| Project/Area Number |
63570712
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Fujita Health University |
|---|
Principal Investigator |
YOSHIZAWA Hidezo Fujita Health University, Depatrment of Medicine, Professor, 医学部, 教授 (60084555)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYACHI Masaya Fujita Health University, Department of Medicine, Assistant, 医学部, 助手
SHIBAYAMA Toru Fujita Health University, Department of Medicine, Assistant, 医学部, 助手
HACHIYA Yudo Fujuta Health University, Department of Medicine, Assistant, 医学部, 助手
KOBAYASHI Shigeru Fujita Health University, Department of Medicine, Assistant, 医学部, 助手
NAKAI Sadaaki Fujita Health University, Department of Medicine, Assistant, 医学部, 助手
西沢 活史 藤田学園保健衛生大学, 医学部, 助手
黒瀬 純一 藤田学園保健衛生大学, 医学部, 研究員
|
|---|
| Project Period (FY) |
1988 – 1990
|
| Project Status |
Completed (Fiscal Year 1990)
|
| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
|
|---|
| Keywords | Nerve Root / Spinal cord / Anatomical structure / Blood flow / Oxygen partial pressure / Cerebro spinal fluid flow / Compression disturbance / 塩酸エペリゾン / 後根神経節 / 脊髄誘発電位 / 解部学的構造 |
|---|
| Research Abstract |
The fine structure, circulatory dynamics and the role of cerebrospinal fluid in the spinal cord and nerve roots of adult dogs have been studied to clarify the pathophysiology of the spinal cord and nerve roots disturbance, using scanning electron micro-scope, transmission electron microscope, motor, driven high speed camera, micro-blood flow meter (electro chemically generated hydrogen washout method), partial oxygen pressure meter and electromygraphy (DANTEC-N2000).
Results
1. Redicular arteriesand veins nourishing nerve roots are loosely connected with the nerve root sheath and flooring in the cerebrospinal fluid.
2. The endoneurial space is communicating with the subarachnoid space through the nerve root sheath which is very thin and permeable for the cerebrospinal fluid.
3. The blood flow in the nerve root decreases by 20 percent due to interception or exclusion of the cerebrospinal fluid.
4. Intraradicular capillaries are all continuous type and so the bloodnerve barrier is strong, but
… More
vasogenic edema occurs due to breakage of the barrier when the nerve root is compressed by more than 30 Grs.
5. Intravenous injection of proper amount of Eperisone hydrochloride (4-Ethy-2-methy-3-piperidinopropiopheone) increases the blood flow in the nerve root.
6. The blood flow in the lumbosacral spinal cord is reduced severely by interception of thoracic aorta. Evoked spinal cord action potentials are also decreased severely and the latency is prolonged.
7. When the clamp is released 30 minutes after interception of thoracic aorta, evoked spinal cord action potentials recover quickly, but the blood flow in the lumbosacral spinal cord specially in the gray matter stays in the reduced level for longer time.
8. The spinal cord is also soaked in the cerebrospinal fluid, because the pia mater is permeable for the cerebrospinal fluid and Virchow-Robin perivascular space reaches endarteries and endveins in all over the spinal cord.
9. The blood flow in the spinal cord decreases by about 15 percent due to interception or exclusion of the cerebrospinal fluid.
10. The partial oxygen pressure of the normal cerebrospinal fluid is considerably higher than the pressure in the spinal cord and the latter decreases by about 15 percent due to interception or exclusion of the cerebrospinal fluid.
11. These results indicate that the spinal cord and nerve roots are closely concerned with the cerebrospinal fluid, and changes in the condition of the cerebrospinal fluid flow exert serious influence upon the spinal cord and nerve roots. Less
|
