多重線形スパースコーディング法を用いた4次元生物画像のモデリングと解析

• Project Area: Resonance Biology for Innovative Bioimaging
• Project/Area Number: 16H01436
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Ritsumeikan University
• Principal Investigator: 陳 延偉 立命館大学, 情報理工学部, 教授 (60236841)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 4次元生物画像 / 多重線形解析 / ３階テンソル / 正規化 / モデリング / 多重線形スパースコーディング / 4次元生体動態画像 / 多時相CT画像 / 生物画像 / スパースコーディング / 多重線形代数 / データベース / 特徴抽出 / スパースモデリング / 多重線型代数 / テンソル / ４次元医用画像 / 核のセグメンテーション / Shape Index / 表現型解析

Outline of Annual Research Achievements

生物・医用画像は３次元空間情報に加え, 動的時間情報ももつ. このような膨大な多次元データを統一的に表現し，コアとなる時空間特徴を見つけることは, ４次元生物・医用画像の解析において重要な課題である. 本研究では，多重線形代数の枠組で４次元生物・医用画像の解析法を提案した．主に以下の成果が得られた．
1. 本研究は，理化学研究所で公開されている4次元生体動態画像データを対象とし， Shape Indexを用いた胚領域や核領域のセグメンテーション法を開発した．既存の手法に比べると，高精度であることがわかった．また，セグメンテーションされた胚領域のマスク画像（ボリュームデータ）を用いて楕円球フィッティングによる高精度な位置合わせ手法も開発した．さらに，セグメントされた核の円形度を計算し，円形度に応じた時間軸の正規化法を確立した．このように大規模多次元生物画像の解析に必要な前処理枠組を確立した．
2. 前処理枠組で正規化された核データ（ボリュームデータ）を一つ3階テンソルとして表現し，一般化N次元主成分分析（GND-PCA）を用いて入力テンソルを複数のテンソル基底の線形和で表現できるよう，テンソル基底（成分）を学習した．求められた基底（成分）は核の形状や位置，大きさなどの変化を表す．異なるデータは異なる係数を持つので，今後生物学と関連づけて解析していくことが期待される．
3. 多重線形解析の枠組で多重線形スパースコーディング法を提案し，多時相CT画像（４次元画像）を一つのテンソルとして取り扱うことによって時相間の共起を考慮した時空間特徴抽出法を開発した．従来のベクトル表現手法（時相間の共起を考慮しない手法）に比べ，多時相CT画像を用いた診断支援の精度を向上させた.

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] 浙江大学(中国)
• [Journal Article] Multi-Dimentional Data Reperensentation Using Linear Tensor Coding (2017)
  • Author(s): Xu Qiao, Xiaoqing Liu, Yen-Wei Chen, Zhi-Ping Liu
  • Journal Title: IET Image Processing Volume: 11 Issue: 7 Pages: 492-501
  • DOI: 10.1049/iet-ipr.2016.0795
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An Improved Random Walker with Bayes Model for Volumetric Medical Image Segmentation (2017)
  • Author(s): Chunhua Dong, Xiangyan Zeng, Lanfen Lin, Hongjie Hu, Xianhua Han, Masoud Naghedolfeizi, Dawit Aberra and Yen-Wei Chen
  • Journal Title: Journal of Healthcare Engineering Volume: 2017 Pages: 1-11
  • DOI: 10.1155/2017/6506049
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phenotype Analysis Method for Identification of Gene Functions Involved in Asymmetric Division of Caenorhabditis elegans (2017)
  • Author(s): Sihai Yang, Xiang-Hua Han, Yukako Tohsato, Koji Kyoda, Shuichi Onami, Ikuko Nishikawa and Yen-Wei Chen
  • Journal Title: International Journal of Computational Biology Volume: 24 Issue: 5 Pages: 436-446
  • DOI: 10.1089/cmb.2016.0210
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sparse codebook model of local structures for retrieval of focal liver lesions using multi-phase medical images (2017)
  • Author(s): Jian Wang, Xian-Hua Han, Yingying Xu, Lanfen Lin, Hongjie Hu, Yen-Wei Chen
  • Journal Title: International Journal of Biomedical Imaging Volume: 2017 Pages: 1-2
  • DOI: 10.1155/2017/1413297
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] HEp-2 Staining Pattern Recognition Using Stacked Fisher Network for Encoding Weber Local Descriptor (2017)
  • Author(s): Xian-Hua Han and Yen-Wei Chen
  • Journal Title: Pattern Recognition Volume: 63 Pages: 542-550
  • DOI: 10.1016/j.patcog.2016.09.025
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Integration of spatial and orientation contexts in local ternary patterns for HEp-2 cell classification (2016)
  • Author(s): Xian-Hua Han, Yen-Wei Chen, Gang Xu
  • Journal Title: Pattern Recognition Letters Volume: 印刷中 Pages: 23-27
  • DOI: 10.1016/j.patrec.2016.02.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nuclear detection in 4D microscope images of a developing embryo using an enhanced probability map of top-ranked intensity-ordered descriptors (2016)
  • Author(s): Xiang-Hua Han, Yukako Tohsato, Koji Kyoda, Shuichi Onami, Ikuko Nishikawa and Yen-Wei Chen
  • Journal Title: IPSJ Trans. Computer Vision and Applications Volume: 8 Issue: 1 Pages: 1-15
  • DOI: 10.1186/s41074-016-0010-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Computational Anatomy: Towards Automatic Understating of Human Anatomy (2017)
  • Author(s): Yen-Wei Chen
  • Organizer: 2nd International Conference on Devices for Integrated Circuit (DevIC)
  • Place of Presentation: Kolkata（India）
  • Year and Date: 2017-03-24
  • Int'l Joint Research / Invited
• [Presentation] Robust hepatic vessel segmentation using multi deep convolution networks (2017)
  • Author(s): Titinunt Kitrungrotsakul, Xian-Hua Han, Yutaro Iwamoto, Wei Xiong, Lanfen Lin and Yen-Wei Chen
  • Organizer: Proc. of SPIE Medical Imaging
  • Place of Presentation: Florida（USA）
  • Year and Date: 2017-02-14
  • Int'l Joint Research
• [Presentation] A Tensor Codebook-Model for Multiphase Medical Image Retrieval (2017)
  • Author(s): Jian Wang, Xianhua Han, Yingying Xu, Lanfen Lin, Hongjie Hu, Chongwu Jin, and Yen-Wei Chen
  • Organizer: International Forum on Medical Imaging in Asia (IFMIA) 2017
  • Place of Presentation: 天府那覇（沖縄県・那覇市）
  • Year and Date: 2017-01-20
  • Int'l Joint Research
• [Presentation] Automatic Segmentation of Cellular/ Nuclear Boundaries Based on the Shape Index of Image Intensity Surfaces (2017)
  • Author(s): Si-Hai Yang, Xian-Hua Han, Yen-Wei Chen
  • Organizer: International Conference on Innovation in Medicine and Healthcare (InMed2017)
  • Int'l Joint Research
• [Presentation] Tensor Sparse Representation of Temporal Features for Content-Based Retrieval of Focal Liver Lesions Using Multi-Phase Medical Images (2017)
  • Author(s): Jian Wang, Xian-Hua Han, Yingying Xu, Lanfen Lin, Hongjie Hu, Chongwu Jin, and Yen-Wei Chen
  • Organizer: The 19th IEEE International Symposium on Multimedia (ISM2017)
  • Int'l Joint Research
• [Presentation] A preliminary study on tensor codebook model for multiphase medical image retrieval (2016)
  • Author(s): Jian Wang, Xian-Hua Han, Yingying Xu, Lanfen Lin, Hongjie Hu, Chongwu Jin and Yen-Wei Chen
  • Organizer: 電子情報通信学会医用画像研究会（MI）
  • Place of Presentation: 東京農工大学（東京都・小金井市）
  • Year and Date: 2016-09-16
• [Presentation] A preliminary study on multilinear sparse coding for medical image retrieval (2016)
  • Author(s): Jian Wang, Xian-Hua Han, Yingying Xu, Lanfen Lin, Hongjie Hu, Chongwu Jin and Yen-Wei Chen
  • Organizer: 第19回画像の認識・理解シンポジウム（MIRU2016）
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2016-08-03
• [Presentation] Super-Resolution for 3D Anisotropic Low-resolution MR Images Using Multilayer Convolutional Neural Networks (2016)
  • Author(s): Qiaochu Zhao, Yutaro Iwamoto, Xian-Hua Han, Yen-Wei Chen
  • Organizer: 第19回画像の認識・理解シンポジウム（MIRU2016）
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2016-08-03
• [Presentation] Patch-based codebook model for focal liver lesions retrieval of multiphase medical volumes (2016)
  • Author(s): Jian Wang, Xianhua Han, Yingying Xu, Lanfen Lin, Hongjie Hu, Chongwu Jin, Yen-Wei Chen
  • Organizer: Int. J. CARS
  • Place of Presentation: Heidelberg（Germany）
  • Year and Date: 2016-06-23
  • Int'l Joint Research
• [Book] Innovation in Medicine and Healthcare 2017 (2017)
  • Author(s): Yen-Wei Chen, Satoshi Tanaka, Robert I. Howlett and Lakhmi C. Jain (Eds)
  • Total Pages: 290
  • Publisher: Springer
  • ISBN: 9783319593975
• [Book] Springer (2016)
  • Author(s): Yen-Wei Chen, Satoshi Tanaka, Robert I. Howlett and Lakhmi C. Jain (Eds)
  • Total Pages: 347
  • Publisher: Innovation in Medicine and Healthcare 2016