Noradrenergic regulation of fear and extinction learning
Publicly Offered Research
Project Area | Principles of memory dynamism elucidated from a diversity of learning systems |
Project/Area Number |
16H01291
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
JOHANSEN JOSHUA 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (80625351)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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Keywords | Locus Coeruleus / Noradrenaline / fear / extinction / prefrontal cortex / amygdala / noradrenaline / locus coeruleus / learning and memory / fear learning / behavioral flexibility / Locus coeruleus |
Outline of Annual Research Achievements |
In the last fiscal year we examined how locus coeruleus noradrenaline neurons in the brainstem encode information when animals are learning to fear a sensory stimulus and when the animals realizes that the sensory stimulus is no longer threatening and reduce their fear responses (a process termed fear extinction). We found that some LC-noradrenaline neurons increased their firing rate in high fear states while others increased their response when animals realized they should no longer be afraid during extinction. In addition we found that LC-noradrenaline synaptic inputs to the amygdala are important for fear learning while synaptic innervation of the medial prefrontal cortex is important for extinction. Together with our previous results this showed that different populations of LC-noradrenaline neurons control fear and extinction learning.
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Research Progress Status |
29年度が最終年度であるため、記入しない。
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Strategy for Future Research Activity |
29年度が最終年度であるため、記入しない。
|
Report
(2 results)
Research Products
(11 results)
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[Journal Article] A dopaminergic switch for fear to safety transitions2018
Author(s)
Luo, R., Uematsu, A., Weitemier, A., Aquili, L., Koivumaa, J., McHugh, T.J. and Johansen, J.P.
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Journal Title
Nature Communications
Volume: In press
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A feedback neural circuit for calibrating aversive memory strength2017
Author(s)
Ozawa, T., Ycu, E.A., Kumar, A., Yeh. L-F., Ahmed, T., Koivumaa, J., and Johansen, J.P.
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Journal Title
Nature Neuroscience
Volume: 20(1)
Issue: 1
Pages: 90-97
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] β-Adrenergic Receptors Regulate the Acquisition and Consolidation Phases of Aversive Memory Formation Through Distinct, Temporally Regulated Signaling Pathways2017
Author(s)
Schiff, H.C., Johansen, J.P., Hou, M., Bush, D.E., Smith, E.K., Klein, J.E., LeDoux, J.E., Sears, R.M.
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Journal Title
Neuropsychopharmacology
Volume: 42(4)
Issue: 4
Pages: 895-903
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Evaluation of ambiguous associations in the amygdala by learning the structure of the environment.2016
Author(s)
Madarasz, T.J., Diaz-Mataix, L., Akhand, O., Ycu, E.A., LeDoux, J.E., Johansen, J.P.
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Journal Title
Nature Neuroscience
Volume: In press
Issue: 7
Pages: 965-972
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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