高精細全脳イメージングによるマイクロ精神病態の探索

• Project Area: Unraveling micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels.
• Project/Area Number: 15H01288
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: 橋本 均 大阪大学, 薬学研究科, 教授 (30240849)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000); Fiscal Year 2016: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000); Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 精神疾患 / 脳 / イメージング / 疾患モデル / 疾患モデル動物

Outline of Annual Research Achievements

脳は高度に機能が局在しており、脳疾患の解明のためには、全脳細胞の形態・機能を捉え、仮説を設定することなく、その中に潜む症状と相関する変化を見出し、それを手掛かりに病態と治療機序の究明を目指す研究が必要である。本課題は、疾患モデル動物における脳細胞の形態・機能変化およびそれらと疾患モデルの表現型との関連を全脳レベルで解析して、新たなマイクロエンドフェノタイプの創出を目指すことを目標としている。このため申請者が最近構築した、全脳細胞をサブミクロンの分解能でイメージングするシステムを用いて、精神疾患モデル動物の全脳細胞の分布や神経活動等をメゾスコピックに解析して、新たなマイクロ精神病態を明らかにすることを目的とする。
平成28年度は、昨年度に改良した高精細の全脳イメージング装置を用いて、統合失調症モデルマウスのイメージングを実施した。仮説なしに正常マウスと疾患モデルマウスの神経活動パターンを網羅的に比較した結果、統合失調症のマウスモデルとして考えられるNMDA受容体阻害薬MK-801投与マウスにおいて、これまでに着目されてこなかった内側眼窩前頭皮質が強く活性化することが見出された。一方で、MK-801投与マウスと同様に多動を示すメタンフェタミン投与マウスの脳では、内側眼窩前頭皮質の活性化はみられなかった。また、内側眼窩前頭皮質を化学的に損傷すると、MK-801により誘発される行動異常が部分的に抑制されることがわかった。さらに、MK-801誘発行動異常を改善する非定型抗精神病薬クロザピンは、内側眼窩前頭皮質の活性化を抑制し、このモデルの行動異常を改善しない定型抗精神病薬ハロペリドールは内側眼窩前頭皮質の活性化を抑制しないことがわかった。以上より、高精細な全脳イメージングにより、統合失調症モデルの新たなマイクロ精神病態が明らかになった。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] カリフォルニア大学ロサンゼルス校(米国)
• [Journal Article] Decreased cohesion in the brain leads to defective synapse development and anxiety-related behavior (2017)
  • Author(s): Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T.
  • Journal Title: J. Exp. Med. Volume: 印刷中 Issue: 5 Pages: 1431-1452
  • DOI: 10.1084/jem.20161517
  • Peer Reviewed / Open Access
• [Journal Article] Early Neurobehavioral Development of Mice Lacking Endogenous PACAP (2017)
  • Author(s): Farkas J, Sandor B, Tamas A, Kiss P, Hashimoto H, Nagy AD, Fulop BD, Juhasz T, Manavalan S, Reglodi D.
  • Journal Title: J. Mol. Neurosci. Volume: 61(4) Issue: 4 Pages: 468-478
  • DOI: 10.1007/s12031-017-0887-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia. (2017)
  • Author(s): Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T.
  • Journal Title: Int J Mol Sci. Volume: 18 Issue: 3 Pages: 632-632
  • DOI: 10.3390/ijms18030632
  • NAID: 120006535029
  • Peer Reviewed / Open Access
• [Journal Article] Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. (2017)
  • Author(s): Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R.
  • Journal Title: Schizophr Res. Volume: 181 Pages: 75-82
  • DOI: 10.1016/j.schres.2016.10.012
  • NAID: 120007037467
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice (2016)
  • Author(s): Tanaka T, Ago Y, Umehara C, Imoto E, Hasebe S, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Int. J. Neuropsychopharmacol. Volume: 20 Pages: 410-420
  • DOI: 10.1093/ijnp/pyw115
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice. (2016)
  • Author(s): Seiriki K, Kasai A, Kuwaki T, Nakazawa T, Yamaguchi S, Hashimoto H.
  • Journal Title: Biochem Biophys Res Commun. Volume: 480 Issue: 4 Pages: 558-563
  • DOI: 10.1016/j.bbrc.2016.10.089
  • Peer Reviewed / Open Access
• [Journal Article] Double In situ Hybridization for MicroRNAs and mRNAs in Brain Tissues. (2016)
  • Author(s): Kasai A, Kakihara S, Miura H, Okada R, Hayata-Takano A, Hazama K, Niu M, Shintani N, Nakazawa T, Hashimoto H.
  • Journal Title: Front Mol Neurosci. Volume: 9 Pages: 126-126
  • DOI: 10.3389/fnmol.2016.00126
  • Peer Reviewed / Open Access
• [Journal Article] PACAP Protects the Adolescent and Adult Mice Brain from Ethanol Toxicity and Modulates Distinct Sets of Genes Regulating Similar Networks (2016)
  • Author(s): Lacaille H, Duterte-Boucher D, Vaudry H, Zerdoumi Y, Flaman JM, Hashimoto H, Vaudry D.
  • Journal Title: Mol. Neurobiol. Volume: 印刷中 Issue: 9 Pages: 7534-7548
  • DOI: 10.1007/s12035-016-0204-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction. (2016)
  • Author(s): Onaka Y, Shintani N, Nakazawa T, Kanoh T, Ago Y, Matsuda T, Hashimoto R, Ohi K, Hirai H, Nagata KY, Nakamura M, Kasai A, Hayata-Takano A, Nagayasu K, Takuma K, Ogawa A, Baba A, Hashimoto H.
  • Journal Title: Behav Brain Res. Volume: 314 Pages: 477-486
  • DOI: 10.1016/j.bbr.2016.07.050
  • Peer Reviewed / Open Access
• [Journal Article] Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation (2016)
  • Author(s): Kawanai T, Ago Y, Watanabe R, Inoue A, Taruta A, Onaka Y, Hasebe S, Hashimoto H, Matsuda T, Takuma K.
  • Journal Title: Neurochem. Res. Volume: 41(10) Issue: 10 Pages: 2574-2584
  • DOI: 10.1007/s11064-016-1969-y
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism (2016)
  • Author(s): Hara Y, Ago Y, Taruta A, Katashiba K, Hasebe S, Takano E, Onaka Y, Hashimoto H, Matsuda T, Takuma K
  • Journal Title: Autism Research Volume: - Issue: 9 Pages: 926-939
  • DOI: 10.1002/aur.1596
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency (2016)
  • Author(s): Ago Y, Hasebe S, Hiramatsu N, Mori K, Watabe Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Psychopharmacology(Berl) Volume: 233(17) Issue: 17 Pages: 3125-3134
  • DOI: 10.1007/s00213-016-4353-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers (2016)
  • Author(s): Kormos V, Gaspar L, Kovacs, Farkas J, Gaszner T, Csernus V, Balogh A, Hashimoto H, Reglodi D, Helyes Z, Gaszner B.
  • Journal Title: Neuroscience Volume: 330 Pages: 335-358
  • DOI: 10.1016/j.neuroscience.2016.06.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] PACAP suppresses dry eye signs by stimulating tear secretion (2016)
  • Author(s): Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Mark L, Lanekoff I, Kiss P, Farkas J, Reglodi D, Shioda S.
  • Journal Title: Nat. Commun. Volume: 7 Issue: 1 Pages: 12034-12034
  • DOI: 10.1038/ncomms12034
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ (2016)
  • Author(s): Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H.
  • Journal Title: J. Mol. Psychiatry Volume: 4 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s40303-016-0016-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in adult mouse hippocampal neurogenesis after stroke (2016)
  • Author(s): Matsumoto M, Nakamachi T, Watanabe J, Sugiyama K, Ohtaki H, Murai N, Sasaki S, Xu Z, Hashimoto H, Seki T, Miyazaki A, Shioda S.
  • Journal Title: J Mol Neurosci. Volume: 未定
  • Peer Reviewed
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor. (2016)
  • Author(s): Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, Matsumoto M, Hashimoto H, Hiraizumi Y, Numazawa S, Shioda S.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 22373-22373
  • DOI: 10.1038/srep22373
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Erratum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders (Nature Communications (2016) 7 (10594) DOI: 10.1038/ncomms10594) (2016)
  • Author(s): Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M.
  • Journal Title: Nat Commun. Volume: 7 Issue: 1 Pages: 10594-10594
  • DOI: 10.1038/ncomms11466
  • Peer Reviewed / Open Access
• [Journal Article] Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice (2016)
  • Author(s): Higashino K, Ago Y, Umeki T, Hasebe S, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Psychopharmacology (Berl). Volume: 233(3) Issue: 3 Pages: 521-528
  • DOI: 10.1007/s00213-015-4123-7
  • Peer Reviewed
• [Journal Article] Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder. (2015)
  • Author(s): Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H.
  • Journal Title: Journal of Human Genetics Volume: 61 Issue: 3 Pages: 199-206
  • DOI: 10.1038/jhg.2015.141
  • Peer Reviewed / Open Access
• [Journal Article] Structured line illumination Raman microscopy (2015)
  • Author(s): Watanabe K, Palonpon AF, Smith NI, Chiu LD, Kasai A, Hashimoto H, Kawata S, Fujita K.
  • Journal Title: Nat Commun. Volume: 6 Issue: 1 Pages: 10095-10095
  • DOI: 10.1038/ncomms10095
  • Peer Reviewed / Open Access
• [Journal Article] The female encounter test, a novel method for evaluating reward-seeking behavior or motivation in mice (2015)
  • Author(s): Ago Y, Hasebe S, Nishiyama S, Oka S, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Neuropsychopharmacol. Volume: 18(11) Issue: 11 Pages: pyv062-pyv062
  • DOI: 10.1093/ijnp/pyv062
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice (2015)
  • Author(s): Hasebe S, Ago Y, Nishiyama S, Oka S, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Behav Pharmacol. Volume: 26(7) Issue: 7 Pages: 681-690
  • DOI: 10.1097/fbp.0000000000000140
  • Peer Reviewed
• [Journal Article] Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). (2015)
  • Author(s): hibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Waschek JA, Köves K, Reglődi D, Tamas A, Matsuda T, Baba A, Hashimoto H.
  • Journal Title: Neuroscience Volume: 297 Pages: 95-104
  • DOI: 10.1016/j.neuroscience.2015.03.062
  • Peer Reviewed
• [Journal Article] Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model (2015)
  • Author(s): Hara Y, Takuma K, Takano E, Katashiba K, Taruta A, Higashino K, Hashimoto H, Ago Y, Matsuda T.
  • Journal Title: Behav Brain Res. Volume: 289 Pages: 39-47
  • DOI: 10.1016/j.bbr.2015.04.022
  • Peer Reviewed
• [Journal Article] CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice (2015)
  • Author(s): Yusuke Onaka, Norihito Shintani, Takanobu Nakazawa, Ryota Haba, Yukio Ago, Hyper Wang, Takuya Kanoh, Atsuko Hayata-Takano, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Ryota Hashimoto, Toshio Matsuda, James A. Waschek, Atsushi Kasai, Kazuki Nagayasu, Akemichi Baba, Hitoshi Hashimoto
  • Journal Title: Behavioural Brain Research Volume: 284 Pages: 131-137
  • DOI: 10.1016/j.bbr.2015.02.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Anxiolytic-like effects of restraint during the dark cycle in adolescent mice (2015)
  • Author(s): Ota Y, Ago Y, Tanaka T, Hasebe S, Toratani Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T
  • Journal Title: Behavioural Brain Research Volume: 284 Pages: 103-111
  • DOI: 10.1016/j.bbr.2015.02.010
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] High-speed whole brain imaging with subcellular resolution and comparison analysis (2017)
  • Author(s): 笠井淳司、橋本均
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] 精神的ストレスにより活性化する神経核の情動行動における役割 (2017)
  • Author(s): 丹生光咲、笠井淳司、勢力薫、五十嵐久人、山口瞬、山中章弘、中澤敬信、橋本均
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] 全脳活動マッピングを用いたNMDA受容体拮抗薬誘発行動異常に関わる脳部位の解析 (2017)
  • Author(s): 勢力薫、笠井淳司、桑木崇宏、丹生光咲、中雄一郎、五十嵐久人、中澤敬信、山口瞬、吾郷由希夫、橋本均
  • Organizer: 第90回薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-15
• [Presentation] CNS創薬を支援する疾患モデルの開発 (2017)
  • Author(s): 橋本均、笠井淳司、中澤敬信
  • Organizer: 日本安全性薬理研究会第8回学術年会
  • Place of Presentation: 東京
  • Year and Date: 2017-02-10
• [Presentation] Activation of the VPAC2 receptor inhibits neurite outgrowth and branching of cortical neurons by a PKA-dependent mechanism (2016)
  • Author(s): Hashimoto H, Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Waschek JA.
  • Organizer: Neuroscience 2016
  • Place of Presentation: アメリカ
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 全脳イメージングによる脳機能・疾患機序の解析 (2016)
  • Author(s): 橋本均、勢力薫、丹生光咲、中雄一郎、笠井淳司
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-08
• [Presentation] Overactivation of the VPAC2 receptor during the early postnatal period causes prefrontal synaptic abnormalities and cognitive dysfundtion in mice (2016)
  • Author(s): Ago Y, Hayata A, Kawanai T, Yamauchi R, Waschek JA, Hashimoto H
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: 韓国
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] iPS細胞技術を用いた統合失調症患者のクロザピン応答性の個人間の相違の分子機構解析 (2016)
  • Author(s): 中澤敬信、橋本亮太、橋本均
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: 韓国
  • Year and Date: 2016-07-02
• [Presentation] 統合失調症におけるVIP/PACAP受容体VPAC2活性化の病態的意義 (2016)
  • Author(s): 吾郷由希夫、河内琢也、山内良介、早田敦子、James Waschek、橋本均
  • Organizer: 第13回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-05-13
• [Presentation] 発育期の環境要因が精神・神経機能に及ぼす影響 (2016)
  • Author(s): 田熊一敞, 吾郷由希夫, 長谷部 茂, 橋本均, 松田敏夫
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（神奈川・横浜市）
  • Year and Date: 2016-03-09
• [Presentation] Whole Brain Imaging to Investigate Physiology and Pathophysiology of Brain Disorders (2016)
  • Author(s): Hashimoto H
  • Organizer: VIMM Seminar (日伊国交150周年事業)
  • Place of Presentation: イタリア
  • Invited
• [Presentation] 精神疾患の分子機構の解析と創薬に向けた疾患モデル研究 (2016)
  • Author(s): 橋本均
  • Organizer: 第61回脳の医学・生物学研究会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 社会的敗北ストレスによる社会的忌避行動時の全脳神経活動マッピング (2016)
  • Author(s): 五十嵐久人、笠井淳司、勢力薫、丹生光咲、中雄一郎、山浦港生、中澤敬信、橋本均
  • Organizer: 第130回日本薬理学会近畿部会
  • Place of Presentation: 京都
• [Presentation] 脳病態を解明するモデル動物の全脳イメージング (2015)
  • Author(s): 橋本均, 笠井淳司, 勢力薫, 丹生光咲, 中澤敬信
  • Organizer: 第6回脳表現型の分子メカニズム研究会
  • Place of Presentation: コンベンションルームAP品川アネックスIルーム（東京・品川区）
  • Year and Date: 2015-11-14
• [Presentation] A new block-face serial microscopy tomography for computational mapping of brain cells, and unbiased comparative analysis. (2015)
  • Author(s): Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Nakazawa T, Hashimoto H.
  • Organizer: 45th Society for Neuroscience Annual meeting (Neuroscience2015)
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Practical optimization of in situ hybridization procedure for the detection of microRNAs and mRNA expression in brain tissues (2015)
  • Author(s): Kasai A, Kakihara S, Okada R, Hazama K, Nakazawa T, Nagayasu K, Hayata-Takano A, Shintani N, Hashimoto H.
  • Organizer: 45th Society for Neuroscience Annual meeting (Neuroscience2015)
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Overactivation of the VPAC2 receptor during postnatal brain development causes prefrontal synaptic abnormalities and cognitive dysfunction in mice (2015)
  • Author(s): Ago Y, Condro MC, Tan YV, Hayata A, Kawanai T, Cushman JD, Fanselow MS, Hashimoto H, Waschek JA.
  • Organizer: 12th International Symposium on VIP/PACAP and Related Peptides
  • Place of Presentation: カッパドキア（トルコ）
  • Year and Date: 2015-09-21
  • Int'l Joint Research
• [Presentation] Roles of PACAP in Depressopm-Like Behavior (2015)
  • Author(s): Hashimoto H, Shintani N, Ago Y, Hayata-Takano A, Waschek JA, Baba A.
  • Organizer: 12th International Symposium on VIP/PACAP and Related Peptides
  • Place of Presentation: カッパドキア（トルコ）
  • Year and Date: 2015-09-21
  • Int'l Joint Research
• [Presentation] ストレスにより活性化する神経細胞の全脳マッピングと定量的解析 (2015)
  • Author(s): 丹生光咲, 笠井淳司, 勢力薫, 山口瞬, 橋本岳, 中澤敬信, 橋本均
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2015
  • Place of Presentation: 東京大学薬学部（東京・文京区）
  • Year and Date: 2015-08-29
• [Presentation] 構造および神経活動の変化を定量的に検出する高精細三次元全脳形態計測システム (2015)
  • Author(s): 勢力薫, 笠井淳司, 丹生光咲, 山口瞬, 橋本岳, 中澤敬信, 橋本均
  • Organizer: 第38回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] 自閉症の疾患特異的候補遺伝子の機能的スクリーニング (2015)
  • Author(s): 松村憲佑, 橋本亮太, 中澤敬信, 鶴崎美徳, 安田由華, 永安一樹, 川島和, 山森英長, 藤本美智子, 大井一高, 梅田知美, 福永雅喜, 藤野陽生, 笠井淳司, 早田敦子, 新谷紀人, 武田雅俊, 松本直通, 橋本均
  • Organizer: 第38回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] 雌選択性試験：マウス間相互作用を基盤とした新規うつ様行動評価系 (2015)
  • Author(s): 長谷部茂, 岡智史, 尾中勇祐, 橋本均, 松田敏夫, 吾郷由希夫, 田熊一敞
  • Organizer: 第38回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] マウス活動期における拘束ストレスは抗不安様作用を示す (2015)
  • Author(s): 田中辰典, 太田友樹, 大住康晃, 長谷部茂, 尾中勇祐, 橋本均, 松田敏夫, 田熊一敞, 吾郷由希夫
  • Organizer: 第38回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] リバスチグミンのムスカリン受容体を介したプレパルスインヒビション障害改善作用 (2015)
  • Author(s): 東野功典, 梅木孝弘, 尾中勇祐, 橋本均, 松田敏夫, 田熊一敞, 吾郷由希夫
  • Organizer: 第38回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] がん治療後の脳機能障害の解明に有用な動物モデルの作製 (2015)
  • Author(s): 尾中勇祐, 木野村元彦, 新谷紀人, 平井博之, 永田欽也, 中村正孝, 長谷部茂, 永安一樹, 吾郷由希夫, 笠井淳司, 早田敦子, 中澤敬信, 田熊一敞, 松田敏夫, 馬場明道, 橋本均
  • Organizer: 第127回日本薬理学会近畿部会
  • Place of Presentation: 長良川国際会議場（岐阜・岐阜市）
  • Year and Date: 2015-06-26
• [Remarks] 大阪大学大学院 薬学研究科 神経薬理学分野
  • URL: http://molpharm.umin.jp/index.html