Chronic effects of non-24 hour solar days
Publicly Offered Research
| Project Area | "LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE" |
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| Project/Area Number |
16H01652
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
Myung Jihwan 沖縄科学技術大学院大学, 計算脳科学ユニット, 客員研究員 (80643204)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Discontinued (Fiscal Year 2017)
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| Budget Amount *help |
¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | Chronobiology / Suprachiasmatic nucleus / Choroid plexus / 特殊環境 / 生理学 / 神経科学 / 情報工学 / Circadian rhythms / Solar day / Synchronization / Phase oscillator / Neural network / Phase-repulsive coupling / Photoperiodism / 生物物理 / 数理物理 |
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| Outline of Annual Research Achievements |
In this project, we discovered that chronic extra-terrestrial solar day (non-24-h) light-dark condition reorganizes the network of circadian clocks in the suprachiasmatic nucleus (SCN). The reorganization patterns are analogous to those under seasonal light-dark conditions. We created a computational tool for analyzing the reorganization (Moran's I) and a simple model that describes the network dynamics. Through collaborations with Switzerland and USA, we reported our experimental finding in Neuron (2017), which showed that tunable GABA excitability is responsible for this reorganization and region-specific changes at the epigenetic level underlie the tunability. We then moved our focus to analysis and mathematical modeling of the data. The SCN network can be seen as a generator of spatial patterns. We developed a new quantitative measure for spatiotemporal patterns in the SCN and published in Bioinformatics (2017), with collaborators in Germany. We also worked out the detailed mathematics of the network dynamics in the SCN in relation to the external light environment, published in European Journal of Neuroscience through collaboration with USA. To understand how this reorganization influences the overall in vivo dynamics, we extended our study beyond the SCN to accessory circadian clocks in the brain. We found compelling evidence that internal disorganization of circadian clocks between the SCN and the choroid plexus directly affects behavioral rhythms. This work is currently under revision at Nature Communications and is a result of collaborations with Germany and USA.
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| Research Progress Status |
29年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
29年度が最終年度であるため、記入しない。
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Report
(2 results)
Research Products
(17 results)
