腫瘍幹細胞を標的としたプラズマ技術を用いた新たな腫瘍制御法の確立

• Project Area: Plasma medical innovation
• Project/Area Number: 15H00894
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Osaka University
• Principal Investigator: 池田 純一郎 大阪大学, 医学系研究科, 准教授 (20379176)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: プラズマ医療 / 腫瘍幹細胞 / 癌 / アルデヒド脱水素酵素 / 病理学 / 抗癌剤

Outline of Annual Research Achievements

腫瘍（がん）には「腫瘍（がん）幹細胞」と呼ばれる化学療法や放射線療法に抵抗性で，再発や転移の原因になると考えられている細胞群が存在し，この腫瘍幹細胞の制御ががん治療の重要な鍵となっている．光・電子・イオン・ラジカルの集合体であり固体・液体・気体に続く物質の第4の状態といわれるプラズマは，多彩な作用点を有することから，プラズマ照射による治療が腫瘍幹細胞に対して有効であれば，治療に伴う正常組織の破壊を抑えた低侵襲性のがん治療法として有用になる可能性がある．そこで，多くの腫瘍で腫瘍幹細胞のマーカーとされているアルデヒド脱水素酵素（ALDH）をターゲットとして，プラズマ活性溶液(plasma-activated medium: PAM)による腫瘍幹細胞制御の検討を行った．PAMを投与することにより子宮類内膜腺癌細胞や胃癌細胞は，cell viabilityの低下，アポトーシスの増加がみられ，ALDH高発現細胞の減少が認められた．また，抗癌剤シスプラチンとPAMを併用することにより各々単独投与に比べより高い抗腫瘍効果が得られ，抗癌剤の投与量を調整することでその副作用を軽減できる可能性が示唆される結果となった．これらの抗腫瘍効果は腫瘍幹細胞，非腫瘍幹細胞ともに同程度認められた．さらに担癌マウスを用いた結果においてもPAM投与群の方が非投与群と比較して高い抗腫瘍効果を示す傾向が認められた．以上の結果はこれまでに行ったプラズマ直接照射による検討と同様の結果であり，PAM投与においても腫瘍幹細胞を制御できる可能性が示唆された．

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer. (2017)
  • Author(s): Ohshima K, Nojima S, Tahara S, Kurashige M, Hori Y, Hagiwara K, Okuzaki D, Oki S, Wada N, Ikeda JI, Kanai Y, Morii E.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 45504-45504
  • DOI: 10.1038/srep45504
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gnathic giant cell-rich conventional osteosarcoma with MDM2 and CDK4 gene amplification. (2017)
  • Author(s): Hirose K, Okura M, Sato S, Murakami S, Ikeda JI, Noda Y, Fukuda Y, Morii E, Toyosawa S.
  • Journal Title: Histopathology Volume: in press Issue: 7 Pages: 1171-1173
  • DOI: 10.1111/his.13141
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of the novel marginal-zone B-cell marker IRTA1 in malignant lymphoma. (2017)
  • Author(s): Ikeda JI, Kohara M, Tsuruta Y, Nojima S, Tahara S, Ohshima K, Kurashige M, Wada N, Morii E.
  • Journal Title: Hum Pathol Volume: 59 Pages: 70-79
  • DOI: 10.1016/j.humpath.2016.09.011
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of plasma-activated medium on the decrease of tumorigenic population in lymphoma. (2017)
  • Author(s): Wada N, Ikeda J, Tanaka H, Sakakita H, Hori M, Ikehara Y, Morii E.
  • Journal Title: Pathol Res Pract Volume: in press
  • Peer Reviewed
• [Journal Article] Comprehensive phenotypic analysis of knockout mice deficient in cyclin G1 and cyclin G2. (2016)
  • Author(s): Ohno S, Ikeda JI, Naito Y, Okuzaki D, Sasakura T, Fukushima K, Nishikawa Y, Ota K, Kato Y, Wang M, Torigata K, Kasama T, Uchihashi T, Miura D, Yabuta N, Morii E, Nojima H.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 39091-39091
  • DOI: 10.1038/srep39091
  • Peer Reviewed / Open Access
• [Journal Article] S100A4 accelerates the proliferation and invasion of endometrioid carcinoma and is associated with the ‘MELF’ pattern. (2016)
  • Author(s): Tahara S, Nojima S, Ohshima K, Hori Y, Kurashige M, Wada N, Ikeda J, Morii E.
  • Journal Title: Cancer Sci Volume: 109 Issue: 9 Pages: 1345-1352
  • DOI: 10.1111/cas.12999
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Angiogenic Factor with G-patch and FHA Domain 1 (AGGF1) Expression in Human Vascular Lesions (2016)
  • Author(s): Zhan M, Hori Y, Wada N, Ikeda J, Hata Y, Osuga K, Morii E.
  • Journal Title: ACTA HISTOCHEMICA ET CYTOCHEMICA Volume: 49 Issue: 2 Pages: 75-81
  • DOI: 10.1267/ahc.15035
  • NAID: 130005149557
  • ISSN: 0044-5991, 1347-5800
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ID1 upregulation and FoxO3a downregulation by Epstein-Barr virus-encoded LMP1 in Hodgkin lymphoma. (2016)
  • Author(s): Ikeda JI, Wada N, Nojima S, Tahara S, Tsuruta Y, Oya K, Morii E.
  • Journal Title: Mol Clin Oncol Volume: 5 Pages: 562-566
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Red Blood Cell Coagulation Induced by Low-temperature Plasma Treatment. (2016)
  • Author(s): Miyamoto K, Ikehara S, Takei H, Akimoto Y, Sakakita H, Ishikawa K, Ueda M, Ikeda J, Yamagishi M, Kim J, Yamaguchi T, Nakanishi H, Shimizu N, Hori M, Ikehara Y.
  • Journal Title: Arch Biochem Biophys Volume: in press Pages: 95-101
  • DOI: 10.1016/j.abb.2016.03.023
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Requirement of CXCL12-CXCR7 signaling for CD20- CD138- double-negative population in lymphoplasmacytic lymphoma. (2016)
  • Author(s): Wada N, Ikeda J, Nojima S, Tahara S, Ohshima K, Okuzaki D, Morii E.
  • Journal Title: Lab Invest. Volume: 96 Issue: 5 Pages: 517-525
  • DOI: 10.1038/labinvest.2016.28
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prognostic significance of a component of Hippo pathway, TAZ, in human endometrioid adenocarcinoma of uterus. (2016)
  • Author(s): Zhan M, Ikeda J, Wada N, Hori Y, Nojima S, Tahara S, Ueda Y, Yoshino K, Kimura T, Morii E.
  • Journal Title: Oncol Lett Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Plasma blood coagulation without involving the activation of platelets and coagulation factors. (2015)
  • Author(s): Ikehara S, Sakakita H, Ishikawa K, Yamaguchi T, Kim J, Ueda M, Ikeda J, Nakanishi H, Shimizu N, Hori M, Ikehara Y.
  • Journal Title: Plasma Process Polym Volume: 12 Issue: 12 Pages: 1348-1353
  • DOI: 10.1002/ppap.201500132
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Anti-Cancer Effects of Nonequilibrium Atmospheric Pressure Plasma on Cancer-Initiating Cells in Human Endometrioid Adenocarcinoma Cells. (2015)
  • Author(s): Ikeda J, Tsuruta Y, Nojima S, Sakakita H, Hori M, Ikehara Y.
  • Journal Title: Plasma Process Polym. Volume: 12 Issue: 12 Pages: 1370-1376
  • DOI: 10.1002/ppap.201500097
  • Peer Reviewed
• [Journal Article] Epithelioid Rhabdomyosarcoma; A case report with immunohistochemical and molecular study. (2015)
  • Author(s): Jokoji R, Ikeda J, Tsujimoto M, Morii E.
  • Journal Title: Diagn Pathol Volume: 10 Issue: 1 Pages: 124-124
  • DOI: 10.1186/s13000-015-0349-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Poorly differentiated hepatocellular carcinoma accompanied by anti-Hu antibody-positive paraneoplastic peripheral neuropathy. (2015)
  • Author(s): Matsui T, Hori Y, Nagano H, Eguchi H, Marubashi S, Wada H, Wada N, Ikeda J, Sakamoto M, Morii E.
  • Journal Title: Pathol Int. Volume: 65 Issue: 7 Pages: 388-392
  • DOI: 10.1111/pin.12304
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] ANTI-CANCER EFFECT ON CANCER-INITIATING CELLS TREATED WITH PLASMA-ACTIVATED MEDIUM (PAM) IN CANCER CELLS (2017)
  • Author(s): J. Ikeda, H. Tanaka, K. Ishikawa, H. Sakakita, Y. Ikehara, M. Hori
  • Organizer: International Conference on Plasma Medical Science Innovation 2017(ICPMSI2017)
  • Place of Presentation: 名古屋大学
  • Year and Date: 2017-02-27
  • Int'l Joint Research
• [Presentation] ROS and RON production in liquid under the various plasma irradiation conditions (2017)
  • Author(s): G.Uchida, T.Ito, Y.Mino, K.Takenaka, J.Ikeda, Y.Setsuhara
  • Organizer: International Conference on Plasma Medical Science Innovation 2017(ICPMSI2017)
  • Place of Presentation: 名古屋大学
  • Year and Date: 2017-02-27
  • Int'l Joint Research
• [Presentation] CHARACTERIZATION OF ATMOSPHERIC-PRESSURE PLASMA JETS AND INTERACTION WITH LIQUID FOR CONTROL OF REACTIVE SPECIES IN PLASMA-ACTIVATED AQUEOUS SOLUTIONS (2017)
  • Author(s): Yuichi Setsuhara, Giichiro Uchida, Taiki Ito, Junichiro Ikeda,Yusuke Mino, Kosuke Takenaka
  • Organizer: International Conference on Plasma Medical Science Innovation 2017(ICPMSI2017)
  • Place of Presentation: 名古屋大学
  • Year and Date: 2017-02-27
  • Int'l Joint Research
• [Presentation] MECHANISUM OF BLOOD COAGULATION INDUCED BY LOW TEMPERATURE PLASMA TREATMENT (2017)
  • Author(s): Y. Ikehara, S. Ikehara, Y. Akimoto, H. Sakakita, K. Ishikawa, M. Ueda, J. Ikeda, J. Kim, T. Yamaguchi, H. Nakanishi, T. Shimizu, N. Shimizu, M. Hori
  • Organizer: International Conference on Plasma Medical Science Innovation 2017(ICPMSI2017)
  • Place of Presentation: 名古屋大学
  • Year and Date: 2017-02-27
  • Int'l Joint Research
• [Presentation] 子宮内膜細胞診で癌肉腫を推定できた一例 (2017)
  • Author(s): 大西崇文，長友忠相，川嶋真由美，内藤賢郎，堀由美子，和田直樹，池田純一郎，森井英一
  • Organizer: 第42回臨床細胞学会大阪府支部学術集会
  • Place of Presentation: 大阪市立総合医療センター さくらホール
  • Year and Date: 2017-02-25
• [Presentation] Plasma-Liquid Interactions with Atmospheric-Pressure Plasma Jets for Controlling Reactive Species in Plasma-Activated Aqueous Solutions (2017)
  • Author(s): Yuichi Setsuhara, Giichiro Uchida, Taiki Ito, Junichiro Ikeda,Yusuke Mino, Kosuke Takenaka
  • Organizer: THE 3rd INTERNATIONAL WORKSHOP ON ADVANCED PLASMA TECHNOLOGY AND APPLICATIONS -Agriculture and Bio Technology by Plasma-
  • Place of Presentation: Nong Lam University, Vietnam
  • Year and Date: 2017-01-11
  • Int'l Joint Research
• [Presentation] Effects of plasma-jet irradiation on the surface of liquid and its effects on ROS and RNS generations in bulk solution (2016)
  • Author(s): G. Uchida, T. Ito, K. Takenaka,, J. Ikeda, Y. Setsuhara
  • Organizer: 第26回 日本ＭＲＳ年次大会
  • Place of Presentation: 横浜市開港記念会館
  • Year and Date: 2016-12-19
• [Presentation] Evaluation of H2O2 and NO2- concentrations in plasma-activated liquid produced under various plasma-jet conditions (2016)
  • Author(s): T. Ito, G. Uchida, K. Takenaka, J. Ikeda, Y. Setsuhara
  • Organizer: 第26回 日本ＭＲＳ年次大会
  • Place of Presentation: 横浜市開港記念会館
  • Year and Date: 2016-12-19
• [Presentation] 乳腺紡錘細胞癌の3例 (2016)
  • Author(s): 前野悦子，吉村英雄，堀由美子．野島聡，和田直樹，池田純一郎，森井英一
  • Organizer: 第55回日本臨床細胞学会秋期大会
  • Place of Presentation: ビーコンプラザ（大分県別府市）
  • Year and Date: 2016-11-18
• [Presentation] Significance of hypoxia and CXCL12-CXCR7 signaling in lymphoplasmacytic lymphoma (2016)
  • Author(s): Naoki Wada, Junichiro Ikeda, Eiichi Morii
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-14
• [Presentation] Control of ROS and RNS productions in liquid in atmospheric pressure plasma-jet system (2016)
  • Author(s): Giichiro Uchida, Taiki Ito, Kosuke Takenaka, Junichiro Ikeda, Yuichi Setsuhara
  • Organizer: 69th Annual Gaseous Electronics Conference
  • Place of Presentation: Bochum, Germany
  • Year and Date: 2016-10-10
  • Int'l Joint Research
• [Presentation] S100A4 は子宮内膜癌の増殖と浸潤を促進する (2016)
  • Author(s): 田原紳一郎、池田純一郎、森井英一
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-08
• [Presentation] リンパ形質細胞性リンパ腫におけるCXCL12-CXCR7 シグナル (2016)
  • Author(s): 和田直樹、池田純一郎、森井英一
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-06
• [Presentation] 周辺ガス制御型大気圧プラズマジェット照射による純水中RNS/ROS濃度比制御 (2016)
  • Author(s): 伊藤泰喜 ，内田儀一郎，竹中弘祐 ，池田純一郎，節原裕一
  • Organizer: 第77回応用物理学会秋期学術講演会
  • Place of Presentation: 朱鷺メッセ（新潟）
  • Year and Date: 2016-09-13
• [Presentation] 大気圧プラズマジェット照射による培地中ROS，RNS 生成制御 (2016)
  • Author(s): 内田儀一郎，伊藤泰喜 ，竹中弘祐 ，池田純一郎，節原裕一
  • Organizer: 第77回応用物理学会秋期学術講演会
  • Place of Presentation: 朱鷺メッセ（新潟）
  • Year and Date: 2016-09-13
• [Presentation] Therapeutic approach for cancer-initiating cells with non-thermal plasma: for new medical application (2016)
  • Author(s): Jun-ichiro Ikeda
  • Organizer: Workshop for Current concept for LTP at atmospheric pressure in medical practice
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-09-10
  • Int'l Joint Research / Invited
• [Presentation] Mechanism of blood coagulation induced by plasma treatment in addition to the acceleration of the natural blood coagulation process (2016)
  • Author(s): Y. Ikehara, S. Ikehara, Y. Akimoto, H. Sakakita, K. Ishikawa, M. Ueda, J. Ikeda, J. Kim, T. Yamaguchi, H. Nakanishi, T. Shimizu, N. Shimizu, M. Hori
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] Effects of surrounding gas flow on ROS and RNS productions in non-thermal plasma-jet system (2016)
  • Author(s): Y. Setsuhara, G. Uchida, T. Ito, A. Nakajima, K. Takenaka, J. Ikeda
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] Effect of plasma-activated medium (PAM) on cancer-initiating cells for cancer therapy (2016)
  • Author(s): J. Ikeda, H. Tanaka, K. Ishikawa, H. Sakakita, M. Hori, Y. Ikehara
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] SPATIO-TEMPORAL BEHAVIORS OF ATMOSPHERIC-PRESSURE PLASMA JETS FOR INVESTIGATION OF REACTIVE-SPECIES PRODUCTION IN LIQUID (2016)
  • Author(s): Y. Setsuhara, A. Nakajima, G. Uchida, T. Ito, K. Takenaka and J. Ikeda
  • Organizer: 43rd IEEE International Conference on Plasma Science (ICOPS)
  • Place of Presentation: Alberta, Canada
  • Year and Date: 2016-06-19
  • Int'l Joint Research
• [Presentation] Anti-cancer effect of non-thermal plasma on cancer initiating cells: a new medical application for cancer therapy (2016)
  • Author(s): Jun-ichiro Ikeda
  • Organizer: The 19th International Congress of Cytology (ICC 2016)/第57回日本臨床細胞学会総会（春期大会）
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-05-29
  • Int'l Joint Research / Invited
• [Presentation] 当院における子宮癌肉腫の術前細胞診・組織診についての検討 (2016)
  • Author(s): 松崎聖子，吉野潔，堀由美子，長友忠相，高田友美，上田豊，和田直樹，池田純一郎，森井英一
  • Organizer: 第57回日本臨床細胞学会総会（春期大会）
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-05-28
• [Presentation] 低温大気圧プラズマによる腫瘍（がん）幹細胞を標的としたがん制御の検討 (2016)
  • Author(s): 池田 純一郎、鶴田 陽子、野島 聡
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-13
• [Presentation] S100A4はMMP-2を介して子宮内膜癌の浸潤を促進する (2016)
  • Author(s): 田原 紳一郎、野島 聡、大島 健司、倉重 真沙子、堀 由美子、和田 直樹、池田 純一郎、森井 英一
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-13
• [Presentation] 鼻腔に発生したCD34陰性Solitary fibrous tumorの１例 (2016)
  • Author(s): 城光寺 龍、辻本 正彦、池田 純一郎、森井 英一
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-13
• [Presentation] リンパ形質細胞性リンパ腫（LPL）におけるCXCL12-CXCR7シグナルの意義 (2016)
  • Author(s): 和田 直樹、池田 純一郎、野島 聡、田原 紳一郎、大島 健司、奥崎 大介、森井 英一
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-13
• [Presentation] 堀 由美子、武鑓 美沙、野島 聡、和田 直樹、池田 純一郎、森井 英一 (2016)
  • Author(s): 堀 由美子、武鑓 美沙、野島 聡、和田 直樹、池田 純一郎、森井 英一
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-12
• [Presentation] THERAPEUTIC APPROACH FOR CANCER-INITIATING CELLS WITH NON-THERMAL PLASMA (2016)
  • Author(s): 池田 純一郎，榊田 創，堀 勝，池原 譲
  • Organizer: The 3rd International Workshop on Plasma For Cancer Treatment (IWPCT2016)
  • Place of Presentation: ワシントンDC (USA)
  • Year and Date: 2016-04-11
  • Int'l Joint Research / Invited
• [Presentation] 大気圧プラズマを用いたがん幹細胞の制御ーがん治療への応用に向けてー (2016)
  • Author(s): 池田 純一郎
  • Organizer: 日本学術振興会153委員会 プラズマ材料科学スクール「プラズマ医療の基礎と応用」
  • Place of Presentation: 弘済会館（東京）
  • Year and Date: 2016-02-08
  • Invited
• [Presentation] 鼻腔腫瘍の1例 (2015)
  • Author(s): 城光寺龍，岡安唯，赤羽誉，辻本正彦，池田純一郎，森井英一
  • Organizer: 第70回日本病理学会近畿支部学術集会
  • Place of Presentation: 関西医科大学（大阪）
  • Year and Date: 2015-09-26
• [Presentation] プラズマ培養液（PAM）を用いた抗腫瘍効果と腫瘍幹細胞への影響 (2015)
  • Author(s): 池田 純一郎
  • Organizer: 新学術領域研究「プラズマ医療科学の創成」＋「統合的神経機能の制御を標的とした糖鎖の作動原理解明」合同公開シンポジウム
  • Place of Presentation: 名古屋大学
  • Year and Date: 2015-08-05
• [Presentation] 肺腺癌のEGFR遺伝子変異の有無と細胞所見 (2015)
  • Author(s): 長友忠相，川嶋真由美，内藤賢郎，¬辻洋美，野島聡，堀由美子，和田直樹，池田純一郎，南雲サチ子，森井英一
  • Organizer: 第56回日本臨床細胞学会総会（春期大会）
  • Place of Presentation: くにびきメッセ・松江テルサ
  • Year and Date: 2015-06-14
• [Presentation] 子宮体癌の細胞診における漿液性腺癌の特徴と臨床所見の検討 (2015)
  • Author(s): 松崎聖子，吉野潔，堀由美子，高田友美，上田豊，和田直樹，池田純一郎，藤田征巳，森井英一
  • Organizer: 第56回日本臨床細胞学会総会（春期大会）
  • Place of Presentation: くにびきメッセ・松江テルサ
  • Year and Date: 2015-06-14
• [Presentation] Epithelioid Rhabdomyosarcomaの1例 (2015)
  • Author(s): 城光寺龍，辻本正彦，池田純一郎，森井英一
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-05-01
• [Presentation] 悪性リンパ腫における未分化状態を維持する因子の検討 (2015)
  • Author(s): 池田純一郎．和田直樹，野島聡．田原紳一郎，森井英一
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-04-30
• [Presentation] リンパ形質細胞リンパ腫におけるCD20陰性CD138陰性細胞群 (2015)
  • Author(s): 和田直樹，戦茂生，堀由美子，本間圭一郎，野島聡，田原紳一郎，池田純一郎，森井英一
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-04-30
• [Presentation] 抗Hu抗体陽性腫瘍随伴性末梢神経障害を伴った低分化型肝細胞癌の一例 (2015)
  • Author(s): 松井崇浩，堀由美子，和田直樹，池田純一郎，森井英一
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-04-30
• [Presentation] 背景の子宮壁内にリンパ脈管筋腫症と伴ったポリープ状のPEComaの一例 (2015)
  • Author(s): 堀由美子，廣瀬勝俊，小林栄仁，辻洋美，野島聡，和田直樹，池田純一郎，豊澤悟，森井英一
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-04-30
• [Book] 超・入門 臨床血液内科アトラス ～病理組織診断の苦手意識を克服する！～ (2015)
  • Author(s): 池田純一郎 編集：金倉譲，森井英一
  • Total Pages: 164
  • Publisher: 南江堂