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D-アミノ酸への転換反応追跡用次元拡張型振動円二色性分光法の開発

Publicly Offered Research

Project AreaScience on Function of Soft Molecular Systems by Cooperation of Theory and Experiment
Project/Area Number 16H00840
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionEhime University

Principal Investigator

佐藤 久子  愛媛大学, 理工学研究科(理学系), 教授 (20500359)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords振動円二色性分光法 / D-アミノ酸 / 超分子キラリティ / キラル認識 / キラリティ / キラル分光法 / アミノ酸
Outline of Annual Research Achievements

本プロジェクトでは、(1)次元拡張型VCD装置の開発を行い、(2)ペプチドオリゴマー中のD-アミノ酸の検出を目指した研究を行った。(1)に関しては、VCD装置のバージョンアップを行い、ベースラインの長期間安定性を実現し、信号/雑音比をあげて微弱シグナルの測定を可能とした。それと同時に直線偏光の測定も可能とし、固体VCD法の開発をおこなった。(2)(2A)粘土鉱物(モンモリロナイト)表面にキラルな金属錯体Δ-あるいはΛ-[Ru(phen)3]2+(phen=1,1-phenanthroline)を吸着させて、モンモリロナイト表面にキラル認識場を作製した。インターカレートした錯体のΔ、Λ体に対応して反転したシグナルを得ることができた。さらに、この試料中にキラル物質として有機分子であるR,-あるいはS-BINOL(1,1’-bi-2-naphthol)を吸着させ、モンモリロナイト面上におけるキラル分子間の相互作用を検討した。モンモリロナイトを含めた3成分系にVCD法を適用した結果、金属錯体との相互作用により柔らか分子の有機分子BINOLがコンフォーメーションを変える証拠を得ることができた。VCD法を層状化合物に初めて適用した例である。(2B)パーフルオロ基をもつ低分子量ゲル化剤とアルキル基をもつ2成分系のキラルゲルに対してVCD法を適用した。ゲル化速度と熱力学的安定性への影響を検討した。特に、ゲル化剤のキラリティの影響(立体化学的効果)の検討をおこなった。VCD吸収がゲル化に伴い増大してく現象を観察した。(2C)ペプチドオリゴマー関連のテーマとしては、抗菌ペプチド ボンビニンH2,H4のD体アロイソロイシン残基の役割に関して領域内で共同研究をおこなった。VCDの結果から1残基目の側鎖と2残基目の側鎖の関係がH2ではトランス型、H4ではシス型であることがわかった。

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (43 results)

All 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 8 results,  Acknowledgement Compliant: 3 results) Presentation (24 results) (of which Int'l Joint Research: 6 results) Book (1 results) Remarks (4 results)

  • [Int'l Joint Research] Gyeongsang National University(韓国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Different Origins of Strain-Induced Chirality Inversion of Co2+-Triggered Supramolecular Peptide Polymers2018

    • Author(s)
      Park Hyesong、Kim Ka Young、Jung Sung Ho、Choi Yeonweon、Sato Hisako、Jung Jong Hwa
    • Journal Title

      Chemistry of Materials

      Volume: 30 Issue: 6 Pages: 2074-2083

    • DOI

      10.1021/acs.chemmater.8b00057

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of d - allo -isoleucine in the deposition of the anti- Leishmania peptide bombinin H4 as revealed by 31 P solid-state NMR, VCD spectroscopy, and MD simulation2018

    • Author(s)
      Mijiddorj Batsaikhan、Kaneda Shiho、Sato Hisako、Kitahashi Yuki、Javkhlantugs Namsrai、Naito Akira、Ueda Kazuyoshi、Kawamura Izuru
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

      Volume: 1866 Issue: 7 Pages: 789-798

    • DOI

      10.1016/j.bbapap.2018.01.005

    • NAID

      120006649291

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Stereochemical effects on dynamics in two-component systems of gelators with perfluoroalkyl and alkyl chains as revealed by vibrational circular dichroism2018

    • Author(s)
      Sato Hisako、Yajima Tomoko、Yamagishi Akihiko
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 20 Issue: 5 Pages: 3210-3215

    • DOI

      10.1039/c7cp06264h

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Solid state vibrational circular dichroism towards molecular recognition: chiral metal complexes intercalated in a clay mineral2018

    • Author(s)
      Sato Hisako、Tamura Kenji、Takimoto Kazuyoshi、Yamagishi Akihiko
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 20 Issue: 5 Pages: 3141-3147

    • DOI

      10.1039/c7cp05114j

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microscopic chiral pockets in a tris(chelated) iridium(iii) complex as sites for dynamic enantioselective quenching2018

    • Author(s)
      Takimoto Kazuyoshi、Tamura Kenji、Watanabe Yutaka、Yamagishi Akihiko、Sato Hisako
    • Journal Title

      New Journal of Chemistry

      Volume: 42 Issue: 7 Pages: 4818-4823

    • DOI

      10.1039/c7nj04688j

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bio-inorganic hybrid photoanodes of photosystem II and ferricyanide-intercalated layered double hydroxide for visible-light-driven water oxidation2018

    • Author(s)
      Kato Masaru、Sato Hisako、Yagi Ichizo、Sugiura Miwa
    • Journal Title

      Electrochim. Acta

      Volume: 264 Pages: 386-392

    • DOI

      10.1016/j.electacta.2018.01.133

    • NAID

      120006783650

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of signal-to-noise ratio in oxygen sensitive emission from hybrid Langmuir?Blodgett films of amphiphilic iridium complexes with the exfoliated nanosheets using a metal layer2018

    • Author(s)
      Ozaki Ryotaro、Yamada Tetsuya、Yudate Shinji、Kadowaki Kazunori、Sato Hisako
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 3S2 Pages: 03EG03-03EG03

    • DOI

      10.7567/jjap.57.03eg03

    • NAID

      210000148757

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two-dimensional Arrays of Molecular Rods as a Precursor of Gel Fibrils2017

    • Author(s)
      Akihiko Yamagishi, Kenji Tamura, Tomoko Yajima, Hisako Sato*
    • Journal Title

      Chem. Lett.

      Volume: 46 Issue: 11 Pages: 1679-1682

    • DOI

      10.1246/cl.170774

    • NAID

      130006837440

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxygen Sensing by the Hybrid Langmuir-Blodgett Films of Iridium(III) Complexes and Synthetic Saponite on the Basis of Energy Transfer2017

    • Author(s)
      Sato Hisako、Tamura Kenji、Yamagishi Akihiko
    • Journal Title

      Chemosensors

      Volume: 5 Issue: 4 Pages: 27-27

    • DOI

      10.3390/chemosensors5040027

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 嵩高い金属錯体を用いたキラル液晶の構造研究2017

    • Author(s)
      吉田純,渡辺豪,佐藤久子
    • Journal Title

      日本液晶学会誌 液晶 (表紙に採択)

      Volume: 21 Pages: 105-112

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Solid State VCD spectra of Isoleucine and its Related Compounds: Effects of Interplay between Two Chiral Centers.2017

    • Author(s)
      Hisako Sato*, Izuru Kawamura, Akihiko Yamagishi, Fumi Sato
    • Journal Title

      Chemistry Letters (Editor's choice)

      Volume: 46 Issue: 4 Pages: 449-452

    • DOI

      10.1246/cl.161043

    • NAID

      130005549111

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vibrational Circular Dichroism and Single Crystal X-Ray Diffraction Analyses of [Ir(bzq)2(phen)]+ (bzq = benzo[h]quinoline; phen = 1,10-phenanthroline): Absolute Configuration and Role of CH-pi Interaction in Molecular Packing2017

    • Author(s)
      Kazuyoshi Takimoto, Yutaka Watanabe, Shigeki Mori, Hisako Sato
    • Journal Title

      Dalton Trans.

      Volume: 46 Issue: 13 Pages: 4397-4402

    • DOI

      10.1039/c7dt00606c

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chiral Phosphorescent Probes for Amino Acids: Hybrids of Iridium(III) Complexes with Synthetic Saponite2017

    • Author(s)
      Hisako Sato, Kenji Tamura, Tomoko Yajima,Fumi Sato, Akihiko Yamagishi
    • Journal Title

      New J. Chem.

      Volume: 41 Issue: 7 Pages: 2780-2785

    • DOI

      10.1039/c6nj03777a

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 振動円二色性分光法による固体表面における不斉識別機構の解明2018

    • Author(s)
      佐藤久子、瀧本和誉、山岸晧彦
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ペルフルオロアルキル鎖とフェニル基を有する低分子ゲル化剤2018

    • Author(s)
      叶野花菜子、佐藤久子、山岸晧彦、矢島知子
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] パーフルオロ基をもつゲル化剤の2次元膜挙動2018

    • Author(s)
      山岸晧彦、矢島知子、田村堅志、佐藤久子
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Syntheses of Multinuclear Pd(II) Complexes with Axial Chirality2018

    • Author(s)
      Youtaro Goto, Hisako Sato, Yutaka Watanabe
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Construction and Functional Characterization of Chiral Two dimensional Supramolecular Sheets Composed of Achiral Organic Salts Having Long Alkyl Chains2018

    • Author(s)
      Toshiyuki Sasaki, Hisako Sato, Mikiji Miyata, Ichiro Hisaki, Norimitsu Tohnai
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 合成サポナイトに吸着したキラルイリジウム錯体の発光挙動2018

    • Author(s)
      瀧本和誉、渡邉裕、山岸晧彦、佐藤久子
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chiral-Linkage-Induced Helical Ordering of Rigid Cylindrical Inorganic Polymer in their Thixotropic Gel2017

    • Author(s)
      Kazuhiro Shikinaka, Hiroto Kikuchi, Tei Maki, Hiroyasu Masunaga, Hisako Sato
    • Organizer
      Gel Symposium2017
    • Place of Presentation
      日本大学津田沼キャンパス、Chiba
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Solid State VCD Spectra of Amino Acids: Effects of Interplay between Two Chiral Centers in Isoleucine2017

    • Author(s)
      Hisako Sato, Izuru Kawamura, Fumi Sato, Akihiko Yamagishi
    • Organizer
      Chirality2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural difference of functional peptide fibers between L-Phe-L-Phe-OH, L-Phe-D-Phe-OH and D-Phe-D-Phe-OH2017

    • Author(s)
      Yumi Ozawa, Batsaikhan Mijiddorj, Hisako Sato, Namsrai Javkhlantugs, Akira Naito, Kazuyoshi Ueda, Izuru Kawamura
    • Organizer
      The 3rd international conference D-amino acid research(Best Young Researcher Award)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structure of bombinin H4 containing a D-allo-isoleucine by solid-state VCD and solid-state NMR2017

    • Author(s)
      Izuru Kawamura, Shiho Kaneda, Yuki Kitahashi, Hisako Sato, Akira Naito
    • Organizer
      The 3rd international conference D-amino acid research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of Vibrational Circular Dichroism to Chiral Iridium and Ruthenium Complexes2017

    • Author(s)
      Hisako Sato, Kazuyoshi Takimoto, Jun Yoshida, Akihiko Yamagishi
    • Organizer
      第67回錯体化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 立体反転によって誘起されるペプチドファイバーの形態変化と固体NMRによる構造解析2017

    • Author(s)
      尾澤夢実、佐藤久子、内藤晶、川村出
    • Organizer
      高分子学会17-1NMR研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] キラルイリジウム錯体の合成と性質2017

    • Author(s)
      瀧本和誉、渡邉裕、森重樹、佐藤久子
    • Organizer
      第67回錯体化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 軸性キラリティを持つ多核パラジウム錯体の合成と性質2017

    • Author(s)
      後藤勇太朗、渡邉裕、佐藤久子
    • Organizer
      第67回錯体化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 発光性イリジウム錯体の粘土面への吸着:発光キラルセンシングへの応用2017

    • Author(s)
      山岸晧彦、瀧本和誉、田村堅志、渡邉裕、佐藤久子
    • Organizer
      第67回錯体化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 繊維状粘土に取り込まれたランタニド錯体からなる多機能性無機有機複合発光体の光安定性2017

    • Author(s)
      海崎純男、城谷大、岩松雅子、加藤由美子、佐藤久子、日置亜矢子、梶原篤、山崎鈴子
    • Organizer
      第67回錯体化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] キラル分離用HPLC カラム充填剤応用に適したヘクトライト被覆シリカ粒子の合成2017

    • Author(s)
      小栗睦基、佐藤久子、山岸晧彦、岡田友彦
    • Organizer
      第61回粘土科学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヘクトライト被覆シリカ粒子を用いたトリスアセチルアセトナト Ru (Ⅲ)の TLC 光学分割2017

    • Author(s)
      田島一輝、佐藤久子、山岸晧彦、岡田友彦
    • Organizer
      第61回粘土科学討論会(優秀講演賞)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 粘土鉱物へのイリジウム錯体吸着による発光キラルセンシグ2017

    • Author(s)
      山岸晧彦、瀧本和誉、田村堅志、渡邉裕、佐藤久子
    • Organizer
      第61回粘土科学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 繊維状粘土に取り込まれた光増感配位子を含むランタニド錯体からなる無機有機複合の安定性2017

    • Author(s)
      海崎純男、城谷大、岩松雅子、加藤由美子、佐藤久子、日置亜矢子、梶原篤
    • Organizer
      第61回粘土科学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フェニル基を有する含フッ素化合物の合成と超分子ゲルの形成2017

    • Author(s)
      叶野花菜子、佐藤久子、山岸晧彦、矢島知子
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 干渉法による発光性イリジウム錯体LB膜の発光特性の向上2017

    • Author(s)
      山田達也、尾崎良太郎、弓達新治、門脇一則、佐藤久子
    • Organizer
      第2回フォトニクス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Solid-state VCD Spectroscopy as a Tool for Characterization of Supramolecular Chirality2016

    • Author(s)
      Toshiyuki Sasaki, Mikiji Miyata, Ichiro Hisaki, Norimitsu Tohnai, Hisako Sato
    • Organizer
      MCASIA2016
    • Place of Presentation
      ナレッジキャピタルコングレコンベンションセンター, Oosaka
    • Year and Date
      2016-04-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An Evidence for Effects of Elongation of Perfluoroalky Chains on Gelation by Means of Vibrational Circular Dichroism2016

    • Author(s)
      Hisako Sato, Tomoko Yajima, Akihiko Yamaghsi
    • Organizer
      MCASIA2016
    • Place of Presentation
      ナレッジキャピタルコングレコンベンションセンター, Oosaka
    • Year and Date
      2016-04-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] 低分子ゲルの開発と応用,第5章 振動円二色性分光法によるゲル形成過程の解析2016

    • Author(s)
      佐藤久子、矢島知子
    • Total Pages
      7
    • Publisher
      シーエムシー出版
    • Related Report
      2016 Annual Research Report
  • [Remarks] 教員情報業績システム

    • URL

      http://yoran.office.ehime-u.ac.jp/profile/ja.fb2f237dd556c9a760392a0d922b9077.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 愛媛大学理学部化学科複合体研究室

    • URL

      http://chem.sci.ehime-u.ac.jp/~comchem1/publications.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 愛媛大学理学部化学科複合体化学研究室

    • URL

      http://chem.sci.ehime-u.ac.jp/~comchem1/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 教員業績情報システム

    • URL

      https://kenqweb2.office.ehime-u.ac.jp/userpage/login.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-26   Modified: 2022-04-28  

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