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Dynamic mechanical-properties and ATPase activities in masticatory muscles.

Research Project

Project/Area Number 63570881
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionTsurumi University

Principal Investigator

SAEKI Yasutake  Tsurumi Univ. Sch. Dent. Med., Associate Professor, 歯学部, 助教授 (20046113)

Co-Investigator(Kenkyū-buntansha) SHIOZAWA Kouichi  The same as the above, Instructor, 歯学部, 助手 (30097315)
加藤 千賀子  鶴見大学, 歯学部, 助手 (90148049)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1989: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1988: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsMasticatory muscle / Cross-bridge kinetics / ATPase activity / Shortening velocity / isometric tension / Cross-bridge Kinetics / 力学特性 / ATDase活性
Research Abstract

To evaluate the dynanic mechanical-properties of contractile system and the ATPase activity in jaw muscles, we analyzed the tension transients in response to small ( 1% of muscle length ) step and sinusoidal length perturbations, and the Ca^<2+> sensitivity of isometric tension development, ATPase activity and maximum shortening velocity (Vmax) in guinea pig glycerinated masseter, temporal and digastric muscles, using a newly developed length servocontrol system. The transient tension responses could be approximated by three exponential functions, each of which has a time constant, T_1, T_2, T_3 in the order of large to small, as has been observed in other skeletal muscles. T_2 and T_3, which are believed to reflect the rate of cross-bridge cycling, were different among the three muscles (in the digastric in the temporalis in the masseter) when the preparations were activated maximally. These results indicate higher cross-bridge cycling rate in the masseter and lower rate in the digastric muscle. The isometric tension increased in a sigmoid fashion with an increase in Ca^<2+> concentration from about pCa 6.6 to pCa 5.8 in all of the three muscles. The ATPase activity also increased sigmoidally with an increase in Ca^<2+> concentration from slightly above pCa 6.6 to slightly below pCa 5.8. The tension cost (ATPase activity / isometric tension) estimated from above results was lower in the digastrib than in the temporalis or masseter, indicating more economical ATP consumption in the digastric. Vmax increased, with an increase in Ca^<2+> concentration (i.ei., with an increase in isometric tension), and greater in the masseter than in the other two muscles when compared at the same developed tension level. These results seem to be consistent with the results obtained from the transient tension response analysis.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 加藤千賀子: "モルモット咀嚼筋のグリセリン処理標本における最大短縮速度" 鶴見歯学. 14. 285-293 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] C.H.Paik: "Bite-raising treatment alters the mechanical properties in guinea-pig masticatory muscles." 2nd International Congress of Japan Orthodontic Society(Abstracts). 215 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K.Shiozawa: "Effects of mechanical stimulation of the tongue and electrical stimulation of the glossopharyngeal nerve on the activity of the inhrahyoid muscle in the frog,Rana Catesbeiana." Jpn.J.Oral Biol.31. 745-748 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 塩沢光一: "カエル舌刺激で胸骨舌骨筋に誘発される反射応答の比較" 歯基礎誌. 31. 54 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] C.H.Paik: "Increase in vertical dimension alters tension cost in glycerinated masseter of guinea pig." 20th European Orthodontic Society. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] C.H.Paik: "Increase in vertical dimension alters mechanical properties and ATPase activity in guinea pig masseter." Submitted to Am.J.Orthod.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] C. Kato: "The maximum velocity of shortening in glycerinated guinea-pig masticatory muscle." Tsurumi Shigaku 14, 1988, 285-293.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] C.H. Paik: "Bite-raising treatment alters the mechanical properties in guinea-pig masticatory muscles." 2nd International Congress of Japan Orthodontic Society, Abstract, 1988, 215.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Shiozawa: "Effects of mechanical stimulation of the tongue and electrical stimulation of the glossopharyngeal nerve on the activity of the inhrahyoid muscle in the frog, Rana catesbeiana." Jpn. J. Oral Biol. 31, 1989, 745-748.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Shiozawa: "Refrex responses of sternohyoid muscle to mechanical stimulation of the tongue in the frog, Rana catesbeiana." Jpn. J. Oral Biol. 31, 1989, 54.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] C.H. Paik: "Increase in vertical dimension alters tension cost in glycerinated masseter of guinea pig." 20th European Orthodontic Society 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] C.H. Paik: "Increase in vertical dimension alters mechanical properties and ATPase activity in guinea pig masseter." Am. J. Orthod.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shiozawa,K.: "Effects of mechanical Stimulation of the tongue and electrical stimulation of the glossophatyngeal nerve on the activity of the infrahyoid muscles in the frog,Rana catesbeiana." Jpn.J.Oral Biol.31. 745-748 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 柴山秀雄: "筋の力学特性測定時の信号処理における問題点" 医用電子と生体工学. 27. 87 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 塩沢光一: "カエル舌刺激で胸骨舌骨筋に誘発される反射応答の比較" 歯基礎誌. 31. 54 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Paik,C.H.: "Increase in vertical dimension alters tension cost in glycerinated massetrt of guinea pig." 20th European Orthodontic Society. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 柴山秀雄: "ディジタル信号処理技術を用いた心筋の力学特性測定システム" 第29回日本ME学会大会. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Paik,C.H.: "Increasa in vertical dimension alters mechanical properties and ATPase activity in guinea pig masseter." Submitted to AM.J.Orthod.

    • Related Report
      1989 Annual Research Report
  • [Publications] 加藤千賀子: 鶴見歯学. 14巻. 285-293 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] C,H,Paik.: 2nd Internafional Congress of Japan Orfhodontic Society.Abstracts. 215 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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