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Studies on the Prophylaxis, the Diagnosis and the Treatment of Malignant Hyperthermia

Research Project

Project/Area Number 63570726
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionHiroshima University

Principal Investigator

FUJIOKA Yasuhiro  Hiroshima University, Medical Hospital Instructor, 医学部・附属病院・集中治療部, 助手 (00192310)

Co-Investigator(Kenkyū-buntansha) KIKUCHI Hirosato  Touhou University, School of Medicine Professor, 医学部・麻酔学教室, 教授 (40034029)
KUBOTA Minoru  Hiroshima University, Medical Hospital Instructor, 医学部・附属病院・手術部, 助手 (00221226)
MUKAIDA Keiko  Hiroshima University, Medical Hospetal Instructor, 医学部・附属病院・手術部, 助手 (20182066)
FUJII Kohyu  Hiroshima University, School of Medicine Assistant Professor, 医学部・麻酔蘇生学教室, 講師 (60034021)
MORIO Michio  Hiroshima University, School of Medicine Professor, 医学部・麻酔蘇生学教室, 教授 (80033950)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1989: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsMalignant Hyperthermia / Skinned Fiber Test / Ca^<2+>-induced Ca^<2+> release (CICR) / Normal range of human skeletal muscle / Volatile narcotics / Local anesthetics narcotics / Statistical Analysis / Incidence of MH in Japan / Ca^<2+>ーinduced Ca^<2+> release(CICR) / ヒト正常値 / 統計的解析 / Ca-induced Ca release(CICR) / 麻酔系鎮痛薬 / アルコ-ル類 / 正常値 / スキンドファイバー法 / Ca-tnduced Ca release(CICR) / 悪性症候群
Research Abstract

<Studies with the Skinned Fiber Technique> In malignant hyperthermia patients, the rate of Ca^<2+>-induced Ca^<2+> release (CICR) from the sarcoplasmic reticulum (SR) seems to be abnormally potentiated in genetic.
This abnormality is observed with the skinned fiber technique. So we studied the effects of drugs used perioperatively on CICR and the rate of CICR of human skeletal muscle with the skinned fiber technique.
1) All volatile anesthetics in clinical concentration accelarated the rate of CICR at the mammalian temperature. All local anesthetics in clinical concentration didn't affect the rate of CICR, but according to their effects on the rate of CICR in about one thousand times higher concentration than clinical, the cocal anesthetic were divided into two groups ; CICR accelerators (lidocaime, mepivacaine, bupivacaine, prilocain) and CICR inhibitors (procaine, tetracaine). Muscle relaxants (depolarizing and non-depolarizing) didn't affected the rate of CICR, and all narcotics didn' … More t too.
2) In order to determine the standard value of the rate of CICR in human skeletal muscle, in normal 28 volunteers the rates of CICR were measured by skinned fiber technique. No significant difference couldn't be observed by sex and age. So we determined the value of mean<plus-minus>2SD as the normal rang
3) The rate of CICR of 116 patients suspected MH were measured. In 16 cases out of 18 fulminant MH cases the rate of CICR potentieted, but in 25 cases out of 27 abortive MH within normal range.
<Statistical review of fulminant malignant hyperthermea in Japan>
We collected fulminant MH cases reported from 1961 to 1990 in Japan and analyzed them retrospectively.
Total number of fulminant MH cases that we could collect were 252, 196 in male and 56 in female.
Mortality rate was 34.9%. The mortality rate in patients whose maximum body temperature above 40^゚C was 46.2%, but that below 40^゚C was 4.4%. The mortality in dantloren-treated patients was lower than one in dantloren-no-treated.
In recent years (1986-1990), the mortality decreased to 13.0% and the cases anesthetized by enflurane increased.
<Various incidences of fulminant malignant hyperthermia in Japan>
The total number of general anesthesias from 1976 to 1987 was 8,900,000 and 140 cases of fulminant MH were reported for the same period. The average incidence was 1 out of 64,000 general anesthesias.
The incidence of male MH was 3.6 times greater than that of female MH.
Based on the age distribution of general anesthesia and the number of fulminant MH cases, the calculated incidence of fulminant MH was proved to be highest in male twenties (1 : 11,000). Less

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] Fujioka,Y.: "Effects of volatile and local anesthetics on Ca^<2+> release in the skinned skeletal muscle of guinea pig" Malignant Hyperthermia on Update.(Proceeding of VI Myology Colloguium). Berlin. 229-235 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Matsui,K.: "Differences of Ca^<2+>ーrelates functions in skeletal muscle between malignant hyperthemia and neureleptic malignant sysdrome" Malignant Hyperthermia on Update.(Proceeding of VI Myology Colloguium). Berlin. 160-167 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Nakao,M.: "Incidence and clinical features of fulminant malignant hyperthemia in Japan" Malignant Hyperthermia on Update.(Proceeding of VI Myology Colloguium). Berlin. 30-37 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Matsui,K.: "Effects of several volatile anesthetics on Ca^<2+>ーrelated functions of skinned muscle fibers from the guinea pig." Hiroshima J.of Medical Sciences. 40(1). 9-13 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 藤岡 泰博: "局所麻酔薬のCaーinduced Careleaseに与える影響" 麻酔と蘇生(別冊悪性高熱研究の進歩XI). 24. 19-23 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 向田 圭子: "筋生検テストの行われた悪性高熱症の検討" 麻酔と蘇生(別冊悪性高熱研究の進歩XIII). 26. 41-45 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 久保田 稔: 麻酔と蘇生(別冊悪性高熱研究の進歩XIII). 26. 19-25 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 盛生 倫夫: "悪性高熱症" 金原出版株式会社, 224 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujioka, Y., Matsui, K., Morio, M., Fujii, K. and Mukaida, K.: "Effects of volatile and local anesthetics on Ca^<2+> release in the skinned skeletal muscle" Malignant Hyperthermia an Update, (Proc of the VI Myology Collogium). 229-235 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Matsui, K., Fujioka, Y., Takahashi, M., Fujii, K. and Morio, M.: "Differences in Ca^<2+>-related functions in skeletal muscle between malignant hyperthermia and neuroleptic malignant syndrome" Malignant Hyperthermia an Update, (Proc of the VI Myology Colloqium). 160-167 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Nakao, M., Morio, M., Mukaida, K., Arai, K., Fujioka, Y., Matsui, K. and Yuge, O.: "Incidence and clinical features of fulminant hyperthermea in Japan" Malignant Hyperthermia an Update, (Proc of the VI Myology Colloqium). 30-37 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujioka, Y., Matsui, K., Mukaida, K., Yuge, O., Kikuchi, H. and Morio, M.: "Effects of lidocaine on Ca^<2+> recruitment in the skinned skeletal muscle of the guinea pig" Hiroshima Journal of Anesthesia. 24(Supplement). 19-23 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Matsui, K., Fujioka, Y., Mukaida, K., Takahashi, M., Fujii, K., Kikuchi, H. and Morio, M.: "Ca^<2+> metabolism in skeletal muscle biopsied from neuroleptic malignant syndrome patients examined with the skinned fiber technique" Hiroshima Journal of Anesthesia. 24(Supplement). 1-6 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morio, M., Kikuchi, H., Yuge, O., Murata, K., Fujioka, Y., Mukaida, K. and Mori, K: "Clinical criteria of Malignant Hyperthermia-Revised Criteria-" Hiroshima Journal of Anesthesia. 24(Supplement). 104-110 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Mukaida, K., Kikuchi, H., Morio, M., Arai, K., Fujioka, Y., Matsui, K., Nakao, M., Kinoshita, H., Nakao, M., Shiraishi, M., Murata, K. and Yuge, O.: "Statistical review of Malignant Hyperthermia in Japan(1987)" Hiroshima Journal of Anesthesia. 24(Supplement). 97-103 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fjjioka, Y., Matsui, K., Mukaida, K., Takahashi, M., Fujii, K., Yuge, O. and Morio, M.: "Effects of depolarizing muscle relaxant(Succinylcholine chloride) on Ca^<2+> recruitment in the skinned skeletal muscle of the guinea pig" Hirohima Journal of Anesthesia. 25(Supplement). 31-25 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Mukaida, K., Morio, M., Fujioka, Y., Takahashi, M., Matsui, K., Nakao, M., Kinoshita, H., Shiraishi, M., Yuge, O. and kikuchi, H.: "Statistical review of Malignant Hyperthermia in Japan(1988)" Hirosima Journal of Anesthesia. 25(Supplement). 119-125 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Matsui, K., Fujioka, Y., Mukaida, K., Takahashi, M., Fujii, K. and Morio, M.: "The effect of the various volatile anesthetics on Ca-induced Ca release of the sarcoplasmic reticulum in the skinned skeletal muscle from the guinea pig at the mammalian body temperature" Hiroshima Journal of Anesthesia. 25(Supplement). 27-30 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Matsui, K., Fujioka, Y., Mukaida, K., Takahashi, M. and Morio, M.: "The diagnosis of Malignant Hyperthermia by the skinned fiber test -the results of the last two years-" Hiroshima Journal of Anesthesia. 25(Supplement). 55-59 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takahashi, M., Matsui, K., Fujioka, Y., Mukaida, K., Hoshino, S., Ohtani, M. and Morio, M.: "Ca^<2+> metabolism in skeletal muscle biopsied from a Heat Stroke patient with multiple organ failure examined with the skinned fiber technique" Hiroshima Journal of Anesthesia. 25(Supplement). 71-75 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takahashi, M., Mukaida, K., Nakagawa, I., Matsui, Fujioka, Y., Shiraishi, M., Fujii, K., Yuge O. and Morio, M.: "Normal value of Ca^+-induced Ca release rates in human skeletal muscle" Hiroshima Journal of Anesthesia. 26(Supplement). 37-40 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Mukaida, K., Fujioka, Y., Matsui, K., Takahashi, M., Shiraishi, M., Nakao, M., Kinoshita, H., Yuge O. and Morio, M.: "A study on Malignant Hyperthermia patients tested muscle contracture test" Hiroshima Journal of Anesthesia. 26(Supplement). 41-45 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kubota, M. et al: "Statistical review of Malignant Hyperthermia in Japan(1989)" Hiroshima Journal of Anesthesia. 26(Supplement). 19-25 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morio, M. and Mori, K.: Kanehara & Co. Ltd., Tokyo. Manual for treatment of Malignant Hyperthermia, 224 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 久保田 稔: "わが国の悪性高熱症の集計(1989年)" 麻酔と蘇生(別冊悪性高熱研究の進歩XIII). 26. 19-25 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 高橋 雅子: "Ca^<2+>ーinduced Ca^<2+> releaseにおける正常値の検討" 麻酔と蘇生(別冊悪性高熱研究の進歩XIII). 26. 37-40 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 向田 圭子: "筋生検テストの行われた悪性高熱症の検討" 麻酔と蘇生(別冊悪性高熱研究の進歩XIII). 26. 41-45 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 高橋 雅子: "ヒト骨格筋小胞体からのCa^<2+>ーinduced Ca^<2+> release速度の正常値の検討" 麻酔と蘇生. 26(4). 325-330 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsui,K.: "Effects of several volatile anesthetics on Ca^<2+>ーrelated functions of skinned muscle fibers form the guinea pig" Hiroshima J.of Medical Sciences. 40(1). 9-13 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 菊地 博達: "悪性高熱症の筋生検診断法" 医学のあゆみ. 152. 382 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤岡泰博: "リドカインは悪性高熱症に禁忌か?" 医学のあゆみ. 148(10). 660 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 藤岡泰博: "脱分極性筋弛緩薬サワシニ-ルコリン・クロライドとCa-induced Ca release" 麻酔と蘇生(別冊悪性高熱研究の進歩XII). 25. 31-35 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 松井一幸: "哺乳類体温における各種揮発性麻酔薬のモルモット骨格筋小胞体のCa-induced Ca releaseへの作用" 麻酔と蘇生(別冊悪性高熱研究の進歩XII). 25. 27-30 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 松井一幸: "過去2年間におけるスキンドファィバ-法による悪性高熱症の診断" 麻酔と蘇生(別冊悪性高熱研究の進歩XII). 25. 55-59 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 高橋雅子: "多臓器障害を併発した熱中症患者の骨格筋におけるカルシウム動態の検討" 麻酔と蘇生(別冊悪性高熱研究の進歩XII). 25. 71-75 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 向田圭子: "わが国の悪性高熱症の集計(1988年)" 麻酔と蘇生(別冊悪性高熱研究の進歩XII). 25. 119-125 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Fujioka, Y.: Proceeding of VI Myology Colloquium. Workshop on Malignant Hyperthernua.(Jena/GDR). (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Matsui, K.: Proceadings of VI Myology Colloquium Workshop on Malignant Hyperthernua.(Jena/GDR). (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Nakao, M.: Proceadings of VI Myology Colloquium Workshop on Malignant Hyperthernua.(Jena/GDR). (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 藤岡泰博: 麻酔と蘇生(悪性高熱研究の進歩×1). 23(別冊). 19-23 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 松井一幸: 麻酔と蘇生(悪性高熱研究の進歩×1). 23(別冊). 1-6 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 向田圭子: 麻酔と蘇生(悪性高熱研究の進歩×1). 23(別冊). 97-108 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 松井一幸: 麻酔. 38巻. 195-201 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 盛生倫夫: "悪性高熱症" 金原出版株式会社, 224 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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