Publicly Offered Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
The shape of the midfacial skeleton changes drastically during development; it is presumably established during the early fetal period. The understanding the normal growth trait during the early fetal period could elucidate the pathogenesis of congenital craniofacial anomalies, however, mechanisms explaining these phenomena have remained unclear because obtaining imaging data that accurately analyze shape changes is difficult. Recent developments in imaging modalities allowed us to study these small specimens in detail. In this study, we aimed to elucidate the morphogenesis of craniofacial structures in humans using imaging data. We applied landmark-based geometric morphometrics (GM) to analyze the shape change. In GM, the landmark coordinates of the shape are used as the variables without dividing the shape. Hence, the landmark configurations are preserved through this analysis, and the outcomes are represented as a shift of landmark coordinates. Visualization of shape change is the major advantage of geometric morphometrics.We applied linear and non-linear approximation for the growth of the facial skeleton during late embryonic and early fetal periods and constructed a spatio-temporal statistical model correspondingly. Evaluating the tendency of growth patterns and showing the difference of the growth speed were effective. The shape of the facial skeleton, especially in the zygoma and the mandible, changed drastically in the period we investigated. Furthermore, the non-linear estimation demonstrated the timing of the development was different in the facial skeleton.
平成30年度が最終年度であるため、記入しない。
All 2019 2018 2017 Other
All Int'l Joint Research (2 results) Journal Article (22 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 22 results, Open Access: 15 results, Acknowledgement Compliant: 1 results) Presentation (43 results) (of which Int'l Joint Research: 4 results, Invited: 5 results) Book (4 results)
Orthodontic and Craniofacial Research
Volume: 印刷中
Anat Rec.
The Anatomical Record
Volume: 印刷中 Issue: 11 Pages: 1887-2104
10.1002/ar.24103
The Cleft Palate-Craniofacial Journal
Volume: - Issue: 8 Pages: 1026-1037
10.1177/1055665619827189
J Anat,
Volume: 印刷中 Issue: 1 Pages: 88-95
10.1111/joa.12989
Cells, Tissues and Organs
Volume: Review Article Issue: 5-6 Pages: 314-319
10.1159/000490672
Anat Rec
Volume: 印刷中 Issue: 6 Pages: 1004-1011
10.1002/ar.23785
AnatRec
Volume: 301 Issue: 8 Pages: 1312-1319
10.1002/ar.23794
Advanced Biomedical Engineering
Volume: 7 Issue: 0 Pages: 146-155
10.14326/abe.7.146
130007530705
PLoS ONE 13
Volume: 9 Issue: 9 Pages: e0203623-e0203623
10.1371/journal.pone.0203623
Congenital Anomalies
Volume: 印刷中 Issue: 5 Pages: 152-157
10.1111/cga.12261
Volume: 印刷中 Issue: 6 Pages: 947-950
10.1002/ar.23786
Volume: 印刷中 Issue: 6 Pages: 973-986
10.1002/ar.23791
Journal of Anatomy
Volume: 232 Issue: 5 Pages: 806-811
10.1111/joa.12774
120006796096
Volume: 301 Issue: 5 Pages: 757-764
10.1002/ar.23760
日本周産期・新生児医学会誌
Pediatr Phys Ther
Volume: 30(1) Issue: 1 Pages: 34-38
10.1097/pep.0000000000000460
Congenit Anom (Kyoto)
Volume: 58 Issue: 2 Pages: 48-55
10.1111/cga.12229
IEICE Transactions on Information and Systems
Volume: E100.D Issue: 7 Pages: 1505-1515
10.1587/transinf.2016EDP7493
130006792950
Prenatal Diag
Volume: 37 Issue: 9 Pages: 907-915
10.1002/pd.5106
PlosOne
Volume: 12(4) Issue: 4 Pages: 43-108
10.1371/journal.pone.0173852
