可視～近赤外域分光機能型超高分解能OCTイメージング

• Project Area: Multidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy
• Project/Area Number: 15H01114
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Nagoya University
• Principal Investigator: 西澤 典彦 名古屋大学, 工学研究科, 教授 (30273288)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 計測工学 / 光源技術 / 光断層計測 / 医用光学 / 光コヒーレンストモグラフィ / 多元計算解剖学 / 光計測 / レーザー / 非破壊計測 / 医用工学

Outline of Annual Research Achievements

１．可視域における超高分解能OCTシステムの開発　―　超短パルスチタンサファイアレーザーとフォトニック結晶ファイバを用いて，波長400-600nmの可視域に，超高分解能OCT用のスーパーコンティニューム光を生成した．更に，ファイバデバイスを用いて可視域の超高分解能OCTシステムを開発し，光源と合わせて用いることで，断層イメージングシステムを開発した．
２．生体サンプルの波長依存性の評価　―　これまでに開発した近赤外域のOCTに加えて，上記で開発した可視域の超高分解能OCTを用いて，ラットの肺組織や，ラットの肝臓サンプルのOCTイメージングを行った．それぞれのサンプルにおいて，高精細な断層イメージを得ることができた．また，波長依存性の評価を行い，長波長帯において深い侵達長が得られることを確認した．
３．OCTを用いた疾患サンプルのイメージング　―　これまでに開発した数種のOCTを用いてラット肺組織の非破壊断層イメージングを行った．更に，計画班の森によって開発された医用３Ｄ表示・解析ソフトであるNewVESを用いて，ラット肺組織のイメージングと解析を行い，COPDによる肺胞の体積変化量の算出に非破壊計測で初めて成功した．
４．本研究のまとめ　―　本研究の考察・検討，および解析を行った．特に，正常・疾患サンプルのOCTイメージングの波長依存性を検討・解析し，疾患部の特定や早期発見の手法を検討した．更に，本研究の総括を行った．

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Optical coherence microscopy in 1700 nm spectral band for high-resolution label-free deep-tissue imaging (2016)
  • Author(s): M. Yamanaka, T. Teranishi, H. Kawagoe, N. Nishizawa
  • Journal Title: Scientific Report Volume: 6 Issue: 1 Pages: 31715-31715
  • DOI: 10.1038/srep31715
  • Peer Reviewed / Open Access
• [Journal Article] Full-range ultrahigh resolution spectral domain optical coherence tomography in 1.7 um wavelength region for deep penetration and high resolution imaging of turbid tissue (2016)
  • Author(s): H. Kawagoe, M. Yamanaka, S. Makita, Y. Yasuno, and N. Nishizawa
  • Journal Title: Applied Physics Express Volume: 9 Issue: 12 Pages: 127002-127002
  • DOI: 10.7567/apex.9.127002
  • Peer Reviewed / Open Access
• [Journal Article] High-resolution optical coherence microscopy using high power supercontinuum source in 1700 nm spectral band (2016)
  • Author(s): M. Yamanaka, T. Teranishi, H. Kawagoe, and N. Nishizawa
  • Journal Title: CLEO 2016 Volume: AM4J.6 Pages: 2-2
  • Peer Reviewed
• [Journal Article] Ultrahigh resolution spectral domain optical coherence tomography in 1.7 um wavelength region (2016)
  • Author(s): H. Kawagoe, M. Yamanaka, S. Makita, Y. Yasuno, and N. Nishizawa
  • Journal Title: CLEO 2016 Volume: JW2A.140 Pages: 2-2
  • Peer Reviewed
• [Journal Article] High-speed ultrahigh resolution spectral domain optical coherence tomography using high-power supercontinuum at 0.8 um wavelength (2015)
  • Author(s): Y. Hattori, H. Kawagoe, Y. Andou, M. Yamanaka, and N. Nishizawa
  • Journal Title: Applied Physics Express Volume: 8 Issue: 8 Pages: 082501-082501
  • DOI: 10.7567/apex.8.082501
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] スーパーコンティニューム光を用いた超高分解能OCT (2015)
  • Author(s): 西澤典彦
  • Journal Title: 日本レーザー医学会誌 Volume: 35 Pages: 432-437
  • NAID: 130005152326
  • Peer Reviewed
• [Journal Article] 超高分解能光コヒーレンストモグラフィー用広帯域ファイバレーザー光源の開発 (2015)
  • Author(s): 西澤典彦，川越寛之，山中真仁，石田周太郎
  • Journal Title: レーザー研究 Volume: 43 Pages: 521-525
  • NAID: 130007957170
  • Peer Reviewed
• [Journal Article] Development of ultrahigh-resolution spectral domain OCT system using supercontinuum source in 1.7 um wavelength region (2015)
  • Author(s): H. Kawagoe, M. Yamanaka, and N. Nishizawa
  • Journal Title: CLEO/Europe-EQEC 2015 Volume: CL_5 Pages: 2-2
  • Peer Reviewed
• [Presentation] Optical coherence microscopy in 1700 nm spectral band for high-resolution deep-tissue imaging (2017)
  • Author(s): M. Yamanaka, T. Teranishi, H. Kawagoe, and N. Nishizawa
  • Organizer: SPIE Photonics West, BIOS2017
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2017-01-28
  • Int'l Joint Research
• [Presentation] 超高分解能光コヒーレンストモグラフィーのための可視広帯域光源の開発 (2017)
  • Author(s): 南部真志，山中真仁，西澤典彦
  • Organizer: レーザー学会学術講演会第37回年次大会
  • Place of Presentation: 徳島大学
  • Year and Date: 2017-01-07
• [Presentation] 微細構造の計測を可能にする光コヒーレンストモグラフィー(OCT)を用いた肺組織イメージング (2016)
  • Author(s): 西澤典彦，川部 勤
  • Organizer: 第39回日本呼吸器内視鏡学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2016-06-23
  • Invited
• [Presentation] High power supercontinuum generation using 182 MHz soliton similariton mode-locked fiber laser for ultrahigh resolution optical coherence tomography in 1600 nm spectral band (2016)
  • Author(s): M. Yamanaka, H. Kawagoe, and N. Nishizawa
  • Organizer: The 5th Advanced Lasers and Photon Sources Conference (ALPS'16)
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2016-05-17
  • Int'l Joint Research
• [Presentation] High power supercontinuum generation with Gaussian-like spectral shape in 2100 nm spectral band for optical coherence tomography (2016)
  • Author(s): T. Sato, H. Kawagoe, M. Yamanaka, and N. Nishizawa
  • Organizer: The 5th Advanced Lasers and Photon Sources Conference (ALPS'16)
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2016-05-17
• [Presentation] Optical coherence microscopy in 1700 nm spectral band for deep and 3D high-resolution imaging of biological samples (2016)
  • Author(s): T. Teranishi, M. Yamanaka, H. Kawagoe, and N. Nishizawa
  • Organizer: The 5th Advanced Lasers and Photon Sources Conference (ALPS'16)
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2016-05-17
  • Int'l Joint Research
• [Presentation] Three dimensional imaging of diseased rat lung and liver using ultrahigh resolution optical coherence tomography (2016)
  • Author(s): M. Nanbu, Y. Ando, H. Kawagoe, M. Yamanaka, M. Matsushima, K. Mori, T. Kawabe, H. Shoji, and N. Nishizawa
  • Organizer: The 5th Advanced Lasers and Photon Sources Conference (ALPS'16)
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2016-05-17
  • Int'l Joint Research
• [Presentation] Ultrahigh resolution optical coherence tomography using ultra-broadband fiber laser source and applicaiton for biomedical imaging (2016)
  • Author(s): N. Nishizawa, H. Kawagoe, and M. Yamanaka
  • Organizer: IS Plasma2016/IC-PLANT2016
  • Place of Presentation: 名古屋大学，名古屋
  • Year and Date: 2016-03-06
  • Int'l Joint Research
• [Presentation] 高繰り返し超短パルスファイバレーザーを用いた波長1600nm帯超高分解能OCT用スーパーコンティニューム光生成 (2016)
  • Author(s): 山中真仁，川越寛之，西澤典彦
  • Organizer: レーザー学会学術講演会第36回年次大会
  • Place of Presentation: 名城大学，名古屋
  • Year and Date: 2016-01-09
• [Presentation] 波長1600nm帯超高分解能OCTイメージングに向けた高繰り返し超短パルスファイバーレーザーベースのSC光源開発 (2015)
  • Author(s): 山中真仁，川越寛之，西澤典彦
  • Organizer: Optics & Photonics Japan 2015
  • Place of Presentation: 筑波大学，東京
  • Year and Date: 2015-10-28
• [Presentation] High-resolution optical coherence microscopy using a high power supercontinuum source in 1700 nm spectral band (2015)
  • Author(s): M. Yamanaka, T. Teranishi, H. Kawagoe, and N. Nishizawa
  • Organizer: SPIE/OSJ Biophotonics Japan
  • Place of Presentation: 筑波大学，東京
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] High power supercontinuum generation by high repetition rate ultrashort pulse fiber laser for ultrahigh resolution OCT in 1600 nm spectral band (2015)
  • Author(s): M. Yamanaka, H. Kawagoe, and N. Nishizawa
  • Organizer: 第76回応用物理学会秋季学術講演会
  • Place of Presentation: 名古屋国際会議場，名古屋
  • Year and Date: 2015-09-13
• [Presentation] Development of highly functional ultrashort pulse fiber laser sources for ultrahigh resolution optical coherence tomography (2015)
  • Author(s): 西澤典彦
  • Organizer: Topical Problems of Biophotonics (TPB)
  • Place of Presentation: Nizhny Novgorod, Russia
  • Year and Date: 2015-07-20
  • Int'l Joint Research / Invited
• [Remarks] 名古屋大学 西澤研究室
  • URL: http://www.nuee.nagoya-u.ac.jp/labs/optelelab/
• [Remarks] 名古屋大学西澤研究室
  • URL: http://www.nuee.nagoya-u.ac.jp/labs/optelelab/