Computer-aided diagnosis for colonoscopy designed to assist endoscopists' decision making regarding the treatment

• Project Area: Multidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy
• Project/Area Number: 17H05305
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Showa University
• Principal Investigator: 森 悠一 昭和大学, 医学部, 講師 (20459209)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 人工知能 / 大腸内視鏡 / 自動診断 / 内視鏡 / 超拡大内視鏡 / 大腸がん / 大腸ポリープ / 診断支援

Outline of Annual Research Achievements

大腸内視鏡で腫瘍性ポリープを摘除することで、大腸がん死を約60%減少できることが立証されているため、腫瘍/非腫瘍を内視鏡で判別することが重要視されている(Zauber, et al. N Engl J Med 2012)。しかし、大規模研究において、医師による診断精度が80%台に留まっている事が指摘されており、非腫瘍性のポリープに不要な治療がされている現況にある(Ladabaum, et al. Gastroenterology 2013)。この過剰治療により、例えば米国では年間40億円の医療費が浪費されており、医療経済的な問題となっている(Hassan, et al. Clin Gastroenterol Hepatol 2010)。
この課題を、人工知能(AI)で解決するという発想のもと、申請者は科研費補助の下、医工連携研究（昭和大-名大）を行い、超拡大内視鏡(CF-290ECI, オリンパス社)を用いて、腫瘍/非腫瘍の鑑別能が90%超の自動診断システムの開発に成功(Mori, et al. Gastointest Endosc 2015)した。
本課題では開発した自動診断システムの臨床での実用性を評価するために、７００人以上の患者に実際にAIを用いた内視鏡診断を行う、大規模な前向き試験を実施、90%以上の精度が担保されることを実証した（Mori, et al. Ann Intern Med 2018）。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Artificial Intelligence-Assisted Polyp Detection for Colonoscopy: Initial Experience. (2019)
  • Author(s): Misawa M, Kudo SE, Mori Y, Cho T, Kataoka S, Yamauchi A, Ogawa Y, Maeda Y, Takeda K, Ichimasa K, Nakamura H, Yagawa Y, Toyoshima N, Ogata N, Kudo T, Hisayuki T, Hayashi T, Wakamura K, Baba T, Ishida F, Itoh H, Roth H, Oda M, Mori K.
  • Journal Title: Gastroenterology Volume: epub ahead of print Issue: 8 Pages: 2027-2029
  • DOI: 10.1053/j.gastro.2018.04.003
  • Peer Reviewed / Open Access
• [Journal Article] Artificial intelligence and upper gastrointestinal endoscopy: Current status and future perspective. (2019)
  • Author(s): Mori Y, Kudo SE, Mohmed HEN, Misawa M, Ogata N, Itoh H, Oda M, Mori K
  • Journal Title: Dig Endosc. Volume: epub ahead of print Issue: 4 Pages: 378-388
  • DOI: 10.1111/den.13317
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Artificial intelligence for early gastric cancer: early promise and the path ahead. (2019)
  • Author(s): Mori Y, Berzin TM, Kudo SE
  • Journal Title: Gastrointest Endosc. Volume: 89 Issue: 4 Pages: 816-817
  • DOI: 10.1016/j.gie.2018.12.019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Artificial intelligence and colonoscopy: the time is ripe to begin clinical trials. (2019)
  • Author(s): Mori Y
  • Journal Title: Endoscopy Volume: 51 Issue: 03 Pages: 219-220
  • DOI: 10.1055/a-0754-5556
  • Peer Reviewed
• [Journal Article] Simultaneous detection and characterization of diminutive polyps with the use of artificial intelligence during colonoscopy. (2019)
  • Author(s): Mori Y, Kudo SE, Misawa M, Mori K.
  • Journal Title: VideoGIE Volume: 4 Issue: 1 Pages: 7-10
  • DOI: 10.1016/j.vgie.2018.10.006
  • Peer Reviewed / Open Access
• [Journal Article] Fully automated diagnostic system with artificial intelligence using endocytoscopy to identify the presence of histologic inflammation associated with ulcerative colitis (with video). (2019)
  • Author(s): Maeda Y, Kudo SE, Mori Y, Misawa M, Ogata N, Sasanuma S, Wakamura K, Oda M, Mori K, Ohtsuka K.
  • Journal Title: Gastrointest Endosc Volume: 89 Issue: 2 Pages: 408-415
  • DOI: 10.1016/j.gie.2018.09.024
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Real-Time Use of Artificial Intelligence in Identification of Diminutive Polyps During Colonoscopy: A Prospective Study (2018)
  • Author(s): Mori Y, Kudo SE, Misawa M, Saito Y, Ikematsu H, Hotta K, Ohtsuka K, Urushibara F, Kataoka S, Ogawa Y, Maeda Y, Takeda K, Nakamura H, Ichimasa K, Kudo T, Hayashi T, Wakamura K, Ishida F, Inoue H, Itoh H, Oda M, Mori K
  • Journal Title: Ann Intern Med Volume: 169 Issue: 6 Pages: 357-366
  • DOI: 10.7326/m18-0249
  • Peer Reviewed / Open Access
• [Journal Article] Artificial intelligence may help in predicting the need for additional surgery after endoscopic resection of T1 colorectal cancer. (2018)
  • Author(s): Ichimasa K, Kudo SE, Mori Y, Misawa M, Matsudaira S, Kouyama Y, Baba T, Hidaka E, Wakamura K, Hayashi T, Kudo T, Ishigaki T, Yagawa Y, Nakamura H, Takeda K, Haji A, Hamatani S, Mori K, Ishida F, Miyachi H.
  • Journal Title: Endoscopy Volume: 50 Pages: 230-240
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] White light-emitting contrast image capsule endoscopy for visualization of small intestine lesions: a pilot study. (2018)
  • Author(s): Ogata N, Ohtsuka K, Sasanuma S, Ogawa M, Maeda Y, Ichimasa K, Mori Y, Misawa M, Kudo T, Hisayuki T, Hayashi T, Wakamura K, Miyachi H, Baba T, Ishida F, Kudo SE
  • Journal Title: Endosc Int Open Volume: 6 Issue: 03 Pages: E315-E321
  • DOI: 10.1055/s-0044-102092
  • Peer Reviewed / Open Access
• [Journal Article] A novel ability of endocytoscopy to diagnose histological grade of differentiation in T1 colorectal carcinomas. (2018)
  • Author(s): Sako T, Kudo SE, Miyachi H, Wakamura K, Igarashi K, Misawa M, Mori Y, Kudo T, Hayashi T, Katagiri A, Ishida F, Azuma T, Inoue H, Hamatani S.
  • Journal Title: Endoscopy Volume: 50 Pages: 69-74
  • DOI: 10.1055/s-0043-117403
  • Peer Reviewed
• [Journal Article] The concept of 'Semi-clean colon' using the pit pattern classification system has the potential to be acceptable in combination with a <3-year surveillance colonoscopy. (2017)
  • Author(s): Maeda Y, Kudo SE, Wakamura K, Miyachi H, Misawa M, Mori Y, Ogata N, Kudo T, Kodama K, Hisayuki T, Hayashi T, Katagiri A, Ishida F.
  • Journal Title: Oncol Lett Volume: 14 Issue: 3 Pages: 2735-2742
  • DOI: 10.3892/ol.2017.6491
  • Peer Reviewed / Open Access
• [Journal Article] Use of endocytoscopy for identification of sessile serrated adenoma/polyps and hyperplastic polyps by quantitative image analysis of the luminal areas (2017)
  • Author(s): Yushi Ogawa, Shin-ei Kudo, Yuichi Mori, Nobunao Ikehara, Yasuharu Maeda, Kunihiko Wakamura, Masashi Misawa, Toyoki Kudo, Takemasa Hayashi, Hideyuki Miyachi, Atsushi Katagiri, Fumio Ishida, Haruhiro Inoue
  • Journal Title: Endoscopy international open Volume: 5 Issue: 08 Pages: E769-E774
  • DOI: 10.1055/s-0043-113562
  • Peer Reviewed / Open Access
• [Journal Article] Retrospective analysis of large bowel obstruction or perforation caused by oral preparation for colonoscopy. (2017)
  • Author(s): Yamauchi A, Kudo SE, Mori Y, Miyachi H, Misawa M, Kamo H, Hisayuki T, Kudo T, Hayashi T, Wakamura K, Katagiri A, Baba T, Hidaka E, Ishida F.
  • Journal Title: Endosc Int Open Volume: 5 Issue: 06 Pages: E471-E476
  • DOI: 10.1055/s-0043-106200
  • Peer Reviewed / Open Access
• [Journal Article] Computer-aided diagnosis for colonoscopy (2017)
  • Author(s): Yuichi Mori, Shin-ei Kudo, Tyler M Berzin, Masashi Misawa, Kenichi Takeda
  • Journal Title: Endoscopy Volume: 49 Issue: 08 Pages: 813-819
  • DOI: 10.1055/s-0043-109430
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Accuracy of diagnosing invasive colorectal cancer using computer-aided endocytoscopy (2017)
  • Author(s): Kenichi Takeda, Shin-ei Kudo, Yuichi Mori, Masashi Misawa, Toyoki Kudo, Kunihiko Wakamura, Atsushi Katagiri, Toshiyuki Baba, Eiji Hidaka, Fumio Ishida, Haruhiro Inoue, Masahiro Oda, Kensaku Mori
  • Journal Title: Endoscopy Volume: 49 Issue: 08 Pages: 799-802
  • DOI: 10.1055/s-0043-105486
  • Peer Reviewed
• [Journal Article] In vivo detection of desmoplastic reaction using endocytoscopy: A new diagnostic marker of submucosal or more extensive invasion in colorectal carcinoma. (2017)
  • Author(s): Sugihara Y, Kudo SE, Miyachi H, Wakamura K, Mori Y, Misawa M, Hisayuki T, Kudo T, Hayashi T, Hamatani S, Okoshi S, Okada H.
  • Journal Title: Mol Clin Oncol. Volume: 6 Issue: 3 Pages: 291-295
  • DOI: 10.3892/mco.2017.1138
  • Peer Reviewed / Open Access
• [Journal Article] Patient gender as a factor associated with lymph node metastasis in T1 colorectal cancer: A systematic review and meta-analysis. (2017)
  • Author(s): Ichimasa K, Kudo SE, Miyachi H, Kouyama Y, Ishida F, Baba T, Katagiri A, Wakamura K, Hayashi T, Hisayuki T, Kudo T, Misawa M, Mori Y, Matsudaira S, Kimura Y, Kataoka Y
  • Journal Title: Mol Clin Oncol. Volume: 6 Issue: 4 Pages: 517-524
  • DOI: 10.3892/mco.2017.1172
  • Peer Reviewed / Open Access
• [Journal Article] Accuracy of computer-aided diagnosis based on narrow-band imaging endocytoscopy for diagnosing colorectal lesions: comparison with experts. (2017)
  • Author(s): Misawa M, Kudo SE, Mori Y, Takeda K, Maeda Y, Kataoka S, Nakamura H, Kudo T, Wakamura K, Hayashi T, Katagiri A, Baba T, Ishida F, Inoue H, Nimura Y, Oda M, Mori K.
  • Journal Title: Int J Comput Assist Radiol Surg Volume: 印刷中 Issue: 5 Pages: 757-766
  • DOI: 10.1007/s11548-017-1542-4
  • Peer Reviewed
• [Presentation] EndoBRAIN -Artificial intelligence system that supports optical biopsy of colorectal polyps (2019)
  • Author(s): Mori Y
  • Organizer: ESGE days 2019
  • Int'l Joint Research / Invited
• [Presentation] Lower GI Endocytoscopy and AI-assisted endoscopy (2019)
  • Author(s): Mori Y
  • Organizer: 49th GEST /28th DEST
  • Int'l Joint Research / Invited
• [Presentation] Lower GI Endocyto scopy and AI assisted endoscopy (2018)
  • Author(s): Mori Y
  • Organizer: APDW2018
  • Int'l Joint Research / Invited
• [Presentation] Optical biopsy of diminutive polyps with real-time use of artificial intelligence assisted endoscopy. (2018)
  • Author(s): Mori Y
  • Organizer: UEGW2018
  • Int'l Joint Research
• [Presentation] AI-assisted colonoscopy: A road map for clinical application (2018)
  • Author(s): Mori Y
  • Organizer: DDW2018
  • Int'l Joint Research / Invited
• [Presentation] AI-assisted colonoscopy (2018)
  • Author(s): 森 悠一
  • Organizer: 16th GI Endoscopy Live demonstration 2018
  • Int'l Joint Research / Invited
• [Presentation] The current status and future of the AI-assisted endoscopy. (2018)
  • Author(s): 森 悠一
  • Organizer: 25th EUS and 22nd Early GI Cancer Conference of Taiwan
  • Int'l Joint Research / Invited
• [Presentation] Diagnostic yield of “artificial intelligence”-assisted endocytoscopy for colorectal polyps: a prospective study. (2017)
  • Author(s): 森 悠一
  • Organizer: UEGW2017
  • Int'l Joint Research
• [Presentation] Endocytoscopy and AI in colorectal cancer screening. (2017)
  • Author(s): 森 悠一
  • Organizer: Colorectal Screening Meeting of WEO
  • Int'l Joint Research / Invited
• [Presentation] Endoscopic automated diagnosis for colorectal neoplasia, (2017)
  • Author(s): 森 悠一
  • Organizer: APDW2017
  • Int'l Joint Research / Invited
• [Presentation] Artificial intelligence correctly diagnose sessile serrated adenomas/polyps? (2017)
  • Author(s): 森 悠一
  • Organizer: DDW2017
  • Int'l Joint Research
• [Patent(Industrial Property Rights)] 内視鏡観察支援装置、内視鏡観察支援方法、及びプログラム (2018)
  • Inventor(s): 森悠一・三澤将史・工藤進英・森健策
  • Industrial Property Rights Holder: 昭和大学・名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018