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生体多元情報取得のための粘弾性画像の高空間分解能化手法の開発

Publicly Offered Research

Project AreaMultidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy
Project/Area Number 15H01104
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionChiba University

Principal Investigator

菅 幹生  千葉大学, フロンティア医工学センター, 准教授 (00294281)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords生体工学 / 解析・評価 / 物性 / 粘弾性 / エラストグラフィ / 振動子
Outline of Annual Research Achievements

画像診断装置の性能や機能の向上により様々な疾患の早期発見が可能になっているが,膵がんに対しては有効な早期発見法がなく,死亡者数も20年で倍増している.近年,粘弾性という物理情報を非侵襲的に得られる新しい画像診断法として「エラストグラフィ」が開発され,新たなバイオマーカーとして研究開発や臨床での利用が進んできている.現状のエラストグラフィでは,生体深部領域の粘弾性率の微小な変化を定量的に捉えることが困難であるが,この問題を解決すれば,膵がんなどの早期発見や良悪性の鑑別,浸潤範囲の確定に有効と考えられる.本研究では,生体の深部に存在する膵臓のような小さな臓器や組織の多元情報を定量的に取得可能なシステムを開発することを目的とする.
H28年度では,従来の振動子で発生する弾性波と比較して3次元的に複雑になるが生体深部領域に弾性波を発生させることが可能なH27年度に開発した振動子を利用した.MRエラストグラフィのシステムは臨床用3 T MRIと0.3 T MRIおよび,小動物用の1 T MR顕微鏡を利用して開発した.また,複数周波数と複数位相の弾性波を利用することで,小さな臓器や組織に対しても形態情報と共に定量的な粘弾性率分布とその周波数特性と形態画像などの多元情報が得られる手法を開発した.
また,構築したエラストグラフィシステムの定量性や再現性を粘弾性が既知なファントムを利用して評価し,定量性と再現性が高いことを確認した.

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (32 results)

All 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (20 results) (of which Int'l Joint Research: 9 results,  Invited: 1 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] Mayo Clinic(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Siemens(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Measuring shear-wave speed with point shear-wave elastography and MR elastography: a phantom study2017

    • Author(s)
      Riwa Kishimoto, Mikio Suga, Atsuhisa Koyama, Tokuhiko Omatsu, Yasuhiko Tachibana, Daniel K Ebner and Takayuki Obata
    • Journal Title

      BMJ Open

      Volume: 7(1) Issue: 1 Pages: e013925-e013925

    • DOI

      10.1136/bmjopen-2016-013925

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Local Integral Type Reconstruction Formula for Magnetic Resonance Elastography2017

    • Author(s)
      Urume R, Suga M, Maekawa S, Fujiwara H
    • Journal Title

      Proceedings of International Forum on Medical Imaging in Asia

      Volume: - Pages: 60-62

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRエラストグラフィ用パルスシーケンスの位相数削減による撮像時間短縮の検討2017

    • Author(s)
      大橋幸司, 菅幹生, 石井孝樹, 岸本理和, Stephan Kannengiesser, 小畠隆行
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 116(292) Pages: 59-60

    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] 磁気共鳴エラストグラフィ: 技術と応用2016

    • Author(s)
      菅幹生
    • Journal Title

      MEDICAL IMAGING TECHNOLOGY

      Volume: 34(4) Pages: 217-225

    • NAID

      130005265935

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MR Elastography using SS-SE-EPI with reduced FOV: phantom study and preliminary volunteer study for the pancreas2016

    • Author(s)
      Yohei Itoh, Yasuo Takehara, Naoki Ooishi, Masanori Kawade, Tetsuya Wakayama, Mikio Suga, Takasuke Ushio, Yuki Hirai, Nobuko Yoshizawa, Shuhei Yamashita, Hatsuko Nasu, and Harumi Sakahara
    • Journal Title

      Proceedings of the International Society for Magnetic Resonance in Medicine

      Volume: - Pages: 1955-1955

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A hybrid-segmentation atlas method to construct the attenuation correction factor for human pelvic PET/MRI2016

    • Author(s)
      Hiroshi Kawaguchi, Tkayuki Obata, Hiromi Sano, Eiji Yoshida, Mikio Suga, Yoko Ikoma, Yukari Tanikawa, Taiga Yamaya
    • Journal Title

      Proceedings of the International Society for Magnetic Resonance in Medicine

      Volume: - Pages: 2186-2186

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bo and SAR calculation for a full-ring human head PET system integrated with an 8-element Birdcage coil at 3T2016

    • Author(s)
      Md Shahadat Hossain Akram, Takayuki Obata, Mikio Suga, Fumihiko Nishikido, Eiji Yoshida, Taiga Yamaya
    • Journal Title

      Proceedings of the International Society for Magnetic Resonance in Medicine

      Volume: - Pages: 2193-2193

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Assessment of a MR Elastography System using Low Static Magnetic Field Open MRI2017

    • Author(s)
      Mikio Suga, Hiroki Yoshida
    • Organizer
      The 5th International Congress on Magnetic Resonance Imaging
    • Place of Presentation
      Grand Hilton Hotel, Seoul, Korea
    • Year and Date
      2017-03-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Local Integral Type Reconstruction Formula for Magnetic Resonance Elastography2017

    • Author(s)
      Urume R, Suga M, Maekawa S, Fujiwara H
    • Organizer
      International Forum on Medical Imaging in Asia
    • Place of Presentation
      Tenbusu Naha, Okinawa, Japan
    • Year and Date
      2017-01-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MRエラストグラフィ用パルスシーケンスの位相数削減による撮像時間短縮の検討2017

    • Author(s)
      大橋幸司, 菅幹生, 石井孝樹, 岸本理和, Stephan Kannengiesser, 小畠隆行
    • Organizer
      メディカルイメージング連合フォーラム
    • Place of Presentation
      那覇市ぶんかテンブス館
    • Related Report
      2016 Annual Research Report
  • [Presentation] Assessment of shielding materials for the add-on PET at different magnetic field strengths of MRI2016

    • Author(s)
      Masanori Fujiwara, Mikio Suga, Fumihiko Nishikido, Munetaka Nitta, Yoshihiko Kawabata, Taiga Yamaya, Takayuki Obata
    • Organizer
      2016 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      Strasbourg, France
    • Year and Date
      2016-10-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超音波エラストグラフィとMRエラストグラフィで利用可能な生体組織を模擬した高粘性ファントムの開発2016

    • Author(s)
      稲葉大貴,菅幹生,岸本理和,小畠隆行
    • Organizer
      日本超音波医学会 第28回関東甲信越地方会学術集会
    • Place of Presentation
      ビックサイトTFTホール
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] 0.3 Tオープン型MRIによるMRエラストグラフィシステムの評価2016

    • Author(s)
      吉田洋樹,菅幹生,関根雅
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 低グリセリン濃度で高粘性なMRエラストグラフィ用生体模擬ファントムの開発2016

    • Author(s)
      石井孝樹 , 菅幹生 , 岸本理和 , 小畠隆行
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] MR顕微鏡における複数針刺し振動子を用いたMRエラストグラフィシステムの開発2016

    • Author(s)
      護摩堂和剛,菅 幹生,村上顕央,山口匡
    • Organizer
      第35回日本医用画像工学会大会
    • Place of Presentation
      千葉大学
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 0.3 TオープンMRIを用いたMRエラストグラフィシステムの開発2016

    • Author(s)
      吉田洋樹,菅幹生,関根雅
    • Organizer
      第35回日本医用画像工学会大会
    • Place of Presentation
      千葉大学
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高分解能MRエラストグラフィのための積分型再構成手法の改良2016

    • Author(s)
      潤米亮,菅幹生,Stephan Kannengiesser,發田英華,岸本理和,小畠隆行
    • Organizer
      第35回日本医用画像工学会大会
    • Place of Presentation
      千葉大学
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] MR Elastography using SS-SE-EPI with reduced FOV: phantom study and preliminary volunteer study for the pancreas2016

    • Author(s)
      Yohei Itoh, Yasuo Takehara, Naoki Ooishi, Masanori Kawade, Tetsuya Wakayama, Mikio Suga, Takasuke Ushio, Yuki Hirai, Nobuko Yoshizawa, Shuhei Yamashita, Hatsuko Nasu, and Harumi Sakahara
    • Organizer
      The ISMRM 24th Annual Meeting & Exhibition
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A hybrid-segmentation atlas method to construct the attenuation correction factor for human pelvic PET/MRI2016

    • Author(s)
      Hiroshi Kawaguchi, Tkayuki Obata, Hiromi Sano, Eiji Yoshida, Mikio Suga, Yoko Ikoma, Yukari Tanikawa, Taiga Yamaya
    • Organizer
      The ISMRM 24th Annual Meeting & Exhibition
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bo and SAR calculation for a full-ring human head PET system integrated with an 8-element Birdcage coil at 3T2016

    • Author(s)
      Md Shahadat Hossain Akram, Takayuki Obata, Mikio Suga, Fumihiko Nishikido, Eiji Yoshida, Taiga Yamaya
    • Organizer
      The ISMRM 24th Annual Meeting & Exhibition
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MR Elastography using SS-SE-EPI with reduced FOV: phantom study and preliminary volunteer study for the pancreas2016

    • Author(s)
      Yohei Itoh, Yasuo Takehara, Naoki Ooishi, Masanori Kawade, Tetsuya Wakayama, Mikio Suga, Takasuke Ushio, Yuki Hirai, Nobuko Yoshizawa, Shuhei Yamashita, Hatsuko Nasu, and Harumi Sakahara
    • Organizer
      International Society for Magnetic Resonance in Medicine 24th Annual meeting
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Comparison of ShearWave Velocity measurement using VTQ and VTIQ: Phantom and Cervical Lymph Node Studies2016

    • Author(s)
      R. Kishimoto, T. Omatsu, Y. Tachibana, T. Obata, M. Suga, H. Tsuji
    • Organizer
      Eu- ropean Congress of Radiology (ECR) 2016
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-03-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Improvement of Inversion Algorithm for Magnetic Resonance Elastography2015

    • Author(s)
      M. Suga, R. Urume, R. Kishimoto, T. Obata
    • Organizer
      International Symposium on Info Comm and Medical Technology in Bio-Medical and Healthcare Application
    • Place of Presentation
      Chiba, Japan
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of a tissue-mimicking polyacrylamide gel phantom for MR elastography2015

    • Author(s)
      T. Mori, M. Suga, D. Inaba, T. Kurokawa, R. Kishimoto, T. Obata, H. Tsuji
    • Organizer
      International Symposium on Info Comm and Medical Technology in Bio-Medical and Healthcare Application
    • Place of Presentation
      Chiba, Japan
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高粘性組織測定のための2つの凹面型振動子を用いたMRエラストグラフィシステムの評価2015

    • Author(s)
      島崎 晋平,菅 幹生,森 昂也,関根 雅,岸本 理和,小畠 隆行
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      奈良先端科学技術大学院大学(奈良県生駒市)
    • Year and Date
      2015-11-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] MR Elastographyにおける積分型粘弾性率分布推定手 法の波長依存パラメータの自動推定化2015

    • Author(s)
      潤米亮, 菅幹生, 岸本理和, 小畠隆行
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生体組織の粘性を模擬した高粘性MRE用ゲルファントムの開発2015

    • Author(s)
      稲葉大貴, 菅幹生, 森昂也, 黒川孝幸, 築根まり子, 小林洋, 藤江正克, 岸本理和, 小畠隆行, 辻 比呂志
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Book] 肝臓疾患診断におけるMREハンドブック2015

    • Author(s)
      菅幹生(執筆担当: 弾性算出法, pp.9-13)
    • Total Pages
      104
    • Publisher
      診断と治療社
    • Related Report
      2015 Annual Research Report
  • [Remarks] 千葉大学フロンティア医工学センター

    • URL

      http://www.cfme.chiba-u.jp/

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] ファントムの製造方法及びこれにより製造されるファントム2016

    • Inventor(s)
      菅幹生
    • Industrial Property Rights Holder
      菅幹生
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-206251
    • Filing Date
      2016-10-20
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2022-01-28  

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