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Effect of Drugs for Intravenous Sedation on Human Neutrophil Chemiluminescence

Research Project

Project/Area Number 63570946
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionShowa University

Principal Investigator

YOSHIMURA Setsu  Showa university, dentistry, associate professor, 歯学部, 助教授 (50112735)

Co-Investigator(Kenkyū-buntansha) IKUMI Shuji  Showa university, dentistry, assistant, 歯学部, 助手 (70211026)
GOTOH Kinuko  Showa university, dentistry, assistant, 歯学部, 助手 (70176262)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1989: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1988: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsChemiluminescence / Neutrophil / Intravenous sedation / Diazepam / Benzodiazepine / ミダゾラム / フルニトラゼパム
Research Abstract

The chemiluminescence is an index of oxygen free-radical generation, which is an important bactericidal mechanism. The effect of benzodiazepine compound, diazepam on human neutrophil chemiluminescence was evaluated. Chemiluminescence was measured after neutrophil activation of the opsonized zymosan . ht emission was measured using an ATP photometer.
In vitro studies, we found that diazepam produce reductions in chemiluminescence at concentrations of 1 ug/ml to 40ug/ml and the depression was dose dependent. This inhibitory effect of diazepam was reversible and chemiluminescence was recovered after washing out of diazepam.
In clinical practice, we investigated plasma concentrations and the effect of diazepam on human neutrophil chemiluminescence in healthy volunteers received intravenous sedation with diazepam (0.2mg/kg). Mean plasma umiconcentration at three minutes after administration of diazepam was 14.1 <plus-minus>1.9 mu/ml. we found the chemiluminescence was inhibited transiently undergoing intravenous sedation with diazepa

Report

(3 results)
  • 1990 Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 吉村 節: "ベンゾジアゼピン系薬剤による好中球chenulumunescenceへの影響" 麻酔. 37巻10号. 343- (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 吉村 節: "ベンゾジアゼピン系薬剤が好中球chenuluminescenceに及ぼす影響" 日本歯科麻酔学会雑誌. 17巻1号. 142- (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 吉村 節: "ジアゼパム投与が好中球chenulumnescenceに及ぼす影響" 麻酔. 38巻9号. 238- (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 吉村 節: "水溶性ベンゾジアゼピン系薬剤が好中球化学発光に及ぼす影響について" 18巻1号. 147- (1980)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Setsu YOSHIMURA: "Effect of benzodiazepine drugs on human neutrophil chemiluminescence" Jpn J Anesthesiol. 37. 343 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Setsu YOSHIMURA: "Effect of diazepam for intravenous sedation on human neutrophil chemiluminescence." Jpn J Anesthesiol. 38. 238 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 吉村節: "ジアゼパム投与が好中球Chemi lumrniscenceに及ぼす影響" 麻酔. 38巻9号. 238 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 吉村節: "水溶性ベンゾジアゼピン系薬剤が好中球化学発光に及ぼす影響について" 日本歯科麻酔学会雑誌. 18巻1号. 147 (1980)

    • Related Report
      1989 Annual Research Report
  • [Publications] 吉村節: 麻酔. 37巻10号. 343 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 吉村節: 日本歯科麻酔学会雑誌. 17巻1号. 142 (1989)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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