Experimental studies on Reversed smooth muscle flap transplantation for the treatment of internal anal sphincter insufficiency
| Project/Area Number |
63570653
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
NANBU Kiyoshi Kanazawa Medical University, Pediatric Surgery, Assistant, 小児外科, 助手 (90180554)
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| Co-Investigator(Kenkyū-buntansha) |
IKAWA Hiromichi Kanazawa Medical University, Instructor, 小児外科, 講師 (20124935)
KONUMA Kunio Kanazawa Medical University, Assistant, 小児外科, 助手 (10178296)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Internal and Sphincter insufficiency / Reversed smooth muscle flap transplantation / Electro-myogram of internal anal sphincter / Manometric study / Cystometrogram / Urethrogram / Electro-myogram of rectal smooth muscle / Electro-myogram of uretral sphincter |
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| Research Abstract |
Electromanometric, electromyographic and radiological studies on the subjects of division of internal anal sphincter(IAS)and reversed autologous graft of rectal smooth muscle were carried out in dogs. Normal group(1) were in 10 dogs for control. IAS was totally removed in 5(II). Reversed autologous smooth muscle was transplanted after division of IAS in 5 dogs(III). These groups had been examined by obtaining continuous recording for 24 postoperative weeks.
The results were as follows. II: All subjects defecated 5 to 6 times per day, frequent defecation and small amount of feces were presented markedly. Radiological study showed the poor continence. In manometric study, arial resting pressure remained between 22 cmH_2O to 29 cmH_2O, anal canal length was shortened to 61.1 per cent in comparison with preoperative length. Atypical recto anal reflex was presented in 2 dogs after 24 postoperative weeks. Electrical activity of the IAS was not presented in the high pressure zone, but spike bu
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rst activity and slow wave were recorded in all cases. III: Defecational pattern resembled that of the normal one. Radiological studies were akin to the normal findings in all cases. The anal resting pressure was presented in a state of normal range, while anal canal length was shortened to 42.9 %. Electromyographic showed low potential spike burst activity in reversed smooth muscle. Electrical spike burst activity in the high pressure zone showed coordinately rectal stimulation, and atypical recto anal reflex were presented in all cases.
The IAS contributes about 65 % of the anal canal pressure, 60 % of the anal canal length, and 55 % of the square of high pressure zone at rest. The reversed grafts preserved in a state of the resting pressure of the IAS.
Based on these results, it is concluded that the IAS is chiefly responsible for anal continence at rest, Reversed smooth muscle transplantation is a suitable replacement, particularly to gain function of the IAS. Experimental findings suggest that atypical reflex in the postoperative stage are controlled by the intestinal intrinsic reflex. Less
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Report
(3 results)
Research Products
(5 results)
