| Project/Area Number |
63570805
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | TOKYO MEDICAL AND DENTAL UNIVERSITY |
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Principal Investigator |
TANIGUCHI Ikuo Tokyo Medical and Dental University Medical Research Institute, Assoc. Professor, 難治疾患研究所, 助教授 (60014255)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Hidekazu Ogawa Red Cross Hospital Dept. of Otolaryngology, Head, 耳鼻咽喉科, 部長 (50163556)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1988: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Regeneration / Synaptic reorganization / Post-lesion plasticity / Inferior colliculus / Commissure of inferior colliculus / Auditory central nerve |
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| Research Abstract |
Regenerative responses to damage in the central nervous system (CNS) can be elicited may two types of mechanisms. One is regenerative sprouting or axonal regeneration from damaged neurons and the other is collateral sprouting from intact neurons. Collateral sprouting occurs widely in the CNS, as well as in the peripheral nervous system. On the other band, in the mammalian CNS, axonal regeneration is usually abortive. In this study, we observed axonal regeneration in the commissure of the inferior colliculus (CIC) of mice following its transection. While evidence concerning morphological re-organization of the CNS is accumulating, little is known about the consequent recovery of function at the cellular level. The purpose of this study was to examine whether the regenerated CIC axons could re-establish synapses with neurons in the inferior colliculus (IC). If the synapses were re-established, our concern was their functional features. Some statistical differences were found between the two neuronal populations of the operated mice and the unoperated controls. However, the re-established synapses seem to be properly re-organized into newly established neural circuits which may be similar to those in the intact animals. This means the restitution of synaptic integrity occurs even after mechanical transection of the axons within mammalian brain.
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