MCH neurons ablation improve memory function by function shift

• Project Area: Mechanisms underlying the functional shift of brain neural circuitry for behavioral adaptation
• Project/Area Number: 17H05563
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Nagoya University
• Principal Investigator: 山中 章弘 名古屋大学, 環境医学研究所, 教授 (60323292)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 視床下部 / MCH神経 / 記憶 / マウス / アデノ随伴ウイルスベクター / 光遺伝学 / 化学遺伝学 / ファイバーフォトメトリー / 睡眠覚醒 / メラニン凝集ホルモン / 薬理遺伝学 / 電気生理学

Outline of Annual Research Achievements

遺伝子操作によって記憶力が悪くなる動物はたくさん存在するが、記憶力が良くなる例は数少ない。メラニン凝集ホルモン産生神経(MCH神経)は、視床下部だけに少数の細胞体が存在し、睡眠中に活性化される。MCH神経の生理的役割解明のために、MCH神経を時期特異的に脱落させたマウスを作成したところ、記憶が有意に良くなることを見いだした。このことは、レム睡眠中のMCH神経活動が、記憶抑制・消去に関わっていることを示している。本研究では、MCH神経脱落により、神経回路の機能シフトが生じ、記憶が向上するメカニズムに迫り、睡眠と記憶消去との関係も明らかにすることを目的としている。MCH神経の活動を光遺伝学、化学遺伝学にて操作可能なマウスを作出し、神経活動操作を行った。その結果、MCH神経活動を活性化させると、海馬依存的な記憶が阻害・消去されること、逆に抑制すると記憶が向上することを見いだした。これらの結果から、MCH神経活動が海馬において記憶制御に関わっていることを示している。さらに、MCH神経活動をカルシウムインジケータであるGCaMP6を用いてインビボ記録するファイバーフォトメトリーを適用し、脳波筋電図記録による睡眠解析と同時に行ったところ、MCH神経活動がレム睡眠中、覚醒中に高くなることを見いだした。そこで、MCH神経活動をレム睡眠中、覚醒時それぞれにおいて光遺伝学で抑制を行った。その結果、レム睡眠中のMCH神経活動を抑制すると海馬依存的な記憶に影響があることを見いだした。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo (2019)
  • Author(s): Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, *Yawo H
  • Journal Title: J Physiol Sci Volume: 69(1) Issue: 1 Pages: 65-77
  • DOI: 10.1007/s12576-018-0618-4
  • NAID: 40021804699
  • Peer Reviewed
• [Journal Article] Large Timescale Interrogation of Neuronal Function by Fiberless Optogenetics Using Lanthanide Micro-particles (2019)
  • Author(s): Toh Miyazaki, Srikanta Chowdhury, Takayuki Yamashita, Takanori Matsubara, Hiromu Yawo, Hideya Yuasa and Akihiro Yamanaka
  • Journal Title: Cell Reports Volume: 26 Issue: 4 Pages: 1033-1043
  • DOI: 10.1016/j.celrep.2019.01.001
  • Peer Reviewed / Open Access
• [Journal Article] Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning. 2019 (in press) (2019)
  • Author(s): Macpherson T, Mizoguchi H, Yamanaka A, Hikida T
  • Journal Title: Neurochem Int Volume: 126 Pages: 11-18
  • DOI: 10.1016/j.neuint.2019.02.011
  • Peer Reviewed / Open Access
• [Journal Article] Upconversion Amplification through Dielectric Superlensing Modulation (2019)
  • Author(s): Liang L, Teh DBL, Dinh ND, Chen W, Chen Q, Wu Y, Chowdhury S, Yamanaka A, Sum TC, Chen CH, Thakor NV, All AH, Liu X
  • Journal Title: Nat Commun Volume: 10(1) Issue: 1 Pages: 1391-1391
  • DOI: 10.1038/s41467-019-09345-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Opposing roles of dopamine receptor D1- and D2-expressing neurons of the anteromedial olfactory tubercle in acquisition of place preference (2019)
  • Author(s): Koshi Murata, Tomoki Kinoshita, Yugo Fukazawa, Kenta Kobayashi, Akihiro Yamanaka, Takatoshi Hikida, Hiroyuki Manabe, and Masahiro Yamaguchi
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 13 Pages: 50-50
  • DOI: 10.3389/fnbeh.2019.00050
  • Peer Reviewed / Open Access
• [Journal Article] Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice (2019)
  • Author(s): Zhang Tong、Yanagida Junko、Kamii Hironori、Wada Shintaro、Domoto Masaki、Sasase Hitoki、Deyama Satoshi、Takarada Takeshi、Hinoi Eiichi、Sakimura Kenji、Yamanaka Akihiro、Maejima Takashi、Mieda Michihiro、Sakurai Takeshi、Nishitani Naoya、Nagayasu Kazuki、Kaneko Shuji、Minami Masabumi、Kaneda Katsuyuki
  • Journal Title: Addiction Biology Volume: 印刷中 Issue: 1 Pages: 1-11
  • DOI: 10.1111/adb.12723
  • Peer Reviewed / Open Access
• [Journal Article] Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience (2018)
  • Author(s): Miyazaki K*, Miyazaki KW*, Yamanaka A, Tokuda T, Tanaka KF, Doya K *These authors contributed equally to this work.
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 2048-2048
  • DOI: 10.1038/s41467-018-04496-y
  • Peer Reviewed / Open Access
• [Journal Article] Partial ablation of the orexin field induces a sub narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration (2018)
  • Author(s): Black SW,* Sun JD, Santiago P, Laihsu A, Kimura N, Yamanaka A, Bersot R, Humphries PS
  • Journal Title: Sleep Volume: 41(9) Issue: 9
  • DOI: 10.1093/sleep/zsy116
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Inactivation of Serotonergic Neurons in the Rostral Medullary Raph? Attenuates Stress-Induced Tachypnea and Tachycardia in Mice (2018)
  • Author(s): Ikoma Yoko、Kusumoto-Yoshida Ikue、Yamanaka Akihiro、Ootsuka Youichirou、Kuwaki Tomoyuki
  • Journal Title: Frontiers in Physiology Volume: 9 Pages: 1-16
  • DOI: 10.3389/fphys.2018.00832
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Acute aversive stimuli rapidly increase the activity of ventral tegmental area dopamine neurons in awake mice. (2018)
  • Author(s): *Moriya S, Yamashita A, Kawashima S, Nishi R, Yamanaka A, Kuwaki T
  • Journal Title: Neuroscience Volume: 386 Pages: 16-23
  • DOI: 10.1016/j.neuroscience.2018.06.027
  • Peer Reviewed / Open Access
• [Journal Article] Parallel arousal pathways in the lateral hypothalamus (2018)
  • Author(s): Heiss JE, Yamanaka A, *Kilduff TS
  • Journal Title: eNeuro Volume: 5(4) Issue: 4 Pages: 0228-18
  • DOI: 10.1523/eneuro.0228-18.2018
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys (2018)
  • Author(s): Kondo T, Saito R, Otaka M, Yoshino-Saito K, Yamanaka A, Yamamori T, Watakabe A, Mizukami H, Schnitzer MJ, Tanaka KF, *Ushiba J, *Okano H
  • Journal Title: Cell Rep Volume: 24(8) Issue: 8 Pages: 2191-2195
  • DOI: 10.1016/j.celrep.2018.07.057
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy (2018)
  • Author(s): Thannickal Thomas C.、John Joshi、Shan Ling、Swaab Dick F.、Wu Ming-Fung、Ramanathan Lalini、McGregor Ronald、Chew Keng-Tee、Cornford Marcia、Yamanaka Akihiro、Inutsuka Ayumu、Fronczek Rolf、Lammers Gert Jan、Worley Paul F.、Siegel Jerome M.
  • Journal Title: Science Translational Medicine Volume: 10 Issue: 447 Pages: 447-447
  • DOI: 10.1126/scitranslmed.aao4953
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice (2018)
  • Author(s): Matsui Sho、Sasaki Tsutomu、Kohno Daisuke、Yaku Keisuke、Inutsuka Ayumu、Yokota-Hashimoto Hiromi、Kikuchi Osamu、Suga Takayoshi、Kobayashi Masaki、Yamanaka Akihiro、Harada Akihiro、Nakagawa Takashi、Onaka Tatsushi、Kitamura Tadahiro
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 1-17
  • DOI: 10.1038/s41467-018-07033-z
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia (2018)
  • Author(s): Futatsuki Takahiro、Yamashita Akira、Ikbar Khairunnisa Novita、Yamanaka Akihiro、Arita Kazunori、Kakihana Yasuyuki、Kuwaki Tomoyuki
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 2717-2717
  • DOI: 10.1038/s41598-018-21252-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors. (2018)
  • Author(s): Suda Y, Kuzumaki N, Narita M, Hamada Y, Shibasaki M, Tanaka K, Tamura H, Kawamura T, Kondo T, Yamanaka A, Narita M.
  • Journal Title: Biochem Biophys Res Commun. Volume: 496 Issue: 4 Pages: 1102-1108
  • DOI: 10.1016/j.bbrc.2018.01.145
  • Peer Reviewed
• [Journal Article] Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer (2018)
  • Author(s): Watanabe Moe、Narita Michiko、Hamada Yusuke、Yamashita Akira、Tamura Hideki、Ikegami Daigo、Kondo Takashige、Shinzato Tatsuto、Shimizu Takatsune、Fukuchi Yumi、Muto Akihiro、Okano Hideyuki、Yamanaka Akihiro、Tawfik Vivianne L、Kuzumaki Naoko、Navratilova Edita、Porreca Frank、Narita Minoru
  • Journal Title: Molecular Pain Volume: 14 Pages: 1-10
  • DOI: 10.1177/1744806918756406
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system (2018)
  • Author(s): Watanabe M, Sugiura Y, Sugiyama E, Narita M, Navratilova E, Kondo T, Uchiyama N, Yamanaka A, Kuzumaki N, Porreca F, Narita M
  • Journal Title: Molecular Pain Volume: 14 Pages: 1-10
  • DOI: 10.1177/1744806918754934
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sex differences in olfactory-induced neural activation of the amygdala. (2018)
  • Author(s): Kikusui T, Kajita M, Otsuka N, Hattori T, Kumazawa K, Watarai A, Nagasawa M, Inutsuka A, Yamanaka A, Matsuo N, Covington HE 3rd, Mogi K.
  • Journal Title: Behav Brain Res. Volume: 27 Pages: 96-104
  • DOI: 10.1016/j.bbr.2017.11.034
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optogenetic identification of hypothalamic orexin neuron projections to paraventricular spinally projecting neurons. (2017)
  • Author(s): Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, *Mendelowitz D.
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 312 Issue: 4 Pages: H808-H817
  • DOI: 10.1152/ajpheart.00572.2016
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lateral hypothalamic circuits for sleep-wake control. (2017)
  • Author(s): Yamashita T, *Yamanaka A.
  • Journal Title: Current Opinion in Neurobiology Volume: 44 Pages: 94-100
  • DOI: 10.1016/j.conb.2017.03.020
  • Peer Reviewed
• [Journal Article] Hypothalamic regulation of the sleep/wake cycle. (2017)
  • Author(s): Ono D, *Yamanaka A.
  • Journal Title: Neurosci Res Volume: 118 Pages: 74-81
  • DOI: 10.1016/j.neures.2017.03.013
  • NAID: 120006349128
  • Peer Reviewed
• [Journal Article] オレキシン神経活動操作による機能解明. (2017)
  • Author(s): 山中章弘
  • Journal Title: 睡眠医療 Volume: 11(1) Pages: 19-25
• [Journal Article] 光遺伝学による神経科学研究の新展開. (2017)
  • Author(s): 山中章弘
  • Journal Title: 医学のあゆみ Volume: 262(5) Pages: 491-495
• [Journal Article] 光遺伝学による睡眠覚醒の制御. (2017)
  • Author(s): 山中章弘
  • Journal Title: 生体の科学 Volume: 65(5) Pages: 484-485
• [Journal Article] 睡眠のマニピュレーション-光遺伝学、薬理遺伝学を用いた睡眠覚醒の操作. (2017)
  • Author(s): 山中章弘
  • Journal Title: 医学のあゆみ Volume: 263(9) Pages: 765-774
• [Journal Article] Oxytocin-Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice (2017)
  • Author(s): Nasanbuyan Naranbat、Yoshida Masahide、Takayanagi Yuki、Inutsuka Ayumu、Nishimori Katsuhiko、Yamanaka Akihiro、Onaka Tatsushi
  • Journal Title: Endocrinology Volume: 159 Issue: 2 Pages: 763-775
  • DOI: 10.1210/en.2017-00606
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Purkinje cells in the mouse cerebellar vermis directly project their axons to medial parabrachial nucleus. (2017)
  • Author(s): Hashimoto, M., Yamanaka, A., Tanifuji, M., Yaginuma, H.
  • Journal Title: Front Neural Circuit, Volume: 12 Pages: 00006-00006
  • DOI: 10.3389/fncir.2018.00006
  • Peer Reviewed / Open Access
• [Journal Article] Challenges in the development of therapeutics for narcolepsy (2015)
  • Author(s): Black SW, Yamanaka A, Kilduff TS
  • Journal Title: Prog Neurobiol Volume: 印刷中 Pages: 89-113
  • DOI: 10.1016/j.pneurobio.2015.12.002
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 睡眠覚醒調節と記憶の制御に関わる神経の活動記録と操作 (2019)
  • Author(s): 山中章弘
  • Organizer: 平成30年度生命融合科学教育部シンポジウム 神経科学が解き明かす動物の行動：機能の変容と疾患
  • Invited
• [Presentation] 睡眠覚醒調節神経の機能的同定 (2019)
  • Author(s): 山中章弘
  • Organizer: 第92回日本薬理学会年会
  • Invited
• [Presentation] Adeno-associated virus vector micro injection into mice brain to reveal function of neural circuitry involved in the regulation of sleep/wakefulness. (2019)
  • Author(s): Yamanaka A
  • Organizer: FAOPS2019
  • Int'l Joint Research / Invited
• [Presentation] Regulation of sleep and memory (2018)
  • Author(s): Yamanaka A
  • Organizer: 第10回光操作研究会・第2回脳情報動態合同国際シンポジウムJoint symposium of 10th Optogenetics Research Conference and Second International Symposium on Brain Information Dynamics 2018
  • Int'l Joint Research / Invited
• [Presentation] Dissociating orexin-dependent and -independent functions of orexin neurons using novel orexin-Flp knock-in mice (2018)
  • Author(s): Yamanaka A
  • Organizer: 7th International Symposium on Narcolepsy
  • Int'l Joint Research / Invited
• [Presentation] Sleep/wakefulness analysis of orexin and MCH neurons double ablated mice (2018)
  • Author(s): Hung CJ, Ono D, Yamanaka A
  • Organizer: 7th International Symposium on Narcolepsy
  • Int'l Joint Research / Invited
• [Presentation] Orexin and MCH neurons double ablation mice. Isolation of effect of orexin using orexin-Flippase mice. (2018)
  • Author(s): Yamanaka A
  • Organizer: 7th International Symposium on Narcolepsy
  • Int'l Joint Research / Invited
• [Presentation] Neural activity manipulation and behavior control by using fiber-less optogenetics (2018)
  • Author(s): Yamanaka A
  • Organizer: National University of Singapore, Department of Chemistry, Research Seminar
  • Int'l Joint Research / Invited
• [Presentation] Regulatory mechanism of sleep/wakefulness and memory by the hypothalamic neurons (2018)
  • Author(s): 山中章弘
  • Organizer: 島根大学セミナー
  • Invited
• [Presentation] 睡眠覚醒調節、痛み調節におけるオレキシンの役割 (2018)
  • Author(s): 山中章弘
  • Organizer: 第12回日本緩和医療薬学会年会
  • Invited
• [Presentation] 睡眠覚醒調節におけるオレキシンの役割 (2018)
  • Author(s): 山中章弘
  • Organizer: 第41回日本神経科学大会 ランチョンセミナー10
  • Invited
• [Presentation] Role of cholinergic neurons in the septum on the regulation of sleep and memory (2018)
  • Author(s): 山中章弘、宮﨑杜夫
  • Organizer: 第41回日本神経科学大会 シンポジウム： 神経修飾物質による脳状態制御： 先進的実験と計算論的アプローチを結ぶ
  • Invited
• [Presentation] アップコンバージョンを用いたファイバーレス光遺伝学の開発 (2018)
  • Author(s): 宮﨑杜夫、Chowdhury Srikanta、山下貴之、八尾 寛、湯浅英哉、山中章弘
  • Organizer: 第56回日本生物物理学会年会
  • Invited
• [Presentation] Study of regulatory mechanism of sleep/wakefulness and memory by optogenetical neural activity manipulation (2018)
  • Author(s): 山中章弘
  • Organizer: 第91回日本生化学会大会
  • Invited
• [Presentation] 内側中核アセチルコリン作動性神経による睡眠と記憶の制御 (2018)
  • Author(s): 山中章弘
  • Organizer: 記憶研究会2018 記憶・学習の基盤機構と回路研究の新展開へのアプローチ
  • Invited
• [Presentation] 睡眠と記憶を制御する神経活動の操作と記録 (2018)
  • Author(s): 山中章弘
  • Organizer: 第８回生理学研究所・名古屋大学医学系研究科合同シンポジウム
  • Invited
• [Presentation] 睡眠と記憶を制御する神経活動の操作と記録 (2018)
  • Author(s): 山中章弘
  • Organizer: 星薬科大学セミナー
  • Invited
• [Presentation] ファイバーレス光遺伝学を用いた睡眠覚醒と記憶制御のメカニズム解明 (2018)
  • Author(s): 山中章弘
  • Organizer: 第三回ルミノジェネティクス研究会
  • Invited
• [Presentation] 生活習慣病と睡眠覚醒とのただならぬ関係 (2018)
  • Author(s): 山中章弘
  • Organizer: 第3回Cortin Conference
  • Invited
• [Presentation] 腹側被蓋野(VTA)のGABA作動性神経はノンレム睡眠を調節する (2018)
  • Author(s): 山中章弘
  • Organizer: 平成30年度脳研究所共同利用共同研究合同セミナー
  • Invited
• [Presentation] Remote control of deep brain function using scintillation (2018)
  • Author(s): 山下貴之
  • Organizer: 遺伝研研究会「哺乳類脳の機能的神経回路の構築メカニズム」
  • Invited
• [Presentation] オレキシンとは？睡眠覚醒調節における役割について. (2018)
  • Author(s): 山中章弘
  • Organizer: 第70回九州精神神経学会 第63回九州精神医療学会
  • Invited
• [Presentation] 光遺伝学、薬理遺伝学による特定神経活動操作を用いた睡眠覚醒、リズム研究. (2018)
  • Author(s): 山中章弘
  • Organizer: 時間学特別セミナー
  • Invited
• [Presentation] Regulatory mechanism of sleep/wakefulness and memory. (2018)
  • Author(s): Yamanaka A
  • Organizer: The BRI International Symposium 2018 "The innovative progress of neuroscientific research through the use of advanced animal models"
  • Int'l Joint Research / Invited
• [Presentation] 起きるべきか？、寝るべきか？、それが問題だ. (2018)
  • Author(s): 山中章弘
  • Organizer: 第二回名古屋リズム研究会
  • Invited
• [Presentation] ファイバーレス光遺伝学を用いた神経活動操作と行動制御. (2018)
  • Author(s): 山中章弘
  • Organizer: 第123回日本解剖学会総会・全国学術集会
  • Invited
• [Presentation] Optogenetics and pharmacogenetics reveals regulatory mechanism of sleep/wakefulness and memory. (2017)
  • Author(s): Yamanaka A
  • Organizer: Cell biology and systems biology course meeting
  • Int'l Joint Research / Invited
• [Presentation] Hypothalamic neurons erase memory during sleep. (2017)
  • Author(s): Yamanaka A
  • Organizer: New York University Seminar
  • Int'l Joint Research / Invited
• [Presentation] Hypothalamic neurons regulate sleep/wakefulness and memory. (2017)
  • Author(s): Yamanaka A
  • Organizer: Mount Sinai seminar
  • Int'l Joint Research / Invited
• [Presentation] The physiological role of orexinergic neurons in the regulation of sleep wakefulness, pain and metabolism. (2017)
  • Author(s): Yamanaka A
  • Organizer: International Conference of Sleep Medicine and Research (ISSR 2017)
  • Int'l Joint Research / Invited
• [Presentation] Generation of sleep disorder model mice by ablation of specific types of neurons. (2017)
  • Author(s): Yamanaka A
  • Organizer: World Sleep
  • Int'l Joint Research / Invited
• [Presentation] Regulatory mechanism of sleep and memory by the hypothalamic neurons. (2017)
  • Author(s): Yamanaka A
  • Organizer: World Sleep
  • Int'l Joint Research / Invited
• [Presentation] Regulatory mechanism of sleep/wakefulness by the hypothalamic neuropeptide-producing neurons. (2017)
  • Author(s): Yamanaka A
  • Organizer: 120th WPI-IIIS Seminar
  • Int'l Joint Research / Invited
• [Presentation] オレキシン神経活動の操作と記録～摂食行動ー睡眠覚醒調節における役割の解明～. (2017)
  • Author(s): 山中章弘
  • Organizer: 第15回桜山睡眠研究会
  • Invited
• [Presentation] 視床下部神経による摂食代謝・睡眠覚醒・記憶の制御. (2017)
  • Author(s): 山中章弘
  • Organizer: 第27回日本行動神経内分泌研究会 教育講演
  • Invited
• [Presentation] 光遺伝学・薬理遺伝学を用いた睡眠覚醒と記憶の制御. (2017)
  • Author(s): 山中章弘
  • Organizer: 島根大学大学院セミナー
  • Invited
• [Presentation] 技術革新が切り拓く最新神経科学研究. (2017)
  • Author(s): 山中章弘
  • Organizer: 星薬科大学薬理学教室 平成29年度同門会学術セミナー
  • Invited
• [Presentation] 光遺伝学・薬理遺伝学を用いた睡眠覚醒と記憶の制御：メカニズム解明. (2017)
  • Author(s): 山中章弘
  • Organizer: 第64回日本実験動物学会総会
  • Invited
• [Presentation] 特定神経活動操作で迫る. (2017)
  • Author(s): 山中章弘
  • Organizer: 代謝疾患フォーラム2017
  • Invited
• [Presentation] アップコンバージョンを用いたファイバーレス光遺伝学の開発と応用. (2017)
  • Author(s): 山中章弘
  • Organizer: 第二回ルミノジェネティクス研究会
  • Invited
• [Presentation] オレキシンとは？睡眠覚醒調節における役割ついて. (2017)
  • Author(s): 山中章弘
  • Organizer: Tochigi Insomnia研究会2017
  • Invited
• [Presentation] オレキシンとは？睡眠覚醒調節における役割について. (2017)
  • Author(s): 山中章弘
  • Organizer: SLEEP SYMPOSIUM 2017
  • Invited
• [Presentation] 視床下部神経による睡眠覚醒調節と記憶の制御. (2017)
  • Author(s): 山中章弘
  • Organizer: 第40回日本神経科学大会
  • Invited
• [Presentation] ファイバーレス光遺伝学の開発. (2017)
  • Author(s): 山中章弘
  • Organizer: 第4回包括的緩和医療科学学術研究会・第5回Tokyo 疼痛緩和次世代研究会 合同研究会
  • Invited
• [Presentation] オレキシン神経に対するドーパミンの長期的作用の解析. (2017)
  • Author(s): 山中章弘、向井康敬
  • Organizer: 第52回日本アルコール・アディクション医学会学術総会
  • Invited
• [Presentation] 光遺伝学・薬理遺伝学を用いた睡眠覚醒調節メカニズムの解明. (2017)
  • Author(s): 山中章弘
  • Organizer: 第47回日本小児神経学会小児神経学セミナー
  • Invited
• [Presentation] 視床下部神経による睡眠と記憶の制御. (2017)
  • Author(s): 山中章弘
  • Organizer: 第47回日本神経精神薬理学会
  • Invited
• [Presentation] オレキシンとは？睡眠覚醒調節における役割について. (2017)
  • Author(s): 山中章弘
  • Organizer: 香川県睡眠治療セミナー
  • Invited
• [Presentation] オレキシンとは？睡眠覚醒調節における役割について. (2017)
  • Author(s): 山中章弘
  • Organizer: 第6回世田谷クリニカルフォーラム
  • Invited
• [Presentation] 視床下部神経による睡眠覚醒・記憶・代謝内分泌調節. (2017)
  • Author(s): 山中章弘
  • Organizer: 第42回日本比較内分泌学会
  • Invited
• [Presentation] 光遺伝学・光生理による睡眠覚醒と記憶の制御メカニズム解明. (2017)
  • Author(s): 山中章弘
  • Organizer: 日本比較生理生化学会 第39回福岡大会
  • Invited
• [Presentation] シングルセル解析による本能行動に関わる視床下部神経回路の機能解明. (2017)
  • Author(s): 山中章弘
  • Organizer: 2017年度生命科学系学会合同年次大会
  • Invited
• [Presentation] ファイバーレス光遺伝学を用いた神経活動操作と行動制御. (2017)
  • Author(s): 山中章弘
  • Organizer: 光量子工学研究領域セミナー
  • Invited