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X線動画イメージングによる胸郭運動ならびに肺機能評価の試み

Publicly Offered Research

Project AreaMultidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy
Project/Area Number 15H01113
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKanazawa University

Principal Investigator

田中 利恵  金沢大学, 保健学系, 准教授 (40361985)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords画像 / X線 / 放射線 / 情報工学 / 生理学
Outline of Annual Research Achievements

本研究では,胸部領域の筋・骨格・臓器・組織の動態機能の中でも,呼吸機能と密接な関係のある肋骨を含めた胸郭運動に注目した.その動態機能の理解と評価を可能にする画像解析法を開発するために,今年度は下記(4)~(5)に取り組んだ.
(4) 正常な胸郭運動の理解と異常な胸郭運動の特徴抽出
(5) 胸郭運動評価のためのCADシステム開発
対象は,本学附属病院の呼吸器内科/外科・整形外科を受診した患者である.基礎疾患として,慢性閉塞性肺疾患(COPD),間質性肺炎,肺線維症,気管支喘息,気胸,肺癌,心不全,脊椎側弯症などを有する.本研究では,先行研究で取得した129症例の胸部X線動画像を解析対象とした.管電圧110 kV,管電流80 mA,パルス幅6.3 msec,フレームレート5 fps,撮影距離1.5 mにて,呼吸過程を5~10秒間撮影した,合計50枚のX線動画像から成る.前年度作成した(1) 骨X線動画像ならびに (2) 胸郭運動の定量解析プログラムを用いて,正常症例の胸郭運動を検証した.その結果,正常な胸郭運動は,左右対称でかつ横隔膜運動に同調する動きを示すことを明らかにした.一方,呼吸器疾患症例や肺癌術後症例では,左右対称性ならびに横隔膜運動との同調性が低下することを確認した.正常パターンからの逸脱を根拠に,異常な胸郭運動を検出できる可能性がある.疾患ごとに十分な数の症例が集まっていないため,(5)は初期検討段階に留まったが,研究期間内に肺葉切除の術後症例を中心に,新規で150症例のデータを収集できた.これらの症例を対象とした更なる検討が今後の課題である.

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (17 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 4 results) Presentation (11 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Time-series analysis of the lung texture on bone-suppressed dynamic chest radiography for the evaluation of pulmonary function: a preliminary study2017

    • Author(s)
      Rie Tanaka, Hiroaki Matsuda, Shigeru Sanada
    • Journal Title

      Proc. SPIE 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging

      Volume: 101371R Pages: 101371R-101371R

    • DOI

      10.1117/12.2254377

    • Related Report
      2016 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Computerized method to compensate a breathing body motion in dynamic chest radiographs2017

    • Author(s)
      Hiroaki Matsuda, Rie Tanaka, Shigeru Sanada
    • Journal Title

      Proc. SPIE 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging

      Volume: 101371Q Pages: 101371Q-101371Q

    • DOI

      10.1117/12.2254359

    • Related Report
      2016 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 一軸性関節による肋骨運動の制約付き2D-3D位置合わせ精度の評価2017

    • Author(s)
      日朝祐太,大竹義人,田中利恵,横田太,真田茂,佐藤嘉伸
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 116 Pages: 7-12

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dynamic chest radiography: flat-panel detector (FPD) based functional X-ray imaging2016

    • Author(s)
      Rie Tanaka
    • Journal Title

      Radiol Phys Technol

      Volume: 9 Issue: 2 Pages: 139-153

    • DOI

      10.1007/s12194-016-0361-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Improved accuracy of markerless motion tracking on bone suppression images: Preliminary study for image-guided radiation therapy (IGRT)2015

    • Author(s)
      Rie Tanaka, Shigeru Sanada, Keita Sakuta, Hiroki Kawashima
    • Journal Title

      Physics in Medicine and Biology

      Volume: 60 Issue: 10 Pages: N209-N218

    • DOI

      10.1088/0031-9155/60/10/n209

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of rib kinematics based on dynamic chest bone images: preliminary results2015

    • Author(s)
      Rie Tanaka, Shigeru Sanada, Keita Sakuta, Hiroki Kawashima
    • Journal Title

      Journal of Medical Imaging

      Volume: 2 Issue: 2 Pages: 024002-024002

    • DOI

      10.1117/1.jmi.2.2.024002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Time-series analysis of the lung texture on bone-suppressed dynamic chest radiography for the evaluation of pulmonary function: a preliminary study2017

    • Author(s)
      Rie Tanaka, Hiroaki Matsuda, Shigeru Sanada
    • Organizer
      The international society for optical engineering. Medical imaging 2017
    • Place of Presentation
      Renaissance Orlando at Sea World, Orlando, FL, United States
    • Year and Date
      2017-02-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Computerized method to compensate a breathing body motion in dynamic chest radiographs2017

    • Author(s)
      Hiroaki Matsuda, Rie Tanaka, Shigeru Sanada
    • Organizer
      The international society for optical engineering. Medical imaging 2017
    • Place of Presentation
      Renaissance Orlando at Sea World, Orlando, FL, United States
    • Year and Date
      2017-02-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fundamentals of dynamic chest radiography: Low-cost and high performance functional imaging2016

    • Author(s)
      Rie Tanaka, Shigeru Sanada, Kazuo Kasahara, Isao Matsumoto, Keita Sakuta, Yasushi Kishitani
    • Organizer
      RSNA 102nd Scientific Assembly and Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago, IL, USA
    • Year and Date
      2016-11-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胸部X線動画イメージングにおける体動検出・補正法の開発2016

    • Author(s)
      松田紘明,田中利恵,真田茂
    • Organizer
      第44回日本放射線技術学会秋季学術大会
    • Place of Presentation
      ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Constrained piecewise rigid 2D-3D registration for patient-specific analysis of rib cage motion using X-ray video2016

    • Author(s)
      Yuta Hiasa, Yoshito Otake, Rie Tanaka, Futoshi Yokota, Shigeru Sanada, Yoshinobu Sato
    • Organizer
      International Journal of Computer Assisted Radiology and Surgery (CARS2016)
    • Place of Presentation
      Heidelberg Convention Center, Heidelberg, Germany
    • Year and Date
      2016-06-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Computerized evaluation of the rib kinetics with vector analysis in dynamic chest radiography2016

    • Author(s)
      Hiroaki Matsuda, Rie Tanaka, Shigeru Sanada, Keita Sakuta
    • Organizer
      International Journal of Computer Assisted Radiology and Surgery (CARS2016)
    • Place of Presentation
      Heidelberg Convention Center, Heidelberg, Germany
    • Year and Date
      2016-06-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Diagnostic Criteria for the Evaluation of RibMovements with a Dynamic Chest Radiography: Preliminary Study2016

    • Author(s)
      松田紘明,田中利恵,真田茂
    • Organizer
      第72回日本放射線技術学会総会学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 拘束条件付き2D-3Dレジストレーションを用いたX線動画像からの胸郭動態2015

    • Author(s)
      日朝 祐太, 大竹 義人, 田中 利恵, 真田 茂, 佐藤 嘉伸
    • Organizer
      電子情報通信学会医用画像研究会(MI)
    • Place of Presentation
      奈良先端科学技術大学院大学,奈良
    • Year and Date
      2015-11-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 胸部X線動画イメージングのための体動補正法の開発2015

    • Author(s)
      松田紘明,田中利恵,真田茂
    • Organizer
      公益社団法人 日本放射線技術学会 第8回中部放射線医療技術学術大会
    • Place of Presentation
      AOSSA,福井
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 胸部X 線動画イメージングのための体動補正法の開発2015

    • Author(s)
      松田紘明,田中利恵,真田茂
    • Organizer
      放射線技術科学教育系 第5回全国大学交流夏季研修会
    • Place of Presentation
      伊達市大滝セミナーハウス,北海道
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Application of bone suppression technique to inspiratory/expiratory chest radiography2015

    • Author(s)
      Rie Tanaka, Shigeru Sanada, Keita Sakuta, Hiroki Kawashima, Yasushi Kishitani
    • Organizer
      American Association of Physicists in Medicine, 57th Annual Meeting & Exhibition
    • Place of Presentation
      Anaheim Convention Center, Anaheim, USA
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-28  

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