| Project/Area Number |
63870103
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
医学一般
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| Research Institution | Osaka University |
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Principal Investigator |
HAYASHI Norio Osaka University Medical School Lecturer, 医学部, 講師 (00144478)
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Yutaka Shimadzu Corporation Engineer, プロセス計測事業部, 主任研究員
KONO Michikazu Osaka University Hospital Staff, 医学部附属病院, 医員
SASAKI Yutaka Osaka University Hospital Staff, 医学部附属病院, 医員
KASAHARA Akinori Osaka University Medical School Assistant, 医学部, 助手 (70214286)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥17,800,000 (Direct Cost: ¥17,800,000)
Fiscal Year 1989: ¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1988: ¥11,200,000 (Direct Cost: ¥11,200,000)
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| Keywords | ultrasonic tissue characterization / frequency dependent attenuation / cepstrum analysis / space among scatterers / chronic liver disease / 超音波 / 組織性状診断 / cepstrum / 散乱体間距離 / kurtosis |
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| Research Abstract |
In order to evaluate the pathological changes in chronic liver disease non-invasively, we calculated frequency dependent attenuation coefficient (FDA) and space among scatterers of the liver from the ultrasonic waveforms obtained from human livers using the modified conventional ultrasonic scanner.
FDA showed positive correlation with the grading of fatty infiltration of the liver. and it is suggested that we could measure the severity of fatty change of the liver non-invasively and quantitatively.
Assuming that liver tissue is the collection of semi-regularly arrayed small scatterers of ultrasouncwe could measure the space among scatterers(SAS) by the cepstral analysis. In this study, two parameters, mode and kurtosis, were yielded from the distribution of the SAS for each patient. Using mode and kurtosis, we could evaluate the pathological change of chronic liver disease non-invasively and quantitatively.
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