| Project/Area Number |
63570689
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Toho University, School of Medicine |
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Principal Investigator |
SAMEJIMA Hirotsugu (1990) Toho University, Neurosurgery, Assist. Prof., 医学部・脳神経外科研究室, 助教授 (70057636)
溝上 徹 (1988-1989) 東邦大学, 医学部, 助手 (00157520)
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| Co-Investigator(Kenkyū-buntansha) |
IWABUCHI Satoshi Toho University, Neurosurgery, Resident, 医学部脳神経外科研究室, 助手 (30213309)
USHIKUBO Yukio Toho University, Neurosurgery, Instructor, 医学部脳神経外科研究室, 講師 (50160239)
YOSHII Nobuo Toho University, Neurosurgery, Prof., 医学部脳神経外科研究室, 教授 (60057453)
笠井 敬一郎 東邦大学, 医学部, 助手 (60183258)
鮫島 寛次 東邦大学, 医学部, 助教授 (70057636)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1990: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1989: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | WHHL rabbit / Carotid arteries / Intracranial arteries / Intimal thickening / Atherosclerosis / Intimal thickening / Atherosclerosis |
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| Research Abstract |
In an attempt to investigate atherosclerosis developing in WHHL rabbits, the author carried out a histological study on bilateral carotid arteries and intracranial arteries, particularly those present in the basilar area. In addition, serum level of cholesterol as well as triglyceride was measured. Thirty-seven WHHL rabbits in a range of 2-to 64-month-old were used in this experiment.
Histologically, intimal thickening of carotid arteries was observed in rabbits above 2-month-old, and the incidence was 92%. In contrast, no intracranial arteries were involved with intimal thickening. Atherosclerosis of WHHL rabbits was characterized by intimal thickening which consisted mainly of foam cells and proliferation of smooth muscle cells as well as elastic fibers. However, internal elastic lamina was relatively preserved. The atherosclerosis had cholesterine crystals and calcification as additional features. A constellation of these findings was considered to be in keeping with atherosclerosis commonly seen in humans.
A topographic distribution of the intimal thickening of carotid arteries seemed to have no correlation with the cholesterol level as well as the triglyceride level. Progressive thickening of the intima in bifurcations was demonstrated as the rabbits aged upto 20-month-old. In the rabbits above 20-month-old, almost all segments had intimal thickening. The lesion progressed from the bifurcations along a blood flow.
In conclusion, the author considers that WHHL rabbit is a suitable animal mode l to study atherosclerosis of carotid arteries ; however, some additional factor(s), presumably such as a hypertensive state, seems to be necessary to induced the atherosclerosis in intracranial arteries.
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