| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Research Abstract |
Of the five cytokines tested (tumor necrosis factor, interleukin 1, colony-stimulating factor, interferon alpha, beta, and gamma), only tumor necrosis factor (TNF) showed a potent stimulatory effect on the acetyltransferase activity of human neutrophils, which is a key enzyme for the production of platelet-activating factor. This potentiating effect of TNF was time- and dose-dependent and could be effectively blocked by antiserum against TNF. None of Intracellular Ca^<++> elevation, protein kinase C activation, and arachidonic acid metabolites appeared to be involved in the TNF-induced potentiation of the acetyltransferase activity in neutrophils, and the mechanism of TNF potentiation remains to be clarified.
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