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デフォルトモードネットワークの動作原理と機能解明

Publicly Offered Research

Project AreaNon-linear Neuro-oscillology: Towards Integrative Understanding of Human Nature
Project/Area Number 16H01626
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

林 拓也  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (50372115)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywordsデフォルトモードネットワーク / ドパミン / セロトニン / 安静時脳機能活動 / 安静時機能MRI / 機能的ネットワーク / 独立成分分析 / 機能ネットワーク / 共振活動 / デフォルトモード / 脳 / MRI / PET
Outline of Annual Research Achievements

本研究ではデフォルトモードネットワーク(DMN)がどのいった行動や脳機能を担うのか、DMNが他の神経機構とどのように関連しているか、の二つのアプローチで調べることでDMNの成因や機構を明らかにすることを目的とする。初年度に進めた、基盤技術としての安静時脳活動・DMNの測定・解析技術によって、本年度はパーキンソン病モデル動物におけるネットワークの複雑性とドパミン機能やセロトニン機能との関連性を明らかにする実験と解析を進めた。更なる詳細かつ高度な解析を行うことでDMNの神経伝達物質機能との関連性を明らかにすることができると考えている。

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (19 results)

All 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (12 results) (of which Int'l Joint Research: 7 results,  Invited: 6 results) Funded Workshop (1 results)

  • [Int'l Joint Research] ワシントン大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] オックスフォード大学(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ロンドン大学(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ワシントン大学セントルイス(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Neurite imaging reveals microstructural variations in human cerebral cortical gray matter2018

    • Author(s)
      Fukutomi, H., Glasser, M.F., Zhang, H., Autio, J.A., Coalson, T.S., Okada, T., Togashi, K., Van Essen, D.C., and Hayashi, T.
    • Journal Title

      Neuroimage

      Volume: in press Pages: 488-499

    • DOI

      10.1016/j.neuroimage.2018.02.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular, Functional, and Structural Imaging of Major Depressive Disorder2016

    • Author(s)
      Zhang Kai, Zhu Yunqi, Zhu Yuankai, Wu Shuang, Liu Hao, Zhang Wei, Xu Caiyun, Zhang Hong, Hayashi Takuya, Mei Tian.
    • Journal Title

      Neuroscience bulletin

      Volume: 32(3) Pages: 273-85

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 霊長類脳コネクトーム2018

    • Author(s)
      林 拓也
    • Organizer
      第20回ヒト脳機能マッピング学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Brain Connectome in Primates.2018

    • Author(s)
      Takuya Hayashi
    • Organizer
      International Symposium of Marmoset Science
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 林 拓也2017

    • Author(s)
      高精度脳MRI画像研究の最前線と神経精神疾患診断への展望
    • Organizer
      第17回 京滋神経変性疾患研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Challenges of Brain Connectome in Primates2017

    • Author(s)
      Takuya Hayashi
    • Organizer
      ABiS international symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト・霊長類動物脳コネクトームとパイプライン2017

    • Author(s)
      林 拓也
    • Organizer
      第1回ヒト脳イメージング研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Cortical surface and brain volume atlases of high-resolution diffusion and structural MRI in rhesus macaques2016

    • Author(s)
      Hayashi Takuya, Glasser Matthew F, Urayama Shin-ichi, Ose Takayuki, Watabe Hiroshi, Onoe Kayo, Tanki Nobuyoshi, Autio Joonas, Murata Yumi, Higo Noriyuki, Onoe Hirotaka, Van Essen David
    • Organizer
      OHBM2016
    • Place of Presentation
      Palexpo Exibision and Cogress Centre, Geneva, Switzerland
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A ‘grayordinate’ pipeline for magnetic resonance imaging of marmoset brain2016

    • Author(s)
      Hayashi Takuya, Glasser Matthew F, Yokoyama Chihiro, Ose Takayuki, Takeda Chiho, Kawasaki Akihiro, Autio Joonas, Van Essen David
    • Organizer
      Neuroscience 2016(Society for Neuroscience, SfN)
    • Place of Presentation
      San Diego Convention Center, San Diego, United States
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A ‘grayordinate’ pipeline for magnetic resonance imaging of marmoset brain2016

    • Author(s)
      Hayashi Takuya, Glasser Matthew F, Yokoyama Chihiro, Ose Takayuki, Takeda Chiho, Kawasaki Akihiro, Autio Joonas, Van Essen David. A
    • Organizer
      第6回 日本マーモセット研究会大会
    • Place of Presentation
      東京大学農学部弥生講堂、東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] Preclinical perspectives on the mechanism of aberrant brain network and dopamine dysfunction2016

    • Author(s)
      Hayashi Takuya, Autio Joonas
    • Organizer
      国立研究開発法人国立精神・神経医療研究センター脳病態統合イメージングセンター5周年記念国際シンポジウム
    • Place of Presentation
      国立精神・神経医療研究センター、東京
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vivo dopamine D2 receptor binding in the brain cortical surface of humans, macaque monkeys and common marmosets2016

    • Author(s)
      Yokoyama Chihiro, Autio Joonas, Kawasaki Akihiro, Takeda Chiho, Takahashi Kayo, Igesaka Ami, Doi Hisashi, Hayashi Takuya
    • Organizer
      第6回 日本マーモセット研究会大会
    • Place of Presentation
      東京大学農学部弥生講堂、東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] Plastic resting-state network changes in MPTP-treated monkeys2016

    • Author(s)
      Autio Joonas, Tanki Nobuyoshi, Ose Takayuki, Takahashi Jun, Hayashi Takuya
    • Organizer
      Neuroscience 2016(Society for Neuroscience, SfN)
    • Place of Presentation
      San Diego Convention Center, San Diego, United States
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo cortical dopamine D2 receptor binding in humans, macaques and marmosets2016

    • Author(s)
      Yokoyama Chihiro, Autio Joonas, Ose Takayuki, Kawasaki Akihiro, Takeda Chiho, Takahashi Kayo, Igesaka Ami, Doi Hisashi, Watanabe Yasuyoshi, Hayashi Takuya
    • Organizer
      Neuroscience 2016(Society for Neuroscience, SfN)
    • Place of Presentation
      San Diego Convention Center, San Diego, United States
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Funded Workshop] Moleculer Imaging Seminar2016

    • Place of Presentation
      理化学研究所 ライフサイエンス技術基盤研究センター、神戸
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-26   Modified: 2022-02-28  

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