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Inhibition of tumor neovascularizatuon in the experimental brain tumors by hydrocortisone.

Research Project

Project/Area Number 63570692
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKawasaki Medical School

Principal Investigator

SUZUKI Yasuo  Kawasaki Medical School, Department of Neurosurgery, Assistant Professor, 脳神経外科, 助教授 (90143809)

Co-Investigator(Kenkyū-buntansha) WATANABE Akira  Kawasaki Medical School, Department of Neurosurgery, Lecturer, 脳神経外科, 講師 (20192437)
ISHII Ryoji  Kawasaki Medical School, Department of Neurosurgery, Professor, 脳神経外科, 教授 (40111710)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1989: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsMicrovascular architecture / Corrosion cast / Experimental brain tumor / Bromodeoxyuridine / Anti-angiogenesis / 免疫組織化学 / 走査電顕
Research Abstract

Tumor microcirculation is of crucial importance not only for the metabolism and behavior of tumor tissue but also for tumor therapy. Scanning electron microscopy of vascular corrosion casts and immuno- cytochemical study was undertaken to demonstrate the inhibition of the tumor neovasucularization by hydrocortisone in ethyinitrosourea induced brain tumors. Although a reduction in tumor developmental rate was observed in rats treated with hydrocotisone, microvascular architecture and bromodeoxyuridine(BrdU) labeled endothelial cells did not varied with or without hydrocortisone. In tumors less than 2mm in diameter no tumor vessels and BrdU labeled endothelial cells were observed, indicating an avascular phase of tumor growth. On the other hand, in tumors more than 2 mm in diameter, various vascular phases were observed. In particular, the peripheral zone of the tumors consisted of dilated and tortuous vessels and rich BrdU labeled endothelial cells which may be characteristic of angiogenesis.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 菊岡政久: "ラット脳における微小血管構築の検討ー血管鋳型走査電顕法による解析ー" 川崎医学会誌. 14. 539-551 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 菊岡政久: "Ethylnitrosourea誘発ラット実験脳腫瘍の微小血管構築に関する研究ー血管鋳型走査電顕法による検討ー" 川崎医学会誌. 15. 62-71 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masahisa Kikuoka: "Microvascular Architecture of the Rat Brain: Scanning Electron Microscopic Study of Vascular Corrosion Casts" Kawasaki medical Journal 14: 539-551, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masahisa Kikuoka: "Microvascular Architecture of Ethylnitrosourea-Induced Brain Tumors in Rats: Scanning Electron Microscopic Study of Vascular Corosion Casts" Kawasaki Medical Journal 15: 62-71, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 菊岡政久: "ラット脳における微小血管構築の検討-血管鋳型走査電顕法による解析-" 川崎医学会誌. 14. 539-551 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 菊岡政久: "Ethylnitrosourea誘発ラット実験脳腫瘍の微小血管構築に関する研究-血管鋳型走査電顕法による検討-" 川崎医学会誌. 15. 62-71 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 菊岡政久: 川崎医学会誌. 14. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 菊岡政久: 川崎医学会誌. 15. (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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