Publicly Offered Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
We made great progress in Heisei 28. Our goal was to anatomically functionally map aversive shock outputs from the periaqueductal gray (PAG) to the lateral amygdala. Previously we identified pathways from the PAG to the centromedial and paraventricular thalamus. In the last year we optogenetically manipulated these pathways and found that the PAG to paraventricular thalamus, but not the PAG-centromedial thalamus, circuit was necessary for aversive shocks to produce fear learning. Furthermore, we performed viral based efferent mapping of the projections of the thalamus projecting PAG neurons and revealed their brainwide efferent arborization throughout the brainIn addition to examining this ascending aversive signaling pathway we also studied how sensory predictive cues inhibit this pathway during learning to set the strength of fear memories (learning asymptotes). Previously we found that a pathway from the central nucleus of the amygdala controlled this process. Last year, we identified a specific population of PAG cells which are important for setting learning asymptotes using viral tracing and optogenetic manipulation approaches. This work was published this year (Ozawa et al. Nature Neuroscience 2017).
28年度が最終年度であるため、記入しない。
All 2017 2016 2015
All Journal Article (5 results) (of which Int'l Joint Research: 5 results, Peer Reviewed: 5 results, Acknowledgement Compliant: 3 results, Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results, Invited: 7 results)
Nature Neuroscience
Volume: 20(1) Issue: 1 Pages: 90-97
10.1038/nn.4439
Neuropsychopharmacology
Volume: 42(4) Issue: 4 Pages: 895-903
10.1038/npp.2016.238
Volume: In press Issue: 7 Pages: 965-972
10.1038/nn.4308
Pain
Volume: 157(1) Issue: 1 Pages: 166-173
10.1097/j.pain.0000000000000344
Learning & Memory
Volume: 22 Issue: 9 Pages: 444-451
10.1101/lm.037283.114
