Computerized Evaluation of Pulmonary Function based on the Rib and Diaphragm motion by Dynamic Chest Radiography

• Project Area: Multidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy
• Project/Area Number: 17H05286
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kanazawa University
• Principal Investigator: 田中 利恵 金沢大学, 保健学系, 准教授 (40361985)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 画像 / X線 / 放射線 / 情報工学 / 生理学 / 医学物理学

Outline of Annual Research Achievements

本研究では，胸部領域の筋・骨格・臓器・組織の動態機能の中でも，呼吸機能と密接な関係のある肋骨を含めた胸郭運動ならびに横隔膜運動に注目した．その動態機能の理解と評価を可能にする画像解析法を開発するために，今年度は「横隔膜運動の理解：正常な胸郭・横隔膜運動のパターン化と異常な胸郭・横隔膜運動の特徴ならびに肺野内濃度変化との関連の検証」に取り組んだ．
対象は，基礎疾患として慢性閉塞性肺疾患（COPD），間質性肺炎，肺線維症，気管支喘息，気胸，肺癌，心不全，脊椎側弯症などを有する125症例（2015年12月～2017年10月に撮影，うち60症例は肺葉切除等の手術前後で撮影）ならびに，豚の無気肺モデル（6匹）とした．管電圧120 kV，パルス線量4.0 mAs/pulse，撮影レート15 fps，撮影距離2.0mにて，呼吸過程を10秒間撮影し，合計150枚のX線動画像を取得した．今回は新たに深層学習を用いた胸部X線動画像のための肺セグメンテーション技術を開発し，呼吸による肺面積変化や変化率を解析項目に加えた．臨床研究では，肺面積変化や変化率と肺機能（肺活量）との間に高い相関があることを確認した．また，肺機能障害を肺面積変化量の減少として検出できることを明らかにした．さらに，肺葉切除症例については切除部位と手術前後変化の関連を検証し，術後の経過観察における横隔膜運動計測の有用性を示す結果を得た．豚の無気肺モデルを対象とした動物実験では，異常肺の横隔膜・胸郭運動が健側肺に比べて有意に減少することを確認した．これらの研究成果を国内外の学会で発表し，英語論文2本として公開した．さらに本研究の成果の一部を実用化につなげた．

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] デューク大学/ノースカロライナ大学(米国)
• [Int'l Joint Research] Duku University/North Carolina University(米国)
• [Journal Article] Detection of pulmonary embolism based on reduced changes in radiographic lung density during cardiac beating using dynamic flat-panel detector: an animal-based study (2019)
  • Author(s): Rie Tanaka, Tohru Tani, Norihisa Nitta, Takahisa Tabata, Noritsugu Matsutani, Shintaro Muraoka, Tsutomu Yoneyama, Shigeru Sanada
  • Journal Title: Academic Radiology Volume: Online Issue: 10 Pages: 1-8
  • DOI: 10.1016/j.acra.2018.12.012
  • Peer Reviewed
• [Journal Article] Recovery of 3D rib motion from dynamic chest radiography and CT data using local contrast normalization and articular motion model (2019)
  • Author(s): Yuta Hiasa, Yoshito Otake, Rie Tanaka, Shigeru Sanada, Yoshinobu, Sato. Recovery of 3D rib motion from dynamic chest radiography and CT data using local contrast normalization and articular motion model
  • Journal Title: Medical Image Analysis Volume: 51 Pages: 144-156
  • DOI: 10.1016/j.media.2018.10.002
  • Peer Reviewed / Open Access
• [Journal Article] Lung segmentation based on a deep learning approach for dynamic chest radiography (2019)
  • Author(s): Yuki Kitahara, Rie Tanaka, Holger R. Roth, Hirohisa Oda, Kensaku Mori, Kazuo Kasahara, Isao Matsumoto
  • Journal Title: Proc. SPIE 10950, Medical Imaging 2019: Computer-aided diagnosis Volume: 109503M Pages: 1-7
  • DOI: 10.1117/12.2512711
  • Peer Reviewed
• [Journal Article] Dynamic chest radiography for pulmonary function diagnosis: A validation study using 4D extended cardiac-torso (XCAT) phantom (2019)
  • Author(s): Rie Tanaka, Ehsan Samei, William Paul Segars, Ehsan Abadi, Holger Roth, Hirohisa Oda, Kensaku Mori
  • Journal Title: Proc. SPIE 10948, Medical Imaging 2019: Physics of Medical Imaging Volume: 109483I Pages: 1-8
  • DOI: 10.1117/12.2512332
  • Peer Reviewed
• [Journal Article] Computerized Evaluation of the Rib Kinetics and Pulmonary Function based on the Rib and Diaphragm motion by Dynamic Chest Radiography (2019)
  • Author(s): Rie Tanaka, Kazuo Kasahara, Isao Matsumoto, Shigeru Sanada
  • Journal Title: Proceedings of the 5th international symposium on the project “Multidisciplinary computational anatomy” Volume: - Pages: 141-145
• [Journal Article] Pulmonary function diagnosis based on respiratory changes in lung density with dynamic flat-panel detector imaging: An animal-based study (2018)
  • Author(s): Rie Tanaka, Tohru Tani, Norihisa Nitta, Takahisa Tabata, Noritsugu Matsutani, Shintaro Muraoka, Tsutomu Yoneyama, Shigeru Sanada
  • Journal Title: Investigative Radiology Volume: 53 Issue: 7 Pages: 417-423
  • DOI: 10.1097/rli.0000000000000457
  • Peer Reviewed
• [Journal Article] 胸部X線画像を用いた畳み込みニューラルネットワークによる肋骨2D-3D 位置合わせの自動初期化 (2018)
  • Author(s): 椛島基嵩，日朝祐太，大竹義人，田中利恵，真田茂，佐藤嘉伸
  • Journal Title: 電子情報通信学会技術研究報告 Volume: 117 Pages: 5-8
• [Journal Article] 一軸性関節による肋骨運動の制約付き2D-3D位置合わせ精度の評価 (2017)
  • Author(s): 日朝祐太，大竹義人，田中利恵，横田太，真田茂，佐藤嘉伸
  • Journal Title: 電子情報通信学会技術研究報告 Volume: 116 Pages: 7-12
• [Journal Article] Computerized method to compensate a breathing body motion in dynamic chest radiographs (2017)
  • Author(s): Hiroaki Matsuda, Rie Tanaka, Shigeru Sanada
  • Journal Title: Proc. SPIE 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging Volume: 101371Q Pages: 101371Q-101371Q
  • DOI: 10.1117/12.2254359
  • Acknowledgement Compliant
• [Journal Article] Time-series analysis of the lung texture on bone-suppressed dynamic chest radiography for the evaluation of pulmonary function: a preliminary study (2017)
  • Author(s): Rie Tanaka, Hiroaki Matsuda, Shigeru Sanada
  • Journal Title: Proc. SPIE 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging Volume: 101371R Pages: 101371R-101371R
  • DOI: 10.1117/12.2254377
  • Acknowledgement Compliant
• [Journal Article] ３．次世代FPDイメージング．IV. 総論．Digital Radiographyの将来展望．特集 FPDの進化とDigital Radiographyの新次元【静止画編】 (2017)
  • Author(s): 田中利恵
  • Journal Title: INNERVISION Volume: 32 Pages: 70-73
• [Presentation] Evaluation of Visceral Pleural Invasion of Lung Tumor Using Oblique Views of Dynamic Chest Radiography: a Computer-based Phantom Study (2019)
  • Author(s): Nozomi Ishihara, Rie Tanaka, Ehsan Samei, William Paul Segars, Ehsan Abadi, Isao Matsumoto, Masaya Tamura, Junsei Horii, Yukihiro Matsuura
  • Organizer: The 52nd Annual Meeting of the Taiwan Society of Radiological Technologists (TWSRT) and the International Conference of Medical Imaging
  • Int'l Joint Research
• [Presentation] Lung segmentation based on a deep learning approach for dynamic chest radiography. (2019)
  • Author(s): Yuki Kitahara, Rie Tanaka, Holger R. Roth, Hirohisa Oda, Kensaku Mori, Kazuo Kasahara, Isao Matsumoto
  • Organizer: International society for optics and photonics (SPIE), Medical imaging 2019
  • Int'l Joint Research
• [Presentation] Dynamic chest radiography for pulmonary function diagnosis: A validation study using 4D extended cardiac-torso (XCAT) phantom (2019)
  • Author(s): Rie Tanaka, Ehsan Samei, William Paul Segars, Ehsan Abadi, Holger Roth, Hirohisa Oda, Kensaku Mori
  • Organizer: International society for optics and photonics (SPIE), Medical imaging 2019
  • Int'l Joint Research
• [Presentation] Pulmonary perfusion diagnosis based on time-series analysis of X-ray translucency with dynamic flat-panel detector imaging: an animal-based study (2018)
  • Author(s): Rie Tanaka, Tohru Tani, Norihisa Nitta, Takahisa Tabata, Noritsugu Matsutani, Shintaro Muraoka, Sho Noji, Tsutomu Yoneyama, Sanada Shigeru
  • Organizer: International Journal of Computer Assisted Radiology and Surgery (CARS2018)
  • Int'l Joint Research
• [Presentation] Pulmonary function diagnosis based on diaphragm movement with dynamic flat-panel detector imaging: an animal-based study (2018)
  • Author(s): Rie Tanaka, Tohru Tani, Norihisa Nitta, Takahisa Tabata, Noritsugu Matsutani, Shintaro Muraoka, Sho Noji, Tsutomu Yoneyama, Haruna Kawakami, Shigeru Sanada
  • Organizer: 第74回日本放射線技術学会総会学術大会
• [Presentation] Pulmonary perfusion diagnosis based on temporal changes in X-ray translucency with dynamic flat-panel detector imaging: an animal-based study (2018)
  • Author(s): Rie Tanaka, Tohru Tani, Norihisa Nitta, Takahisa Tabata, Noritsugu Matsutani, Shintaro Muraoka, Sho Noji, Tsutomu Yoneyama, Shigeru Sanada
  • Organizer: 第74回日本放射線技術学会総会学術大会
• [Presentation] 胸部X線動画像を対象とした深層学習による肺野セグメンテーション (2018)
  • Author(s): 北原侑季，田中利恵，Roth Holger，小田紘久，森健作，笠原寿朗，松本勲
  • Organizer: 放射線技術科学教育系 第8回全国大学交流夏季研修会
• [Presentation] 4D extended cardiac-torsophantomを用いた胸部Ｘ線動態撮影の撮影方向の検討 (2018)
  • Author(s): 石原のぞみ，田中利恵，Ehsan Samei, Paul William Segars, Ehsan Abadi
  • Organizer: 放射線技術科学教育系 第8回全国大学交流夏季研修会
• [Presentation] 胸部X線動態撮影による血流動態解析の基礎的検討：肺血流計測能の評価 (2018)
  • Author(s): 浅野友希，田中利恵
  • Organizer: 第11回中部放射線医療技術学術大会
• [Presentation] 仮想人体ファントム（4D extended cardiac-torso phantom）を用いた胸部X線動態撮影の撮影方向の検討 (2018)
  • Author(s): 石原のぞみ，田中利恵，Ehsan Samei，William Paul Segars, Ehsan Abadi
  • Organizer: 第11回中部放射線医療技術学術大会
• [Presentation] Pulmonary function diagnosis based on diaphragm movement using dynamic flat-panel detector imaging: An animal-based study (2018)
  • Author(s): Rie Tanaka, Tohru Tani, Norihisa Nitta, Takahisa Tabata, Noritsugu Matsutani, Shintaro Muraoka, Shikou Kaneko, Sho Noji, Tsutomu Yoneyama, Sanada Shigeru
  • Organizer: International society for optics and photonics (SPIE) 2018
  • Int'l Joint Research
• [Presentation] Pulmonary function diagnosis based on temporal changes in lung density with dynamic flat-panel detector (FPD) imaging: An animal-based study (2017)
  • Author(s): Rie Tanaka, Tohru Tani, Norihisa Nitta, Takahisa Tabata, Noritsugu Matsutani, Shintaro Muraoka, Shikou Kaneko, Sho Noji, Tsutomu Yoneyama, Sanada Shigeru
  • Organizer: RSNA 103rd Scientific Assembly and Annual Meeting
  • Int'l Joint Research
• [Presentation] Horii, Yukihiro Matsuura, Sanada Shigeru. Dynamic chest radiography for follow-up assessment of diaphragm movement (2017)
  • Author(s): Rie Tanaka, Isao Matsumoto, Masaya Tamura, Shuhei Yoshida, Seiichi Kakegawa, Kazuo Kasahara, Shikou Kaneko, Shintaro Muraoka, Tsutomu Yoneyama, Junsei Horii, Yukihiro Matsuura, Sanada Shigeru
  • Organizer: RSNA 103rd Scientific Assembly and Annual Meeting
  • Int'l Joint Research
• [Presentation] Fundamental of Dynamic chest radiography: Low-dose and high performance functional imaging (2017)
  • Author(s): Rie Tanaka
  • Organizer: 4th World Congress of Thoracic Imaging
  • Int'l Joint Research / Invited
• [Presentation] Dynamic chest radiography for pulmonary function diagnosis based on temporal changes in lung density: an animal-based study (2017)
  • Author(s): Rie Tanaka, Tohru Tani, Norihisa Nitta, Takahisa Tabata, Noritsugu Matsutani, Shintaro Muraoka, Shikou Kaneko, Sho Noji, Tsutomu Yoneyama, Sanada Shigeru
  • Organizer: International Journal of Computer Assisted Radiology and Surgery (CARS2017)
• [Presentation] Development of “Dynamic chest radiography (DCXR)” (2017)
  • Author(s): Rie Tanaka
  • Organizer: Korean Society of Radiological Science conference 2017
  • Int'l Joint Research / Invited
• [Presentation] 胸部X線画像を用いた畳み込みニューラルネットワークによる肋骨2D-3D 位置合わせの自動初期化 (2017)
  • Author(s): 椛島基嵩，日朝祐太，大竹義人，田中利恵，真田茂，佐藤嘉伸
  • Organizer: 電子情報通信学会 医用画像研究会
• [Presentation] 胸部X線動画像を対象とした横隔膜運動計測による肺ボリューム変化推定：動物実験による検証 (2017)
  • Author(s): 川上春菜，田中利恵，谷 徹，新田哲久，田畑貴久，松谷哲嗣，村岡慎太郎，金子志行，野地翔，米山努，真田茂
  • Organizer: 第45回日本放射線技術学会秋季学術大会
• [Presentation] 胸部X線動画像を対象とした横隔膜運動計測による肺ボリューム変化推定：動物実験による検証 (2017)
  • Author(s): 川上春菜，田中利恵
  • Organizer: 放射線技術科学教育系 第7回全国大学交流夏季研修会
• [Presentation] 胸部X線動画像の機能情報にもとづく投影部位自動認識法の開発 (2017)
  • Author(s): 宋佳子，田中利恵
  • Organizer: 放射線技術科学教育系 第7回全国大学交流夏季研修会
• [Presentation] Dynamic chest radiography for follow-up assessment of diaphragmatic movement (2017)
  • Author(s): Rie Tanaka, Isao Matsumoto, Shuhei Yoshida, Seiichi Kakegawa, Shikou Kaneko, Shintaro Muraoka, Tsutomu Yoneyama, Kazuo Kasahara, Junsei Horii, Yukihiro Matsuura, Shigeru Sanada, Toshifumi Gabata
  • Organizer: 第73回日本放射線技術学会総会学術大会
• [Presentation] Measurement capability of regional pulmonary function in dynamic chest radiography: a preliminary study in pigs (2017)
  • Author(s): Rie Tanaka, Tohru Tani, Norihisa Nitta, Takahisa Tabata, Noritsugu Matsutani, Shintaro Muraoka, Shikou Kaneko, Sho Noji, Tsutomu Yoneyama, Sanada Shigeru.
  • Organizer: 第73回日本放射線技術学会総会学術大会
• [Presentation] 一軸性関節による肋骨運動の制約付き2D-3D位置合わせ精度の評価 (2017)
  • Author(s): 日朝祐太，大竹義人，田中利恵，横田太，真田茂，佐藤嘉伸
  • Organizer: 電子情報通信学会 医用画像研究会
• [Book] 第3章-9 肺機能評価／多元計算解剖学の基礎と臨床への応用 橋爪 誠（著） (2018)
  • Author(s): 田中利恵（分担執筆）
  • Publisher: 誠文堂新光社
  • ISBN: 4416518242
• [Book] 多元計算解剖の基礎と臨床への応用 (2018)
  • Author(s): 橋爪 誠 （第3章-10 肺機能評価 田中利恵）
  • Total Pages: 303
  • Publisher: 誠文堂新光社
  • ISBN: 4416518242
• [Remarks] 金沢大学大学院医薬保健学総合研究科保健学専攻 田中研究室
  • URL: http://tanakalab.w3.kanazawa-u.ac.jp
• [Patent(Industrial Property Rights)] 放射線画像解析装置及び放射線画像解析システム (2018)
  • Inventor(s): 村岡慎太郎，笠原寿郎，松本勲，田中利恵，他3名
  • Industrial Property Rights Holder: コニカミノルタ株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-084693
  • Filing Date: 2018