(CV6209) on shook caused by temporary hepatic inflow occlusion" Life scince. 47. 565-570 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] MICHIYOSHI HISANAGA: "Evaluation of initial hepatic allograft function with changes of free plasma amino acids in canine onthotopic liver transplantation" Journal of Surgical Research. 50. 139-145 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 久永倫聖: "移植肝の早期機能評価に関する研究特に血漿アミノ酸と動脈血中ケトン体比の変動から" 日本移植学会雑誌. 24. 477-485 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 和田隆昭: "肝虚血障害に対するCa拮抗剤塩酸diltiazenの効果" 日本消化器外科学会雑誌. 22. 2018-2024 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] YOSHIYUKI NAKAJIMA: "An Experimental Evalution of the Order of Revascularization after Interrupting Hepatic Afferent Blood Flow" Journal of Surgical Research. 48. 111-115 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 中島祥介: 日本移植学会雑誌. 23. 243-252 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 福岡敏幸: 日本外科学会雑誌. 89. 788 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 久永倫聖: 奈良医学雑誌. 39. 612-623 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 和田隆昭: 日本消化器外科学会雑誌.

    • Related Report
      1988 Annual Research Report
  • [Publications] 久永倫聖: 日本移植学会雑誌.

    • Related Report
      1988 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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