ヒト脳内身体表現の直接記録・刺激介入を用いた神経機構と変容の解明

• Project Area: Understanding brain plasticity on body representations to promote their adaptive functions
• Project/Area Number: 15H01664
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Kyoto University
• Principal Investigator: 松本 理器 京都大学, 医学研究科, 准教授 (00378754)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000); Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
• Keywords: 運動主体感 / 行為 / 病変研究 / 臨床皮質電気刺激マッピング / 皮質皮質間誘発電位 / デコーディング / 失行 / 前頭・頭頂葉ネットワーク / 神経科学 / 脳疾患 / てんかん / 皮質脳波 / 道具使用 / 皮質間結合 / 皮質電気刺激 / トラクトグラフィー / てんかん外科

Outline of Annual Research Achievements

上縦束第III枝がかかわる腹側前頭・頭頂葉ネットワークに焦点をあて、左半球では‘行為’、右半球では運動主体感に関わる皮質活動の探索と変容様式の同定を進めた。
左半球は術前評価のために硬膜下電極を留置し、研究に同意を得た難治てんかん患者を対象とした。昨年度に、臨床脳機能マッピングとしての高頻度皮質電気刺激を用いて、行為における腹側運動前野とPF野の機能相違を示した5症例(国内学会発表)で追加解析を行った。皮質皮質間誘発電位(cortico-cortical evoked potential: CCEP)から、下頭頂小葉から側頭葉底部への機能結合を3例で見いだした。側頭葉底部は皮質脳波のdecoding研究（論文発表）からも意味認知機能の存在が示唆されており、行為における意味機能へのアクセスが示唆された。
また課題遂行中の皮質脳波にdecoding手法を活用し、中心前回からの同側上肢運動の解読（論文発表）や意味認知における側頭葉前方領域の重要性（論文発表）を報告した。このような研究的背景から、行為中の広域周波数帯域の神経活動にdecodingを導入し、4症例で求められる‘重み’と 、CCEPによる機能的結合、高頻度電気刺激による機能変容を比較検討し、ネットワーク内のハブの局在を検討した。同定したハブ(腹側運動前野)に対し刺激介入し、モーションキャプチャーシステムを用いて運動変容の定量解析を行った。今後はネットワーク内の２つのハブ領域に同時介入を行い、ネットワークレベルでの変容の解明をめざす。
右半球では、右頭頂葉弁蓋部・島皮質に脳腫瘍がある３症例を対象に、切除術前後に運動主体感を定量的に計測し、術後の運動主体感の変容を、急性期から亜急性期への遷移に関して検討した。術後運動主体感については変容が認められ、切除部位が責任領域と示唆された。今後は安静時機能的MRI によるネットワーク解析を術前後に縦断的に施行し、ネットワークの動的遷移の解明をめざす。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] University of Manchester/King's College of London(United Kingdom)
• [Int'l Joint Research] The Cleveland Clinic Foundation/Johns Hopkins University(米国)
• [Int'l Joint Research] Manchester大学(英国)
• [Journal Article] Magnetoencephalography with temporal spread imaging to visualize propagation of epileptic activity (2017)
  • Author(s): Shibata S, Matsuhashi M, Kunieda T, Yamao Y, Rika Inano R, Kikuchi T, Imamura H, Takaya S, Matsumoto R, Ikeda A, Takahashi R, Mima T, Fukuyama H, Mikuni N, Miyamoto S
  • Journal Title: Clin Neurophysiol Volume: 128 Issue: 5 Pages: 734-743
  • DOI: 10.1016/j.clinph.2017.01.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway (2017)
  • Author(s): Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi, T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Human Brain Mapping Volume: 38 (4) Issue: 4 Pages: 1977-1991
  • DOI: 10.1002/hbm.23498
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A novel LGI1 mutation in a Japanese ADLTE family (2017)
  • Author(s): Fumoto N, Matsumoto R, Kawamata J, Koyasu S, Kondo T, Shimotake A, Kitamura K, Koshiba Y, Kinoshita M, Kawasaki J, Yamashita H, Takahashi R, Ikeda A
  • Journal Title: Neurol Clin Neurosci Volume: 5 (1) Issue: 1 Pages: 44-45
  • DOI: 10.1111/ncn3.12105
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phasic REM transiently approaches wakefulness in the human cortex; a single-pulse electrical stimulation study. (2017)
  • Author(s): Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
  • Journal Title: Sleep Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Neural pattern similarity between contra- and ipsilateral movements in high-frequency band of human electrocorticograms (2017)
  • Author(s): Fujiwara Y, Matsumoto R, Nakae T, Usami K, Matsuhashi M, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Mima T, Ikeda A, Osu R
  • Journal Title: Neuroimage Volume: 15 Pages: 302-313
  • DOI: 10.1016/j.neuroimage.2016.11.058
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy (2017)
  • Author(s): Matsumoto R, Kunieda T, Nair D
  • Journal Title: Seizure Volume: 44 Pages: 27-36
  • DOI: 10.1016/j.seizure.2016.11.003
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Epileptic network of hypothalamic hamartoma: An EEG-fMRI study. (2016)
  • Author(s): Usami K, Matsumoto R, Sawamoto N, Murakami H, Inouchi M, Fumuro T, Shimotake A, Kato T, Mima T, Shirozu H, Masuda H, Fukuyama H, Takahashi R, Kameyama S, Ikeda A
  • Journal Title: Epilepsy Res Volume: 125 Pages: 1-9
  • DOI: 10.1016/j.eplepsyres.2016.05.011
  • NAID: 120006305999
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Network specific change in white matter integrity in mesial temporal lobe epilepsy. (2016)
  • Author(s): Imamura, H., R. Matsumoto, S. Takaya, T. Nakagawa, A. Shimotake, T. Kikuchi, N. Sawamoto, T. Kunieda, N. Mikuni, S. Miyamoto, H. Fukuyama, R. Takahashi and A. Ikeda
  • Journal Title: Epilepsy Research Volume: 120 Pages: 65-72
  • DOI: 10.1016/j.eplepsyres.2015.12.003
  • NAID: 120005749848
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elderly woman with exaggerated startle reflex and unconscious drop attack (in press) (2016)
  • Author(s): Neshige S, Kobayashi K, Shimotake A, Iemura T, Matsumoto R, Nishinaka K, Matsumoto M, Takahashi R, Ikeda A.
  • Journal Title: Neurology and Clinical Neuroscience Volume: in press Issue: 4 Pages: 156-158
  • DOI: 10.1111/ncn3.12055
  • Peer Reviewed / Open Access
• [Journal Article] Paraneoplastic Limbic Encephalitis in a Human Epidermal Growth Factor Receptor-2-positive Gastric Cancer Patient Treated with Trastuzumab-combined Chemotherapy: A Case Report and Literature Review (2016)
  • Author(s): Uneno Y, Yokoyama A, Nishikawa Y, Funakoshi T, Ozaki Y, Aoyama I, Yamaguchi D, Morita S, Mori Y, Kanai M, Kinoshita H, Inoue T, Sawamoto N, Matsumoto R, Matsumoto S, Muto M.
  • Journal Title: Internal Medicine Volume: 55 Issue: 18 Pages: 2605-2609
  • DOI: 10.2169/internalmedicine.55.6917
  • NAID: 130005414847
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The ‘when’and ‘where’of semantic coding in the anterior temporal lobe: temporal representational similarity analysis of electrocorticogram data (2016)
  • Author(s): Chen Y, Shimotake A, Matsumoto R, Kunieda T, Kikuchi T, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A, Lambon-Ralph MA
  • Journal Title: Cortex Volume: 印刷中 Pages: 1-13
  • DOI: 10.1016/j.cortex.2016.02.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Benign adult familial myoclonus epilepsy is a progressive disorder: no longer idiopathic generalized epilepsy. (2016)
  • Author(s): Hitomi T, Kobayashi K, Sakurai T, Ueda S, Jingami N, Kanazawa K, Matsumoto R, Takahashi R, Ikeda A.
  • Journal Title: Epileptic Disord Volume: 18(1) Issue: 1 Pages: 67-72
  • DOI: 10.1684/epd.2016.0807
  • Peer Reviewed / Open Access
• [Journal Article] てんかん外科における術前皮質・白質機能マッピング（特集：神経生理最前線） (2016)
  • Author(s): 松本理器、下竹昭寛、山尾幸広、國枝武治
  • Journal Title: 最新精神医学 Volume: 21(2) Pages: 101-109
• [Journal Article] てんかん病態下の脳内ネットワーク (2016)
  • Author(s): 十川純平、松本理器、池田昭夫
  • Journal Title: Clinical Neuroscience Volume: 34(5)
• [Journal Article] 皮質電気刺激によるヒト脳機能ネットワークの探索 (2016)
  • Author(s): 山尾幸広、國枝武治、松本理器
  • Journal Title: 脳神経外科速報 Volume: 25(5) Pages: 411-420
  • NAID: 130005153208
• [Journal Article] くすぶり型辺縁系脳炎と自律神経 (2016)
  • Author(s): 武山博文、松本理器、池田昭夫
  • Journal Title: 神経内科 Volume: 84(1) Pages: 58-61
• [Journal Article] Different Mode of Afferents Determines the Frequency Range of High Frequency Activities in the Human Brain: Direct Electrocorticographic Comparison between Peripheral Nerve and Direct Cortical Stimulation (2015)
  • Author(s): Kobayashi K, Matsumoto R, Matsuhashi M, Usami K, Shimotake A, Kunieda T, Kikuchi T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: PLoS One Volume: 10 (6) Issue: 6 Pages: e0130461-e0130461
  • DOI: 10.1371/journal.pone.0130461
  • NAID: 120005674657
  • Peer Reviewed / Open Access
• [Journal Article] Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single-pulse electrical stimulation. (2015)
  • Author(s): Usami K, Matsumoto R, Kobayashi K, Hitomi T, Shimotake A, Kikuchi T, Matsuhashi M, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A.
  • Journal Title: Hum Brain Mapp Volume: 36(11) Issue: 11 Pages: 4714-4729
  • DOI: 10.1002/hbm.22948
  • Peer Reviewed / Open Access
• [Journal Article] Direct Exploration of the Role of the Ventral Anterior Temporal Lobe in Semantic Memory: Cortical Stimulation and Local Field Potential Evidence From Subdural Grid Electrodes (2015)
  • Author(s): Shimotake A, Matsumoto R, Ueno T, Kunieda T, Saito S, Hoffman P, Kikuchi T, Fukuyama H, Miyamoto S, Takahashi R, Ikeda A, Lambon Ralph MA
  • Journal Title: Cerebral Cortex Volume: 印刷中 Issue: 10 Pages: 3802-3817
  • DOI: 10.1093/cercor/bhu262
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Proceedings of the Seventh International Workshop on Advances in Electrocorticography. (2015)
  • Author(s): Ritaccio A, Matsumoto R, Morrell M, Kamada K, Koubeissi M, Poeppel D, Lachaux JP, Yanagisawa Y, Hirata M, Guger C, Schalk G
  • Journal Title: Epilepsy Behav Volume: 51 Pages: 312-320
  • DOI: 10.1016/j.yebeh.2015.08.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] New Approach for Exploring Cerebral Functional Connectivity: Review of Cortico-cortical Evoked Potential (2015)
  • Author(s): Kunieda T, Yamao Y, Kikuchi T, Matsumoto R
  • Journal Title: Neurologia medico-chirurgica Volume: 55 Issue: 5 Pages: 374-382
  • DOI: 10.2176/nmc.ra.2014-0388
  • NAID: 130005069876
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reply to Commentary on "Neural correlates of mirth and laughter: a direct electrical cortical stimulation study" (2015)
  • Author(s): Yamao Y, Kunieda T, Matsumoto R
  • Journal Title: Cortex Volume: 印刷中 Pages: 244-246
  • DOI: 10.1016/j.cortex.2015.03.019
  • NAID: 120005749925
  • Peer Reviewed / Open Access
• [Journal Article] Network hyperexcitability in a patient with partial reading epilepsy: Converging evidence from magnetoencephalography, diffusion tractography, and functional magnetic resonance imaging (2015)
  • Author(s): Fumuro T, Matsumoto R, Shimotake A, Matsuhashi M, Inouchi M, Urayama S, Sawamoto N, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Clinical Neurophysiology Volume: 126 (4) Issue: 4 Pages: 675-681
  • DOI: 10.1016/j.clinph.2014.07.033
  • NAID: 120005625620
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A possible variant of negative motor seizure arising from the supplementary negative motor area. (2015)
  • Author(s): Yamao Y, Matsumoto R, Kunieda K, Arakawa Y, Kikuchi T, Shibata S, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Clin Neurol Neurosurg Volume: 134 Pages: 126-129
  • DOI: 10.1016/j.clineuro.2015.04.024
  • NAID: 120005749924
  • Peer Reviewed / Open Access
• [Journal Article] Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody (2015)
  • Author(s): Matsumoto R, Mikuni N, Tanaka K, Usami K, Fukao K, Kunieda T, Takahashi Y, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Epileptic Disorders Volume: 17 (1) Issue: 1 Pages: 89-94
  • DOI: 10.1684/epd.2015.0725
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Alpha-band desynchronization in human parietal area during reach planning (2015)
  • Author(s): Fumuro T, Matsuhashi M, Miyazaki T, Inouchi M, Hitomi T, Matsumoto R, Takahashi R, Fukuyama H, Ikeda A
  • Journal Title: Clinical Neurophysiology Volume: 126(4) Issue: 4 Pages: 756-762
  • DOI: 10.1016/j.clinph.2014.07.026
  • NAID: 120005661555
  • Peer Reviewed / Open Access
• [Journal Article] システム神経科学とてんかんの接点 (2015)
  • Author(s): 松本理器、國枝武治、池田昭夫
  • Journal Title: 最新医学 Volume: 70(6) Pages: 1051-1060
• [Journal Article] EMUの整備と課題 (2015)
  • Author(s): 池田昭夫、松本理器、國枝武治
  • Journal Title: Epilepsy Volume: 9 Pages: 23-28
  • NAID: 40020489939
• [Journal Article] 春期・成人発症てんかんの治療 (特集 てんかん : 基礎・臨床研究の最新知見) (2015)
  • Author(s): 井上岳司、松本理器、池田昭夫
  • Journal Title: 日本臨床 Volume: 72 Pages: 853-858
• [Journal Article] Neural correlates of mirth and laughter: A direct electrical cortical stimulation study. (2014)
  • Author(s): Yamao, Y., R. Matsumoto, T. Kunieda, S. Shibata, A. Shimotake, T. Kikuchi, T. Satow, N. Mikuni, H. Fukuyama, A. Ikeda and S. Miyamoto
  • Journal Title: Cortex Volume: - Pages: 134-40
  • DOI: 10.1016/j.cortex.2014.11.008
  • NAID: 120005749923
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Epileptogenicity and related network: Approach from “interventional” clinical neurophysiology. Translatability between basic&clinical studies for the pathophysiology of epilepsy: Approach from Oscillology. (2017)
  • Author(s): Matsumoto R, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Ikeda A.
  • Organizer: The 94th Annual meeting of the Physiological Society of Japan
  • Place of Presentation: 浜松
  • Year and Date: 2017-03-28
  • Invited
• [Presentation] Cortico-cortical Evoked Potentials -a practical review (2017)
  • Author(s): Ikeda A.
  • Organizer: Annual meeting of American Clinical Neurophysiology Society
  • Place of Presentation: Phoenix, AZ, USA
  • Year and Date: 2017-02-11
  • Int'l Joint Research / Invited
• [Presentation] 指名講演１：皮質電気刺激によるヒト脳内ネットワークの可視化：着想から臨床応用への道のり． (2017)
  • Author(s): 松本理器
  • Organizer: 平成２８年度名古屋大学脳とこころの研究センターシンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2017-02-11
  • Invited
• [Presentation] Probing Dorsal and Ventral Language Networks by Integrated Invasive Neurophysiology (2016)
  • Author(s): Matsumoto R
  • Organizer: 11th International Workshop on Advances in Electrocorticography
  • Place of Presentation: Houston, Texas
  • Year and Date: 2016-12-01
  • Int'l Joint Research / Invited
• [Presentation] Cortico-cortical evoked potentials: methods, its research and clinical perspectives (2016)
  • Author(s): Matsumoto R.
  • Organizer: Seminar at Laboratory of Behavioral & Cognitive Neuroscience
  • Place of Presentation: Department of Neurology, Stanford University; Pala Alto
  • Year and Date: 2016-11-15
  • Invited
• [Presentation] エキスパートレクチャー 12 ．てんかんの臨床神経生理学と硬膜下電極 (2016)
  • Author(s): 松本理器, 下竹昭寛, 吉田和道, 松橋眞男, 國枝武治 池田昭夫
  • Organizer: 第 46 回日本臨床神経生理学会学術大会
  • Place of Presentation: 郡山
  • Year and Date: 2016-10-28
  • Invited
• [Presentation] CCEP のオフライン解析と解釈．（ワークショップ 2 CCEP の skills workshop : clinical practice parameter （臨床実践指標）を目指して）． (2016)
  • Author(s): 松本理器, 小林勝哉, 菊池隆幸、國枝武治、池田昭夫
  • Organizer: 第 46 回日本臨床神経生理学会学術大会
  • Place of Presentation: 郡山
  • Year and Date: 2016-10-28
  • Invited
• [Presentation] Functional brain mapping of primary sensorimotor cortex by means of MRCP and ERS/ERD comparing with CSM (2016)
  • Author(s): Neshige S, Sakurai T, Kobayashi K, Shimotake A, Matsuhashi M, Matsumoto R, Hitomi T, Matsumoto M, Takahashi R, Ikeda A
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 郡山
  • Year and Date: 2016-10-27
• [Presentation] 呼称課題を用いた低刺激強度皮質電気刺激の言語機能マッピングの有用性 学会等名第50回日本てんかん学会学術集会 (2016)
  • Author(s): 下竹昭寛, 松本理器, 坂本光弘, 中谷光良, 太田真紀子, 小林勝哉, 菊池隆幸, 吉田和道, 國枝武治, 宮本享, 髙橋良輔 池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07
• [Presentation] Repeated, cortical stimulation inhibits cortical epileptic excitability in human epileptic focus. (2016)
  • Author(s): Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N, Ikeda A
  • Organizer: 第 50 回てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-07
• [Presentation] Probing dynamics of cortico-cortical connectivity with direct cortical stimulation in physiological and pathologic states. (2016)
  • Author(s): Matsumoto R.
  • Organizer: Symposium: Network disruption in brain disorders Biomag 2016
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-10-03
  • Int'l Joint Research / Invited
• [Presentation] 単発電気刺激による脳内ネットワークの可視化：着想から臨床応用への道のり（特別企画４ 機能ネットワーク解明から治療への応用） (2016)
  • Author(s): 松本理器, 山尾幸広, 菊池隆幸, 吉田和道, 國枝武治
  • Organizer: 第 75 回日本脳神経外科学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-30
  • Invited
• [Presentation] 左中心前回中・下部に限局した腫瘍切除後にanarthriaを呈した1例 (2016)
  • Author(s): 坂本光弘, 松本理器, 下竹昭寛, 太田真紀子, 中谷光良, 菊池隆幸, 吉田和道, 國枝武治, 池田昭夫
  • Organizer: 第40回日本神経心理学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 2016-09-15
• [Presentation] Ventral part of the anterior temporal lobe actively engages in Kanji reading: Evidence from direct cortical stimulation of the basal temporal language area. (2016)
  • Author(s): Daifu M, Matsumoto R, Shimotake A, Sakamoto M, Ota M, Kunieda T, Miyamoto S, Takahashi R, Lambon Ralph MA, Ikeda A
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Antero-posterior gradients exist in functional connections between human inferior frontal gyrus and middle&posterior temporal gyri. An intraoperative cortico-cortical evoked potential study (2016)
  • Author(s): Nakae T, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi T, Inada T, Takahashi Y, Nishida S, Inano R, Kobayashi K, Shimotake A, Matsuhashi M, Kikuchi T, Takahashi R, Ikeda A, Miyamoto S
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Functional mapping of praxis: Electrical cortical stimulation study (2016)
  • Author(s): Shimotake A, Matsumoto R, Kobayashi K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第39回神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Human motor inhibition network as revealed by epicortical ERP, CCEP and high frequency cortical stimulation. (2016)
  • Author(s): Takeyama H, Matsumoto R, Usami K, Shimotake A, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Functional connectivity from medial parietal cortex and superior parietal lobule: a cortico-cortical evoked potential study (2016)
  • Author(s): Togo M, Matsumoto R, Takeyama H, Kobayashi K, Shimotake A, Usami K, Inouchi M, Nakae T, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第39回日本神経科学学会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Wide-band Electrocorticographic (ECoG) data analysis in primary sensorimotor (SI-MI) area (2016)
  • Author(s): Neshige S, Sakurai T, Kobayashi K, Shimotake A, Matsuhashi M, Matsumoto R, Hitomi T, Matsumoto M, Takahashi R, Ikeda A
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2016-05-18
• [Presentation] Which areas inhibit motor responses? Direct evidence from subdural recordings. (2016)
  • Author(s): Takeyama H, Matsumoto M, Usami K, Shimotake A, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] Enhancement of coupling between slow waves and high gamma activities during slow wave sleep in human (2016)
  • Author(s): Togawa J, Inouchi M, Matsumoto R, Matsuhashi M, Kobayashi K, Usami K, Hitomi T, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] Advanced techniques in HFO analysis (2016)
  • Author(s): Ikeda A.
  • Organizer: Workshop HFOs and the Epileptogenic Zone, 11th Asian & Oceanian Epilepsy Congress (AOEC)
  • Place of Presentation: Hongkong, China
  • Year and Date: 2016-05-13
  • Int'l Joint Research / Invited
• [Presentation] Functional mapping of praxis network: Electrical cortical stimulation study. (2016)
  • Author(s): Shimotake A, Matsumoto R, Togo M, Kunieda T, Ikeda A
  • Organizer: The 1st International Symposium on Embodied-Brain Systems Science (EMBOSS2016)
  • Place of Presentation: 東京
  • Year and Date: 2016-05-08
  • Int'l Joint Research
• [Presentation] Role of left ventral precentral gyrus in apraxia of speech: documents with electrical cortical stimulation and focal resection. (2016)
  • Author(s): Sakamoto M, Matsumoto R, Shimotake A, Nakae T, Kunieda T, Ikeda A
  • Organizer: The 1st International Symposium on Embodied-Brain Systems Science (EMBOSS2016)
  • Place of Presentation: 東京
  • Year and Date: 2016-05-08
  • Int'l Joint Research
• [Presentation] Functional connectivity from human superior pariental lobule and medial pariental lobe: a cortico-cortical evoked potential (CCEP) study. (2016)
  • Author(s): Togo M, Matsumoto R, Shimotake A, Inouchi M, Kunieda T, Ikeda A
  • Organizer: The 1st International Symposium on Embodied-Brain Systems Science (EMBOSS2016)
  • Place of Presentation: 東京
  • Year and Date: 2016-05-08
  • Int'l Joint Research
• [Presentation] Intracranially recorded ictal DC shifts and HFOs as surrogate markers of epileptogenicity in human focal epilepsy (2016)
  • Author(s): Daifu M, Inouchi M, Kanazawa K, Matsuhashi M, Inoue T, Kobayashi K, Shimotake A, Hitomi T, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 2nd International workshop on High Frequency Oscillations in Epilepsy
  • Place of Presentation: Freiburg, Germany
  • Year and Date: 2016-03-10
  • Int'l Joint Research
• [Presentation] The ventral language network - its function, connectivity and plasticity: insights from direct cortical stimulation and ECoG recordings (2015)
  • Author(s): Matsumoto R
  • Organizer: Special Seminar at Cognitive Neurophysiology and Brain–Machine Interface Laboratory
  • Place of Presentation: Johns Hopkins University, Baltimore, USA
  • Year and Date: 2015-12-08
  • Invited
• [Presentation] 皮質・皮質間誘発電位（ＣＣＥＰ）記録・解析の実際 (2015)
  • Author(s): 松本理器、國枝武治、池田昭夫
  • Organizer: 第45回日本臨床神経生理学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-11-08
  • Invited
• [Presentation] ヒト内側頭頂葉の機能的結合性：皮質―皮質間誘発電位を用いた検討 (2015)
  • Author(s): 十河正弥、松本理器、武山博文、小林勝哉、下竹昭寛、宇佐美清英、中江卓郎、國枝武治、宮本享、高橋良輔、池田昭夫
  • Organizer: 第45回日本臨床神経生理学会学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2015-11-06
• [Presentation] 慢性電極留置におけるてんかん原性評価 (2015)
  • Author(s): 小林勝哉、 松本理器、 國枝武治、池田昭夫
  • Organizer: 第45回日本臨床神経生理学会学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2015-11-05
  • Invited
• [Presentation] 術中電気的線維追跡法を用いた腹側言語経路の検討 (2015)
  • Author(s): 中江卓郎、松本理器、國枝武治、荒川芳輝、下竹昭寛、小林勝哉、稲野理賀、西田誠、高橋由紀、稲田拓、菊池隆幸、松橋眞生、高橋良輔、池田昭夫、宮本享
  • Organizer: 第45回日本臨床神経生理学会学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2015-11-05
• [Presentation] Functional connectivity of the human entorhinal cortex: a cortico-cortical evoked potential study (2015)
  • Author(s): Takeyama, H、 Matsumoto, R、 Kobayashi, K、 Usami, K、 Shimotake, A、 Kikuchi, T、 Kunieda, T、 Miyamoto, S、 Takahashi, R、 Ikeda, A
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-31
• [Presentation] 側頭葉底部前方領域での意味認知機能 マッピング：事象関連電位の皮質記録の検討 (2015)
  • Author(s): 下竹昭寛、松本理器、太田真紀子、國枝武治、三國信啓、宮本亨、高橋良輔、池田昭夫
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-31
• [Presentation] 睡眠と前頭葉てんかん (2015)
  • Author(s): 小林勝哉、 松本理器、 宇佐美清英、國枝武治、 池田昭夫
  • Organizer: 第49回日本てんかん学会学術大会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-30
  • Invited
• [Presentation] VNSの効果作動機構の検討 (2015)
  • Author(s): 池田昭夫、Bayasgalan Borgil, 松橋眞生、文室知之、中野直樹、飯田幸治、片桐匡弥、松本理器、國枝武治、加藤天美、髙橋良輔
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-30
  • Invited
• [Presentation] Co-occurrence of slow shifts and high frequency oscillations(HFOs) in invasively recorded, interictal state: Is it called 'Red slow'? (2015)
  • Author(s): Daifu M, Inouchi M, Inoue T, Kanazawa K, Matsuhashi M, Kobayashi K, Shimotake A, Hitomi T, Matsumoto R, Kunieda T, Miyamoto S, Takahashi, R, Ikeda, A
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-30
• [Presentation] 側頭葉腫瘍切除症例における神経心理学的検討 (2015)
  • Author(s): 中江卓郎、國枝武治、松本理器、荒川芳輝、西田誠、稲野理賀、高橋由紀、稲田拓、下竹昭寛、菊池隆幸、吉田和道、高木康志、池田昭夫、宮本享
  • Organizer: 日本脳神経外科学会第74回学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-10-14
• [Presentation] Status epilepticus in the elderly in the super-aging society: clinical and EEG features and prognostic factors (2015)
  • Author(s): Yoshimura H, Matsumoto R, Ishii J, Kono T, Hoshi T, Todo K, Kawamoto M, Ariyoshi K, Ikeda A, Kohara N
  • Organizer: 31st International Epilepsy Congress
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2015-09-05
  • Int'l Joint Research
• [Presentation] Non-structural evidence of seizure focus: The role of functional imaging (2015)
  • Author(s): Ikeda A
  • Organizer: Istanbul, Turkey
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2015-09-05
  • Int'l Joint Research / Invited
• [Presentation] Kanji word processing in the ventral anterior temporal lobe: a postoperative neuropsychological study in patients with temporal lobe epilepsy (2015)
  • Author(s): Ota M, Matsumoto R, Shimotake A, Daifu M, Kunieda T, Miyamoto S, Takahashi R, Lambon-Ralph MA, Ikeda A
  • Organizer: 第38回日本神経科学学会 (Neuroscience 2015)
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] The when and where of semantics in the anterior temporal lobe:: temporal representational similarity analysis of electrocorticogram data (2015)
  • Author(s): Shimotake A, Chen Y, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Lambon Ralph MA, Ikeda A
  • Organizer: 第38回日本神経科学学会(Neuroscience 2015)
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] Clinical implications of intraoperative CCEP monitoring in evaluating the white matter functional integrity of the dorsal language network (2015)
  • Author(s): Matsumoto R, Yamao Y, Kunieda T, Arakawa Y, Shimotake A, Kikuchi T, Shibata S, Inano R, Sawamoto N, Ikeda A, Mikuni N, Miyamoto S
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] 発作間欠期の徐波と高周波数律動（HFO）の共起：難治部分てんかん患者の皮質脳波の症例検討 (2015)
  • Author(s): 井上岳司、井内盛遠、松橋眞生、松本理器、人見健文、大封昌子、小林勝哉、金澤恭子、下竹昭寛、國枝武治、高橋良輔、池田昭夫
  • Organizer: 第17回日本ヒト脳機能マッピング学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-02
• [Presentation] 行為関連ネットワークの機能分化と症状の解明：皮質電気刺激による研究 (2015)
  • Author(s): 下竹昭寛、松本理器、小林勝哉、宇佐美清英、國枝武治、三國信啓、宮本亨、高橋良輔、池田昭夫
  • Organizer: 第9回Motor Control 研究会
  • Place of Presentation: 京都
  • Year and Date: 2015-06-26
• [Presentation] Network Disorders (2015)
  • Author(s): Matsumoto R
  • Organizer: 20th Korean Epilepsy Congress
  • Place of Presentation: Gwangju, South Korea
  • Year and Date: 2015-06-13
  • Int'l Joint Research / Invited
• [Presentation] Functional connectivity revealed by Cortico-Cortical Evoked Potentials (2015)
  • Author(s): Matsumoto R
  • Organizer: 20th Korean Epilepsy Congress
  • Place of Presentation: Gwangju, South Korea
  • Year and Date: 2015-06-12
  • Int'l Joint Research / Invited
• [Presentation] ヒト脳の機能可塑性：皮質電気刺激・外科的脳切除の観点から (2015)
  • Author(s): 松本理器、 國枝武治、 池田昭夫
  • Organizer: 第30回日本生体磁気学会大会
  • Place of Presentation: 旭川
  • Year and Date: 2015-06-05
  • Invited
• [Presentation] Importance of very low frequency EEG to evaluate VNS therapy of epilepsy (2015)
  • Author(s): Borgil B, Matsuhashi M, Nakano N, Iida K, Katagiri M, Shimotake A, Matsumoto R, Fumuro T, Kunieda T, Kato A, Takahashi R, Ikeda A
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-21
• [Presentation] Functional mapping of praxis network: Electrical cortical stimulation study (2015)
  • Author(s): Shimotake A, Matsumoto R, Kobayashi K, Usami K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-20
• [Presentation] Long-term prognosis of smoldering autoimmune encephalitis (2015)
  • Author(s): Matsumoto R, Kanazawa K, Togawa J, Hikiami R, Inoue T, Kobayashi K, Shimotake A, Sawamoto N, Takahashi R, Ikeda A
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-20
• [Presentation] 高齢者のてんかん重積状態：臨床的特徴と予後因子について (2015)
  • Author(s): 吉村 元、松本 理器、藤原 悟、上田 哲大、村瀬 翔、十河 正弥、石井 淳子、河野 智之、星 拓、藤堂 謙一、川本 未知、幸原 伸夫
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-20
• [Presentation] 皮質電気刺激によるヒト脳機能ネットワークの探索 (2015)
  • Author(s): 松本理器、 山尾幸広、 下竹昭寛、 國枝武治、 池田昭夫
  • Organizer: 第35回日本脳神経外科コングレス総会
  • Place of Presentation: 横浜
  • Year and Date: 2015-05-08
  • Invited
• [Book] Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy. (2017)
  • Author(s): Matsumoto R, Kunieda T.
  • Publisher: Oxford University Press
• [Book] Clinical Neuroscience (2016)
  • Author(s): 下竹昭寛，國枝武治，松本理器
  • Publisher: 中外医学社
• [Book] Clinical Neuroscience (2016)
  • Author(s): 十川純平，松本理器，池田昭夫
  • Publisher: 中外医学社
• [Book] 脳神経外科速報 (2016)
  • Author(s): 山尾幸広，國枝武治，松本理器
  • Publisher: メディカ出版
• [Book] 最新精神医学 (2016)
  • Author(s): 松本理器，下竹昭寛，山尾幸広，國枝武治
  • Publisher: 世論時報社
• [Book] ここが知りたい！臨床神経生理 (2016)
  • Author(s): 下竹昭寛，池田昭夫
  • Publisher: 中外医学社
• [Book] 不随意運動の診断と治療 (2016)
  • Author(s): 人見健文，寺田清人，池田昭夫
  • Publisher: 診断と治療社
• [Book] 内科診療実践マニュアル第２版 (2016)
  • Author(s): 塚田剛史，井上岳司，池田昭夫
  • Publisher: 日本医学出版
• [Book] てんかん白書 (2016)
  • Author(s): 松本理器
  • Publisher: 南江堂
• [Book] Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy: Chapter 36 Cortico-cortical evoked potential mapping (Section 5: Human Brain Mapping) (2016)
  • Author(s): Matsumoto R, Kunieda T.
  • Publisher: Oxford University Press, London
• [Book] 神経内科シリーズ４、てんかん外来 (診断に必要な検査．II外来診察の基本的な流れ). (2016)
  • Author(s): 吉村 元、松本理器
  • Total Pages: 232
  • Publisher: メジカルビュー社
• [Book] 臨床神経生理. (意識障害). (2016)
  • Author(s): 十川純平、松本理器
  • Publisher: 中外医学社
• [Book] 臨床神経生理．(脳死．脳波) (2016)
  • Author(s): 大封昌子、松本理器
  • Publisher: 中外医学社
• [Book] 臨床てんかん学（チャプター名：5. 頭頂葉てんかん．D．年齢非依存性焦点性てんかん．第11章てんかんおよびてんかん類似症候群．） (2015)
  • Author(s): 下竹昭寛、松本理器
  • Total Pages: 671
  • Publisher: 医学書院
• [Book] 臨床てんかん学（チャプター名：1. 側頭葉てんかん. D．年齢非依存性焦点性てんかん．第11章てんかんおよびてんかん類似症候群．） (2015)
  • Author(s): 井内盛遠、松本理器
  • Total Pages: 671
  • Publisher: 医学書院
• [Book] 臨床てんかん学（チャプター名：2. 前頭葉てんかん（ジャクソン発作を除く） (2015)
  • Author(s): 宇佐美清英、松本理器、池田昭夫
  • Total Pages: 671
  • Publisher: 医学書院
• [Book] 臨床てんかん学（チャプター名：4. Jackson発作関連てんかん．D．年齢非依存性焦点性てんかん．第11章てんかんおよびてんかん類似症候群．） (2015)
  • Author(s): 芝田純也、松本理器
  • Total Pages: 671
  • Publisher: 医学書院
• [Book] 臨床てんかん学（チャプター名：3. 後頭葉てんかん．D．年齢非依存性焦点性てんかん．第11章てんかんおよびてんかん類似症候群．） (2015)
  • Author(s): 金澤恭子、松本理器
  • Total Pages: 671
  • Publisher: 医学書院
• [Remarks] 京都大学大学院医学研究科てんかん・運動異常生理学講座webpage（研究：日本語）
  • URL: http://epilepsy.med.kyoto-u.ac.jp/research
• [Remarks] 京都大学大学院医学研究科てんかん・運動異常生理学講座webpage（研究：英語）
  • URL: http://epilepsy.med.kyoto-u.ac.jp/research_en