| Project/Area Number |
63570641
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
MORI Masaki Kyushu University, Faculty of Medicine, Assistant, 医学部, 助手 (70190999)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHIMA Tetsuya Kyushu University, Faculty of Medicine, Resident
木戸 晶孔 九州大学, 医学部, 医員
井上 哲也 九州大学, 医学部, 医員
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| Project Period (FY) |
1988 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Hyperthermia / Chemotherapy / Preoperative radiotherapy / Rectal cancer / Hyperthermosensitivity / Radiosensitivity / Succinate dehydrogenase inhibition test / 大腸癌 / 放射線療法 / 局所再発 / 内腔加温 / 術前合併療法 / 腔内加温 / 内腔電極 |
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| Research Abstract |
Preoperative Hyperthermo-chemo-Radiotherapy (HCR therapy), consists of a combination of hyperthermia at 42 to 45^ﾟC for 40 minutes (2 times per week for two weeks), 5-fluorouracil (5-FU) or 1-hexylcarbamoyl-5-fluorouracil (HCFU), and a total of 30 Gy irradiation. The therapy was prescribed preoperatively most recently for 36 patients with rectal cancer. We used a radio-frequency system involving an endotract electrode with thermosensors for the hyperthermia. The effectiveness of preoperative HCR therapy was evaluated by irrigography, fiberscopy, and histopathologic findings in the resected specimens. Reduction in tumor size and amount was evident in most patients with all modes of assessment. Histologically, no or only a few viable cancer cells were seen in the resected specimens in twelve patients, a small number of viable cancer cells in thirteen, and a fair number of viable cancer cells in eleven patients ; there were no complications. This method of treatment is expected to play an important role in the interdisciplinary treatment for rectal cancer.
The sensitivity to heat and radiation of 22 rectal cancer tissues obtained at biopsy was studied using the in vitro succinate dehydrogenase inhibition test. The succinate dehydrogenase activities of heat-treated cells were significantly lower than that of the radiation-treated cells (P<0.01). The succinate dehydrogenase activities of heat plus radiation treated cells were the lowest in tissues from cancer lesions. Although the number was small, there was a correlation between this test and clinical outcome in seven of nine cases.
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