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Research for Clarifying Aetiologic Factors of Periodontal Disease -the Role of Neutrophil-

Research Project

Project/Area Number 63870115
Research Category

Grant-in-Aid for Developmental Scientific Research (B).

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionAichigakuin University

Principal Investigator

NOGUCHI Toshihide  School of Dentistry, Aichigakuin University Professor, 歯学部, 教授 (50014262)

Co-Investigator(Kenkyū-buntansha) AOYAMA Yukihiko  School of Dentistry, Aichigakuin University assistant, 歯学部, 助手 (80221034)
UMEMURA Masataka  School of Dentistry, Aichigakuin University assistant, 歯学部, 助手 (70191921)
FUKUDA Mitsuo  School of Dentistry, Aichigakuin University Lecturer, 歯学部, 講師 (40156790)
小嶋 久雄  愛知学院大学, 歯学部, 助手
本多 隆保  愛知学院大学, 歯学部, 講師 (40192322)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1990: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1989: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsPeriodontal disease / Systemic factor / Neutrophil / G-CSF / Methotrexate / 好中球減少症 / GーCSF / 炎症 / 歯槽骨の吸収 / 全身的要因 / メソトレキセート / 歯槽骨吸収 / 走化性
Research Abstract

The purpose of the present study was to investigate the role of neutrophil on the development of periodontal disease. In animal study, the effect of a long-term methotrexate-induced neutropenia on the periodontal resion was histrogically and histometrically investigated.
In the experimental side of the animals, a suturing nylon thread was inserted into the interdental space between the left maxillary 1 st and 2 nd molars.
The right side of the animals of the same area was used as control side without doing any treatments. Then, the animals were divided equally into two groups.
The animals in one group were injected with 1.0mg/kg of methotrexate (MTX), whereas in the another group with no injection of M T X. Results obtained were as follows.
The numbers of white blood cell and neutrophil in the M T X injected group decreased remarkably from 3 to 9 weeks. The experimental side of non M T X injected group showed a slight gingival inflammation and moderate alveolar bone resorption at 7 and 9 weeks. In the experimental side of M T X- injected group, severe alveolar bone resorptions were found at 7 and 9 weeks.
The difference of bone resorption between these two groups was statistically significant. The results of the present study indicated that long-term M T X induced neutropenia changed the moderate periodontitis into the severe one. From the study of congenital neutropenia in human beings, it was also suggested that neutrophil play a important role for developing of periodontal disease.

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 青山 行彦: "ラットの歯周病変におよぼすメソトレキセ-トによる好中球減少の影響" 愛知学院大学歯学会会誌. 27. 115-136 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 野口 俊英: "歯周病の多様性を考慮したメンテナンス" 日本歯科評論. 568号. 135-144 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 吉成 伸夫: "ラットの実験的歯周病変におよぼす長期間のメソトレキセ-トによる好中球減少の影響" 愛知学院大学歯学会会誌. 28. 345-366 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 野口 俊英: "免疫学からみた歯周病" 歯科ジャ-ナル. 31. 817-829 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yukihiko AOYAMA: "Effect of Methotrexate-induced Neutropenia on the Periodontal Lesion in Rats." The Aichi-Gakuin Journal of Dental Science. Vol 27, No. 1. 115-136 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Nobuo YOSHINARI: "Effect of Long-term methotrexateinduced Neutropenia on Experimental Periodontal Lesion in Rats." The Aichi-Gakuin Journal of Dental Science. Vol 28, No. 1. 345-366 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Toshihide NOGUCHI: "A New Concept for Maintenance Care on Various Types of Periodontal Diseases." The Nippon Shika Hyoron. Vol 568. 135-144 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Toshihide NOGUCHI: "The Immunological Host Responses in Periodontal Disease." The Shika Journal. Vol 31, No. 6. 817-829 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 吉成 伸夫: "ラットの実験的歯周病変におよぼす長期間のメソトレキセ-ト投与による好中球減少の影響" 愛知学院大学歯学会誌. 28. 345-366 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 野口 俊英: "免疫学からみた歯周病" 歯科ジャ-ナル. 31. 817-829 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 青山行彦: "ラットの歯周病変におよぼすメソトレキセ-トによる好中球減少の影響" 愛知学院大学歯学会誌. 27. 115-136 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 吉成伸夫: "ラットの実験的歯周病変におよぼす長期間のメソトレキセ-ト投与による好中球減少の影響" 愛知学院大学歯学会誌. 28. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 野口俊英: "歯周病の多様性を考慮したメインテナンス" 日本歯科評論. 568. 135-144 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 野口俊英 他: 日本歯周病学会会誌. 30. 70 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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