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Investigation of Activation on Hepatic Functional Reserve in Cirrhotic Patients with Hepatocellular Carcinoma

Research Project

Project/Area Number 63570620
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

ISHIKAWA Akio  Univ. of Tsukuba, Inst. of Clin. Med., Assist.Prof., 臨床医学系, 講師 (50134226)

Co-Investigator(Kenkyū-buntansha) ISHIKAWA Nobuyoshi  Univ. of Tsukuba, Inst. of Clin. Med., Associate Prof., 臨床医学系, 助教授 (10026932)
TANAKA Einosuke  Univ. of Tsukuba, Inst. of Community Med., Assist.Prof., 社会医学系, 講師 (30138416)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1989: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1988: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordshepatic microsomal function / trimethadione / reticuloendothelial system(RES) / ^<99m>Tc-phytate / hepatic functional reserve / liver cirrhosis / 肝癌 / Tc-フチン酸 / 肝ミクロゾーム機能 / RES機能 / 凝血能 / 肝予備能の賦活
Research Abstract

We synthesized the microsomal function and the function of the reticuloendothelial system(RES), an estimation as a functional reserve in the liver. Trimethadione(TMO) is exclusively metabolized to dimethadione(DMO) by cytochrome P-450 dependent mono-oxygenase in liver microsomes. TMO tolerance test could also determine quantitatively the changes of the functional capacity and critical level of the liver. These results suggest that TMO tolerance test is a useful tool for the surgical indication in the hepatectomy. We examined the RES function, using parmacokinetic study. As a result, the decrease of the RES function may cause severe infection because of less hepatic functional reserve after hepatectomy in hepatoma with cirrhosis. Clinically, the functional test on the RES with ^<99m>Tc-phytate may be useful for one of the estimation of hepatic functional reserve. We administered protease-inhibitor on endotoxin induced DIC-model in rats to activate the RES and studied its effect on RES. The RES function decreased in these rats. The proteolytic actions of human leukocytal elastase on human fibronectin, in vitro, were analyzed SDS-polyacrylamide gel electrophoresis. The protease-inhibitor prevented actions of the elastase on human fibronectin. These findings suggest that the protease-inhibitor could also improvement on RES.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 石川詔雄,ほか: "肝癌切除例に対するウリナスタチンの使用経験-RES機能に対する影響-" 外科診療. 30. 1019-1024 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Einosuke Tanaka,Akio Ishikawa,et.al.: "The methabolism and excretion of trimethadione in patients with percutaneous transhepatic biliary drainage and renal dysfunction." J.Pharmacobio-Dyn.12. 145-148 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akio Ishikawa et.al.: "Clinical experience of urinary trypsin inhibitor in hepatectomized patients with hepatocellular carcinoma." Gekasinryou 30, 1019-1024, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Einosuke Tanaka et.al.: "The metabolism and excretion of trimethadione in patients with percutaneous transhepatic biliary drainage and renal dysfunction." J.Pharmacobio-Dyn 12, 145-148, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 石川詔雄ほか: "肝癌切除例に対するウリナスタチンの使用経験-RES 機能に対する影響-" 外科診療. 30. 1019-1024 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Einosuke Tanaka,Akio Ishikawa et.al.: "The methabolism and excretion of trimethadiome in patients with percutaneous transhepatic biliary drainage and renal dysfunction." J.Pharmacobio-Dyn.12. 145-148 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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