| Project/Area Number |
63870089
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
YAMANAKA Hiroshi Tohoku University, Pharmaceutical Institute Professor, 薬学部, 教授 (40004551)
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| Co-Investigator(Kenkyū-buntansha) |
NIITUMA Setsuko Nippon Kayaku Co. Ltd., Research Laboratories Principal Research Scientist, 総合研究所, 研究主幹
TAKITA Tomohisa Nippon Kayaku Co. Ltd., Research Laboratories Managing Director, 常務取締役
OHNISHI Shuhei Tohoku University, Pharmaceutical Institute Research Associate, 薬学部, 教務系技官 (20213796)
KONNO Shoetsu Tohoku University, Pharmaceutical Institute Instructor, 薬学部, 助手 (10006348)
SAKAMOTO Takao Tohoku University, Pharmaceutical Institute Associate Professor, 薬学部, 助教授 (00006347)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1988: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | oxetanocin / antiviral activity / uracil / pyrrolopyrimidine / acyclonucleoside / C-nucleoside / organotin compound / palladium-catalyzed reaction / デアザプリン環 / オキセタノシン誘導体の合成 / デアザプリンの環合成 / ヌクレオシド / 抗ウイルス薬の開発 |
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| Research Abstract |
In order to develop the chemistry of heterocyclic compounds having antiviral activities, synthesis of nucleosides relating to oxetanocin was investigated. 1) Ring-Closure to Pyrrolopyrimidines New methods for the synthesis of pyrrolo[2,3-d]pyrimidine and pyrrolo[3,2- d]pyrimidine derivatives was established as a basic investigation. 2) Synthesis of Uracil-Type C-Nucleoside Starting from 5-bromo-2,4-bis(benzyloxy)pyrimidine, the synthesis of the 5-pyrimidinyloxetanose was accomplished as shown below. 3) Synthesis of Deazapurine-Type Nucleosides On the basis of the results described in Section 1, the following acyclonucleosides was synthesized.
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