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Secondary Changes of Choroid Followed by Domages of Photoreceptor and Retinal Pigment Epithelium

Research Project

Project/Area Number 63570831
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionOkayama University

Principal Investigator

SHIRAGA Fumio  Okayama Medical School, Asist. Prof, 医学部・附属病院, 助手 (50187530)

Co-Investigator(Kenkyū-buntansha) KAWANISHI Yojiro  Okayama Medical School, Asist. Prof, 医学部・附属病院, 助手 (80211184)
TOYOTA Eiji  Okayama Medical School, Asist. Prof, 医学部・附属病院, 助手 (70207645)
MATSUOKA Tooru  Okayama Medical School, Asist. Prof, 医学部・附属病院, 講師 (10165780)
小山 雅也  岡山大学, 医学部附属病院, 助手 (50195880)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1989: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1988: ¥600,000 (Direct Cost: ¥600,000)
KeywordsChoroidal Circulation / Monoiodoacetic acid / Dark Adaptation / Light Adaptation / Hydrogen Clearance Method / Outer Retina / 視細胞障害モデル / 網膜色素上皮細胞障害 / 脈絡膜組織血流量 / オルニチン / 水素フリアランス法 / モノヨ-ド酢酸 / 網膜色素上皮細胞障害モデル / 網膜剥離
Research Abstract

It is well known that the degeneration of outer retina is caused by choroidal circulatory disturbance. But the choroidal circulatory change followed by outer retinal change is unknown. Thus this study was designed to determine choroidal circulatory change in the model of outer retinal damage.
Choroidal blood flow (CBF) was measured by hydrogen clearance method in albino rabbits whose outer retina had been selectively damaged. In addition histological changes were studied by light and electron microscopy.
In the model of outer retinal damage after monoiodoacetic acid administration, CBF decreased as the degeneration of photoreceptor and retinal pigment epithelium (RPE) proceeded. Histologically, the disappearance of choriocapillaris followed by outer retinal damage was seen at the sites of disappearance of RPE cells, but the choriocappilaris survived at intact sites of RPE.While the dark and light adaptation, which must change oxigen demand of the outer retina, did not influence CBF.
The results showed as follows :
1) The choroidal circulatory disturbance is caused by irreversible damage of the outer retina and the choriocappilaris structure may be regulated by the RPE.
2) Choroidal circulation with large blood flow may have no reaction mechanism for the reversible and minimal change of outer retina such as dark or light adaptation.

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 那須好滋: "網膜外層障害モデルにおける脈絡膜循環の研究 第1報 モノヨード酢酸投与による急性期の変化について" 日本眼科紀要. 40巻. 1659-1668 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 那須好滋: "網膜外層障害モデルにおける脈絡膜循環の研究 第2報 モノヨード酢酸投与による慢性期の変化について" 日本眼科学会雑誌. 93巻. 152-159 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 守本典子: "暗・明順応下の脈絡膜組織血流量に関する研究 第1報 暗順応下の脈絡膜組織血流量" 日本眼科学会雑誌. 93巻. 790-795 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 守本典子: "暗・明順応下の脈絡膜組織血流量に関する研究 第2報 明順応下の脈絡膜組織血流量" 日本眼科学会雑誌. 95巻. 235-240 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Koji Nasu: "Studies on choroidal circulation in the model of which the outer layr of the retina was selectively damaged-Choroidal blood flow in acter stage after monoiodoacetic acid injection-." Folia Ophthalmol Jpn.40. 1659-1668 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Koji Nasu: "Choroidal blood flow in chronic stage of selective retinal damage after monoiodoacetic acid injection." Acta Soc Ophthalmol Jpn.94. 152-159 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Noriko Morimoto: "Study on choroidal blood flow at dark and light adaptation 1. choroidal blood flow at dark adaptation." Acta Soc Ophthalmol Jpn.93. 790-795 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Noriko Morimoto: "Study on choroidal blood flow at dark and light adaptation 2. choroidal blood flow at light adaptation." Acta Soc Ophthalmol Jpn.95. 235-240 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 那須 好滋: "網膜外層障害モデルにおける脈絡膜循環の研究 第1報モノヨ-ド酢酸投与による急性期の変化について" 日本眼科紀要. 40. 1659-1668 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 守本 典子: "暗・明順応下の脈絡膜組織血流量に関する研究 第1報暗順応下の脈絡膜組織血流量" 日本眼科学会雑誌. 93. 790-795 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 那須 好滋: "網膜外層障害モデルにおける脈絡膜循環の研究 第2報モノヨ-ド酢酸投与による慢性期の変化について" 日本眼科学会雑誌. 94. 152-159 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 守本 典子: "暗・明順応下の脈絡膜組織血流量に関する研究 第2報明順応下の脈絡膜組織血流量" 日本眼科学会雑誌. 95. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 那須好滋: "網膜外層障害モデルにおける脈絡膜循環の研究第1報モノヨ-ド酢酸投与による急性期の変化について" 日本眼科紀要. 40. 1659-1668 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 守本典子: "暗・明順応下の脈絡膜組織血流量に関する研究第1報暗順応下の脈絡膜組織血流量" 日本眼科学会雑誌. 93. 790-795 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 那須好滋: "網膜外層障害モデルにおける脈絡膜循環の研究第2報モノヨ-ド酢酸投与による慢性期の変化について" 日本眼科学会雑誌. 94. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 那須好滋: 日本眼科紀要. 40. (1989)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2017-10-19  

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