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ヒトにおける頭蓋顔面形態形成および外鼻形態進化の解析

Publicly Offered Research

Project AreaMultidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy
Project/Area Number 17H05296
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKyoto University

Principal Investigator

山田 重人  京都大学, 医学研究科, 教授 (80432384)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsCraniofacial development / Human Embryology / ヒト発生学 / 解剖学 / 計算解剖学 / 発生学 / 比較解剖学 / 形成外科学
Outline of Annual Research Achievements

The shape of the midfacial skeleton changes drastically during development; it is presumably established during the early fetal period. The understanding the normal growth trait during the early fetal period could elucidate the pathogenesis of congenital craniofacial anomalies, however, mechanisms explaining these phenomena have remained unclear because obtaining imaging data that accurately analyze shape changes is difficult. Recent developments in imaging modalities allowed us to study these small specimens in detail. In this study, we aimed to elucidate the morphogenesis of craniofacial structures in humans using imaging data. We applied landmark-based geometric morphometrics (GM) to analyze the shape change. In GM, the landmark coordinates of the shape are used as the variables without dividing the shape. Hence, the landmark configurations are preserved through this analysis, and the outcomes are represented as a shift of landmark coordinates. Visualization of shape change is the major advantage of geometric morphometrics.
We applied linear and non-linear approximation for the growth of the facial skeleton during late embryonic and early fetal periods and constructed a spatio-temporal statistical model correspondingly. Evaluating the tendency of growth patterns and showing the difference of the growth speed were effective. The shape of the facial skeleton, especially in the zygoma and the mandible, changed drastically in the period we investigated. Furthermore, the non-linear estimation demonstrated the timing of the development was different in the facial skeleton.

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (71 results)

All 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (22 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 22 results,  Open Access: 15 results,  Acknowledgement Compliant: 1 results) Presentation (43 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results) Book (4 results)

  • [Int'l Joint Research] University of British Columbia(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of British Columbia(カナダ)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 「掲載確定」Analysis of facial skeletal asymmetry during fetal development using microCT imaging2019

    • Author(s)
      Katsube M, Rolfe SM, Bortolussi SR, Yamaguchi Y, Richman JM, Yamada S, Vora SR
    • Journal Title

      Orthodontic and Craniofacial Research

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 「掲載確定」Relationship Between Physiological Umbilical Herniation and Liver Morphogenesis During the Human Embryonic Period: A Morphological and Morphometric Study.2019

    • Author(s)
      Kanahashi T, Yamada S. Yoneyama A, Takakuwa T
    • Journal Title

      Anat Rec.

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatial relationship between the metanephros and adjacent organs according to the Carnegie stage of development2019

    • Author(s)
      Ishiyama Hana、Ishikawa Aoi、Imai Hirohiko、Matsuda Tetsuya、Yoneyama Akio、Yamada Shigehito、Takakuwa Tetsuya
    • Journal Title

      The Anatomical Record

      Volume: 印刷中 Issue: 11 Pages: 1887-2104

    • DOI

      10.1002/ar.24103

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical Growth Processes for the Midfacial Morphogenesis in the Early Prenatal Period2019

    • Author(s)
      Katsube Motoki、Yamada Shigehito、Yamaguchi Yutaka、Takakuwa Tetsuya、Yamamoto Akira、Imai Hirohiko、Saito Atsushi、Shimizu Akinobu、Suzuki Shigehiko
    • Journal Title

      The Cleft Palate-Craniofacial Journal

      Volume: - Issue: 8 Pages: 1026-1037

    • DOI

      10.1177/1055665619827189

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Revisiting the infracardiac bursa by multimodal methods.2019

    • Author(s)
      Nakamura T, Shinohara H, Okada T, Hisamori S, Tsunoda S, Obama K, Kurahashi Y, Takai A, Shimokawa T, Matsuda S, Makishima H, Takakuwa T, Yamada S, Sakai Y.
    • Journal Title

      J Anat,

      Volume: 印刷中 Issue: 1 Pages: 88-95

    • DOI

      10.1111/joa.12989

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Kyoto collection of human embryos and fetuses: history and recent advancements in modern methods2018

    • Author(s)
      Yamaguchi Y, Yamada S
    • Journal Title

      Cells, Tissues and Organs

      Volume: Review Article Issue: 5-6 Pages: 314-319

    • DOI

      10.1159/000490672

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel Imaging Modalities for Human Embryology and Applications in Education.2018

    • Author(s)
      Yamada S, Nakano S, Makishima H, Motoki T
    • Journal Title

      Anat Rec

      Volume: 印刷中 Issue: 6 Pages: 1004-1011

    • DOI

      10.1002/ar.23785

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Variations of the circle of Willis at the end of the human embryonic period.2018

    • Author(s)
      Furuichi K, Ishikawa A, Uwabe C, Makishima H, Yamada S, Takakuwa T.
    • Journal Title

      AnatRec

      Volume: 301 Issue: 8 Pages: 1312-1319

    • DOI

      10.1002/ar.23794

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Spatiotemporal Statistical Shape Model of the Brain Surface during Human Embryonic Development2018

    • Author(s)
      Kazuki Kasahara, Atsushi Saito, Tetsuya Takakuwa, Shigehito Yamada, Hiroshi Matsuzoe, Hidekata Hontani, Akinobu Shimizu.
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 7 Issue: 0 Pages: 146-155

    • DOI

      10.14326/abe.7.146

    • NAID

      130007530705

    • ISSN
      2187-5219
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Branching morphogenesis of the urinary collecting system in the human embryonic metanephros2018

    • Author(s)
      Ishiyama H, Ishikawa A, Kitazawa H, Fujii S, Matsubayashi J, Yamada S, Takakuwa T
    • Journal Title

      PLoS ONE 13

      Volume: 9 Issue: 9 Pages: e0203623-e0203623

    • DOI

      10.1371/journal.pone.0203623

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blechschmidt Collection: Revisiting specimens from a historical collection of serially sectioned human embryos and fetuses using modern imaging techniques2018

    • Author(s)
      Miyazaki Reina、Makishima Haruyuki、Maenner J、Sydow Hans-Georg、Uwabe Chigako、Takakuwa Tetsuya、Viebahn Christoph、Yamada Shigehito
    • Journal Title

      Congenital Anomalies

      Volume: 印刷中 Issue: 5 Pages: 152-157

    • DOI

      10.1111/cga.12261

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fortieth Anniversary of the Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine.2018

    • Author(s)
      Yamada S, Nagai M, Hagiwara M
    • Journal Title

      Anat Rec

      Volume: 印刷中 Issue: 6 Pages: 947-950

    • DOI

      10.1002/ar.23786

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and Demographic Evaluation of a Holoprosencephaly Cohort from the Kyoto Collection of Human Embryos2018

    • Author(s)
      Abe Y, Kruszka P, Martinez A, Shiota K, Yamada S, Muenke M
    • Journal Title

      Anat Rec

      Volume: 印刷中 Issue: 6 Pages: 973-986

    • DOI

      10.1002/ar.23791

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tail reduction process during human embryonic development2018

    • Author(s)
      Tojima Sayaka、Makishima Haruyuki、Takakuwa Tetsuya、Yamada Shigehito
    • Journal Title

      Journal of Anatomy

      Volume: 232 Issue: 5 Pages: 806-811

    • DOI

      10.1111/joa.12774

    • NAID

      120006796096

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019939

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphogenesis of the middle ear during fetal development as observed via magnetic resonance imaging.2018

    • Author(s)
      Ohtsuki S, Ishikawa A, Yamada S, Imai H, Matsuda T, Takakuwa T.
    • Journal Title

      Anat Rec

      Volume: 301 Issue: 5 Pages: 757-764

    • DOI

      10.1002/ar.23760

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 日本における出生前遺伝学的検査の動向 1998-20162018

    • Author(s)
      佐々木愛子,左合治彦,吉橋博史,山田重人,三宅秀彦,鈴森伸宏,高田史男,増崎英明,平原史樹,久具宏司,小西郁生
    • Journal Title

      日本周産期・新生児医学会誌

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 超音波検査による胎児甲状腺機能評価を行った胎児甲状腺腫の5例2018

    • Author(s)
      菅 智美,伊尾紳吾,千草義継,谷洋彦,杉並興,濵西潤三,山田重人,松村謙臣,近藤英治
    • Journal Title

      日本周産期・新生児医学会誌

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Number of synergies is dependent on spasticity and gait kinetics in children with cerebral palsy.2018

    • Author(s)
      Hashiguchi Y, Ohata K, Osako S, Kitatani R, Aga Y, Masaki M, Yamada S
    • Journal Title

      Pediatr Phys Ther

      Volume: 30(1) Issue: 1 Pages: 34-38

    • DOI

      10.1097/pep.0000000000000460

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional models of the segmented human fetal brain generated by magnetic resonance imaging2017

    • Author(s)
      Yamaguchi Yutaka、Miyazaki Reina、Kamatani Mikako、Uwabe Chigako、Makishima Haruyuki、Nagai Momoko、Katsube Motoki、Yamamoto Akira、Imai Hirohiko、Kose Katsumi、Togashi Kaori、Yamada Shigehito
    • Journal Title

      Congenit Anom (Kyoto)

      Volume: 58 Issue: 2 Pages: 48-55

    • DOI

      10.1111/cga.12229

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Spatiotemporal Statistical Model for Eyeballs of Human Embryos2017

    • Author(s)
      Kishimoto M, Saito A, Takakuwa T, Yamada S, Matsuzoe H, Hontani H, Shimizu A,
    • Journal Title

      IEICE Transactions on Information and Systems

      Volume: E100.D Issue: 7 Pages: 1505-1515

    • DOI

      10.1587/transinf.2016EDP7493

    • NAID

      130006792950

    • ISSN
      0916-8532, 1745-1361
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitation of nasal development in the early prenatal period using geometric morphometrics and MRI: A new insight into the critical period of Binder phenotype.2017

    • Author(s)
      Katsube M, Yamada S, Miyazaki R, Yamaguchi Y, Makishima H, Takakuwa T, Yamamoto A, Fujii Y, Morimoto N, Ito T, Imai H, Suzuki S.
    • Journal Title

      Prenatal Diag

      Volume: 37 Issue: 9 Pages: 907-915

    • DOI

      10.1002/pd.5106

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 『掲載確定』Cartilage Formation in the Pelvic Skeleton during the Early-Fetal Period.2017

    • Author(s)
      Okumura M, Ishikawa A, Aoyama T, Yamada S, Uwabe C, Imai H, Matsuda T, Yoneyama A, takeda T, Takakuwa T.
    • Journal Title

      PlosOne

      Volume: 12(4) Issue: 4 Pages: 43-108

    • DOI

      10.1371/journal.pone.0173852

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ヒト胎児の顔面骨格形成とそれに必要な因子について2019

    • Author(s)
      勝部 元紀、山田 重人、山口 豊、高桑 徹也、山本 憲、斉藤 篤、清水 昭伸、今井 宏彦、鈴木 茂彦
    • Organizer
      第124回日本解剖学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 幾何学的形態測定学法を用いたヒト胎児脳の成長過程の解析2019

    • Author(s)
      山口豊、勝部元紀、上部千賀子、巻島美幸、山本憲、今井宏彦、冨樫かおり、山田重人
    • Organizer
      第124回日本解剖学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胎児期初期における骨盤形成の解析2019

    • Author(s)
      金橋 徹、奥村 美咲、今井 宏彦、山田 重人、山本 憲、富樫 かおり、高桑 徹也
    • Organizer
      第124回日本解剖学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒト胚子期における気管支分岐形式の3次元的検討2019

    • Author(s)
      藤井瀬菜、村中太河、松林潤、米山明男、武田徹、兵藤一行、山田重人、高桑徹也
    • Organizer
      第124回日本解剖学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 産婦人科に必要な臨床遺伝の基礎知識2018

    • Author(s)
      山田重人
    • Organizer
      第3回新百合ヶ丘産婦人科臨床研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The extracted problems to manage the demands of prenatal genetic testing in the primary maternity clinics」2018

    • Author(s)
      Yamada T, Sekizawa A) Kanai M, Saito K, Samura O, Sawai H, Takada F, Urano M, Nakagomi S, Yoshihashi H, Io S, Miyake H, Yamada S, Konishi I
    • Organizer
      International Joint Conference on Genetics and Medicine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 幾何学的形態学測定法を用いたヒト胎児脳の成長過程の解析2018

    • Author(s)
      山口豊、勝部元紀、上部千賀子、巻島美幸、山本憲、今井宏彦、高桑徹也、冨樫かおり、山田重人
    • Organizer
      第72回日本人類学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 顔面骨格成長予測の試み:ヒト胎児期初期の成長解析2018

    • Author(s)
      勝部 元紀、山田 重人、山口 豊、山本 憲、斉藤 篤、清水 昭伸、 今井 宏彦、鈴木 茂彦
    • Organizer
      第36回日本頭蓋顎顔面外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胎児期初期における骨盤形成の解析2018

    • Author(s)
      金橋徹、奥村美咲、今井宏彦、山田重人、高桑徹也
    • Organizer
      第58回日本先天異常学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒト胎児期初期における大腿骨の形態形成の解析2018

    • Author(s)
      鈴木裕子、山田重人、米山明男、武田徹、今井宏彦、山本憲、青山朋樹、高桑徹也
    • Organizer
      第58回日本先天異常学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒト後腎内における腎小体の発生段階と立体的分布2018

    • Author(s)
      北沢遥、石山華、石川葵、山田重人、高桑徹也
    • Organizer
      第58回日本先天異常学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒト胎児脳の成長に伴う形態変化における幾何学的形態測定学を用いた解析2018

    • Author(s)
      山口豊、勝部元紀、上部千賀子、巻島美幸、山本憲、今井宏彦、米山明男、冨樫かおり、山田重人
    • Organizer
      第58回日本先天異常学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒト胎児期における大脳基底核と視床の形態形成2018

    • Author(s)
      白石直樹、山中美希、岡本育恵、山田重人、今井宏彦、高桑徹也
    • Organizer
      第58回日本先天異常学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒトの上葉気管支は側方分岐により形成される2018

    • Author(s)
      藤井瀬菜、村中太河、松林潤、米山明男、武田徹、兵頭一行、山田重人、高桑徹也
    • Organizer
      第58回日本先天異常学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒトの胎児期初期における顔面骨格4Dアトラスの作成2018

    • Author(s)
      勝部 元紀、山田 重人、宮崎伶菜、山口 豊、山本 憲、斉藤 篤、清水 昭伸、今井 宏彦、鈴木 茂彦
    • Organizer
      第42回日本口蓋裂学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 産婦人科と遺伝医療2018

    • Author(s)
      山田重人
    • Organizer
      第17回東海不妊内分泌研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒト胚子・胎児中枢神経系の半自動セグメンテーションによる三次元立体像の作成2018

    • Author(s)
      山口豊、宮崎伶菜、上部千賀子、巻島美幸、勝部元紀、山本憲、今井宏彦、米山明男、巨瀬勝美、冨樫かおり、山田重人
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ワークショップ2 胎盤の生理と病理 胎盤発生の基礎 ヒト発生学の視点からワークショップ2 胎盤の生理と病理 胎盤発生の基礎〜ヒト発生学の視点から2017

    • Author(s)
      山田重人、伊尾紳吾
    • Organizer
      第25回胎盤学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胎児脳神経系の発生2017

    • Author(s)
      山田重人
    • Organizer
      第19回日本イアンドナルド超音波講座
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 産婦人科に必要な臨床遺伝の基礎知識2017

    • Author(s)
      山田重人
    • Organizer
      第87回石川石川産科婦人科学会臨床懇話会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 頭部顔面の発生と先天異常学への展開2017

    • Author(s)
      山田重人
    • Organizer
      第27回遺伝医学セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒト胎児における頭蓋顔面骨格の形態変化:Geometric morphometricsによる成長の解析と可視化2017

    • Author(s)
      勝部 元紀、山田 重人、巻島 美幸、宮崎伶菜、山口 豊、山本 憲、斉藤 篤、清水 昭伸、今井 宏彦、鈴木 茂彦
    • Organizer
      第35回日本頭蓋学顔面外科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Down症候群を持つ人の自己認識と社会的因子の関連2017

    • Author(s)
      三宅 秀彦、山田 重人、藤井 庸祐、伊尾 紳吾、池田 真理子、浦野 真理、小笹 由香、金井 誠、福島 明宗、松原 洋一、齋藤 加代子、小西 郁生
    • Organizer
      日本人類遺伝学会第62回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 京都大学医学部附属病院における乳がん・卵巣がんに関する遺伝カウンセリング状況2017

    • Author(s)
      本田 明夏、村上 裕美、鳥嶋 雅子、松川 愛未、山田 崇弘、山田 重人、小杉 眞司
    • Organizer
      日本人類遺伝学会第62回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト胎児脳の三次元立体化像の作成における機械学習とマニュアル抽出の比較検討(ポスター)2017

    • Author(s)
      山口 豊、宮崎伶菜、上部 千賀子、巻島 美幸、勝部 元紀、山本 憲、今井 宏彦、米山 明男、巨瀬 勝美、冨樫かおり、山田 重人
    • Organizer
      第57回日本先天異常学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 臨床用MRIを用いたヒト胎児筋骨格系の解析 DTIとT2の比較(ポスター)2017

    • Author(s)
      宮崎伶菜、山本憲、巻島美幸、岡田知久、富樫かおり、上部千賀子、山田重人
    • Organizer
      第57回日本先天異常学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 変形のある連続切片よりヒト胚子の良好な三次元像を得る試み(ポスター)2017

    • Author(s)
      巻島美幸、上部千賀子、梶原武紘、舩冨卓哉、久保尋之、向川康博、山田重人
    • Organizer
      第57回日本先天異常学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト胚発生過程における尾部退縮過程の解明(ポスター)2017

    • Author(s)
      東島沙弥佳、巻島美幸、高桑徹也、山田重人
    • Organizer
      第57回日本先天異常学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト胚子期後腎における腎盂の三次元的解析とネフロンの成熟段階別の分布(ポスター)2017

    • Author(s)
      石山華、山田重人、巻島美幸、上部千賀子、高桑徹也
    • Organizer
      第57回日本先天異常学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト胚子期~胎児期初期における大腿骨の形態形成の解析(ポスター)2017

    • Author(s)
      鈴木裕子、山田重人、上部千賀子、米山明男、武田徹、今井宏彦、松田哲也、高桑徹也
    • Organizer
      第57回日本先天異常学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト胎児期初期の骨盤形成(ポスター)2017

    • Author(s)
      金橋 徹、奥村 美咲、米山 明男、武田 徹、今井 宏彦、松田 哲也、上部千賀子、山田 重人、高桑 徹也
    • Organizer
      第57回日本先天異常学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト気管支分岐形成の三次元的解析(ポスター)2017

    • Author(s)
      藤井 瀬菜、村中 太河、松林 潤、米山 明男、武田 徹、兵頭 一行、上部千賀子、巻島 美幸、山田 重人、高桑 徹也
    • Organizer
      第57回日本先天異常学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高解像度 MRI・DTI を用いたヒト胎児心筋の走行(ポスター)2017

    • Author(s)
      西谷 早織、山田 重人、上部千賀子、原口 亮、今井 宏彦、松田 哲也、高桑 徹也
    • Organizer
      第57回日本先天異常学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒトにおける胎児期の脳形態形成の解析(ポスター)2017

    • Author(s)
      白石 直樹、山中 美希、岡本 育恵、山田 重人、上部千賀子、今井 宏彦、松田 哲也、高桑 徹也
    • Organizer
      第57回日本先天異常学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Relationship between self-perception and social factors in people with Down syndrome(Poster)2017

    • Author(s)
      Miyake H, Yamada S, Fujii Y, Taniguchi-Ikeda M, Urano M, Ozasa Y, Kanai M, Fukushima A, Matsubara Y, Saito K, Konishi I.
    • Organizer
      The 21h International Conference on Prenatal Diagnosis and Therapy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Trends of genetic prenatal testing in Japan; 1998-2016(Poster)2017

    • Author(s)
      Sasaki A, Sago H, Yoshihash H, Yamada S, Miyake H, Suzumori N, Takada F, Masuzaki H, Hirahara F, Kugu K, Konishi I.
    • Organizer
      The 21h International Conference on Prenatal Diagnosis and Therapy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tail reduction process during human embryonic development(Poster)2017

    • Author(s)
      Tojima S, Makishima H, Takakuwa T, Yamada S.
    • Organizer
      The 18th International Society of Developmental Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tail reduction process during human embryonic development(Oral + Poster)2017

    • Author(s)
      Tojima S, Makishima H, Takakuwa T, Yamada S.
    • Organizer
      第50回日本発生生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Three dimensional utilization of human embryo specimens of the “Kyoto Collection” (Poster)2017

    • Author(s)
      Makishima H, Katsube M, Miyazaki R, Yamaguchi Y, Kobayashi S, Uwabe C, Yamamoto A, Imai H, Yoneyama A, Funatomi T, Morimoto N, Takeda T, Nakatsukasa M, Kose K, Takakuwa T, Yamada S.
    • Organizer
      第50回日本発生生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト気管支発生の 3 次元的解析2017

    • Author(s)
      高桑徹也、村中太河、山田重人
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト胚子期における脳形態形成の解析2017

    • Author(s)
      白石直樹、片山愛里、中島崇、山田重人、上部千賀子、巨瀬勝美、高桑徹也
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] EFICを用いた膝関節の形態形成の解析2017

    • Author(s)
      高石亮太、Xiangkai Zhang、青山朋樹、山田重人、高桑徹也
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Down 症候群を持つ人達の自己認識への社会的要因の関与2017

    • Author(s)
      三宅秀彦、他
    • Organizer
      第69回日本産科婦人科学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Book] Congenital Anomalies (Chapter)2018

    • Author(s)
      Nakano S, Makishima H, Uwabe C, Yamada S.
    • Total Pages
      531
    • Publisher
      Intech Publisher
    • ISBN
      9781789231144
    • Related Report
      2018 Annual Research Report
  • [Book] ヒト発生研究への応用と進化発生学への展開。(橋爪誠編「多元計算解剖学の基礎と臨床への応用」)2018

    • Author(s)
      勝部元紀、巻島美幸、山田重人
    • Total Pages
      303
    • Publisher
      誠文堂新光社
    • ISBN
      9784416518243
    • Related Report
      2017 Annual Research Report
  • [Book] Prenatal Diagnosis of the Human Embryo and Fetus. In: “Precision Medicine in Gynecology and Obstetrics”, book editied by Ikuo Konishi,2017

    • Author(s)
      Yamada S, Miyake H.
    • Total Pages
      250
    • Publisher
      Springer Singapore
    • ISBN
      9789811024887
    • Related Report
      2017 Annual Research Report
  • [Book] 産婦人科診療に役立つ早わかり遺伝医療入門2017

    • Author(s)
      山田重人、三宅秀彦
    • Total Pages
      151
    • Publisher
      メディカ出版
    • ISBN
      9784840464956
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2019-12-27  

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