高活性高分子触媒の創製と連続フローシステム化

• Project Area: Middle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis.
• Project/Area Number: 16H01165
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Institute for Molecular Science
• Principal Investigator: 魚住 泰広 分子科学研究所, 生命・錯体分子科学研究領域, 教授 (90201954)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 有機化学 / 触媒・化学プロセス / 有機工業化学

Outline of Annual Research Achievements

平成２９年度においては両親媒性高分子担体に担持した遷移金属錯体や遷移金属ナノ粒子を触媒とする酸化還元型有機分子変換反応および炭素ー窒素結合形成を伴う環化付加反応の開発を中心課題とし，またその連続フローシステムへの展開について検討を加えた。
その結果，親媒性高分子担持白金ナノ粒子触媒を用いカルボニル基の還元反応を実現し，そのフロー化に成功した。また同高分子担持銅錯体触媒あるいは同高分子担持デンドリマー配位子によって安定化した銅コンポジットを創製し，水性媒体中でのHuisgen反応によるトリアゾール環形成反応に成功した。
さらにこのHuisgen環化付加反応をフロー化し，水中でのアセチレンガスを用いた１置換トリアゾール合成に展開した。

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Preparation of Aryl(dicyclohexyl)phosphines by C-P Bond-Forming Cross-Coupling in Water Catalyzed by an Amphiphilic-Resin-Supported Palladium Complex (2017)
  • Author(s): Uozumi Yasuhiro、Hirai Yoshinori
  • Journal Title: Synlett Volume: 28 Issue: 20 Pages: 2966-2970
  • DOI: 10.1055/s-0036-1590926
  • Peer Reviewed
• [Journal Article] Recent Advances in Palladium-Catalyzed Cross-Coupling Reactions at ppm to ppb Molar Catalyst Loadings (2017)
  • Author(s): Roy David、Uozumi Yasuhiro
  • Journal Title: Adv. Synth. Catal. Volume: 360 Issue: 4 Pages: 602-625
  • DOI: 10.1002/adsc.201700810
  • Peer Reviewed
• [Journal Article] Batch and Continuous-Flow Huisgen 1,3-Dipolar Cycloadditions with an Amphiphilic Resin-Supported Triazine-Based Polyethyleneamine Dendrimer Copper Catalyst (2017)
  • Author(s): Pan Shiguang、Yan Shuo、Osako Takao、Uozumi Yasuhiro
  • Journal Title: ACS Sustainable Chem. Eng. Volume: 5 Issue: 11 Pages: 10722-10734
  • DOI: 10.1021/acssuschemeng.7b02646
  • Peer Reviewed
• [Journal Article] Chemoselective Continuous-Flow Hydrogenation of Aldehydes Catalyzed by Platinum Nanoparticles Dispersed in an Amphiphilic Resin (2017)
  • Author(s): Osako Takao、Torii Kaoru、Hirata Shuichi、Uozumi Yasuhiro
  • Journal Title: ACS Catal. Volume: 7 Issue: 10 Pages: 7371-7377
  • DOI: 10.1021/acscatal.7b02604
  • Peer Reviewed
• [Journal Article] Detailed Mechanism for Hiyama Coupling Reaction in Water Catalyzed by Linear Polystyrene-Stabilized PdO Nanoparticles (2017)
  • Author(s): Sakon Akira、Ii Ryoma、Hamasaka Go、Uozumi Yasuhiro、Shinagawa Tsutomu、Shimomura Osamu、Nomura Ryoki、Ohtaka Atsushi
  • Journal Title: Organometallics Volume: 36 Issue: 8 Pages: 1618-1622
  • DOI: 10.1021/acs.organomet.7b00170
  • Peer Reviewed
• [Journal Article] Detailed Structural Analysis of a Self-Assembled Vesicular Amphiphilic NCN-Pincer Palladium Complex by Using Wide-Angle X-Ray Scattering and Molecular Dynamics Calculations (2017)
  • Author(s): Hamasaka Go、Muto Tsubasa、Andoh Yoshimichi、Fujimoto Kazushi、Kato Kenichi、Takata Masaki、Okazaki Susumu、Uozumi Yasuhiro
  • Journal Title: Chem. Euro. J Volume: 23 Issue: 6 Pages: 1291-1298
  • DOI: 10.1002/chem.201603494
  • Peer Reviewed
• [Journal Article] Palladium-Catalyzed Asymmetric Suzuki-Miyaura Cross Coupling with Homochiral Phosphine Ligands Having Tetrahydro-1H-imidazo[1,5-a]indole Backbone (2017)
  • Author(s): Y. Uozumi, Y. Matsuura, T. Suzuka, T. Arakawa, and Y. M. A. Yamada
  • Journal Title: Synthesis Volume: 49 Issue: 01 Pages: 59-68
  • DOI: 10.1055/s-0036-1589407
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Fluoride-Free Hiyama Coupling Reaction Catalyzed by Linear Polystyrene-Stabilized PdO Nanoparticles in Water: Specific Reactivity of PdO Nanoparticles over Pd Nanoparticles (2016)
  • Author(s): Atsuhi Ohtaka, Takamasa Kotera, Akira Sakon, Kouhei Ueda, Go Hamasaka, Yasuhiro Uozumi, Tsutomu Shinagawa, Osamu Shimomura and Ryoki Nomura
  • Journal Title: Synlett Volume: 27 Issue: 08 Pages: 1202-1206
  • DOI: 10.1055/s-0035-1560604
  • Peer Reviewed
• [Journal Article] 2.Recyclable Polystyrene-Supported Copper Catalysts for the Aerobic Oxidative Homocoupling of Terminal Alkynes (2016)
  • Author(s): Shuo Yan, Shiguang Pan, Takao Osako, Yasuhiro Uozumi
  • Journal Title: Synlett Volume: 27 Issue: 08 Pages: 1232-1236
  • DOI: 10.1055/s-0035-1561361
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Linear Polystyrene-stabilized Pt Nanoparticles Catalyzed Indole Synthesis in Water via Aerobic Alcohol Oxidation (2016)
  • Author(s): A. Ohtaka, M. Kozono, K. Takahashi, G. Hamasaka, Y. Uozumi, T. Shinagawa, O. Shimomura, R. Nomura
  • Journal Title: Chem. Lett Volume: 45 Issue: 7 Pages: 758-760
  • DOI: 10.1246/cl.160331
  • NAID: 130005253010
  • Peer Reviewed
• [Journal Article] The Development of a Vesicular Self-assembled Amphiphilic Platinum NCN-Pincer Complex and Its Catalytic Application to Hydrosilylation of Alkenes in Water (2016)
  • Author(s): Go Hamasaka1 and Yasuhiro Uozumi
  • Journal Title: Chem. Lett Volume: 45 Issue: 11 Pages: 1244-1246
  • DOI: 10.1246/cl.160700
  • NAID: 130005509526
  • Peer Reviewed
• [Presentation] Development of Novel Heterogeneous Catalytic Systems (2017)
  • Author(s): Yasuhiro Uozumi
  • Organizer: IMS-IPCMS Joint Symposium
  • Int'l Joint Research / Invited
• [Presentation] 未来の化学合成を支える超活性グリーン触媒を目指して (2017)
  • Author(s): Yasuhiro Uozumi
  • Organizer: 第６回JACI/GSCシンポジウム
  • Invited
• [Presentation] Molecular Architecture-Based Administration of Catalysis in Water via Self-Assembly of Amphiphilic Pincer Complex (2017)
  • Author(s): Yasuhiro Uozumi
  • Organizer: 6th Gratama Workshop
  • Int'l Joint Research / Invited
• [Presentation] Highly Active Self-Assembled Polymeric Transition Metal Catalysts for Coupling Reactions (2016)
  • Author(s): Yasuhiro Uozumi
  • Organizer: The 51st Conference: Advances in Organic, Bioorganic and Pharmaceutical Chemistry "LIBLICE 2016"
  • Place of Presentation: Lazne Belohrad (Czech)
  • Year and Date: 2016-11-11
  • Int'l Joint Research / Invited
• [Presentation] Molecular Architecture-Based Administration of Catalysis in Water via Self-Assembly of Amphiphilic Palladium Pincer Complexes (2016)
  • Author(s): Yasuhiro Uozumi
  • Organizer: JST-NTU Joint Seminar on Sustainable Synthesis and Catalysis
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2016-08-03
  • Int'l Joint Research / Invited
• [Remarks] 分子科学研究所魚住研究室ホームページ
  • URL: https://groups.ims.ac.jp/organization/uozumi_g/