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Studies on surgical treatment for esophageal carcinoma based on biological characteristics of the cancer cell and immunological response of the patients.

Research Project

Project/Area Number 63570654
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKurume University

Principal Investigator

YAMANA Hideaki  Kurume University School of Medicine, Lecture, 医学部, 講師 (30140669)

Co-Investigator(Kenkyū-buntansha) MINAMI Taizo  Kurume University School of Medicine, Assistant, 医学部, 助手 (10181950)
BEKKI Fumitoshi  Kurume University School of Medicine, Assistant, 医学部, 助手 (10165516)
SHIROUZU Genzan  Kurume University School of Medicine, Assistant, 医学部, 助手 (10154379)
FUJITA Hiromasa  Kurume University School of Medicine, Lecture, 医学部, 講師 (90156878)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1988: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsEsophageal carcinoma / Biological characteristics / Host defence phenomenon / DNA histogram / Monoclonal antibody / Proliferating cells / Glycolipids / グライフリピッド / 生体防御反能 / モノクローナル抗体 / 殺細胞効果
Research Abstract

Biological characteristics and immnologic response of esophageal carcinoma were studied clinically and experimentally. DNA contents of the cancer cell nuclear were measured by flow cytometry. From this study, aneuploid cancer showed significant poor survival as compared to diploid one. But there were no significances in patients with radical operation except early cancers between diploid and aneuploid cancers. Proliferating cancer cells were measured by monoclonal antibody Ki-67. By this result, the cancer with Ki-67 positive cells showed significant poor prognosis as compared to the cancer without Ki-67 positive cells. Monoclonal antibody of KISM-1 which was produced in our Institute showed high affinity to esophageal squamous cell carcinoma, and a low affinity was recognized in stomach and colonic carcinoma.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 力武浩: "食道癌細胞の悪性度と生体反応" フロ-サイトメトリ-. 7. 124-128 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 掛川暉夫: "食道癌の診断と治療ーー当教室における最近の研究から" 現代医療. 20. 2157-2161 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 白水玄山: "食道癌における生物学的悪性度ーー最近の研究から" 腫瘍と感染. 1. 1-5 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 掛川暉夫: "食道癌の外科的診断と治療の動向" 消化器外科. 10. 7-16 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 入江均: "A_3胸部食道癌の手術,合併療法とその意義" 日本胸部外科学会雑誌. 37. 901-903 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 南泰三: "ヒト食道癌細胞に対するモノクロ-ナル抗体の作製と免疫組織化学的反応特異性の検討" 日本外科学会雑誌. 90. 1819-1819 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Rikitake H.: "Malignant potential and immunologic reaction in esophageal cancer" Flowcytometry 7:124-128, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kakegawa T.: "Diagnosis and treatment for esophageal carcinoma" Gendaiiryou 20:2157-2161 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shirouzu G.: "Malignant potential of esophageal carcinoma" Syuyou to Kansen 1:1-5, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kakegawa T.: "The trend of surgical diagnosis and treatment for esophageal carcinoma" Syoukakika 10:7-16, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Irie H.: "Surgical treatment and combined therapy for thoracic esophageal carcinoma with invasion of contiguous structures" The Journal of the Japanese Association for Thoracic Surgery. 37:901-903, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Minami T.: "Monoclonal antibody KYSM-1 and immuno-histological specificity against esophageal cancer" Journal of Japan Surgical Society. 90:1819-1819, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 掛川暉夫: "食道癌の外科的診断と治療の動向" 消化器外科. 10. 7-16 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 入江均: "A_3胸部食道癌の手術、合併療法とその意義" 日本胸部外科学会雑誌. 37. 901-903 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 掛川暉夫: "A_3食道癌の治療方針" 外科治療. 60. 659-665 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 南泰三: "ヒト食道癌細胞に対するモノクロ-ナル抗体の作製と免疫組織化学的反応特異性の検討" 日本外科学会雑誌. 90. 1819-1819 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 力武浩: フローサイトメトリー. 7. 124-128 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 掛川暉夫: 現代医療. 20. 2157-2161 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 白水玄山: 腫瘍と感染. 1. 1-5 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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