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Development of Novel Sensors Using Macrocyclic Polyamines as Sensory Elements

Research Project

Project/Area Number 63840019
Research Category

Grant-in-Aid for Developmental Scientific Research (B).

Allocation TypeSingle-year Grants
Research Field 分析・地球化学
Research InstitutionHokkaido University

Principal Investigator

UMEZAWA Yoshio  Hokkaido University, Faculty of Science, Professor, 理学部, 教授 (80011724)

Co-Investigator(Kenkyū-buntansha) KOIKE Tohru  Hiroshima University School of Medicine, Lecturer, 医学部, 講師 (90186586)
KIMURA Eiichi  Hiroshima University School of Medicine, Professor, 医学部, 教授 (30034010)
KATAOKA Masamitsu  Hokkaido University, Faculty of Science, Instructor, 理学部, 助手 (40091425)
SUGAWARA Masao  Hokkaido University, Faculty of Science, Instructor, 理学部, 助手 (50002176)
ODASHIMA Kazunori  Hokkaido University, Faculty of Science, Lecturer, 理学部, 講師 (30152507)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥11,100,000 (Direct Cost: ¥11,100,000)
Fiscal Year 1989: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1988: ¥7,900,000 (Direct Cost: ¥7,900,000)
KeywordsMacrocyclic Polyamine / Anion-selective Electrode / Adenosine Nucleotide / Dicarboxylic Acid / Potentiometry / Langmuir-Blodgett (LB) Membrane Sensor / Permeability Change / Cyclic Voltammetry / 脂溶性大環状ポリアミン / 分子認識素子 / ATP^<4->センサ- / ジカルボン酸陰イオンセンサ- / ボルタンメトリックセンサ- / イオンチャンネル型センサ- / 単分子累積膜 / ATP^<4->センサー / ジカルボン酸陰イオンセンサー / 中性分子センサー
Research Abstract

A novel type of chemical sensors were constructed by using macrocyclic polyamines and related compounds as sensory elements. Potentiometric responses and selectivities were investigated and the following results were obtained, demonstrating a remarkable potentiality of this class of hosts as novel sensory elements.
(1) The macrocyclic polyamine liquid membrane electrodes showed strong potentiometric responses and marked selectivities for organic anions such as adenosine nucleotides and dicarboxylates. Potentiometric selectivities based on the magnitude of charge or the distance between charges within the guest molecule were observed.
(2) These electrodes also showed potentiometric responses to catechol and related compounds that are in the nonionic forms at the experimental pH. A systematic investigation demonstrated proton ejection as a possible mechanism for potentiometric responses to the uncharged molecules.
(3) Sapphyrin (expanded porphyrin) and cytosine-pendant triamine were examined as novel sensory elements for anion-selective liquid membrane electrodes.
(4) Anion responsive Langmuir-Blodgett (LB) membrane sensors were fabricated with polyamine hosts. Selectivities for organic anions were evaluated on the basis of analyte-induced permeability changes detected by cyclic voltammetry.

Report

(3 results)
  • 1990 Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] M.Uto: "Biosensor Development with a Glutsmate Receptor IonーChannel Reconstituted in a Lipid Bilayer" Anal.Sci.6. 221-225 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S.Nagase: "Voltammetric Anion Responsive Sensors Based on Modulation of Ion Permeability through LangmuirーBlodgett Films Containing Synthetic Anion Receptors" Anal.Chem.62. 1252-1259 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M.Sugawara: "Enhancement of Analyte Concentration Based on a Feed/Receiving Volume Effect in Uphill Membrane Transport" Anal.Sci.7. 141-147 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M.Sugawara: "Effect of Membranous Surface Charge on HostーGuest Complexation of Valinomycin in Synthetic Lipid Monolayer at the AirーWater Interface" Langmuir.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Umezawa: "Surface Chemistry and Potential Response of Copper Sulfide Based IonーSelective Membrane in Ligand Solutions" Mikrochim.Acta. I. 231-239 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 長縄 竜一: "脂溶性N_4及びN_5大環状ポリアミンを感応素子とする陰イオン選択性液膜の電位応答挙動の比較" 分析化学. 39. 671-676 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 片岡 正光: "キレ-ト剤を包埋したリポソ-ムを用いる金属イオンの増幅定量" 分析化学. 39. 789-792 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 河合 崇欣: "二酸化炭素センサ-を用いる藻類増殖時の実験池中の溶存無機炭素濃度の連続測定" 分析化学. 39. 649-653 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 小田嶋 和徳: "化学センサ-とホストーゲスト化学" ファルマシア. 26. 350-355 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 管原 正雄: "膜を用いるイオン・分子認識の新しいアプロ-チ" 膜. 15. 112-120 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 管原 正雄: "生体膜機能に学ぶセンシング化学" ぶんせき. 868-875 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 南 尚嗣: "新しい電気分析法のための脂質二分子膜作製法" ぶんせき. 554-556 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Umezawa: "IonーChannel Sensors" Proceedings of the JSPS/NUS Joint Seminar on Analytical Chemistry. 95-109 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Umezawa(編著): "CRC Handbook of IonーSelective Electrodes:Selectivity Coefficients" CRC Press, 848 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 梅澤 喜夫(編著): "膜と界面ー新しい分析法のメディア" 学会出版センタ-, 322 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 小田嶋 和徳(共著): "機能性太環状化合物の分析化学への応用" アイピ-シ-, 78 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K.Odashima(共著): "Biosensor Technology" Marcel Dekker, 23 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. SUGAWARA, M. OMOTO, H. YOSHIDA, Y. UMEZAWA: "Enhancement of Uphill Transport by a Double Carrier Membrane System" Anal. Chem.60. 2301-2303 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. UMEZAWA, M. KATAOKA, W. TAKAMI, E. KIMURA, T. KOIKE AND H. NADA: "Potentiometric adenosine triphosphate polyanion sensor using a lipophilic macrocyclic polyamine liquid membrane" Anal. Chem.60. 2392-2396 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. UOSAKI, Y. SHIGEMATSU, H. KITA, Y. UMEZAWA AND R. SOUDA: "Crystal Face-Specific Response of a Single-Crystal Cadmium Sulfide Based Ion-Selective Electrode" Anal. Chem.61. 1980-1983 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. KATAOKA, R. NAGANAWA, K. ODASHIMA, Y. UMEZAWA, E. KIMURA AND T. KOIKE: "Potentiometric Liquid Membrane Sensors that Discriminate Linear homologs and Geometrical/Positional isomers of Dicarboxylates" Anal. Lett.22. 1089-1105 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. SUGAWARA, M. KATAOKA, K. ODASHIMA, AND Y. UMEZAWA: "Biomimetic Ion-Channel Sensors Based on Host-Guest Molecular Recognition in Langmuir-Blodgett Membrane Assemblies" Thin Solid Films. 180. 129-133 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. UTO, E. K. MICHAELIS, I. F. HU, Y. UMEZAWA AND T. KUWANA: "Biosensor Development with a Glutamate Receptor Ion-Channel Reconstituted in a Lipid Bilayer" Anal. Sci.6. 221-225 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. NAGASE, M. KATAOKA, R. NAGANAWA, R. KOMATSU, K. ODASHIMA, AND Y. UMEZAWA: "Voltammetric Anion Responsive Sensors Based on Modulation of Ion permeability Through Langmuir-Blodgett Films Containing Synthetic Anion Receptors" Anal. Chem.62. 1252-1259 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. SUGAWARA, H. YOSHIDA, A. HENMI, AND Y. UMEZAWA: "Enhancement of Analyte Concentration Based on a Feed/Receiving Volume Effect in Uphill Mimbrane Transport" Anal. Sci.7. 141-147 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. SUGAWARA, H. SAZAWA, AND Y. UMEZAWA: "Effect of Membranous Surface Charge on Host-Guest Complexation of Valinomycin in Synthetic Lipid Monolayer at the Air-Water Interface"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Umezawa, K. Ito, H. Hata, M. Sugawarw, E. Graf-harsanti, K. Tote E. Pungor, M. Soma, and A. Tanaka: "Surface Chemistry and Potential Response of Copper Sulfide Based Ion-Selective Membrane in Ligand Solution" Mikrochim. Acta. 1. 231-239 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] R. NAGANAWA, M. KATAOKA, K. ODASHIMA, Y. UMEZAWA, E. KIMURA, T. KOIKE: "Comparison of Potentiometric Response Behavior of Liquid Membranes Incorporated with N_4 and N_5 Lipophilic Macrocyclic polyamines" Bunseki Kagaku. 39. 671-676 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. KATAOKA, M. TAKINAMI, H. ABE, Y. UMEZAWA: "Amplified Determination of Metal Ions with Liposomes Incorporating Hydrophobic Chelating Agents" Bunseki Kagaku. 39. 789-792 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. KAWAI, K. MIYAMOTO, Y. UMEZAWA: "Continuous Measurement of Dissolved Inorganic Carbon in the Experimental Pond water with a Crbon Dioxide Gas Membrane Electrode During the Growth of Phytolankton" Bunseki Kagaku. 39. 649-653 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Umezawa: "Potentiometric Adenosine Triphosphate Polyanion Sensor Using a Lipophilic Macrocyclic Polyamine Liquid Membrane" Anal.Chem.60. 2392-2396 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Kataoka: "Potentiometric Liquid Membrane Sensors that Discriminate Linear Homologs and Geometrical/Positional Isomers of Dicarboxylates" Anal.Lett.22. 1089-1105 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] S.Nagase: "Voltammetric Anion Responsive Sensors Based on Modulation of Ion Permeability through Langmuir-Blodgett Films Containing Synthetic Anion Receptors" Anal.Chem.(1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Umezawa: "Handbook of Ion-Selective Electrodes,Vol.1" CRC Press, (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Umezawa: "Ion-Selective Electrodes 5" Akademiai Kiado and Pergamon Press, 675 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Umezawa: Anal.Chem.60. 2392-2396 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] M.Kataoka: Anal.Lett.(1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Y.Umezawa: "Handbook of Ion-Selective Electrodes,Vol.1" CRC Press, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Y.Umezawa: "Ion-Selective Electrodes 5" Akademiai Kiado and Elsevier, (1989)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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