• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

精神疾患病態におけるドーパミンシグナル関連マイクロエンドフェノタイプの解明

Publicly Offered Research

Project AreaUnraveling micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels.
Project/Area Number 15H01303
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

池田 和隆  公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2016: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords医療・福祉 / 神経科学 / 生理活性 / 脳・神経 / 薬理学 / 脳神経疾患 / 遺伝子
Outline of Annual Research Achievements

ドーパミンの生理作用は多岐にわたり、詳細な作用機序に関しては未だ不明な点は多い。従来、ドーパミンはヒトおよび動物が活動する上で必須であると考えられてきたが、以前、我々がドーパミン欠乏マウスを用いて活動量を評価したところ、予想外なことに、ドーパミンがほぼ完全に欠乏した状態で、新奇環境曝露下での活動量がむしろ亢進することを見出した。そこで、この活動量亢進がどのような機序で引き起こされているのかを探るため、ドーパミン欠乏マウスの亢進した活動量を抑制する薬剤を探索した。定型抗精神病薬であるハロペリドールは無効だったのに対して、非定型抗精神病薬のクロザピンはドーパミン欠乏マウスの活動量を抑制した。クロザピンの作用点は多数あるので、それぞれに特異的な薬剤の効果を調べたところ、ムスカリニック受容体作動薬のオキソトレモリンがドーパミン欠乏マウスの活動量を抑制した。ドーパミン欠乏時に活動量が亢進するメカニズムとして、ムスカリニック受容体の活動低下が考えられた。次に、ドーパミン欠乏マウスの活動量亢進時の神経活動を野生型マウスと比較し、解析した。c-fos発現を指標に検討したところ、ドーパミン欠乏マウスの線条体の一部領域および海馬CA1、CA3領域において、c-fos発現細胞数が多く、神経活動が過剰になっていることが認められた。これらの領域は、新奇刺激によって活性化されることが報告されており、今回の解析から、新奇刺激に対する脳領域の活性化はドーパミン非依存的であることが認められた。また、複数回曝露による馴化によってこれらの領域の活性化が低下することも報告されていることから、ドーパミン欠乏マウスの活動量亢進にはこれらの領域の過剰な活性化が関与する可能性が示唆された。これらより、ドーパミンはこれらの領域の活性化を抑制し、馴化による活動量の低下に関わる可能性があると考えられる。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (148 results)

All 2017 2016 2015 Other

All Journal Article (31 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 18 results,  Open Access: 10 results,  Acknowledgement Compliant: 1 results) Presentation (107 results) (of which Int'l Joint Research: 43 results,  Invited: 14 results) Book (8 results) Remarks (2 results)

  • [Journal Article] Opioid dose and neuropathic pain before-and-after electroconvulsive therapy.2017

    • Author(s)
      Iwata K, Kobayashi Y, Mera H, Doi N, Suwa H, Ikeda K
    • Journal Title

      日本ペインクリニック学会誌

      Volume: 印刷中

    • NAID

      130006832066

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain.2017

    • Author(s)
      Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
    • Journal Title

      Pain Med

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No association between the polymorphism rs6943555 in the AUTS2 gene and personality traits in Japanese university students.2017

    • Author(s)
      Narita S, Ikeda K, Nishizawa D, Yoshihara E, Numajiri M, Onozawa Y, Ohtani N, Iwahashi K
    • Journal Title

      Psychiatry Investigation

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct roles of opioid and dopamine systems in lateral hypothalamic intracranial self-stimulation.2017

    • Author(s)
      Ide S, Takahashi T, Takamatsu Y, Uhl G, Niki H, Sora I, Ikeda K
    • Journal Title

      Int J Neuropsychopharmacol

      Volume: 印刷中 Pages: pyw113-pyw113

    • DOI

      10.1093/ijnp/pyw113

    • NAID

      120006373767

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Loss of GluN2D subunit results in social recognition deficit, social stress, 5-HT2C receptor dysfunction, and anhedonia in mice.2017

    • Author(s)
      Yamamoto H, Kamegaya E, Hagino Y, Takamatsu Y, Sawada W, Matsuzawa M, Ide S, Yamamoto T, Mishina M, Ikeda K
    • Journal Title

      Neuropharmacology

      Volume: 112(Pt A) Pages: 188-197

    • DOI

      10.1016/j.neuropharm.2016.07.036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ペインクリニックにおける精密医療.2017

    • Author(s)
      池田和隆
    • Journal Title

      ペインクリニック

      Volume: 38 Pages: 557-558

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery.2016

    • Author(s)
      Muraoka W, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Wajima K, Nakagawa T, Ikeda K
    • Journal Title

      Mol Pain

      Volume: 12 Pages: 1-12

    • DOI

      10.1177/1744806916683182

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Opposite associations between the rs3845446 single-nucleotide polymorphism of the CACNA1E gene and postoperative pain-related phenotypes in gastrointestinal surgery versus previously reported orthognathic surgery.2016

    • Author(s)
      Amano K, Nishizawa D, Mieda T, Tsujita M, Kitamura A, Hasegawa J, Inada E, Hayashida M, Ikeda K
    • Journal Title

      J Pain

      Volume: 17(10) Issue: 10 Pages: 1126-1134

    • DOI

      10.1016/j.jpain.2016.07.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese.2016

    • Author(s)
      Kasai S, Nishizawa D, Hasegawa J, Sato N, Tanioka F, Sugimura H, Ikeda K
    • Journal Title

      Pharmacogenomics

      Volume: 17(13) Issue: 13 Pages: 1441-1451

    • DOI

      10.2217/pgs.15.184

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] オピオイド感受性遺伝子の個体差について.2016

    • Author(s)
      西澤大輔, 福田謙一, 林田眞和, 池田和隆
    • Journal Title

      Locomotive Pain Frontier

      Volume: 5(2) Pages: 14-18

    • NAID

      40021039483

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Association between AUTS2 haplotypes and alcohol dependence in a Japanese population.2016

    • Author(s)
      Narita S, Nagahori K, Nishizawa D, Yoshihara E, Kawai A, Ikeda K, Iwahashi K
    • Journal Title

      Acta Neuropsychiatrica

      Volume: 14 Issue: 4 Pages: 1-7

    • DOI

      10.1017/neu.2015.70

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 疼痛緩和における”テーラーメイド治療”の実現に向けて.2016

    • Author(s)
      井手聡一郎, 吉田香織, 西澤大輔, 福田謙一, 池田和隆
    • Journal Title

      医薬ジャーナル

      Volume: Vol. 52 No.3 Pages: 151-155

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 遺伝子多型が麻酔科の臨床にもたらすもの(遺伝子多型を利用した麻酔科臨床への応用).2016

    • Author(s)
      吉田香織, 井手聡一郎, 西澤大輔, 池田和隆, 福田謙一
    • Journal Title

      A net

      Volume: Vol.20 No.1 Pages: 11-14

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] GIRKチャネルと薬物依存.2016

    • Author(s)
      高松幸雄, 池田和隆
    • Journal Title

      脳21

      Volume: 19 Pages: 13-17

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy.2015

    • Author(s)
      Mieda T, Nishizawa D, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M
    • Journal Title

      Pharmacogenomics

      Volume: 17 Issue: 2 Pages: 133-145

    • DOI

      10.2217/pgs.15.151

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Role of the NMDA receptor GluN2D subunit in the expression of ketamine-induced behavioral sensitization and region-specific activation of neuronal nitric oxide synthase.2015

    • Author(s)
      Yamamoto T, Nakayama T, Yamaguchi J, Matsuzawa M, Mishina M, Ikeda K, Yamamoto H
    • Journal Title

      Neurosci Lett

      Volume: 610 Pages: 48-53

    • DOI

      10.1016/j.neulet.2015.10.049

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.2015

    • Author(s)
      Nishizawa D et al.
    • Journal Title

      Mol Brain.

      Volume: 8 Issue: 1 Pages: 50-50

    • DOI

      10.1186/s13041-015-0142-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between AKT1 gene polymorphism rs2498794 and smoking-related traits with reference to cancer susceptibility2015

    • Author(s)
      Nishizawa, D., Kasai, S., Hasegawa, J., Sato,N., Tanioka, F., Sugimura, H., Ikeda, K. and Dobashi, Y.
    • Journal Title

      Biomedical Research. International;

      Volume: 2015.94. Pages: 316829-316829

    • DOI

      10.1155/2015/316829

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The piccolo intronic single nucleotide polymorphism rs13438494 regulates dopamine and serotonin uptake and shows associations with dependence-like behavior in genomic association study.2015

    • Author(s)
      Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda K, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won M-J, Naruse N, Uehara K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A.
    • Journal Title

      Current molecular medicine

      Volume: 15(3) Issue: 3 Pages: 265-274

    • DOI

      10.2174/1566524015666150330145722

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of learning and increase in dopamine level in the frontal cortex by methylphenidate in mice lacking dopamine transporter.2015

    • Author(s)
      Takamatsu Y, Hagino Y, Sato A, Takahashi T, Nagasawa SY, Kubo Y, Mizuguchi M, Uhl GR, Sora I, Ikeda K
    • Journal Title

      Curr Mol Med

      Volume: 15 Issue: 3 Pages: 245-252

    • DOI

      10.2174/1566524015666150330144018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 痛みの遺伝子多型についての基礎研究と臨床研究.2015

    • Author(s)
      西澤大輔, 福田謙一, 林田眞和, 池田和隆
    • Journal Title

      麻酔

      Volume: 64増刊号

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 物質依存症と遺伝子多型.2015

    • Author(s)
      西澤大輔, 池田和隆
    • Journal Title

      日本臨牀

      Volume: 73(9) Pages: 1465-1472

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 自閉症と薬物治療.2015

    • Author(s)
      佐藤敦志, 池田和隆
    • Journal Title

      細胞工学

      Volume: 34 (5) Pages: 490-493

    • Related Report
      2015 Annual Research Report
  • [Journal Article] JSNP Excellent Presentation Award for CINP2014: Reduced supraspinal nociceptive responses and distinct gene expression profile in CXBH recombinant inbred mice.2015

    • Author(s)
      Kasai S, Ikeda K
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 35 Pages: 63-64

    • Related Report
      2015 Annual Research Report
  • [Journal Article] JSNP Excellent Presentation Award for CINP2014: PCLOのSNPrs13438494は転写効率を制御することによりモノアミンの取り込み能を調節し, ヒト依存様行動と遺伝的関連性がある.2015

    • Author(s)
      宇野恭介, 西澤大輔, 徐承姫, 酒井規雄, 大井一高, 鍋島俊隆, 橋本亮太, 尾崎紀夫, 池田和隆, 宮本嘉明, 新田淳美
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 35 Pages: 57-58

    • Related Report
      2015 Annual Research Report
  • [Journal Article] JSNP Excellent Presentation Award for CINP2014: Tsc2 haploinsufficiency is associated with more severe autism-related behavioral deficits in mouse models of tuberous sclerosis complex.2015

    • Author(s)
      佐藤敦志, 高松幸雄, 笠井慎也, 小林敏之, 樋野興夫, 池田和隆, 水口雅
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 35 Pages: 51-52

    • Related Report
      2015 Annual Research Report
  • [Journal Article] JSNP Excellent Presentation Award for CINP2014: ゲノムワイド及び追加関連解析によるニコチン依存関連遺伝子多型の同定.2015

    • Author(s)
      西澤大輔, 笠井慎也, 長谷川準子, 佐藤直美, 谷岡書彦, 長島誠, 氏家寛, 橋本亮太, 田中雅嗣, 椙村春彦, 池田和隆
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 35 Pages: 45-46

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Specific roles of NMDA receptor subunits in mental disorders.2015

    • Author(s)
      Yamamoto H, Hagino Y, Kasai S, Ikeda K
    • Journal Title

      Curr Mol Med

      Volume: 15 Issue: 3 Pages: 193-205

    • DOI

      10.2174/1566524015666150330142807

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elucidating mechanisms for mental disorders: from specific molecules to pathology.2015

    • Author(s)
      Kida S, Sawa A, Ikeda K
    • Journal Title

      Curr Mol Med

      Volume: 15 Issue: 3 Pages: 191-192

    • DOI

      10.2174/1566524015666150330142548

    • Related Report
      2015 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Microphenotypes of mental disorders: a systematic approach to study disease mechanisms.2015

    • Author(s)
      Sawa A, Kida S, Ikeda K
    • Journal Title

      Curr Mol Med

      Volume: 15 Issue: 2 Pages: 109-110

    • DOI

      10.2174/1566524015666150303001535

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Pathology and treatment of autism spectrum disorders2015

    • Author(s)
      古田島(村上)浩子, 佐藤敦志, 池田和隆
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 145 Issue: 4 Pages: 193-200

    • DOI

      10.1254/fpj.145.193

    • NAID

      130005061555

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遺伝子多型と疼痛感受性・オピオイド感受性.2017

    • Author(s)
      林田眞和, 福田謙一, 西澤大輔, 池田和隆
    • Organizer
      日本麻酔科学会第64回学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2017-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 疼痛緩和における“テーラーメイド治療”の実現に向けて.2017

    • Author(s)
      井手聡一郎, 髙橋香央里, 西澤大輔, 福田謙一, 池田和隆
    • Organizer
      第11回日本緩和医療薬学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2017-06-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Inhibition of mTOR improves autism-like behaviors in mice in utero exposed to valproic acid.2017

    • Author(s)
      Kotajima-Murakami H, Kobayashi T, Kashii H, Sato A, Hagino Y, Nishito Y, Takamatsu Y, Uchino S, Ikeda K
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rapamycin treatment of impaired social behavior in adolescent Tsc2+/-mice.2017

    • Author(s)
      Kashii H, Hagino Y, Kasai S, Kotajima H, Sato A, Kobayashi T, Hino O, Mizuguchi M, Ikeda K
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between genetic polymorphisms in Cav2.3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery.2017

    • Author(s)
      Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Ikeda K
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Associations between polymorphisms close to the cAMP responsive element binding protein 1 (CREB1) gene and the activating transcription factor 2 (ATF2) gene and fentanyl sensitivity.2017

    • Author(s)
      Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single nucleotide polymorphisms in the 5’flanking region of interleukin-17A gene significantly associate with pain sensitivity.2017

    • Author(s)
      Ohka S, Nishizawa D, Hasegawa J, Takahashi K, Nakayama K, Ebata Y, Fukuda K, Ikeda K
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic polymorphisms in the orexin system (focusing on a polymorphism associated with nicotine dependence).2017

    • Author(s)
      Nishizawa D, Ikeda K
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association of Proopioimeranocortin gene polymorphism with vulnerability to alcohol dependence in Japanese.2017

    • Author(s)
      Kasai S, Nishizawa D, Higuchi S, Ikeda K
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy.2017

    • Author(s)
      Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The relationship between stress and alcohol consumption in female mice.2017

    • Author(s)
      Moriya Y, Kasahara Y, Hall SF, Uhl GR, Ikeda K, Sora I
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular mechanisms underlying individual differences in pain and analgesic sensitivity.2017

    • Author(s)
      Kasai S, Ikeda K
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The involvement of acetylcholine system in hyperactivity in dopamine-deficient (DD) mice.2017

    • Author(s)
      Ikeda K, Fujita M, Hagino Y, Kobayashi K
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NMDA receptor channel subunit GluN2D: A dark horse molecule in Neuropsychopharmacology.2017

    • Author(s)
      Ikeda K, Hagino Y, Ide S
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
    • Place of Presentation
      Nusa Dua, Indonesia
    • Year and Date
      2017-04-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genome-wide association study of pain sensitivity in cold pressor test.2017

    • Author(s)
      Takahashi K, Fukuda K, Nishizawa D, Kasai S, Kokita Y, Ichinohe T, Ikeda K
    • Organizer
      2017 IADR(International Association for Dental Research)General Session & Exhibition
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2017-03-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The rewarding effect of methylphenidate on attention deficit/hyperactivity disorder model mice.2017

    • Author(s)
      Ikekubo Y, Ide S, Takamatsu Y, Takeda TC, Nagasawa S, Hua J, Ikeda K
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール・長崎新聞文化ホール(長崎県長崎市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 薬物感受性及び疾患脆弱性に関する全ゲノム関連解析結果データベースからのデータ抽出支援.2017

    • Author(s)
      西澤大輔, 福田謙一, 林田眞和, 椙村春彦, 清水千佳子, 田中雅嗣, 池田和隆
    • Organizer
      平成28年度新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
    • Place of Presentation
      琵琶湖ホテル(滋賀県大津市)
    • Year and Date
      2017-02-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 注意欠如/ 多動性障害モデルマウスとしてのドパミントランスポーターノックアウトマウスの有用性.2017

    • Author(s)
      井手聡一郎, 高松幸雄, 池窪結子, Takeda TC, Nagasawa S, Hua J, Uhl GR, 曽良一郎, 池田和隆
    • Organizer
      平成28年度新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
    • Place of Presentation
      琵琶湖ホテル(滋賀県大津市)
    • Year and Date
      2017-02-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生理機能解析支援~薬理学的解析支援~.2017

    • Author(s)
      森屋由紀, 西澤大輔, 井手聡一郎, 池田和隆
    • Organizer
      平成28年度新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
    • Place of Presentation
      琵琶湖ホテル(滋賀県大津市)
    • Year and Date
      2017-02-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 精神疾患病態におけるドーパミンシグナル関連マイクロエンドフェノタイプの解明.2017

    • Author(s)
      池田和隆
    • Organizer
      新学術領域「マイクロ精神病態」班会議
    • Place of Presentation
      月岡ニューホテル冠月(新潟県新発田市)
    • Year and Date
      2017-01-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Distinct roles of opioid and dopamine systems in lateral hypothalamic intracranial self-stimulation.2016

    • Author(s)
      Ikeda K, Ide S, Takahashi T, Takamatsu Y, Uhl GR, Niki H, Sora I
    • Organizer
      The 55th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 55th Annual Meeting)
    • Place of Presentation
      Hollywood, USA
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 本邦の病院小児科におけるTSC患者の診療実態調査.2016

    • Author(s)
      佐藤敦志, 池田和隆, 水口雅
    • Organizer
      第4回日本結節性硬化症学会学術総会
    • Place of Presentation
      大阪大学銀杏会館(大阪府吹田市)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] ドーパミン欠乏マウスにおける異常性行動の脳内メカニズム.2016

    • Author(s)
      藤田雅代, Takeda TC, 萩野洋子, 笠井慎也, 橋本款, 小林和人, 池田和隆
    • Organizer
      第51回日本アルコール・アディクション医学会学術総会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳内自己刺激法を用いた薬物依存性解析および報酬系神経回路の解析.2016

    • Author(s)
      井手聡一郎, 池田和隆
    • Organizer
      第51回日本アルコール・アディクション医学会学術総会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 注意欠如/多動性障害モデルマウスにおけるメチルフェニデートの報酬効果.2016

    • Author(s)
      池窪結子, 井手聡一郎, 高松幸雄, Takeda TC, Nagasawa S, Hua J, Uhl GR, 曽良一郎, 池田和隆
    • Organizer
      第51回日本アルコール・アディクション医学会学術総会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Genetic mechanisms underlying individual differences in sensitivity to pain and opioids.2016

    • Author(s)
      Ikeda K, Nishizawa D, Hayashida M, Fukuda K
    • Organizer
      16th World Congress on Pain
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy.2016

    • Author(s)
      Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A,Hayashida M, Ikeda K
    • Organizer
      16th World Congress on Pain
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 注意欠如/多動性障害モデルマウスにおけるメチルフェニデートの報酬効果.2016

    • Author(s)
      池窪結子, 井手聡一郎, 高松幸雄, Takeda TC, Nagasawa S, Hua J, Uhl GR, 曽良一郎, 池田和隆
    • Organizer
      平成28年度新学術領域研究「学術研究支援基盤形成【先端モデル動物支援プラットフォーム】」若手支援技術講習会
    • Place of Presentation
      蓼科グランドホテル滝の湯(長野県茅野市)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 性差の観点からみたストレスによるアルコール摂取行動変化とmuオピオイド神経伝達系の関与.2016

    • Author(s)
      森屋由紀, 笠原好之, Hall FS, Uhl GR, 池田和隆, 曽良一郎
    • Organizer
      平成28年度新学術領域研究「学術研究支援基盤形成【先端モデル動物支援プラットフォーム】」若手支援技術講習会
    • Place of Presentation
      蓼科グランドホテル滝の湯(長野県茅野市)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 鎮痛薬感受性と関連するオピオイドペプチド遺伝子多型の解析.2016

    • Author(s)
      笠井慎也, 西澤大輔, 林田眞和, 長島誠, 加藤良二, 池田和隆
    • Organizer
      第3回包括的緩和医療科学学術研究会・第4回Tokyo疼痛緩和次世代研究会 合同研究会
    • Place of Presentation
      TKPガーデンシティ永田町(東京都千代田区)
    • Year and Date
      2016-08-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cav2.3(R型)電位依存性Ca2+チャネル遺伝子多型と鎮痛薬感受性との関連.2016

    • Author(s)
      井手聡一郎, 西澤大輔, 福田謙一, 笠井慎也, 長谷川準子, 林田眞和, 池田和隆
    • Organizer
      第36回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      北海道大学薬学部(北海道札幌市)
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] タバコ・ニコチン依存に影響を及ぼすオピオイド受容体関連遺伝子.2016

    • Author(s)
      笠井慎也, 西澤大輔, 佐藤直美, 谷岡書彦, 椙村春彦, 池田和隆
    • Organizer
      第36回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      北海道大学薬学部(北海道札幌市)
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 遺伝子多型と術後オピオイド.2016

    • Author(s)
      池田和隆
    • Organizer
      第6回術後疼痛懇話会
    • Place of Presentation
      青蓮会館(京都府京都市)
    • Year and Date
      2016-07-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] NMDA receptor channel GluN2D subunit as a target molecule for medicines for mental disorders.2016

    • Author(s)
      Ikeda K, Hagino Y, Ide S
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 喫煙関連遺伝子多型の同定とその機能解析.2016

    • Author(s)
      池田和隆, 西澤大輔, 笠井慎也, 高松幸雄, 萩野洋子, 椙村春彦
    • Organizer
      公益財団法人喫煙科学研究財団 第31回平成27年度助成研究発表会
    • Place of Presentation
      京王プラザ(東京都新宿区)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses.2016

    • Author(s)
      Nishizawa D, Yoshida K, Ichinomiya T, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
    • Organizer
      The International Narcotics Research Conference 2016
    • Place of Presentation
      Bath, UK
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased number of glial and neuronal cells in the periaqueductal gray matter (PAG) of mu-opioid receptor knockout mice.2016

    • Author(s)
      Sasaki K, Sora I, Kasahara Y, Ikeda K, Hall FS, Uhl GR, Kawashima R
    • Organizer
      The International Narcotics Research Conference 2016
    • Place of Presentation
      Bath, UK
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sex differences in voluntary drinking by mu-opioid receptor knockout mice following early stress.2016

    • Author(s)
      Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
    • Organizer
      The International Narcotics Research Conference 2016
    • Place of Presentation
      Bath, UK
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オピオイド感受性関連遺伝子多型の同定とテーラーメイド疼痛治療の開始.2016

    • Author(s)
      池田和隆, 西澤大輔, 福田謙一, 林田眞和
    • Organizer
      日本ペインクリニック学会第50回大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The abolished rewarding effect of methylphenidate in dopamine transporter knockout mice, a model for attention deficit/hyperactivity disorder.2016

    • Author(s)
      Ide S, Takamatsu Y, Ikekubo Y, Takeda TC, Nagasawa S, Hua J, Ikeda K
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transcriptome analysis in Tsc2 heterozygous knockout mice.2016

    • Author(s)
      Kasai S, Sato A, Kashii H, Kobayashi T, Hino O, Mizuguchi M, Ikeda K
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy.2016

    • Author(s)
      Nishizawa D, Mieda T, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] c-Fos immunoreactivity in hypoactive and hyperactive Dopamine-deficient mice.2016

    • Author(s)
      Takeda TC, Fujita M, Hagino Y, Mizuguchi M, Ikeda K
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Opposite associations between the rs3845446 single-nucleotide polymorphism of the CACNA1E gene and postoperative pain-related phenotypes in gastrointestinal surgery versus previously reported orthognathic surgery.2016

    • Author(s)
      Amano K, Nishizawa D, Mieda T, Tsujita M, Kitamura A, Hasegawa J, Inada E, Hayashida M, Ikeda K
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between the rs7583431single-nucleotide polymorphism close to the activating transcription factor 2 (ATF2) gene and the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test.2016

    • Author(s)
      Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic effects of cholinergic drug on mechanical allodynia in the mouse partial sciatic nerve ligation model.2016

    • Author(s)
      Yamanishi Y, Takamatsu Y, Ikeda K
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of chronic tryptophan depletion on autism spectrum disorder like behaviors in serotonin transporter knockout and heterozygous mice.2016

    • Author(s)
      Tanaka M, Sato A, Hagino Y, Sora I, Murphy D, Ikeda K
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Methamphetamine induced changes of monoamine neurotransmission in 5-HT1B KO mice.2016

    • Author(s)
      Moriya Y, Kasahara Y, Hagino Y, Hall FC, Hen R, Ikeda K, Uhl GR, Sora I
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic polymorphisms commonly associated with sensitivity to addictive substances.2016

    • Author(s)
      Ikeda K, Nishizawa D, Fukuda K, Hayashida M, Higuchi S, Sugimura H, Sora I
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] レミフェンタニル・プロポフォール全静脈麻酔中にフェンタニルの追加投与を必要とした症例の遺伝子多型.2016

    • Author(s)
      髙橋香央里, 福田謙一, 西澤大輔, 笠井慎也, 須野学, 髙北義彦, 一戸達也, 池田和隆
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] SCN9A遺伝子の一塩基多型rs6746030のマイナーアレル保有者に対する術後鎮痛法の、相関研究および電気生理学的研究に基づく検討.2016

    • Author(s)
      天野功二郎, 堀下貴文, 西澤大輔, 三枝勉, 辻田美紀, 長島誠, 加藤良二, 長谷川準子, 北村晶, 川崎貴士, 林田眞和, 池田和隆
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Activating transcription factor 2(ATF2)遺伝子近傍の遺伝子多型rs7583431と冷水誘発疼痛試験におけるフェンタニルの鎮痛効果との関連.2016

    • Author(s)
      青木謙典, 西澤大輔, 吉田香織, 長谷川準子, 笠井慎也, 髙橋香央里, 髙北義彦, 一戸達也, 林田眞和, 福田謙一, 池田和隆
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウスでの坐骨神経部分結紮後のアロディニアに対するコリン系薬物の治療効果.2016

    • Author(s)
      山西嘉晴, 高松幸雄, 池田和隆
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 注意欠如/多動性障害モデルマウスにおけるメチルフェニデートの報酬効果の変化.2016

    • Author(s)
      井手聡一郎, 高松幸雄, 池窪結子, 武田大志クラーク, 長澤セーラ, Hua J, 池田和隆
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 低活動と多動時のドーパミン欠乏マウスのc-Fos免疫反応性.2016

    • Author(s)
      Takeda TC, 藤田雅代, 萩野洋子, 水口雅, 池田和隆
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] セロトニントランスポーターノックアウトおよびヘテロ欠損マウスにおける自閉症様行動とトリプトファン欠乏食による改善効果.2016

    • Author(s)
      田中美歩, 佐藤敦志, 萩野洋子, 曽良一郎, 池田和隆
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経精神薬理学の動向:国際連携と学術会議の視点から.2016

    • Author(s)
      池田和隆, 山脇成人
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ゲノムワイド関連解析(GWAS)による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定.2016

    • Author(s)
      西澤大輔, 三枝勉, 中川秀之, 辻田美紀, 今西宏和, 寺尾和久, 吉川博昭, 伊藤一志, 天野功二郎, 田代浄, 石井利昌, 有山淳, 山口茂樹, 笠井慎也, 長谷川準子, 中山京子, 江畑裕子, 池田和隆, 北村晶, 林田眞和
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 日本人におけるAUTS2遺伝子多型rs6943555と人格特性との関連研究.2016

    • Author(s)
      成田心, 岩橋和彦, 吉原英児, 西澤大輔, 石郷岡純, 池田和隆
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 健常者におけるストレス反応の性差:トランスローケーター蛋白質(TSPO)、コルチゾール、状態・特性不安検査(STAI)による検討.2016

    • Author(s)
      中本百合江, 中村和彦, 池田和隆, 吉井光信
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] オピオイド投与中の神経因性疼痛患者へのECTによる鎮痛効果.2016

    • Author(s)
      岩田健, 小林雪乃, 米良仁志, 土井永史, 諏訪浩, 池田和隆
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] インターロイキン17Aが発達障害、精神疾患等に及ぼす影響について.2016

    • Author(s)
      大岡静衣, 池田和隆
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 知的障害と妊娠期における物質曝露.2016

    • Author(s)
      古田島(村上)浩子, 池田和隆, 内野茂夫
    • Organizer
      第46回日本神経精神薬理学会年会(JSNP)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] オピオイド不適切使用の評価と中止法において遺伝子検査が貢献する可能性.2016

    • Author(s)
      池田和隆, 西澤大輔, 林田眞和, 福田謙一
    • Organizer
      第21回日本緩和医療学会学術大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 緩和医療領域における遺伝子診断とテーラーメード医療の現状と将来展望.2016

    • Author(s)
      池田和隆
    • Organizer
      第10回日本緩和医療薬学会年会
    • Place of Presentation
      アクトシティ浜松コングレスセンター(静岡県浜松市)
    • Year and Date
      2016-06-05
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 統合失調症と依存性薬物.2016

    • Author(s)
      池田和隆
    • Organizer
      第41回新潟精神医学懇話会
    • Place of Presentation
      ホテル日航新潟(新潟県新潟市)
    • Year and Date
      2016-05-31
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing orthognathic surgery.2016

    • Author(s)
      Muraoka W, Saisu H, Sato H, Usuda S, Inoue M, Ochiai S, Nishizawa D, Hasegawa J, Kasai S, Nakagawa T, Wajima K, Fukuda K, Ikeda K
    • Organizer
      American Academy of Orofacial Pain
    • Place of Presentation
      Lake Buena Vista, USA
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing orthognathic surgery.2016

    • Author(s)
      Muraoka W, Saisu H, Sato H, Usuda S, Inoue M, Ochiai S, Nishizawa D, Hasegawa J, Kasai S, Nakagawa T, Wajima K, Fukuda K, Ikeda K
    • Organizer
      American Academy of Orofacial Pain
    • Place of Presentation
      Florida, USA
    • Year and Date
      2016-04-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ドーパミンの欠乏時と過剰時の異常行動:遺伝子改変マウスの解析.2016

    • Author(s)
      池田和隆
    • Organizer
      第23回多摩キャンパス神経カンファレンス
    • Place of Presentation
      東京都立神経病院(東京都府中市)
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] herapeutic effects of cholinergic drugs on mechanical allodynia in the mouse partial sciatic nerve ligation model.2016

    • Author(s)
      Yamanishi Y, Takamatsu Y, Ikeda K
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜会議センター(神奈川県横浜市)
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 喫煙関連遺伝子多型の同定とのその機能解析.2016

    • Author(s)
      池田和隆
    • Organizer
      喫煙科学特定研究検討会
    • Place of Presentation
      東海大学 校友会館(東京都千代田区)
    • Year and Date
      2016-01-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] NMDA receptor GluN2D subunit is indispensable in phencyclidine (PCP) effects.2015

    • Author(s)
      Ikeda K, Hagino Y, Kasai S, Yamamoto H, Mishina M
    • Organizer
      The 54th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 54th Annual Meeting)
    • Place of Presentation
      Hollywood, USA
    • Year and Date
      2015-12-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胎生期バルプロ酸曝露による発達障害モデルマウスにおけるケモカインCCL5の発見亢進.2015

    • Author(s)
      村上(古田島)浩子, 檜山(和賀)央子, 茂木悠, 鳩山拓史, 瀧口皓大, 関健太, 池田和隆, 内野茂夫
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Genome-wide association study identifies a potent locus associated with human opioid sensitivity.2015

    • Author(s)
      Nishizawa D, Ikeda K
    • Organizer
      4th Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic association with smoking/tobacco use in Japanese.2015

    • Author(s)
      Kasai S, Sugimura H, Ikeda K
    • Organizer
      4th Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of cholinergic system in hyperactivity in dopamine deficient mice.2015

    • Author(s)
      Fujita M, Hagino Y, Kasai S, Setogawa S, Yamaura H, Yanagihara D, Hashimoto M, Kobayashi K, Meltzer HY, Ikeda K
    • Organizer
      4th Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Behavioral and chemokine gene expression analyses in the mice exposed in utero to valproic acid.2015

    • Author(s)
      Kotajima-Murakami H, Nakamura Y, Tsuchiya A, Suzuki E, Waga C, Ikeda K, Uchino S
    • Organizer
      4th Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements.2015

    • Author(s)
      Aoki Y, Nishizawa D, Hasegawa J, Kasai S, Yoshida K, Koukita Y, Ichinohe T, Nagashima M, Katoh R, Satoh Y, Tagami M, Hayashida M, Fukuda K, Ikeda K
    • Organizer
      4th Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and nicotine dependence.2015

    • Author(s)
      Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K
    • Organizer
      4th Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gene expression profile exhibits abnormal responses to nociceptive stimuli in the recombinant inbred mouse strain CXBH.2015

    • Author(s)
      Kasai S, Ikeda K
    • Organizer
      4th Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] transient receptor potential subfamily C member 3 (TRPC3) 遺伝子近傍の遺伝子多型rs1465040と外科手術後における鎮痛薬必要量との関連.2015

    • Author(s)
      青木謙典, 西澤大輔, 長谷川準子, 笠井慎也, 吉田香織, 髙北義彦, 一戸達也, 長島誠, 加藤良二, 佐藤泰雄, 田上惠, 林田眞和, 福田謙一, 池田和隆
    • Organizer
      第35回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      和歌山県立情報交流センターBig・U(和歌山県田辺市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] ドーパミン欠乏時の異常行動とそのメカニズム.2015

    • Author(s)
      池田和隆, 藤田雅代, 萩野洋子
    • Organizer
      平成27年度アルコール・薬物依存関連学会合同学術総会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and nicotine dependence.2015

    • Author(s)
      Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K
    • Organizer
      65th Annual Meeting of the American Society of Human Genetics
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ゲノムワイド関連解析(GWAS)によるオピオイド感受性関連遺伝子多型の同定とその臨床応用.2015

    • Author(s)
      西澤大輔, 池田和隆
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] XBP1 遺伝子多型とアルコール依存症および不安関連人格特性との関連研究.2015

    • Author(s)
      成田心, 岩橋和彦, 吉原英児, 川合厚子, 西澤大輔, 池田和隆, 石郷岡純
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 内臓痛の有無で逆転する、R 型電位依存性カルシウムチャネルの一塩基多型rs3845446 が術後のオピオイド必要量に与える影響.2015

    • Author(s)
      天野功二郎, 三枝勉, 北村晶, 林田眞和, 西澤大輔, 池田和隆
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tsc2 ヘテロ遺伝子欠損による脳内遺伝子発現変化の網羅的解析.2015

    • Author(s)
      笠井慎也, 佐藤敦志, 柏井洋文, 小林敏之, 樋野興夫, 水口雅, 池田和隆
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] GluN2D サブユニット欠損による引きこもりアンヘドニアモデルマウスの行動薬理学的解析.2015

    • Author(s)
      山本秀子, 亀ヶ谷悦子, 萩野洋子, 松澤真彩, 三品昌美, 山本敏文, 池田和隆
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] APT受容体P2X7サブタイプ遺伝子多型と疼痛及び鎮痛薬感受性との相関.2015

    • Author(s)
      井手聡一郎, 西澤大輔, 福田謙一, 笠井慎也, 長谷川準子, 林田眞和, 南雅文, 池田和隆
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 胎生期バルプロ酸曝露マウスにおける行動異常とケモカインの脳内発現.2015

    • Author(s)
      古田島浩子, 中村泰子, 和賀央子, 鳩山拓史, 茂木悠, 関健太, 瀧口皓大, 池田和隆, 内野茂夫
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] セロトニントランスポーターノックアウトおよびヘテロ欠損マウスにおける自閉症様行動.2015

    • Author(s)
      田中美歩, 佐藤敦志, 萩野洋子, 曽良一郎, 池田和隆
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] APT受容体P2X7サブタイプ遺伝子多型と疼痛及び鎮痛薬感受性との相関.2015

    • Author(s)
      井手聡一郎, 西澤大輔, 福田謙一, 笠井慎也, 長谷川準子, 林田眞和, 池田和隆
    • Organizer
      緩和医療薬学研究会/第3回Tokyo 疼痛緩和次世代研究会
    • Place of Presentation
      星薬科大学(東京都品川区)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 精神疾患病態におけるドーパミンシグナル関連マイクロエンドフェノタイプの解明.2015

    • Author(s)
      池田和隆
    • Organizer
      新学術領域「マイクロ精神病態」班会議
    • Place of Presentation
      八ヶ岳ロイヤルホテル(山梨県北杜市)
    • Year and Date
      2015-08-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] GIRK channel as a candidate target for pharmacotherapy of drug and alcohol dependence.2015

    • Author(s)
      Ikeda K, Sugaya N, Ogai Y, Nishizawa D
    • Organizer
      4th APSAAR / 5th IDARS Conference
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2015-08-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] テーラーメイド疼痛治療の有用性の検証状況.2015

    • Author(s)
      池田和隆
    • Organizer
      緩和医療薬学研究会/第3回Tokyo 疼痛緩和次世代研究会
    • Place of Presentation
      星薬科大学(東京都品川区)
    • Year and Date
      2015-08-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Involvement of cholinergic system in hyperactivity in dopamine-deficient mice.2015

    • Author(s)
      Ikeda K, Hagino Y, Kasai S, Fujita M, Setogawa S, Yamaura H, Yanagihara D, Hashimoto M, Kobayashi K
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場・神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 喫煙関連遺伝子多型の同定とその機能解析.2015

    • Author(s)
      池田和隆, 西澤大輔, 笠井慎也, 高松幸雄, 萩野洋子, 椙村春彦
    • Organizer
      公益財団法人喫煙科学研究財団 平成26年度助成研究発表会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慢性疼痛の個別化薬物療法へ向けた研究.2015

    • Author(s)
      池田和隆
    • Organizer
      第23回クリニカルファーマシーシンポジウム 医療薬学フォーラム2015
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-07-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Critical role of NMDA receptor GluN2D subunit in phencyclidine effects.2015

    • Author(s)
      Ikeda K, Hagino Y, Kasai S, Yamamoto H
    • Organizer
      Association for the Study of Neurons and Diseases the 10th International Conference for Neurons and Brain Disease
    • Place of Presentation
      Xi’an China
    • Year and Date
      2015-06-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] テーラーメイド疼痛治療法の開発と実施.2015

    • Author(s)
      池田和隆
    • Organizer
      ゲノム創薬・医療フォーラム第4回 談話会
    • Place of Presentation
      東京大学医科学研究所(東京都港区)
    • Year and Date
      2015-06-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Genetic mechanisms underlying individual differences in opioid sensitivity in Japanese.2015

    • Author(s)
      Ikeda K, Nishizawa D, Hayashida M, Fukuda K
    • Organizer
      WPA Regional Congress OSAKA Japan 2015
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル大阪(大阪府大阪市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 痛みの遺伝子多型についての基礎研究と臨床研究.2015

    • Author(s)
      池田和隆
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] R型電位依存性カルシウムチャネル遺伝子の一塩基多型rs3845446は、内臓性炎症性疼痛の有無により、体性炎症性疼痛に対する術後鎮痛薬必要量に相反する影響を与える.2015

    • Author(s)
      天野功二郎, 三枝勉, 北村晶, 西澤大輔, 池田和隆, 林田眞和
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラミニンbeta3遺伝子 (LAMB3) の一塩基多型rs2076222は、腹腔鏡補助下大腸切除術後のPCAフェンタニル必要量に影響する.2015

    • Author(s)
      林田眞和, 三枝勉, 西澤大輔, 池田和隆, 有山淳, 北村晶
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 疼痛感受性やオピオイド感受性に影響を及ぼす遺伝子多型.2015

    • Author(s)
      林田眞和, 福田謙一, 西澤大輔, 池田和隆
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 遺伝子多型判定に基づくオピオイド性鎮痛薬必要量予測式の構築と検証.2015

    • Author(s)
      吉田香織, 福田謙一, 林田眞和, 西澤大輔, 池田和隆, 一戸達也
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tsc2 haploinsufficiency causes more severe autistic-like behavioral deficit than Tsc1 in mice.2015

    • Author(s)
      Sato A, Tanaka M, Takamatsu Y, Kasai S, Kobayashi T, Hino O, Ikeda K, Mizuguchi M
    • Organizer
      13th Asian and Oceania Congress of Child Neurology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] Addiction Medicine (Second Edition)【分担執筆】2016

    • Author(s)
      Nishizawa D, Ikeda K
    • Total Pages
      672
    • Publisher
      OXFORD UNIVERSITY PRESS
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Book] The Neuropathology of Drug Addictions and Substance Misuse. Volume 1(VR Preedy, Ed)2016

    • Author(s)
      Nishizawa D, Ikeda K
    • Total Pages
      1132
    • Publisher
      Academic Press
    • Related Report
      2016 Annual Research Report
  • [Book] The Neuropathology of Drug Addictions and Substance Misuse. Volume 2 (VR Preedy, Ed)2016

    • Author(s)
      Yamamoto H, Sawada W, Kamegaya E, Hagino Y, Ikeda K, Sora I, Mishina M, Yamamoto T
    • Total Pages
      1143
    • Publisher
      Academic Press
    • Related Report
      2016 Annual Research Report
  • [Book] The Neuropathology of Drug Addictions and Substance Misuse. Volume 12016

    • Author(s)
      Nishizawa D, Ikeda K
    • Publisher
      Academic Press
    • Related Report
      2015 Annual Research Report
  • [Book] The Neuropathology of Drug Addictions and Substance Misuse. Volume 22016

    • Author(s)
      Yamamoto H, Sawada W, Kamegaya E, Hagino Y, Ikeda K, Sora I, Mishina M, Yamamoto T
    • Publisher
      Academic Press
    • Related Report
      2015 Annual Research Report
  • [Book] Curr Mol Med 【編著】Vol 15, Issue 22015

    • Author(s)
      Sawa A, Kida S, Ikeda K (Guest Edited)
    • Publisher
      Bentham Science Publishers
    • Related Report
      2015 Annual Research Report
  • [Book] Curr Mol Med 【編著】Vol 15, Issue 32015

    • Author(s)
      Kida S, Sawa A, Ikeda K (Guest Edited)
    • Publisher
      Bentham Science Publishers
    • Related Report
      2015 Annual Research Report
  • [Book] 分子脳科学 -分子から脳機能と心に迫る-2015

    • Author(s)
      笠井慎也, 池田和隆
    • Total Pages
      312
    • Publisher
      (株) 化学同人
    • Related Report
      2015 Annual Research Report
  • [Remarks] 公益財団法人東京都医学総合研究所ホームページ

    • URL

      http://www.igakuken.or.jp/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 依存性薬物プロジェクトホームページ

    • URL

      http://www.igakuken.or.jp/abuse/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi