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Physiological alteration surrounding blood flow in a segmental pancreatic graft-1. the effect of a distal splenic arterio-venous fistula on blood flow, and 2. correlation between prostaglandins and blood flow.

Research Project

Project/Area Number 63570637
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionShimane Medical University

Principal Investigator

TAMURA Katsuhiro  Shimane Medical University. Assistant Professor, 医学部, 講師 (80155259)

Co-Investigator(Kenkyū-buntansha) NAGAMI Haruhiko  Shimane Medical University. Assistant, 医学部, 助手 (50180518)
TARUMI Takao  Shimane Medical University. Assistant Professor, 医学部, 講師 (10135907)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsSegmental pancreatic graft / Splenic arterial blood flow / Tissue blood flow / Distal splenic arteriovenous fistula / Prostaglandin I2 / Thromboxane A2 / Preservation time / OKY-046 / 移植膵血管血流 / 移植膵組織血流 / PGI_2 / TxA_2 / 膵グラフト血流 / プロスタグランディンI_2 / トロンボキサンA_2 / 生着率 / 血栓症
Research Abstract

1. We investigated the effect of a distal splenic arterio-venous fistula (A-V fistula) on splenic arterial blood flow (SABF) and tissue blood flow (TBF) in a segmental pancreatic autograft both in dogs and in clinical cases, and following conclusions were obtained, (1) After splenectomy, not only SABF but also TBF extremely decreased, which phenomena should result in causing thrombosis of the graft. (2) Both SABF and TBF were significantly increased by performing A-V fistula. (3) We applied A-V fistula in 8 clinical cases, which was very effective to prevent thrombosis and to maintain normal pancreatic function of the autograft in all cases.
2. A pancreatic graft is generally transplanted heterotopiccally, in other words completely denervated. Then, the blood flow must be mainly regulated byhumoral substances. we investigated. correlation between prostaglafidins (PGI_2, TxA_2) and blood flow, and following conclusions were obtained. (1) Both PGI_2 and TxA_2 were secreted from the graft into the simple cold storage solution, and these secretion continued actively till the first 7 hours in preservation. (2) We divided experimental animals into two groups, the one with autograft preserved for 3 hours (3) hrs group and another with autograft preserved for 24 hours (24 hrs group). In 3 hrs groupSIGMA PGI_2 secretion during preservation was dominant, on the other hand in 24 hrs group SIGMA TxA_2 secretion was dominant. (3) After transplantation, both SABF and TBF were significantly higher in 3 hrs group than in situ denervated control group (so called reactive hyperemia), on the other hand they were remarkably lower in 24 hrs group than in control group. PGI_2/TxA_2 ratio was positively correlative to SABF and TBF. (4) Graft survival rate was 80% in 3 hrs group, and 20% in 24 hrs group. (5) TxA_2 synthetic inhibitor (OKY-046) was effective to elevate PGI_2/TxA_2 ratio, resulting in improvement of SABF and TBF.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (47 results)

All Other

All Publications (47 results)

  • [Publications] Tamura K.: "Exocrine function of the heterotopic transplanted pancreas segment:influence of denervation in dogs." Pancreas. 3. 324-331 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 金聲根: "部分膵自家移植術の長期観察例" 移植. 23. 237-242 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 金聲根: "部分膵移植における遠位脾動静脈fistulaの膵組織血流量に及ぼす影響について-特に脾動脈血流と関連して-" 移植. 23. 365-374 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 田村勝洋: "異所性部分膵移植片におけるdenervationの膵外分秘機能に及ぼす影響に関する実験的・臨床的研究" 移植. 23. 390-400 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] G.Kaneko: "Comarison of Graft Survival Between Orthotopic and Heterotopic Segmental Pancreas Allotransplantation." Transplantation Proceedings. 21. 2806-2808 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Seikon Kin: "The Effect of a Distal Splenic Arteriovenous Fistula on Tissue Blood Flow in th Pancreatic Segment." Transplantation Proceedings. 21. 2812-2814 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 田村勝洋: "膵体尾部切除兼尾側膵自家移植術を施行した膵性腹水の1例" 膵臓. 4. 87-93 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 田村勝洋: "膵癌切除症例の検討-特に大血管浸潤膵癌について" 日本外科学会雑誌. 90. 1032-1042 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 田村勝洋: "臨床における尾側膵自家移植の適応とその意義" 膵臓. 4. 500-510 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 田村勝洋: "異所性移植膵の内分秘機能" 内分秘外科. 7. 97-102 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 田村勝洋: "特集/膵臓移植と人工膵に関する諸問題「膵自家移植の適応とその意義」" 肝胆膵. 20. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 長見晴彦: "イヌ部分膵自家移植片のプロスタグランジン産生動態と血流量との関連について-特に保存時間との関連について-" 移植. 25. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 長見晴彦: "遠位脾動脈瘻による脾静脈血中プロスタグランジン値の変動-部分膵モデルを用いての実験的・臨床的研究-" 膵臓. 5. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 長見晴彦: "TxA_2合成阻害剤(OKY-046)の24時間単純冷却保存膵に及ぼす効果について" 移植. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 長見晴彦: "拡大膵摘兼尾側膵自家移植術を施行した膵頭部癌の1例" 膵臓. 5. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Katsuhiro Tamura, David E.R.Sutherland, and Gengo Kaneko: "Exocrine Function of the Heterotopic Transplanted Pancreas Segment : Influence of Denervation in Dogs" Pancreas. 3(3). 324-331 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Seikon Kin, Katsuhiro Tamura, Haruhiko Nagami, Makoto Teramoto and Akira Nakase: "A long-term study of a clinical case with pancreatic segmental autotransplantation" Japanese Journal of Transplantation 23(2), 237-242, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Seikon Kin, Katsuhiro Tamura, Haruhiko Nagami, Makoto Teramoto and Akira Nakase: "The effect of a distal splenic arteriovenous fistula on tissue blood flow of the pancreas segment - The influence of the splenic arterial blood flow -" Japanese Journal of Transplantation 23(4), 365-374, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Katsuhiro Tamura, Seikon Kin, Haruhiko Nagami, Makoto Teramoto, Akira Nakase, Gengo Kaneko and David E.R. Sutherland: "Effect of denervation following heterotopic segmental pancreas autotransplantation on exocrine pancreas function in dogs and clinical cases" Japanese Journal of Transplantation 23(4), 390-400, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] G.Kaneko, L.Barneo, S.Toda, J.Heil, D.Kaufman, K.Tamura, and D.E.R.Sutherland: "Comparison of graft Survival Between Orthotopic and Segmental Pancreas Allotransplantation" Transplantation Proceedings 21(1), 2806-2808, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Seikon Kin, Katsuhiro Tamura, Haruhiko Nagami, Makoto Teramoto, and Akira Nakase: "The Effect of a Distal Splenic Arteriovenous Fistula on Tissue Blood Flow in the Pancreatic Segment" Transplantation Proceedings 21(1), 2812-2814, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Katsuhiro Tamura, Atsushi Naitoh, Haruhiko Nagami, Seikon Kin, Keiji Ono, Toru Ishida, Makoto Taramoto, Yasushi Inoue, Tsuyoshi Yamamoto and Akira Nakase: "A case of resection of the body and the tail of the pancreas and ex vivo trimming of the distal pancreas with auto-transplantation for pancreatic pseudocyst" The Journal of Japan Pancreas Society 4(1), 87-93, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Katsuhiro Tamura, Seikon Kin, Keiji Ono, Haruhiko Nagami, Makoto Teramoto, Takao Tarumi and Akira Nakase: "OPERATIVE RESULTS FOR CANCER OF THE PANCREAS, ESPECIALLY COMPLICATED WITH LARGE VASCULAR INVOLVEMENT" Journal of Japan Surgical Society 90(7), 1032-1042, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Katsuhiro Tamura, Seikon Kin, Haruhiko Nagami, Makoto Taramoto, Keiji Ono, Tohru Ishida, Yasushi Inoue, Atsushi Naitoh, Tsuyoshi Yamamoto, Masahisa Nakagawa and Akira Nakase: "Heterotopic autotransplantation of the distal pancreas for pancreatic cancer and chronic pancreatitis - Its indication and efficacy -" The Journal of Japan Pancreas Society 4(4), 52-62, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Katsuhiro Tamura, Seikon Kin, Haruhiko Nagami, Keiji Ono, Tohoru Ishida, Makoto Teramoto, Yasushi Inoue, Atsushi Naitoh and Akira Nakase, Gengo Kaneko, David E.R. Sutherland: "Endocrine function of the heterotopically transplanted pancreas" Endocrine Surgery 7(1), 97-102, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Katsuhiro Tamura, Akira Nakase: "The indication and efficacy of the pancreatic segmental autotransplantation" KAN.TAN.SUI (Japan) 20, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Haruhiko Nagami, Katsuhiro Tamura, Seikon Kin, Makoto taramoto, Yasushi Inoue, Tohru Ishida, Keiji Ono and Akira Nakase: "Correlation between prostaglandins and blood flow in camine autotransplanted segment of the pancreas. - especially in view of preservation time." Japanese Journal of Transplantation 25, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Haruhiko Nagami, Katsuhiro Tamura, Seikon Kin, Makoto Teramoto, Yasushi Inoue, Tohru Ishida, Keiji Ono and Akira Nakase: "Effect of distal arterio-venous fistula on prostaglandin in splenic vein in experimental and clinical autotransplantation of the pancreas segment" The Journal of Japan Pancreas Society 5, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Haruhiko Nagami, Katsuhiro Tamura, Seikon Kin, Makoto Teramoto, Yasushi Inoue, Tohru Ishida, Keiji Ono and Akira Nakase: "Beneficial effect of thronboxane A2 synthese inhibitor (OK-046) on 24 hour simple hypothermic preservation of the camine pancreas" Japanese Journal of Transplantation 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Haruhiko Nagami, Katsuhiro Tamura, Seikon Kin, Makoto Teramoto, Yasushi Inoue, Tohru Ishida, Keiji Ono and Akira Nakase: "A case of extended total pancreatectomy with autotransplantation of the distal pancreas for cancer of the head of the pancreas." The Journal of Japan Pancreas Society 5, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 田村勝洋: "臨床における尾側膵自家移植の適応とその意義" 膵臓. 4. 500-510 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kin S.: "The effect of a distal splenic arteriovenous fistula on tissue blood flow in the pancreatic segment." Transpl.Proc.21. 2812-2814 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 田村勝洋: "異所性移植膵の内分泌機能" 内分泌外科. 7. 1990.3.25 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tamura K.: "Segmental pancreatic autotransplantation with enteric drainage after total or subtotal pancreatectomy for pancreatic cancer or chronic pancreatitis." World J.Surg.(1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 田村勝洋: "特集/膵臓移植と人口膵に関する諸問題「膵自家移植の適応とその意義」" 肝胆膵. 20. 1990.6 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 長見晴彦: "イヌ部分膵自家移植片のプロスタグランジン産生動態と血流量との関連について-特に保存時間との関連について" 移植. 25. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 長見晴彦: "遠位膵動静脈瘻による脾静脈血中プロスタグランジン値の変動-部分膵モデルを用いての実験的・臨床的研究-" 膵臓. 5. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 長見晴彦: "TxA_2合成阻害剤(OKY-046)の24時間単純冷却保存膵に及ぼす効果について" 移植. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 田村勝洋: 移植. 23. 390-400 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 金聲根: 移植. 23. 237-242 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 金聲根: 移植. 23. 366-374 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Tamura Katsuhiro.: Pancreas. 3. 324-331 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 田村勝洋: 膵臓. 4(1). (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 田村勝洋: 日本外科学会雑誌. 90(7). (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 田村勝洋: Scope. 28(5). (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kin Seikon.: Transplant Proc.(1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kaneko Gengo.: Transplant Proc.(1989)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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