ヒトにおける頭蓋顔面形態形成および外鼻形態進化の解析
Publicly Offered Research
Project Area | Multidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy |
Project/Area Number |
17H05296
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Science and Engineering
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Research Institution | Kyoto University |
Principal Investigator |
山田 重人 京都大学, 医学研究科, 教授 (80432384)
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Project Period (FY) |
2017-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | Craniofacial development / Human Embryology / ヒト発生学 / 解剖学 / 計算解剖学 / 発生学 / 比較解剖学 / 形成外科学 |
Outline of Annual Research Achievements |
The shape of the midfacial skeleton changes drastically during development; it is presumably established during the early fetal period. The understanding the normal growth trait during the early fetal period could elucidate the pathogenesis of congenital craniofacial anomalies, however, mechanisms explaining these phenomena have remained unclear because obtaining imaging data that accurately analyze shape changes is difficult. Recent developments in imaging modalities allowed us to study these small specimens in detail. In this study, we aimed to elucidate the morphogenesis of craniofacial structures in humans using imaging data. We applied landmark-based geometric morphometrics (GM) to analyze the shape change. In GM, the landmark coordinates of the shape are used as the variables without dividing the shape. Hence, the landmark configurations are preserved through this analysis, and the outcomes are represented as a shift of landmark coordinates. Visualization of shape change is the major advantage of geometric morphometrics. We applied linear and non-linear approximation for the growth of the facial skeleton during late embryonic and early fetal periods and constructed a spatio-temporal statistical model correspondingly. Evaluating the tendency of growth patterns and showing the difference of the growth speed were effective. The shape of the facial skeleton, especially in the zygoma and the mandible, changed drastically in the period we investigated. Furthermore, the non-linear estimation demonstrated the timing of the development was different in the facial skeleton.
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Research Progress Status |
平成30年度が最終年度であるため、記入しない。
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Strategy for Future Research Activity |
平成30年度が最終年度であるため、記入しない。
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Report
(2 results)
Research Products
(75 results)
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[Journal Article] Revisiting the infracardiac bursa using multimodal methods: topographic anatomy for surgery of the esophagogastric junction.2019
Author(s)
Nakamura T, Shinohara H, Okada T, Hisamori S, Tsunoda S, Obama K, Kurahashi Y, Takai A, Shimokawa T, Matsuda S, Makishima H, Takakuwa T, Yamada S, Sakai Y
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Journal Title
J Anat
Volume: Epub ahead of print
Pages: -
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The extracted problems to manage the demands of prenatal genetic testing in the primary maternity clinics」2018
Author(s)
Yamada T, Sekizawa A) Kanai M, Saito K, Samura O, Sawai H, Takada F, Urano M, Nakagomi S, Yoshihashi H, Io S, Miyake H, Yamada S, Konishi I
Organizer
International Joint Conference on Genetics and Medicine
Related Report
Int'l Joint Research
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[Presentation] Relationship between self-perception and social factors in people with Down syndrome(Poster)2017
Author(s)
Miyake H, Yamada S, Fujii Y, Taniguchi-Ikeda M, Urano M, Ozasa Y, Kanai M, Fukushima A, Matsubara Y, Saito K, Konishi I.
Organizer
The 21h International Conference on Prenatal Diagnosis and Therapy
Related Report
Int'l Joint Research
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[Presentation] Trends of genetic prenatal testing in Japan; 1998-2016(Poster)2017
Author(s)
Sasaki A, Sago H, Yoshihash H, Yamada S, Miyake H, Suzumori N, Takada F, Masuzaki H, Hirahara F, Kugu K, Konishi I.
Organizer
The 21h International Conference on Prenatal Diagnosis and Therapy
Related Report
Int'l Joint Research
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[Presentation] Three dimensional utilization of human embryo specimens of the “Kyoto Collection” (Poster)2017
Author(s)
Makishima H, Katsube M, Miyazaki R, Yamaguchi Y, Kobayashi S, Uwabe C, Yamamoto A, Imai H, Yoneyama A, Funatomi T, Morimoto N, Takeda T, Nakatsukasa M, Kose K, Takakuwa T, Yamada S.
Organizer
第50回日本発生生物学会大会
Related Report
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