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金属架橋カプセルの異方性機能展開

Publicly Offered Research

Project AreaCoordination Asymmetry: Design of Asymmetric Coordination Sphere and Anisotropic Assembly for the Creation of Functional Molecules
Project/Area Number 17H05359
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTokyo Institute of Technology

Principal Investigator

吉沢 道人  東京工業大学, 科学技術創成研究院, 准教授 (70372399)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords分子カプセル / 配位結合 / 異方性 / 錯体化学 / 超分子化学 / ナノ空間
Outline of Annual Research Achievements

本研究の目的は、我々がこれまでに開発した高い分子内包能の「多環芳香族ナノ空間」を有する金属架橋カプセルを基盤として、これと「異方性(アシンメトリー)」を組み合わせることで、新たな『 異方性ナノ空間の化学 』を創出する。具体的な研究課題として、対称性の高いナノ空間を活用して、非対称性ゲスト分子を内包することで、選択的に異方性ホスト-ゲスト錯体を作製する。また、新規な非対称性ナノ空間を配位結合を使って構築し、その空間が持つ特異物性や相互作用などを解明する。本研究領域のA03班において、他の班との共同研究により、「溶液系」と「多環芳香族骨格」と「孤立ナノ空間」を特徴とした独創的な「空間アシンメトリー」の化学の推進に貢献する。本年度は、芳香環に囲まれたナノ空間が、水中、瞬時にかつ100%の収率で、親水性で非対称性なオリゴ乳酸オリゴを内包できることを見出した。また、結晶構造解析や等温カロリメトリーでの詳細なメカニズムの検証から、内包体は多点の分子間相互作用に基づく負のエンタルピー変化により、水中で安定化することが明らかになった。さらに、両親媒性で対称性のオリゴエチレンオキシドが水中・室温で、瞬時かつ定量的に、金属架橋カプセルと結合することを見出した。結合様式は基質の長さに依存し、約3 nmまでのオリゴエチレンオキシドはカプセル内部に包み込まれ、それより長いオリゴエチレンオキシドはカプセル骨格を貫いて結合した。詳細な熱量分析から、この前例のない貫通型ナノ構造体の形成は、カプセル内面とひも状分子の多点相互作用が駆動力と判明した。水中での芳香環ナノポケットと生体関連分子の相互作用を明らかにした。新たな「多環芳香族ナノ空間」の機能を開拓した。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (20 results)

All 2018 2017 Other

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 4 results) Presentation (11 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results) Remarks (1 results)

  • [Journal Article] A Supramolecular Approach to the Preparation of Nanographene Adlayers Using Water-Soluble Molecular Capsules2018

    • Author(s)
      Origuchi Sakura、Kishimoto Mai、Yoshizawa Michito、Yoshimoto Soichiro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 47 Pages: 15481-15485

    • DOI

      10.1002/anie.201809258

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cramming versus threading of long amphiphilic oligomers into a polyaromatic capsule2018

    • Author(s)
      Yamashina Masahiro、Kusaba Shunsuke、Akita Munetaka、Kikuchi Takashi、Yoshizawa Michito
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 4227-4227

    • DOI

      10.1038/s41467-018-06458-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hydrophilic Oligo(lactic acid)s Captured by a Hydrophobic Polyaromatic Cavity in Water2018

    • Author(s)
      Kusaba Shunsuke、Yamashina Masahiro、Akita Munetaka、Kikuchi Takashi、Yoshizawa Michito
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 14 Pages: 3706-3710

    • DOI

      10.1002/anie.201800432

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-Assembly Process of a Pd2L4 Capsule: Steric Interactions between Neighboring Components Favor the Formation of Large Intermediates2018

    • Author(s)
      Kai Shumpei、Nakagawa Masanori、Kojima Tatsuo、Li Xin、Yamashina Masahiro、Yoshizawa Michito、Hiraoka Shuichi
    • Journal Title

      Chemistry - A European Journal

      Volume: 24 Issue: 16 Pages: 3965-3969

    • DOI

      10.1002/chem.201705253

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exact mass analysis of sulfur clusters upon encapsulation by a polyaromatic capsular matrix2017

    • Author(s)
      Matsuno Sho、Yamashina Masahiro、Sei Yoshihisa、Akita Munetaka、Kuzume Akiyoshi、Yamamoto Kimihisa、Yoshizawa Michito
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 749-749

    • DOI

      10.1038/s41467-017-00605-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A polyaromatic nanocapsule as a sucrose receptor in water2017

    • Author(s)
      Masahiro Yamashina, Munetaka Akita, Taisuke Hasegawa, Shigehiko Hayashi, and Michito Yoshizawa*
    • Journal Title

      Science Advances

      Volume: 3 Issue: 8

    • DOI

      10.1126/sciadv.1701126

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Truncated Molecular Star2017

    • Author(s)
      Prusty Soumyakanta、Yazaki Kohei、Yoshizawa Michito、Chand Dillip Kumar
    • Journal Title

      Chemistry A European Journal

      Volume: 23 Issue: 51 Pages: 12456-12461

    • DOI

      10.1002/chem.201702264

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Polyaromatic molecular peanuts2017

    • Author(s)
      Yazaki Kohei、Akita Munetaka、Prusty Soumyakanta、Chand Dillip Kumar、Kikuchi Takashi、Sato Hiroyasu、Yoshizawa Michito
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 15914-15914

    • DOI

      10.1038/ncomms15914

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Unusual Host Functions of Polyaromatic Coordination Capsules in Water2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      The 2nd International Symposium on Coordination Asymmetry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Polyaromatic Nanocapsules with Unique Host Functions2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      4th International Symposium on Center of Excellence for Innovative Material Sciences Based on Supramolecules
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Phenomena within Polyaromatic Molecular Capsules2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      43rd International Conference on Coordination Chemistry (ICCC 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Polyaromatic Nanoflasks: from Strategic Synthesis to Host Functions2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      Department Seminar, University of Edinburgh
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Unusual Host Functions of Polyaromatic Coordination Capsules2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      The Third Japan-UK Joint Symposium on Coordination Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Polyaromatic Nanocapsules: from Strategic Synthesis to Host Functions2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      Department Seminar, University of Cambridge
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 多環芳香族ナノ空間を活用した水中での二糖認識2017

    • Author(s)
      山科雅裕・吉沢道人
    • Organizer
      第66回 高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多環芳香族ナノ空間のデザイン:アントラセンは便利な分子部品?2017

    • Author(s)
      吉沢道人
    • Organizer
      第3回 「高次複合光応答」若手の会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Anthracene‐based Supramolecular Capsules: Unusual Host Capabilities in Water」2017

    • Author(s)
      M. Yoshizawa
    • Organizer
      International Symposium on Pure & Applied Chemistry (ISPAC2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anthracene-based Supramolecular Nanostructures2017

    • Author(s)
      M. Yoshizawa
    • Organizer
      10th China-Japan Joint Symposium on Functional Supramolecular Architectures
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超分子カプセルの分子内包能と動的挙動2017

    • Author(s)
      林 重彦・吉沢道人
    • Organizer
      日本化学会 第97春季年会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 穐田・吉沢研究室ホームページ

    • URL

      http://www.res.titech.ac.jp/~smart/smartj.html

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2019-12-27  

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