Effect of autonomic alteration on spaceflight deconditioning and countermeasures

• Project Area: "LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE"
• Project/Area Number: 16H01649
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Aichi Medical University
• Principal Investigator: 岩瀬 敏 愛知医科大学, 医学部, 教授 (90184879)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000); Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
• Keywords: 宇宙飛行デコンディショニング / 人工重力 / 運動負荷 / 宇宙酔い / 心血管系デコンディショニング / 筋萎縮 / 骨密度減少 / 筋交感神経活動 / sympathetic nerve / microgravity / spaceflight / countermeasure / artificial gravity / 起立性低血圧 / 骨粗鬆症 / 自律神経デコンディショニング / 微小重力環境 / マイクロニューログラフィ / 自律神経活動

Outline of Annual Research Achievements

これまでに製作した人工重力＋運動負荷装置を改良し，回転半径を1.4 mとし，脚部を挙上し，頭部から体幹部までを水平に保つ姿勢をとった．本装置が有効に働くかを検証するため，宇宙飛行デコンディショニングの改善がこの対抗措置により行われるかを検討した．前庭系のめまいによる「宇宙酔い」，循環系の心血管系デコンディショニング，筋骨格系の筋萎縮，骨代謝系の骨密度の低下がある．現在までに確立したプロトコールには，重力負荷と運動負荷をそれぞれ最初に1G, 60Wに設定し，それぞれを0.2G, 15Wずつ増加させ，30分にわたり過重力のもとで運動させるというG・Ex step-up protocolを提唱している．本年度は，このG・Ex step-up protocolが修理を完了した人工重力＋運動負荷装置において有効に作用するかを検討した．急性のヘッドダウンティルトを行い，人工重力＋運動負荷が，それによる体液移動をどのくらい阻止するかを3名の被験者を用いて検討した．その結果，通常のベッドレストでは，20%減少する循環血液量を減少させることなく，正常範囲内にとどめることが判明した．この体液移動を，バイオインピーダンス法を用いた体液移動測定法により検討したところ，人工重力＋運動負荷により，体液変化量が，胸腔内血液量において12%, 腹部血液量では4%, 下肢血液量では2%まで軽減されることが確認できた．同時に測定した筋交感神経活動は，基礎活動の増加が見られたが，対抗措置により抑制された．さらに長期におこる変化である筋萎縮と骨代謝においては，急性のベッドレストでは変化が認められなかった．以上，循環器系への変化においては，G・Ex step-up protocolが有効であることが確認できたが，筋萎縮と骨代謝に対する影響に関しては，さらに大規模，かつ長期間のベッドレスト実験が必要とされる．

Research Progress Status

平成29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成29年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Effect of spraying of fine water particles on facial skin moisture and viscoelasticity in adult women. (2019)
  • Author(s): Nishimura N1,2, Inoue S3, Yokoyama K3, Iwase S2.
  • Journal Title: Skin Res Technol. 2019 May;25:(3) Volume: 25 Issue: 3 Pages: 294-298
  • DOI: 10.1111/srt.12648
  • Peer Reviewed
• [Journal Article] Effects of catechin-enriched ion beverage intake on thermoregulatory function in a hot environment (2018)
  • Author(s): Nishimura Rumiko、Nishimura Naoki、Iwase Satoshi、Takeshita Masao、Katashima Mitsuhiro、Katsuragi Yoshihisa、Sato Motohiko
  • Journal Title: The Journal of Physiological Sciences Volume: 未定 Issue: 1 Pages: 39-45
  • DOI: 10.1007/s12576-018-0615-7
  • NAID: 40021804649
  • Peer Reviewed / Open Access
• [Journal Article] 人工重力研究の歴史・現状・展望．―国際宇宙ステーションを越えて，月基地，火星探査へのロードマップ (2018)
  • Author(s): 岩瀬 敏，西村直記，間野忠明，田中邦彦
  • Journal Title: 細胞 Volume: 50 Pages: 653-657
  • NAID: 40022118906
  • Peer Reviewed
• [Journal Article] Elevated sympathetic vasomotor outflow in response to increased inspiratory muscle activity during exercise is less in young women compared with men. (2017)
  • Author(s): K. Katayama, JR. Smith, K. Goto, K. Shimizu, M Saito, K. Ishida, T. Koike, S. Iwase, CA. Harms.
  • Journal Title: Experimental Physiology Volume: 103 Issue: 4 Pages: 570-580
  • DOI: 10.1113/ep086817
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intracellular oxygen tension limits muscle contraction- induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion. (2017)
  • Author(s): 214.Takakura H, Ojino M, Jue T, Yamada T, Furuichi Y, Hashimoto T, Iwase S, Masuda K:
  • Journal Title: Physiological Reports Volume: 5 Issue: 2 Pages: 1-10
  • DOI: 10.14814/phy2.13112
  • NAID: 120006226796
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] What is general medicine? (2017)
  • Author(s): Iwase S
  • Journal Title: Health and Primary Care Volume: 1 Pages: 1-1
  • Peer Reviewed
• [Journal Article] 視床下部と自律神経 (2017)
  • Author(s): 岩瀬 敏
  • Journal Title: Clinical Neuroscience Volume: 35 Pages: 399-403
  • Peer Reviewed
• [Journal Article] Respiratory mosulation of human autonomic function on Earth. (2016)
  • Author(s): Eckberg DL, Cooke WH, Eiedrich A, Biaggioni I, Buckey JC Jr, Pawelczyk JA, Ertle AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase s, Baisch FJ, levine BD, Adams-Huet B, Robertson D, Blomqvist CG
  • Journal Title: Journal of Physiology May 29 Volume: Epub Issue: 19 Pages: 5611-5627
  • DOI: 10.1113/jp271654
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Respiratory modulation of human autonomic function. Long-term neuroplasticity in space. (2016)
  • Author(s): Eckberg DL, Diedrich A, Cooke WH, Biaggioni I, Buckey JC Jr. Pawelczyk JA, Ertle AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase s, Baisch FJ, Levine BD, Adams-Huet B, Robertson D, Blomqvist CG.
  • Journal Title: Journal of Physiology May 29 Volume: Epub Issue: 19 Pages: 5629-5646
  • DOI: 10.1113/jp271656
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of left ventricular diastolic dysfunction on the onset of vaso-vagal syncope. (2016)
  • Author(s): 211.Wakita Y, Hamano K, Izumi J, Usami J, Kitagawa W, Yamamoto S, Ibuki E, Iwase S, Maekawa M.
  • Journal Title: The Autonomic Nervous System Volume: 42 Pages: 951-959
  • Peer Reviewed
• [Journal Article] 発汗と交感神経活動 (2016)
  • Author(s): 岩瀬 敏
  • Journal Title: Monthly Book Derma Volume: 244 Pages: 1-16
  • Peer Reviewed
• [Journal Article] マイクロニューログラフィによる無汗症・多汗症の病態解析 (2016)
  • Author(s): 岩瀬 敏
  • Journal Title: 発汗学 Volume: 23 Pages: 39-46
  • Peer Reviewed
• [Journal Article] 宇宙飛行と失神 (2016)
  • Author(s): 岩瀬 敏
  • Journal Title: 心電図 Volume: 36 supple
  • Peer Reviewed
• [Presentation] 心循環器系と自律神経系への影響 (2019)
  • Author(s): 岩瀬 敏
  • Organizer: 分野横断プラットフォーム構築企画・宇宙医学ワークショップ，「人類の宇宙進出時に必要となる宇宙医学・生物学研究」
  • Invited
• [Presentation] G-13 疑似低重力環境下における心機能および交感神経活動の変化 (2019)
  • Author(s): 荒川友希（岐阜大学／愛知医科大学）、岩瀬敏、丸目恭平、佐藤麻紀、西村直記
  • Organizer: 第33回 宇宙環境利用シンポジウム プログラム
  • Invited
• [Presentation] 人工重力＋運動負荷の宇宙ステーション搭載による効果 (2019)
  • Author(s): 岩瀬敏（愛知医科大学）、西村直記、田中邦彦、間野忠明、嶋田和人、増尾善久
  • Organizer: 第33回 宇宙環境利用シンポジウム
  • Invited
• [Presentation] 日常生活における血管機能の意義 (2019)
  • Author(s): 岩瀬 敏
  • Organizer: 第21回健康栄養シンポジウム
  • Invited
• [Presentation] 柱1-8-2-6 微小重力デコンディショニングに対する対抗措置としての人工重力負荷． (2019)
  • Author(s): 岩瀬 敏
  • Organizer: 第30回日本医学会総会2019中部
  • Invited
• [Presentation] Experimental status in Japan (2018)
  • Author(s): Satoshi Iwase
  • Organizer: IAA COMMISSION 2 on Space Life Sciences and IAF Technical Committee on Space Life Sciences Joint Meeting
  • Invited
• [Presentation] Effect of artificial gravity with exercise on spaceflight deconditioning in humans, and project for assessment of artificial gravity in H-II Transfer Vehicle in International Space Station (2018)
  • Author(s): Satoshi Iwase
  • Organizer: 9th International Society for Gravitational Physiology (ISGP) and the European Space Agency (ESA) announce the The Life Sciences Meeting 2018.
  • Invited
• [Presentation] IAC-18 A1.3.1 Effect of artificial gravity with exercise on spaceflight deconditioning in humans, and project for assessment of artifidial gavity in H-II transfer vehicle in International Space Station, (2018)
  • Author(s): Satoshi Iwase, et al.
  • Organizer: International Astronautical Congress Bremen, 11-5, OCT 2018
  • Invited
• [Presentation] IAC-18.A1.3.2 Impact of simulated moon and mars gravities with head-up tilt on cardiac function (2018)
  • Author(s): Kyohei Marume, Satoshi Iwase, et al.
  • Organizer: International Astronautical Congress Bremen, 11-5, OCT 2018
  • Invited
• [Presentation] IIAC-18.A1.2.16 Body fluid distribution during artificial gravity as a countermeasure against space flight deconditioning using a segmental bioelectrical impedance analysis. (2018)
  • Author(s): Naoki Nishimura, Satoshi Iwase, et al.
  • Organizer: International Astronautical Congress Bremen, 11-5, OCT 2018
  • Invited
• [Presentation] 起立耐性における筋交感神経活動の意義 (2018)
  • Author(s): 岩瀬 敏
  • Organizer: 第3回臨床自律神経機能Forum
  • Invited
• [Presentation] シンポジウム１：過重力・低重力に対するヒトの反応「心循環器系、自律神経系の変化」 (2018)
  • Author(s): 岩瀬 敏
  • Organizer: 第64回宇宙航空環境医学会大会
  • Invited
• [Presentation] Space Life Science in Japan (2017)
  • Author(s): Satoshi Iwase
  • Organizer: IAA COMMISSION 2 on Space Life Sciences and IAF Technical Committee on Space Life Sciences Joint Meeting
  • Place of Presentation: CAP 15 Conference Centre 1-13 Quai de Grenelle, 75015 Paris
  • Year and Date: 2017-03-22
  • Int'l Joint Research / Invited
• [Presentation] 国際宇宙ステーション内における人工重力負荷実験 (2017)
  • Author(s): 岩瀬敏、西村直記、田中邦彦、間野忠明、嶋田和人
  • Organizer: 第 31 回 宇宙環境利用シンポジウム
  • Place of Presentation: 宇宙航空研究開発機構 宇宙科学研究所
  • Year and Date: 2017-01-16
• [Presentation] 重力・水圧と自律神経 (2016)
  • Author(s): 岩瀬 敏
  • Organizer: 第69回日本自律神経学会総会
  • Place of Presentation: 熊本市くまもと県民交流館パレア
  • Year and Date: 2016-11-10
  • Invited
• [Presentation] Effect of Artificial Gravity with Exercise on Spaceflight Deconditioning in Humans. (2016)
  • Author(s): Satoshi Iwase, Naoki Nishimura, Kunihiko Tanaka, Tadaaki Mano
  • Organizer: 11th Asian Microgravity Congress in Sapporo, Japan.
  • Place of Presentation: Sapporo, Hokkaido, Japan
  • Year and Date: 2016-10-25
  • Int'l Joint Research / Invited
• [Presentation] Changes in Body Fluid Distribution during Artificial Gravity and -6° Head-Down Bed Rest using a Segment Bioelectrical Impedance Analysis (2016)
  • Author(s): Naoki Nishimura, Satoshi Iwase, Yoshihisa Masuo, Kunihiko Tanaka, Tadaaki Mano
  • Organizer: 11th Asian Microgravity Congress in Sapporo, Japan.
  • Place of Presentation: Sapporo, Hokkaido, Japan
  • Year and Date: 2016-10-25
  • Int'l Joint Research / Invited
• [Presentation] Effectiveness of newly fabricated short radius centrifuge device with erometric or squatting exercise as a countermeasure for spaceflight deconditioning in humans. (2016)
  • Author(s): Iwase S, Nishimura N, Tanaka K, Mano T.
  • Organizer: 67th International Astronautical Congress, 26 - 30 September 2016, Guadalajara EXPO, Guadalajara, Mexico.
  • Place of Presentation: Guadalajara, Mexico
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] The need for artificial gravity in the tethering satelite with connecteion by the space elevator. (2016)
  • Author(s): Satoshi Iwase, Kunihiko Tanaka*, Tadaaki Mano*, Naoki Nishimura,
  • Organizer: 67th International Astronautical Congress, 26 -30 September 2016, Guadalajara EXPO, Guadalajara, Mexico.
  • Place of Presentation: Guadalajara, Mexico
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] 宇宙における体温調節 (2016)
  • Author(s): 岩瀬 敏
  • Organizer: 第24回日本発汗学会総会，大阪
  • Place of Presentation: 大阪大学 銀杏会館
  • Year and Date: 2016-08-27
  • Invited
• [Presentation] Effectiveness of newly fabricated short radius centrifuge device with ergometric or squatting exercise as a countermeasure for spaceflight deconditioning in humans. (2016)
  • Author(s): 7.Satoshi Iwase, Tadaaki Mano, Kunihiko Tanaka, and Naoki Nishimura.
  • Organizer: Joint Life Science Meeting “Life in Space for Life on Earth”, 5-10 June 2016, Toulouse France. 14th European Life Sciences Symposium and 37th Annual International Gravitational Physiology Meeting.
  • Place of Presentation: Toulouse, France
  • Year and Date: 2016-06-05
  • Int'l Joint Research / Invited
• [Presentation] Changes in body fluid distribution with postural changes using segmental bioelectrical impedance analysis. (2016)
  • Author(s): Naoki Nishimura, Satoshi Iwase, Kazuhisa Masuo, Kunihiko Tanaka, and Tadaaki Mano.
  • Organizer: Joint Life Science Meeting “Life in Space for Life on Earth”, 5-10 June 2016, Toulouse France. 14th European Life Sciences Symposium and 37th Annual International Gravitational Physiology Meeting.
  • Place of Presentation: Toulouse, France
  • Year and Date: 2016-06-05
  • Int'l Joint Research
• [Book] Clinical Assessment of the Autonomic Nervous System Ch 4 (2017)
  • Author(s): atoshi Iwase, Naoki Nishimura, Yuko Kuwahara, Junichi Sugenoya.
  • Total Pages: 337
  • Publisher: Springer
• [Book] Clinical Assessment of the Autonomic Nervous System Ch. 5 (2017)
  • Author(s): Satoshi Iwase, Naoki Nishimura, Tadaaki Mano.
  • Total Pages: 337
  • Publisher: Springer
• [Book] 臨床神経内科学 5．自律神経検査法，７．微小神経電図法． (2016)
  • Author(s): 岩瀬 敏
  • Total Pages: 907
  • Publisher: 南山堂
• [Book] 下垂体疾患診療マニュアル2版 １．基礎知識，Ｃ．視床下部の機能， (2016)
  • Author(s): 岩瀬 敏
  • Total Pages: 285
  • Publisher: 診断と治療社
• [Funded Workshop] 40th Annual Meeting of the International Society for Gravitational Physiology and Space Life Science and Medicine Meeting (2019)