キラルセンシングのためのキラル識別金属ナノ空間の構築

• Project Area: Coordination Asymmetry: Design of Asymmetric Coordination Sphere and Anisotropic Assembly for the Creation of Functional Molecules
• Project/Area Number: 17H05393
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: National Institute for Materials Science
• Principal Investigator: 山内 悠輔 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA主任研究者 (10455272)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ナノポーラス金属 / 多孔体

Outline of Annual Research Achievements

本研究では，メソポーラス金属にキラル選択性のある細孔表面を作り出し，キラルセンシングへの応用を目的としている．キラル認識は，電極表面のキラル認識部と認識対象となるキラル分子との親和力に鏡像体間で差が生じることから，認識に伴う出力信号の差をサイクリックボルタンメトリ（電気化学的な手法）により測定することで確認できる．具体的に実験では，メソポーラス金属の作製の際に，ブロックコポリマーを水溶液中でミセル化し，目的とする金属の金属塩類を溶解させた後，キラル分子をその溶液中に共存させ，金属の析出にそのキラル分子の転写を金属表面で行う．すなわち，それらの分子構造の転写された形（完全ではないものの）が金属骨格中に残る．このキラル分子転写した金属表面は，様々な生体物質のキラリティを判断することができることを確認した．

さらに，異なる細孔径や壁厚など，用いる界面活性剤の種類・分子量や金属イオンの種類・量を調整することにより，様々なメソポーラス金属の合成に成功した．特に，合金化することで，グルコースやDOPAなどの生体関連物質の酸化反応を大幅に促進させることができた．

また，リソグラフィー技術により，基板上に導電部位をパターンし，その上でのメソポーラス金属膜の成膜にも成功している．このようにパターンニングすることで，通常の薄膜よりも，ゲスト種がアクセスしやすい構造になっており，またデバイスの一部（検出部）として搭載することを考えた場合にも，非常に魅力的な構造と言える．また，高分子の薄膜を一層均一に塗布することで，食塩などの阻害物質の影響を抑えることにも成功し，実デバイスの設計を考えた上では重要な知見である．

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Synthesis and Characterization of Dendritic Pt Nanoparticles by Using Cationic Surfactant (2018)
  • Author(s): Kani Kenya、Zakaria Mohamed B.、Lin Jianjian、Alshehri Abdulmohsen Ali、Kim Jeonghun、Bando Yoshio、You Jungmok、Hossain Md Shahriar A.、Bo Jiang、Yamauchi Yusuke
  • Journal Title: Bulletin of the Chemical Society of Japan Volume: 91 Issue: 9 Pages: 1333-1336
  • DOI: 10.1246/bcsj.20180129
  • NAID: 130007484212
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Porous nanozymes: the peroxidase-mimetic activity of mesoporous iron oxide for the colorimetric and electrochemical detection of global DNA methylation (2018)
  • Author(s): Bhattacharjee Ripon、Tanaka Shunsuke、Moriam Sofia、Masud Mostafa Kamal、Lin Jianjian、Alshehri Saad M.、Ahamad Tansir、Salunkhe Rahul R.、Nguyen Nam-Trung、Yamauchi Yusuke、Hossain Md. Shahriar A.、Shiddiky Muhammad J. A.
  • Journal Title: Journal of Materials Chemistry B Volume: 6 Issue: 29 Pages: 4783-4791
  • DOI: 10.1039/c8tb01132j
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Emerging Pt-based electrocatalysts with highly open nanoarchitectures for boosting oxygen reduction reaction (2018)
  • Author(s): Li Cuiling、Tan Haibo、Lin Jianjian、Luo Xiliang、Wang Shengping、You Jungmok、Kang Yong-Mook、Bando Yoshio、Yamauchi Yusuke、Kim Jeonghun
  • Journal Title: Nano Today Volume: 21 Pages: 91-105
  • DOI: 10.1016/j.nantod.2018.06.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] In situ coating of a continuous mesoporous bimetallic PtRu film on Ni foam: a nanoarchitectured self-standing all-metal mesoporous electrode (2018)
  • Author(s): Wang Hongjing、Yu Hongjie、Yin Shuli、Xu You、Li Xiaonian、Yamauchi Yusuke、Xue Hairong、Wang Liang
  • Journal Title: Journal of Materials Chemistry A Volume: 6 Issue: 26 Pages: 12744-12750
  • DOI: 10.1039/c8ta03413c
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stable Blue Luminescent CsPbBr3 Perovskite Nanocrystals Confined in Mesoporous Thin Films (2018)
  • Author(s): Malgras Victor、Henzie Joel、Takei Toshiaki、Yamauchi Yusuke
  • Journal Title: Angewandte Chemie International Edition Volume: 57 Issue: 29 Pages: 8881-8885
  • DOI: 10.1002/anie.201802335
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Electrochemical Deposition: An Advanced Approach for Templated Synthesis of Nanoporous Metal Architectures (2018)
  • Author(s): Li Cuiling、Iqbal Muhammad、Lin Jianjian、Luo Xiliang、Jiang Bo、Malgras Victor、Wu Kevin C.-W.、Kim Jeonghun、Yamauchi Yusuke
  • Journal Title: Accounts of Chemical Research Volume: 51 Issue: 8 Pages: 1764-1773
  • DOI: 10.1021/acs.accounts.8b00119
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Micelle-Assisted Strategy for the Direct Synthesis of Large-Sized Mesoporous Platinum Catalysts by Vapor Infiltration of a Reducing Agent (2018)
  • Author(s): Li Yunqi、Liu Yuwei、Yamauchi Yusuke、Kaneti Yusuf、Alsheri Saad、Ahamad Tansir、Alhokbany Norah、Kim Jeonghun、Ariga Katsuhiko、Wu Ning、Xu Jun
  • Journal Title: Nanomaterials Volume: 8 Issue: 10 Pages: 841-841
  • DOI: 10.3390/nano8100841
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Electrochemical Synthesis of Mesoporous Au-Cu Alloy Films with Vertically Oriented Mesochannels Using Block Copolymer Micelles (2018)
  • Author(s): Nugraha Asep Sugih、Malgras Victor、Iqbal Muhammad、Jiang Bo、Li Cuiling、Bando Yoshio、Alshehri Abdulmohsen、Kim Jeonghun、Yamauchi Yusuke、Asahi Toru
  • Journal Title: ACS Applied Materials & Interfaces Volume: 10 Issue: 28 Pages: 23783-23791
  • DOI: 10.1021/acsami.8b05517
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Standing Mesochannels: Mesoporous PdCu Films with Vertically Aligned Mesochannels from Nonionic Micellar Solutions (2018)
  • Author(s): Iqbal Muhammad、Kim Jeonghun、Yuliarto Brian、Jiang Bo、Li Cuiling、Dag Omer、Malgras Victor、Yamauchi Yusuke
  • Journal Title: ACS Applied Materials & Interfaces Volume: 10 Issue: 47 Pages: 40623-40630
  • DOI: 10.1021/acsami.8b13662
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Tailored Design of Bicontinuous Gyroid Mesoporous Carbon and Nitrogen-Doped Carbon from Poly(ethylene oxide-b-caprolactone) Diblock Copolymers (2017)
  • Author(s): Chu Wei-Cheng, Bastakoti Bishnu Prasad, Kaneti Yusuf Valentino, Li Jheng-Guang, Alamri Hatem R., Alothman Zeid A., Yamauchi Yusuke, Kuo Shiao-Wei
  • Journal Title: Chemistry - A European Journal Volume: 23 Issue: 55 Pages: 13734-13741
  • DOI: 10.1002/chem.201702360
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Three-Dimensional Networked Metal-Organic Frameworks with Conductive Polypyrrole Tubes for Flexible Supercapacitors (2017)
  • Author(s): Xu Xingtao、Tang Jing、Qian Huayu、Hou Shujin、Bando Yoshio、Hossain Md. Shahriar A.、Pan Likun、Yamauchi Yusuke
  • Journal Title: ACS Applied Materials & Interfaces Volume: 9 Issue: 44 Pages: 38737-38744
  • DOI: 10.1021/acsami.7b09944
• [Journal Article] Mesoporous Semimetallic Conductors: Structural and Electronic Properties of Cobalt Phosphide Systems (2017)
  • Author(s): Malay Pramanik, Satoshi Tominaka, Zhong-Li Wang, Toshiaki Takei, Yusuke Yamauchi
  • Journal Title: Angewandte Chemie International Edition Volume: ---- Issue: 43 Pages: 13693-13697
  • DOI: 10.1002/ange.201707878
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Block-Copolymer-Assisted Electrochemical Synthesis of Mesoporous Gold Electrodes: Towards a Non-Enzymatic Glucose Sensor (2017)
  • Author(s): Nugraha Asep Sugih、Li Cuiling、Bo Jiang、Iqbal Muhammad、Alshehri Saad M.、Ahamad Tansir、Malgras Victor、Yamauchi Yusuke、Asahi Toru
  • Journal Title: ChemElectroChem Volume: 4 Issue: 10 Pages: 2571-2576
  • DOI: 10.1002/celc.201700548
• [Journal Article] A Simple Approach to Generate Hollow Carbon Nanospheres Loaded with Uniformly Dispersed Metal Nanoparticles (2017)
  • Author(s): Li Yunqi、Tan Haibo、Takei Toshiaki、Hossain Md. Shahriar A.、Islam Md. Tofazzal、Alshehri Saad M.、Ahamad Tansir、Salunkhe Rahul R.、Pradhan Subrata、Henzie Joel、Yamauchi Yusuke、Ariga Katsuhiko
  • Journal Title: European Journal of Inorganic Chemistry Volume: 2017 Issue: 45 Pages: 5413-5416
  • DOI: 10.1002/ejic.201700921
• [Journal Article] Fabrication of Mesoporous Cu Films on Cu Foils and Their Applications to Dopamine Sensing (2017)
  • Author(s): Baba Daisuke、Li Cuiling、Malgras Victor、Jiang Bo、Alamri Hatem R.、Alothman Zeid A.、Hossain Md. Shahriar A.、Yamauchi Yusuke、Asahi Toru
  • Journal Title: Chemistry - An Asian Journal Volume: 12 Issue: 18 Pages: 2467-2470
  • DOI: 10.1002/asia.201700862
• [Journal Article] Strategies for Improving the Functionality of Zeolitic Imidazolate Frameworks: Tailoring Nanoarchitectures for Functional Applications (2017)
  • Author(s): Kaneti Yusuf Valentino, Dutta Saikat, Hossain Md. S. A., Shiddiky Muhammad J. A., Tung Kuo-Lun, Shieh Fa-Kuen, Tsung Chia-Kuang, Wu Kevin C.-W., Yamauchi Yusuke
  • Journal Title: Advanced Materials Volume: 29 Issue: 38 Pages: 1700213-1700213
  • DOI: 10.1002/adma.201700213
  • Peer Reviewed / Int'l Joint Research