Risk of hypothermia for memory function

• Project Area: "LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE"
• Project/Area Number: 16H01629
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: University of Tsukuba
• Principal Investigator: ラザルス ミハエル 筑波大学, 国際統合睡眠医科学研究機構, 准教授 (80469650)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 低体温状態 / 記憶固定 / 薬理遺伝学 / 薬理学 / 随伴ウィルス / 光遺伝学 / 睡眠

Outline of Annual Research Achievements

Whereas hibernation is common in rodents and other animals, there are only a very few cases of suspected hibernation or states similar to hibernation in humans. Induced hibernation, also known as suspended animation, is the slowing or stopping of life processes without termination by cooling the body down. This technology has great potential for long distance space travel and medicine. Induced hypothermia has been used for open-heart surgeries and other clinical procedures, but the risk for brain functions is largely unknown. We elucidated the effects of chemogenetically induced hypothermia on the consolidation of fear memory. Therefore, we developed a telemetric system to measure sleep and body temperature. Moreover, we used an innovative genetically engineered system to induce hypothermia by activating GABAergic neurons in the median preoptic area of the hypothalamus. The induced hypothermia resulted in reduced learning and expression of fear.

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice (2017)
  • Author(s): Oishi Yo、Xu Qi、Wang Lu、Zhang Bin-Jia、Takahashi Koji、Takata Yohko、Luo Yan-Jia、Cherasse Yoan、Schiffmann Serge N.、de Kerchove d’Exaerde Alban、Urade Yoshihiro、Qu Wei-Min、Huang Zhi-Li、Lazarus Michael
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 1-12
  • DOI: 10.1038/s41467-017-00781-4
  • NAID: 120007134733
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The control of sleep and wakefulness by mesolimbic dopamine systems (2017)
  • Author(s): Oishi Yo、Lazarus Michael
  • Journal Title: Neuroscience Research Volume: 118 Pages: 66-73
  • DOI: 10.1016/j.neures.2017.04.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Adenosine and Sleep (2017)
  • Author(s): Lazarus Michael、Chen Jiang-Fan、Huang Zhi-Li、Urade Yoshihiro、Fredholm Bertil B.
  • Journal Title: Handbook of Experimental Pharmacology Volume: - Pages: 1-23
  • DOI: 10.1007/164_2017_36
  • ISBN: 9783030112707, 9783030112721
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 報酬系と睡眠・覚醒 (2017)
  • Author(s): Oishi Yo、Lazarus Michael
  • Journal Title: 医学のあゆみ Volume: 263 Pages: 761-764
  • Peer Reviewed
• [Journal Article] Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2-like receptors in mice (2017)
  • Author(s): Oishi Y, Suzuki Y, Takahashi K, Yonezawa T, Kanda T, Takata Y, Cherasse Y, Lazarus M
  • Journal Title: Brain Structure & Function Volume: - Issue: 6 Pages: 1-9
  • DOI: 10.1007/s00429-017-1365-7
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Interleukin-1β induces sleep independent of prostaglandin D2 in rats and mice. (2016)
  • Author(s): Zhang BJ, Shao SR, Aritake K, Takeuchi A, Urade Y, Huang ZL, Lazarus M, Qu WM.
  • Journal Title: Neuroscience Volume: 340 Pages: 258-267
  • DOI: 10.1016/j.neuroscience.2016.09.053
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption (2016)
  • Author(s): McEown K, Takata Y, Cherasse Y, Nagata N, Aritake K, Lazarus M
  • Journal Title: eLife Volume: 5
  • DOI: 10.7554/elife.20269
  • NAID: 120007135235
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] The link between REM sleep loss and the desire for sugary and fatty foods (2017)
  • Author(s): Lazarus, M
  • Organizer: International Symposium on Living in Space 2017
  • Place of Presentation: Hitotsubashi Hall (Chiyoda-ku, Tokyo)
  • Year and Date: 2017-03-09
  • Int'l Joint Research / Invited
• [Presentation] The waking, sleeping and dreaming brain: New circuits and insights (2017)
  • Author(s): Lazarus Michael, Fuller Patrick
  • Organizer: World Sleep 2017 - 1st Congress of the World Sleep Society
  • Int'l Joint Research
• [Presentation] Why do we fall asleep when bored? - The role of the nucleus accumbens in sleep-wake regulation (2016)
  • Author(s): Lazarus, M
  • Organizer: 23rd Congress of the European Sleep Research Society
  • Place of Presentation: Bologna, Italy
  • Year and Date: 2016-09-13
  • Int'l Joint Research