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胎生期のサブプレートニューロン障害が神経発達障害に及ぼす効果の解析

Publicly Offered Research

Project AreaConstructive Developmental Science; Revealing the Principles of Development from Fetal Period and Systematic Understanding of Developmental Disorders
Project/Area Number 15H01578
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionNagoya University

Principal Investigator

城所 博之  名古屋大学, 医学部附属病院, 助教 (20647466)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsMRI / 発達障害 / 早産児 / サブプレートニューロン / 脳・神経 / 脳神経疾患 / 発生・分化 / MRI
Outline of Annual Research Achievements

超早産児の約50%に自閉スペクトラム症や知的障害といった神経後障害を認めるが、原因となる脳の病態生理は依然解明されていない。子宮外環境に晒される早産児の脳障害の解明には胎児期の脳の発達に着目する必要がある。本研究は、胎生期に一過性に出現し神経回路網構築に重要な役割をもつサブプレートニューロン(SPニューロン)の損傷こそが、超早産児に認める神経発達障害の主犯であるとする新しい仮説を検証することが目的である。
発達早期の脳波上に観察される紡錘波状速波は、SPニューロンの活動を反映する脳波波形であることが齧歯類の研究から明らかにされてきたため、この速波活動の出現頻度・部位を多角的に観測し、コンピュータ解析することでSPニューロンの活動を詳細にモニタリングすることが可能である。
平成28年度は昨年度記録した脳波の中でも、修正32週前後に記録された脳波の中心部導出から得られた紡錘波状速波を定量した。さらに、修正18か月で新版K式発達検査を施行した。最後に、修正32週前後の脳波の紡錘波状速波と修正18か月の新版K式発達検査の発達指数の相関を統計解析した結果、両者には正の相関があることを明らかにした。このことは、紡錘波状速波をモニタリングし定量化することで、修正18か月の発達予後の推定に役立つことを意味し、超早産児のSPニューロン障害に対する早期介入に寄与する。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (21 results)

All 2017 2016 2015

All Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Open Access: 7 results,  Acknowledgement Compliant: 6 results) Presentation (10 results) (of which Invited: 3 results)

  • [Journal Article] phenotypes from infantile lethality to mild learning difficulties2017

    • Author(s)
      Tanigawa J, Mimatsu H, Mizuno S, Okamoto N, Fukushi D, Tominaga K, Kidokoro H, Muramatsu Y, Nishi E, Nakamura S, Motooka D, Nomura N, Hayasaka K, Niihori T, Aoki Y, Nabatame S, Hayakawa M, Natsume J, Ozono K, Kinoshita T, Wakamatsu N, Murakami Y
    • Journal Title

      Human Mutation

      Volume: 印刷中 Issue: 7 Pages: 805-815

    • DOI

      10.1002/humu.23219

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Paroxysmal nonepileptic events in children with epilepsy.2017

    • Author(s)
      Ito Y, Kidokoro H, Negoro T, Tanaka M, Okai Y, Sakaguchi Y, Ogawa C, Takeuchi T, Ohno A, Yamamoto H, Nakata T, Maesawa S, Watanabe K, Takahashi Y, Natsume J
    • Journal Title

      Epilepsy Research

      Volume: 132 Pages: 59-63

    • DOI

      10.1016/j.eplepsyres.2017.02.009

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preterm brain injury and reduced brain growth parameters on term MRI: relation with clinical factors and neurodevelopmental outcome2017

    • Author(s)
      Margaretha J. Brouwer, Karina J. Kersbergen, Britt J.M. van Kooij, Linda S. De Vries, Manon J.N.L. Benders, Floris Groenendaal, Ingrid C. van Haastert, Corine Koopman-Esseboom, Terrie E. Inder, Jeffrey J. Neil, Hiroyuki Kidokoro
    • Journal Title

      PLOS ONE

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Primary psoas abscess caused by group A streptococcus in a child: Case report with microbiologic findings2016

    • Author(s)
      Kamiya Y, Hasegawa T, Takegami Y, Horiba K, Ando S, Torii Y, Kidokoro H, Kato T, Natsume J, Kawada JI, Ito Y
    • Journal Title

      J Infect Chemother

      Volume: 22 Issue: 12 Pages: 811-814

    • DOI

      10.1016/j.jiac.2016.06.011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.2016

    • Author(s)
      Takeuchi T, Natsume J, Kidokoro H, Ishihara N, Yamamoto H, Azuma Y, Ito Y, Kurahashi N, Tsuji T, Suzuki M, Itomi K, Yamada K, Kurahashi H, Abe S, Okumura A, Maruyama K, Negoro T, Watanabe K, Kojima S
    • Journal Title

      Brain Dev

      Volume: 38 Issue: 8 Pages: 723-730

    • DOI

      10.1016/j.braindev.2016.03.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and neuroimaging findings in children with posterior reversible encephalopathy syndrome.2016

    • Author(s)
      Yamamoto H, Natsume J, Kidokoro H, Ishihara N, Suzuki M, Tsuji T, Kubota T, Yamada A, Ozeki M, Kato Z, Kawamura Y, Yoshikawa T, Okumura A, Ando N, Saitoh S, Takahashi Y, Watanabe K, Kojima S.
    • Journal Title

      European Journal of Paediatric Neurology

      Volume: 19 Issue: 6 Pages: 672-8

    • DOI

      10.1016/j.ejpn.2015.07.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increased fetal heart rate variability in periventricular leukomalacia.2016

    • Author(s)
      Kurahashi H, Okumura A, Kubota T, Kidokoro H, Maruyama K, Hayakawa M, Itakura A, Matsuzawa K, Yamamoto H, Kato T, Hayakawa F, Watanabe K
    • Journal Title

      Brain & Development

      Volume: 38 Issue: 2 Pages: 196-203

    • DOI

      10.1016/j.braindev.2015.08.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Rituximab treatment for relapsed opsoclonus-myoclonus syndrome.2016

    • Author(s)
      Toyoshima D, Morisada N, Takami Y, Kidokoro H, Nishiyama M, Nakagawa T, Ninchoji T, Nozu K, Takeshima Y, Takada S, Nishio H, Iijima K
    • Journal Title

      Brain & Development

      Volume: 38 Issue: 3 Pages: 346-9

    • DOI

      10.1016/j.braindev.2015.09.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autopsy findings of a patient with acute encephalitis and refractory, repetitive partial seizures.2016

    • Author(s)
      Ogawa C, Natsume J, Yamamoto H, Ishihara N, Tashiro A, Kidokoro H, Negoro T, Yoshida M, Watanabe K
    • Journal Title

      Seizure

      Volume: 35 Pages: 80-2

    • DOI

      10.1016/j.seizure.2016.01.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] White Matter Abnormality Correlates with Developmental and Seizure Outcomes in West Syndrome of Unknown Etiology2015

    • Author(s)
      Natsume J, Ogawa C, Fukasawa T, Yamamoto H, Ishihara N, Sakaguchi Y, Ito Y, Takeuchi T, Azuma Y, Ando N, Kubota T, Tsuji T, Kawai H, Naganawa S, Kidokoro H
    • Journal Title

      American Journal of Neuroradiology

      Volume: 37 Issue: 4 Pages: 698-705

    • DOI

      10.3174/ajnr.a4589

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Seizure characteristics of epilepsy in childhood after acute encephalopathy with biphasic seizures and late reduced diffusion.2015

    • Author(s)
      Ito Y, Natsume J, Kidokoro H, Ishihara N, Azuma Y, Tsuji T, Okumura A, Kubota T, Ando N, Saitoh S, Miura K, Negoro T, Watanabe K, Kojima S.
    • Journal Title

      Epilepsia

      Volume: 56 Issue: 8 Pages: 1286-93

    • DOI

      10.1111/epi.13068

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 早産児脳波の形態学的発達変化の神経基盤2016

    • Author(s)
      城所博之
    • Organizer
      第27回小児脳機能研究会「小児脳波解析Up-to-Date」
    • Place of Presentation
      ホテルハマツ(福島県郡山市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Resting-state Networks in an Infant with Early Onset Epileptic Encephalopathy with Suppression-burst Pattern on EEG2016

    • Author(s)
      Hiroyuki KIDOKORO , Yuji ITO, Chikako OGAWA, Atsuko OHNO, Yu OKAI, Tomohiko NAKATA, Yoko SAKAGUCHI, Masahiro HAYAKAWA, Jun NATSUME
    • Organizer
      International symposium on acute encephalopathy in infancy and its related disordders
    • Place of Presentation
      一橋講堂(東京都千代田区)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Pattern of Brain Lesions in Neonates with Herpes Simplex Encephalitis2016

    • Author(s)
      Hiroyuki KIDOKORO 1), Chikako OGAWA 1), Yuji ITO 1), Atsuko OHNO, Yu OKAI, Tomohiko NAKATA, Yoko SAKAGUCHI, Shinji SAITOH, Akihisa OKUMURA, Jun NATSUME
    • Organizer
      International symposium on acute encephalopathy in infancy and its related disordders
    • Place of Presentation
      一橋講堂(東京都千代田区)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳波のSBパターンに対応するresting-state networks先天性GPI欠損症の1女児例からの経験2016

    • Author(s)
      城所博之 伊藤祐史 岡井佑 坂口陽子 小川千香子 山本啓之 大野敦子  中田智彦 夏目淳
    • Organizer
      第48回胎児新生児神経研究会
    • Place of Presentation
      順天堂大学(東京都文京区)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 胎児期脳の正常発達とその損傷2016

    • Author(s)
      城所博之
    • Organizer
      日本小児神経学会総会
    • Place of Presentation
      京王プラザホテル新宿(東京都新宿区)
    • Year and Date
      2016-06-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 早産児型白質障害のMRI<PVLと感染症の境界線>2015

    • Author(s)
      城所博之
    • Organizer
      第10回小児神経放射線研究会
    • Place of Presentation
      順天堂大学(東京都文京区)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] EEG predicts delayed maturation on MRI at term in preterm infants.2015

    • Author(s)
      Chikako Ogawa, Hiroyuki Kidokoro, Yuji Ito, Tamiko Negoro, Kazuyoshi Watanabe, Yuichiro Sugiyama, Miharu Ito, Yoshiaki Sato, Masahiro Hayakawa, Jun Natsume.
    • Organizer
      9th international conference, Brain monitoring and neuroprtection in the newborn
    • Place of Presentation
      Cork (Ireland)
    • Year and Date
      2015-10-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新生児期に先天性CMV感染症と診断した児の脳MRI所見2015

    • Author(s)
      城所博之、伊藤嘉規、久保田哲夫、加藤徹、佐藤義朗、伊藤美春、杉山裕一郎、奥村彰久、早川昌弘
    • Organizer
      第51回日本周産期・新生児医学会学術集会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県福岡市)
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新生児単純ヘルペス脳炎における脳病変の局在:第2報2015

    • Author(s)
      城所博之、奥村彰久、辻健史、久保田哲夫、安藤直樹、伊藤祐史、小川千香子、加藤徹、齋藤伸治、夏目淳
    • Organizer
      第57回日本小児神経学会総会
    • Place of Presentation
      帝国ホテル(大阪府大阪市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Distribution of brain lesions in neonatal herpes simplex encephalitis.2015

    • Author(s)
      Hiroyuki Kidokoro, Linda S. de Vries, Chikako Ogawa, Yuji Ito, Shinji Saito, Akihisa Okumura, Jun Natusme.
    • Organizer
      Annual meeting of Pediatric Academic Society
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-28  

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