Hypothalamic control of hippocampal action selection

• Project Area: Mechanisms underlying the functional shift of brain neural circuitry for behavioral adaptation
• Project/Area Number: 17H05591
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: decision making / hypothalamus / hippocampus / social behavior / spatial behavior / supramammillary nucleus / optogenetics

Outline of Annual Research Achievements

We have made great progress on this project. Using viral mediated circuit mapping, activity dependent cellular labeling, behavior and in vivo optogenetics and electrophysiology we have collected a comprehensive data set on the function of the SuM to hippocampal circuits. Our findings demonstrate the SuM can signal environmental novelty to the hippocampus. Unique about this signal is that the SuM can segregate and selectively route different types of information to the dentate gyrus (DG; context novelty) and CA2 (social novelty) for the modulation of mnemonic processing. This content-specific routing of novelty signals represents a new type of modulation of hippocampal processing. A manuscript detailing this findings is currently under peer review. In parallel we have used the efforts of this grant to help our published work demonstrating the application of up-conversion nanoparticles (UCNPs) as a method for minimally-invasive optogenetics (Chen et al, Science 2018).

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics. (2018)
  • Author(s): Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, McHugh TJ.
  • Journal Title: Science Volume: 359 Issue: 6376 Pages: 679-684
  • DOI: 10.1126/science.aaq1144
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Minimally Invasive optogenetics (2018)
  • Author(s): Thomas McHugh
  • Organizer: The Korean Society for Brain and Neural Sciences Meeting
  • Int'l Joint Research
• [Presentation] Information routing in the hippocampus (2018)
  • Author(s): Thomas McHugh
  • Organizer: UCSF Neuroscience Program
  • Invited
• [Presentation] Divergent Information Routing by a Hypothalamo-Hippocampal Circuit During Spatial and Social Memory (2017)
  • Author(s): Linmeng He, Shuo Chen, Marie E. Wintzer, Yanqiu Tao, Hiroshi Hama, Kana Namiki, Atsushi Miyawaki, Roman Boehringer, Denis Polygalov, Arthur J.Y. Huang, Thomas J. McHugh
  • Organizer: Japan Neuroscience Society
  • Int'l Joint Research