ヒト初期胎児組織切片からの三次元モデル作成と発生学教育への応用
Publicly Offered Research
| Project Area | Multidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy |
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| Project/Area Number |
15H01121
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
山田 重人 京都大学, 医学研究科, 教授 (80432384)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 解剖学 / ヒト / 教材 / Human Embryo / Tutorials / 3D reconstruction |
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| Outline of Annual Research Achievements |
Morphogenesis of human embryos is occurring in three-dimensional (3D) manner. To understand sequential changes during the developmental period, 3D models is essential for help to understand the overview of those dynamic morphological alterations temporally and spatially. Since 1961, a large number of human embryos and fetuses have been collected at Congenital Anomaly Research Center, Kyoto University, and it is now called “Kyoto Collection of Human Embryos”. Using histological sections from the Kyoto Collection, we aim to make 3D models of embryonic organs and apply them to self-learning program of human embryology.
The progress in FY2016 is below; the technique for registration of serial sections has developed. The usage of histological sections of human embryos in this research includes 2 important point for the Multidisciplinary Computational Anatomy; First, histological sections have quite huge information in comparison with other medical imaging such as MRI or X-ray CT, commonly used in the research. Second, image data during embryonic period are precious and valuable, and they can add the new aspect such as developmental biology to the research. In addition, 3D models and movies have been made, and platform of the tutorials has been constructed using CMS in FY2016.
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| Research Progress Status |
28年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
28年度が最終年度であるため、記入しない。
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Report
(2 results)
Research Products
(105 results)
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[Journal Article] Merging and fractionation of muscle synergy indicate the recovery process in patients with hemiplegia: the first study of patients after subacute stroke.2016
Author(s)
Hashiguchi Y, Ohata K, Kitatani R, Yamakami N, Sakuma K, Osako S, Aga Y, Watanabe A, Yamada S.
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Journal Title
Neural Plasticity,
Volume: 2,016
Pages: 5282957-5282957
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan.2016
Author(s)
Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanouchi Y, Ozasa Y, Kanai M, Sago H, Sekizawa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K.
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Journal Title
J Hum Gen
Volume: 61(10)
Issue: 10
Pages: 879-884
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] 「The first human embryonic research for the development of the nasal septum using geometric morphometrics: A new insight for the sensitive period for the Binder phenotype.」(Poster) Cleft20172017
Author(s)
Katsube M, Yamada S, Uwabe C, Makishima H, Miyazaki R, Yamaguchi Y, Ishiyama H, Yamamoto A, Morimoto N, Ito T, Imai H, Matsuda T, Suzuki S.
Organizer
INTERNATIONAL CLEFT CONGRESS 2017
Place of Presentation
Radisson Blu Resort, Temple Bay, Mahabalipuram（Chennai, India）
Year and Date
2017-02-08
Related Report
Int'l Joint Research
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[Presentation] ヒト発生学と先天異常2016
Author(s)
山田重人
Organizer
第12回北関東遺伝診療フォーラム
Place of Presentation
大宮パレスホテル 埼玉県大宮市
Year and Date
2016-11-28
Related Report
Invited
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[Presentation] Current Status of Social Issues for People with Down Syndrome in Japan: From Nationwide Survey.2016
Author(s)
Miyake H, Yamada S, Fujii Y, Taniguchi-Ikeda M, Urano M, Ozasa Y, Kanai M, Fukushima A, Matsubara Y, Saito K, Konishi I.
Organizer
The 13th International Congress of Human Genetics.
Place of Presentation
Kyoto International Conterrence Center,Japan (sakyo-ku kyoto)
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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[Presentation] Characteristics of the Genetic Counseling in Kyoto University Hospital to Figure Out the Genetic Counseling Needs in Japan.2016
Author(s)
Matsukawa M, Nishio H, Hiraoka Y, Honda S, Inaba A, Takamine E, Yonei A, Torishima M, Murakami H, Kitajiri S, Wada T, Miyake H, Yamada S, Heike T, Kosugi S.
Organizer
The 13th International Congress of Human Genetics.
Place of Presentation
Kyoto International Conterrence Center,Japan (sakyo-ku kyoto)
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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[Presentation] The current status of conventional prenatal diagnosis in Japan: A Nationwide survey of obstetrics/gynecology facilities.2015
Author(s)
Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanuchi Y, Ozasa Y, Kanai M, Sago H, Sekizasa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K
Organizer
21st The International Federation of Gynecology and Obstetrics (FIGO)
Place of Presentation
Vancouver, Canada
Year and Date
2015-10-04
Related Report
Int'l Joint Research
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[Presentation] ヒト発生学と発生学研究2015
Author(s)
山田重人
Organizer
第25回遺伝医学セミナー
Place of Presentation
三井ガーデンホテル（千葉中央区）
Year and Date
2015-09-04
Related Report
Invited
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[Presentation] Survey of conventional prenatal diagnosis in Japan - Nationwide study for obstetricians about prenatal diagnosis2015
Author(s)
Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanuchi Y, Ozasa Y, Kanai M, Sago H, Sekizasa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K
Organizer
ISPD 19th International Conference on Prenatal Diagnosis and Therapy
Place of Presentation
Columbia, United States
Year and Date
2015-07-12
Related Report
Int'l Joint Research
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