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Effect of H2-blockers on hepatic regeneration

Research Project

Project/Area Number 63570644
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionMedical College of Oita

Principal Investigator

金 良一 (金島 良一)  大分医科大学, 医学部, 講師 (40185905)

Co-Investigator(Kenkyū-buntansha) 御手洗 義信  大分医科大学, 医学部, 助手 (70166049)
小林 迪夫  大分医科大学, 医学部, 教授 (20038657)
多田 出  大分医科大学, 医学部, 助手 (30163463)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1990: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1989: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsH2-blocker / cimetidine / ranitidine / famotidine / liver regeneration / liver resection / Cimidine / Ranitidine / Famotidine
Research Abstract

The effect of H2-blockers(cimetidine, ranitidine and famotidine)on liver regeneration was studied in rats. Cimetidine and ranitidine significantly inhibited hepatocyte proliferation after both types(70% and 90%)of hepatectomy. Although famotidine did not suppress liver regeneration in case of 70% hepatectomy, this agent also suppress the hepatocyte division after 90% ablation of the whole liver.
These data suggest that the inhibition of rat liver regeneration by these agents can be connected to the common properties of H2-receptor antagonist. On the other hand, we did no find hepatotoxic effects of H2-blockers, in terms of serum biochemistry, in the patients undergoing liver resection.

Report

(4 results)
  • 1991 Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Kanashima R: "Famotidine does not inhibit liver regeneration" Eur Surg Res. 21. 190-195 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kim YI: "Influences of ciclosporin pretherapy on 90% hepatectomized rats" Eur Surg Res.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kanashima R: "Famotidine does not inhibit liver regeneration." Eur Surg Res. 21. 190-195 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kim Y. I.: "Influences of ciclosporin pretherapy on 90% hepatectomized rats" Eur Surg Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kanashima: "Famotidine does not inhibit liver regeneration" Eur Surg Res. 21. 190-195 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kanashima,R.: Eur Surg Res.

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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