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Organ Specificity in the responses of isolated arteries to anesthetics.

Research Project

Project/Area Number 63570722
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

HATANO Yoshio  Kyoto University, Faculty of Medicine Associate Professor, 医学部, 助教授 (70115913)

Co-Investigator(Kenkyū-buntansha) MORI Kenjiro  Kyoto University, Faculty of Medicine Professor, 医学部, 教授 (20025620)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1989: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1988: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsVascular smooth muscle / Barbiturates / Halothane / Isoflurane / Cerebral artery / Coronary artery / Organ blood flow / バルビッレ-ト / 肝血流 / αー受容体
Research Abstract

The present study attempts to clarify the organ specificity in the responses to anesthetics of isolated arteries of different organs (cerebral, coronary, mesenteric, renal and femoral arteries). (1) In arterial strips under resting tension, the addition of thiamylal and thiopental(10^<-5> to 10^<-3> M) caused a dose-related contraction; the contraction was significantly more intense in cerebral than in extracerebral arteries. Secobarbital and pentobarbital failed to produce a significant contraction. Thiobarbiturates-induced contraction was attenuated by Ca channel blockers and abolished by the removal of Ca^<++> from extracellular fluids.
(2) In arterial strips previously contracted with KC1 or prostaglandin F_2alpha (PGF_<>alpha), thiobarbiturates in low concentrations (<10^<-4> M) produced a further contraction and in high concentrations (>3x10^<-4> M) a profound relaxation, indicating that thiobarbiturates possess biphasic effects. By contrast, oxybarbiturates were revealed to possess only relaxing effect.
(3) Regional difference of the response to halothane and isoflurane of large (>2.0 mm, OD) and small (<1.0 mm, OD) was investigated. Halothane (1-3 MAC) and nitroglycerin (NTG, 10^<-9> to 10^<-5> m) were revealed to produce greater relaxations in large than in small coronary arteries, and in contrast, isoflxirane (1-3 MAC) and adenosine (10^<-7> to 10^<-4> m) was revealed to produce relaxations greater in small than in large coronary arteries.
These findings with isolated arteries from different organ suggest that the vascular effects of anethetics are uniform in different organs. These different effects may contribute to maldistribution of blood flow during anesthesia.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Toda N: "Mechanisms underlying response to hypercapnia and bicarbonate of isolated dog cerebral arteries." American Journal of Physiology. 257. H141-H146 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshio Hatano: "The contractile responses of isolated dog cerebral and extracerebral arteries to oxybarbiturates and thiorbarbiturates." Anesthesiology. 71. 80-86 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshio Hatano: "Contribution of prostacyclin to d-tubocurarine-induced hypotension in humans." Anesthesiology. 72. 28-32 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Moriyama S:"Responses to barbiturates to isolated dog cerebral and mesenteric arteries contracted with KCL and prostaglandin F_2." Acta Anaesthesiologic Scandinavica.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshio Hatano: "Comparison of the direct effects of halothane and isoflurane on large and small coronary arteries isolated from dog." Anesthesiology.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Toda N: "Mechanisms underlying response to hypercapnia and bicarbonate of isolated dog cerebral arteries." Am J Physiol 257:H141-H146, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hatano Y: "The contractile responses of isolated dog cerebral and extracerebral arteries to oxybarbiturates and thiobarbiturates." Anesthesiology 71(1):80-86, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hatano Y: "Contribution of prostacyclin to d-tubocurarine-induced hypotension in humans." Anesthesiology 72(1):28-32, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Moriyama S: "Responses to barbiturates of isolated dog cerebral and mesenteric arteries contracted with KCl and prostaglandin F_<2alpha>." Acta Anaesth Scandinav.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hatano Y: "Comparison of the direct effects of halothane and isoflurane on large and small coronary arteries isolated from dog." Anesthesiology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Toda N:"Machanisms underlying response to hypercapnia and bicarbonate of isolated dog cerebral arteries." American Journal of Physiology. 257. H141-H146 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hatano Y:"The contractile responses of isolated dog cerebral and extracerebral arteries to oxybarbiturates and thiobarbiturates." Anesthesiology. 71. 80-86 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yoshio Hatano;et al.: Anesthesiology. 70. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Toda,N.;Hatano,Y.;Mori,K.: American Journal of Physiology. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 西和田誠,中村久美,畑埜義雄,薬師寺勤,森健次郎,奥田孝雄: 臨床薬理. (1989)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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