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Theoretical Study of Underlying Mechanism of Tremor with Reference to Its External Control

Research Project

Project/Area Number 63571075
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 医学一般
Research InstitutionUniversity of Tokyo

Principal Investigator

WATANABE Akira  University of Tokyo, Faculty of Medicine, Associate Professor, 医学部(医), 助教授 (00009937)

Co-Investigator(Kenkyū-buntansha) IKEDA Kenji  University of Tokyo, Faculty of Medicine, Instructor, 医学部(医), 助手 (70010030)
SAITO Masao  University of Tokyo, Faculty of Medicine, Professor, 医学部(医), 教授 (60010708)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1989: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1988: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsPhysiological tremor / Biological modeling / Stretch reflex / Biomechanics / モデル
Research Abstract

The purpose of this study is to provide the means of analyzing tremor quantitatively with reference to its external control. Although tremor is expected to provide much neurological information, its underlying mechanism has not been clarified from the control-theoretical point of view so far. Previously, we proposed the two-reflex-loop model incorporating the spinal and supraspinal reflexes. In this study, attempts are made to validate the model experimentally and to develop the methodology of estimating the effect of external tremor control based on the model.
Forced oscillation experiments are performed to validate the model. The wrist is fixed to a vibrator and hand acceleration and demodulated EMG are measured and analyzed by the FFT method. A systematic change in the phase angle between acceleration and demodulated EMG signals is observed. Results of simulation based on the model agree with the experimental results.
In designing external tremor control by mechanical loading or external feedback, information is required of the tendency of oscillation. For the complex variable s=alpha+jomega in Laplace-transformed equations, the real part alpha can become positive or negative, corresponding to self-induced or damped oscillation, respectively. Hence alpha is considered to represent the tendency of oscillation. The effectiveness of this method is demonstrated by calculating the variables as functions of the two reflex loop gains.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 渡辺瞭: "生理的振戦の加速度と筋電図変化の位相解析" 第3回生体・生理工学シンポジウム論文集. 251-254 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A.Watanabe: "Analysis of self-induced hand oscillation as a model of physiological tremor" Proc.World Cong.Med.Phys.Biomed.Eng.(San Antonio). 370 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 渡辺瞭: "手の自励および強制振動時の加速度と筋電図の特性" 第27回生体ME学会大会論文集. 656 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 渡辺瞭: "手の自励および強制振動の位相特性解析" 第28回生体ME学会大会論文集. 184 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 渡辺瞭: "手の自励振動と筋活動との間の位相情報の意味するもの" 第29回生体ME学会大会論文集. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A. Watanabe et al.: "Phase analysis of physiological tremor acceleration and EMG (in Japanese)" Proc. 3rd Symposium Biol. & Physiol. Eng., 251-254, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A. Watanabe et al.: "Mechanical and electromyographic study of self-induced and forced oscillation of the hand (in Japanese)" Proc. 27th Conf. Jap. Soc. MEBE, 656, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A. Watanabe et al.: "Analysis of phase characteristics of self-induced and forced oscillation of the hand (in Japanese)" Proc. 28th Conf. Jap. Soc. MEBE, 184, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A. Watanabe et al.: "Implication of phase information between self-induced hand oscillation and muscle activity (in Japanese)(in press)" Proc. 29th Conf. Jap. Soc. MEBE, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 渡辺瞭: "手の自励および強制振動の位相特性解析" 第28回日本ME学会大会論文集. 184 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 渡辺瞭: "手の自励振動と筋活動との間の位相情報の意味するもの" 第29回日本ME学会大会論文集. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 渡辺瞭: 第3回主体・生理工学シンポジウム論文集. 251-254 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 渡辺瞭: 第27回日本ME学会大会論文集. 656 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] A.Watanabe: Proc.World Cong.Med.Phys.Biomed.Eng(San Antonio). 370 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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