ネオ・セルフ生成機構としての免疫プロテアソームの機能的意義

• Project Area: Creation, function and structure of neo-self
• Project/Area Number: 17H05799
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Wakayama Medical University
• Principal Investigator: 改正 恒康 和歌山県立医科大学, 先端医学研究所, 教授 (60224325)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 炎症 / 自己炎症性疾患 / 免疫プロテアソーム / T細胞 / 遺伝子変異 / プロテアソーム / 抗原提示

Outline of Annual Research Achievements

免疫プロテアソームはいくつかのサブユニットから構成されるタンパク複合体であり、不要または不良のタンパク質の分解除去と共に、MHCクラスIと会合する抗原の生成にも必須であり、ネオセルフの生成にも重要な役割を果たしていると考えられる。免疫プロテアソームのサブユニットの変異により難治性の炎症性疾患が生じることがわかってきており、そのような疾患群をproteasome-associated autoinflammatory syndrome (PRAAS)と総称することが提唱されている。我々は、PRAAS様の症状を呈する患者においてみとめられた、免疫プロテアソームのサブユニットβ1iのアミノ酸置換をきたすde novoの新規のヘテロ遺伝子変異（β1iX）を、CRISPR法によりマウスに導入した。β1iXヘテロ変異マウスは外見には特に異常を認めなかったが、胸腺の細胞数が顕著に減少し、皮髄境界が不明瞭になっていた。また、脾臓においては、CD8陽性T細胞ばかりでなく、CD4陽性T細胞、B細胞の減少が認められ、濾胞の形成が障害されていた。さらに血中では、IgMを含むすべてのアイソタイプの免疫グロブリンが低下していた。一方、脾臓や骨髄などで、好中球、単球など骨髄系の細胞の増加が認められた。これらのマウスの表現型は、患者の症状に似た点が多く認められた。これまでに報告されている免疫プロテアソームのサブユニット欠損マウスでは、CD8陽性T細胞の減少以外の表現型はほとんど報告されていないことから、β1iXヘテロ変異により、単に免疫プロテアソームの機能低下が生じたのではなく、機能修飾が生じている可能性が示唆された。β1iXヘテロ変異マウスの解析をネオセルフの生成という観点から進めることにより、PRAASの病態と共に、免疫プロテアソームの新たな役割が明らかになることが期待される。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Yale Univ./Harvard Medical School/Emory Univ.(米国)
• [Int'l Joint Research] Univ.of Melbourne/Australian National Univ./Telethon Kids Institute(オーストラリア)
• [Int'l Joint Research] Mainz Univ./Bonn Univ./Univ. Hospital Cologne(ドイツ)
• [Int'l Joint Research] London Research Institute/Imperial College/Cardiff Univ.(英国)
• [Int'l Joint Research] San Raffaele Scientific Institute/ICGEB(イタリア)
• [Int'l Joint Research]
• [Int'l Joint Research] Yale Univ./Harvard Medical School/Emory University(米国)
• [Int'l Joint Research] Univ. of Melbourne/Australian National University/Telethon Kids Institute(Australia)
• [Int'l Joint Research] Mainz Univ/Bonn Univ/University Hospital Cologne(Germany)
• [Int'l Joint Research] San Raffaele Scientific Institute(Italy)
• [Int'l Joint Research] London Research Institute(英国)
• [Int'l Joint Research]
• [Journal Article] A defined commensal consortium elicits CD8 T cells and anti-cancer immunity (2019)
  • Author(s): T.Tanoue, S.Morita, D.R.Plichta, A.N.Skelly, W.Suda, Y.Sugiura, S.Narushima, H.Vlamakis, I.Motoo, K.Sugita, A.Shiota, K.Takeshita, K.Yasuma, D.Riethmacher, T.Kaisho, J.M.Norman, D.Mucida, M.Suematsu, T.Yaguchi, V.Bucci, T.Inoue, Y.Kawakami, B.Olle, B.Roberts, M.Hattori, R.J.Xavier, K.Atarashi, K.Honda
  • Journal Title: Nature Volume: 565 Issue: 7741 Pages: 600-605
  • DOI: 10.1038/s41586-019-0878-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome (2019)
  • Author(s): Orimo T, Sasaki I, Hemmi H, Ozasa T, Fukuda-Ohta Y, Ohta T, Morinaka M, Kitauchi M, Yamaguchi T, Sato Y, Tanaka T, Hoshino K, Katayama KI, Fukuda S, Miyake K, Yamamoto M, Satoh T, Furukawa K, Kuroda E, Ishii KJ, Takeda K, Kaisho T
  • Journal Title: International Immunology Volume: 印刷中 Issue: 10 Pages: 657-668
  • DOI: 10.1093/intimm/dxz004
  • Peer Reviewed / Open Access
• [Journal Article] Hyperglycemia is associated with psoriatic inflammation in both humans and mice (2019)
  • Author(s): Ikumi K, Odanaka M, Shime H, Imai M, Osaga S, Taguchi O, Nishida E, Hemmi H, Kaisho T, Morita A, Yamazaki S
  • Journal Title: Journal of Investigative Dermatology Volume: 印刷中 Issue: 6 Pages: 1329-1338
  • DOI: 10.1016/j.jid.2019.01.029
  • Peer Reviewed / Open Access
• [Journal Article] Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice (2019)
  • Author(s): Kimura Shunsuke、Kobayashi Nobuhide、Nakamura Yutaka、Kanaya Takashi、Takahashi Daisuke、Fujiki Ryoji、Mutoh Mami、Obata Yuuki、Iwanaga Toshihiko、Nakagawa Tomoo、Kato Naoya、Sato Shintaro、Kaisho Tsuneyasu、Ohno Hiroshi、Hase Koji
  • Journal Title: The Journal of Experimental Medicine Volume: 216 Issue: 4 Pages: 831-846
  • DOI: 10.1084/jem.20181604
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a novel CCDC22 mutation in a patient with severe Epstein?Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia (2019)
  • Author(s): Yamashita Y, Nishikawa A, Iwahashi Y, Fujimoto M, Sasaki I, Mishima H, Kinoshita A, Hemmi H, Kanazawa N, Ohshima K, Imadome KI, Murata SI、Yoshiura KI, Kaisho T, Sonoki T, Tamura S
  • Journal Title: International Journal of Hematology Volume: 印刷中 Issue: 6 Pages: 744-750
  • DOI: 10.1007/s12185-019-02595-0
  • Peer Reviewed / Open Access
• [Journal Article] Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9‐genome editing promotes antitumor immunity and suppresses ovarian cancer progression (2019)
  • Author(s): Yahata T, Mizoguchi M, Kimura A, Orimo T, Toujima S, Kuninaka Y, Nosaka M, Ishida Y, Sasaki I, Fukuda‐Ohta Y, Hemmi H, Iwahashi N, Noguchi T, Kaisho T, Kondo T, Ino K
  • Journal Title: Cancer Science Volume: 110 Issue: 4 Pages: 1279-1292
  • DOI: 10.1111/cas.13958
  • Peer Reviewed / Open Access
• [Journal Article] antibiotics enhances host resistance to viral infections in a microbiota-independent manner (2018)
  • Author(s): Smita Gopinath, Myoungjoo Kim, Tasfia Rakib, Patrick Wong, Michael Van Zandt, Natasha Barry, Tsuneyasu Kaisho, Andrew Goodman, Akiko Iwasaki
  • Journal Title: Nature MicrobiologyTopical application of aminoglycoside Volume: 3 Issue: 5 Pages: 611-621
  • DOI: 10.1038/s41564-018-0138-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles. (2018)
  • Author(s): Kayama H, Kohyama M, Okuzaki D, Motooka D, Barman S, Okumura R, Muneta M, Hoshino K, Sasaki I, Ise W, Matsuno H, Nishimura J, Kurosaki T, Nakamura S, Arase H, Kaisho T, Takeda K.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 115 Issue: 33 Pages: 8418-8423
  • DOI: 10.1073/pnas.1808426115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] XCR1+樹状細胞による腸管免疫制御機構 (2018)
  • Author(s): 小笹俊哉、改正恒康
  • Journal Title: 医学のあゆみ Volume: 265(13) Pages: 1241-1247
• [Journal Article] 生体内における樹状細胞への腫瘍抗原送達システムによる新規がんペプチドワクチン療法 (2018)
  • Author(s): 2.水本有紀、勝田将裕、宮澤基樹、北畑裕司、宮本篤、中森幹人、尾島敏康、松田健司、邊見弘明、玉田耕治、改正恒康、山上裕機
  • Journal Title: 癌と化学療法 Volume: 45 Pages: 1469-1471
• [Journal Article] CD8+ T cells orchestrate pDC-XCR1+ dendritic cell spatial and functional cooperativity to optimize priming. (2017)
  • Author(s): A. Brewitz, S. Eickhoff, S. Daehling, T. Quast, S. Bedoui, R. A. Kroczek, C. Kurts, N. Garbi, W. Barchet, M. Iannacone, F. Klauschen, W. Kolanus, T. Kaisho, M. Colonna, R. N. Germain, W. Kastenmueller.
  • Journal Title: Immunity Volume: 46 Issue: 2 Pages: 205-219
  • DOI: 10.1016/j.immuni.2017.01.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections. (2017)
  • Author(s): Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H.
  • Journal Title: Immunity Volume: 46 Issue: 5 Pages: 863-874
  • DOI: 10.1016/j.immuni.2017.04.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of a novel CD4+ TCR transgenic line that reveals a dominant role for CD8+ DC and CD40-Signaling in the generation of helper and CTL responses to blood stage malaria. (2017)
  • Author(s): 3.D. Fernandez-Ruiz, LS. Lau, N. Ghazanfari, ..names of 12 authors were removed,,, A. Cozijnsen, V. Mollard, AD. Uboldi, CJ. Tonkin, TF. de Koning-Ward, PR. Gilson, T. Kaisho, A. Haque, BS. Crabb, FR. Carbone, GI. McFadden, WR. Heath.
  • Journal Title: J. Immunol. Volume: 199 Issue: 12 Pages: 4165-4179
  • DOI: 10.4049/jimmunol.1700186
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration. (2017)
  • Author(s): 4.Y. Ishida, A. Kimura, M. Nosaka, Y. Kuninaka, H. Hemmi, I. Sasaki, T. Kaisho, N. Mukaida, T. Kondo.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 16833-16833
  • DOI: 10.1038/s41598-017-17007-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ultraviolet B?Induced Maturation of CD11b-Type Langerin?Dendritic Cells Controls the Expansion of Foxp3+Regulatory T Cells in the Skin (2017)
  • Author(s): Yamazaki Sayuri、Odanaka Mizuyu、Nishioka Akiko、Kasuya Saori、Shime Hiroaki、Hemmi Hiroaki、Imai Masaki、Riethmacher Dieter、Kaisho Tsuneyasu、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi
  • Journal Title: The Journal of Immunology Volume: 200 Issue: 1 Pages: 119-129
  • DOI: 10.4049/jimmunol.1701056
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 樹状細胞による腸管免疫恒常性維持機構 (2017)
  • Author(s): 大田友和、改正恒康
  • Journal Title: 実験医学 Volume: 35 Pages: 1103-1109
• [Journal Article] 樹状細胞 (2017)
  • Author(s): 改正恒康
  • Journal Title: 臨床免疫・アレルギー科 Volume: 67 Pages: 606-611
  • NAID: 40021232347
• [Presentation] Analysis of mice carrying a novel mutation in a proteasome subunit gene identifed in an autoinammatory disease patient (2019)
  • Author(s): 金澤伸雄、小笹俊哉、邊見弘明、加藤喬、折茂貴是、佐々木泉、福田(大田)有里、改正恒康、木下晃、吉浦孝一郎、金城紀子、水島恒裕
  • Organizer: 第2回日本免疫不全・自己炎症学会総会・学術集会
  • Invited
• [Presentation] 皮膚科医に知っていただきたい樹状細胞の機能的および病理的意義 (2018)
  • Author(s): 改正恒康、邊見弘明、小笹俊哉
  • Organizer: 第117回日本日本皮膚科学会総会
  • Invited
• [Presentation] プロテアソーム関連自己炎症性症候群のマウスモデル (2018)
  • Author(s): 改正恒康、邊見弘明、金澤伸雄、加藤喬、稲葉豊、小笹俊哉
  • Organizer: 第39回日本炎症・再生学会
  • Invited
• [Presentation] Current overview of functions and development of dendritic cells (2018)
  • Author(s): Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会
  • Invited
• [Presentation] 中條－西村症候群からプロテアソーム関連自己炎症/免疫不全症候群へ (2018)
  • Author(s): 金澤伸雄、中谷友美、原知之、稲葉豊、国本佳代、古川福実、神人正寿、金城紀子、水島恒裕、三嶋博之、木下晃、吉浦孝一郎、加藤喬、福田有里、邊見弘明、改正恒康
  • Organizer: 第25回分子皮膚科学フォーラム
• [Presentation] 新規LIG4遺伝子変異を導入したLIG4症候群モデルマウス A mouse model of LIG4 syndrome with novel LIG4 mutation (2018)
  • Author(s): 山下友佑、田村志宣、福田有里、小笹俊哉、金澤伸雄、邊見弘明、吉浦孝一郎、改正恒康、園木孝志
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Impaired development of dendritic cells in proteasome subunit mutant mice (2018)
  • Author(s): Hiroaki Hemmi, Toshiya Ozasa, Akira Kinoshita, Takashi Kato, Takashi Orimo, Izumi Sasaki, Yuri Fukuda-Ohta, Noriko Kinjo, Koh-Ichiro Yoshiura, Tsunehiro Mizushima,Nobuo Kanazawa, Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Cholera toxin B can induce interleukine-1β production in peritoneal macrophages through activation of pyrin inflammasome (2018)
  • Author(s): Izumi Sasaki, Takashi Orimo, Hiroaki Hemmi, Toshiya Ozasa, Yuri Fukuda-Ohta, Mio Morinaka, Shinji Fukuda, Koichi Furukawa, Etsushi Kuroda, Ken J. Ishii, Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] The mechanism of action of Spi-B in transcriptional activation of the interferon-α4 gene (2018)
  • Author(s): Ryo Miyazaki, Hiroyuki Saiga, Tsuneyasu Kaisho, Katsuaki Hoshino
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Cancer Vaccine Composed of Whole Tumor Cells Genetically Modified to Secrete the XCL1 (2018)
  • Author(s): Atsushi Miyamoto, Hemmi Hiroaki, Yuki Mizumoto, Masahiro Katsuda, Yuri Ohta,Katsuaki Hoshino, Hiroki Yamaue, Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Dendritic cells expressing a unique set of genes associated with immunological tolerance are specialized to expand thymus-derived Foxp3+ regulatory T cells in the ultraviolet B-exposed skin (2018)
  • Author(s): Sayuri Yamazaki, Mizuyu Odanaka, Akiko Nishioka, Hiroaki Shime, Hiroaki Hemmi,Masaki Imai, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Hyperglycemia is associated with psoriatic inflammation in both humans and mice (2018)
  • Author(s): Mizuyu Odanaka, Kyoko Ikumi, Hiroaki Shime, Masaki Imai, Hiroaki Hemmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Sox8 is essential for the differentiation of M cells and antigen-specific IgA response (2018)
  • Author(s): Nobuhide Kobayashi, Shunsuke Kimura, Yutaka Nakamura, Takashi Kanaya, Tsuneyasu Kaisho, Hiroshi Ohno, Koji Hase
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Osteoprotegerin-dependent M-cell self-regulation balances gut infection and immunity (2018)
  • Author(s): Shunsuke Kimura, Yutaka Nakamura, Nobuhide Kobayashi, Tsuneyasu Kaisho, Koji Hase
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] M-cell-dependent antigen uptake mitigates infectious colitis by shaping mucosal barrier function (2018)
  • Author(s): Yutaka Nakamura, Hitomi Mimuro, Jun Kunisawa, Tsuneyasu Kaisho, Hiroshi Kiyono, Koji Hase
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] A case of neonatal-onset proteasome-associated autoinflammatory syndrome resembling but distinct from Nakajo-Nishimura syndrome (2018)
  • Author(s): Noriko Kinjo, Hiroyuki Mishima, Akira Kinoshita, Koh-Ichiro Yoshiura,Tsunehiro Mizushima, Jun Hamazaki, Shigeo Murata, Hiroaki Hemmi, Tsuneyasu Kaisho,Nobuo Kanazawa
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Analysis of mice carrying a novel mutation in a proteasome subunit gene identified in anautoinflammatory disease patient (2018)
  • Author(s): Toshiya Ozasa, Hiroaki Hemmi, Akira Kinoshita, Takashi Kato, Takashi Orimo, Izumi Sasaki, Yuri Fukuda-Ohta, Noriko Kinjo, Koh-Ichiro Yoshiura, Tsunehiro Mizushima, Nobuo Kanazawa, Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] XCR1+DCへの選択的な送達を目的とした新規抗がんワクチンの開発 (2018)
  • Author(s): 宮本篤、勝田将裕、邊見弘明、宮澤基樹、北畑裕司、水本有紀、小林良平、改正恒康、山上裕機
  • Organizer: 第46回和歌山悪性腫瘍研究会
• [Presentation] CRISPR/Cas9による腫瘍上のPD-L1欠損はマウス卵巣癌モデルにおいて抗腫瘍免疫を促進し、腫瘍進展を抑制する (2018)
  • Author(s): 八幡環、岩橋尚幸、野口智子、溝口美佳、東嶋左緒里、改正恒康、近藤稔和、井篦一彦
  • Organizer: 第46回和歌山悪性腫瘍研究会
• [Presentation] Immune regulation by a dendritic cell subset expressing a chemokine receptor, XCR1 (2018)
  • Author(s): Tsuneyasu Kaisho
  • Organizer: 15th International Symposium on Dendritic Cells
  • Int'l Joint Research / Invited
• [Presentation] Foxp3+ regulatory T cells are expanded by ultraviolet B-exposed PD-L1+ skin dendritic cell expressing a unique set of genes in a CSF1-independent manner (2018)
  • Author(s): Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Akiko Nishioka, Saori Kasuya, Dieter Riethmacher, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
  • Organizer: International Investigative Dermatology 2018
  • Int'l Joint Research / Invited
• [Presentation] Successful treatment of psoriatic inflammation restores hyperglycemia (2018)
  • Author(s): Kyoko Ikumi, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Osamu Taguchi, Hiroaki Hemmi, Tsuneyasu Kaisho, Sayuri Yamazaki, Akimichi Morita
  • Organizer: International Investigative Dermatology 2018
  • Int'l Joint Research
• [Presentation] Time-resolved systems analysis of virus infection fate regulation: the XCL1-XCR1 communication axis links T cell exhaustion with effector maintenance (2018)
  • Author(s): J. Argilaguet, M. Pedragosa, A. Esteve-Codina, G. Riera, E. Vidal, C. Peligero-Cruz, D. Andreu, T. Kaisho, G. Bocharov, B. Ludewig, S. Heath, A. Meyerhans
  • Organizer: 15th International Symposium on Dendritic Cells
  • Int'l Joint Research
• [Presentation] Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections (2018)
  • Author(s): Chikako Shimokawa, Takashi Kanaya, Masami Hachisuka, Kenji Ishiwata, Hajime Hisaeda, Yosuke Kurashima, Hiroshi Kiyono, Tomohiro Yoshimoto, Tsuneyasu Kaisho, Hiroshi Ohno
  • Organizer: The 3rd International Conference on Innate Lymphoid Cells (ILC2018)
  • Int'l Joint Research
• [Presentation] Spi-Bは圧負荷による心不全の病態形成において炎症と線維化を抑制して保護的に機能する (2017)
  • Author(s): 1.木村章彦、福田有里、加藤喬、佐々木泉、改正恒康、近藤稔和
  • Organizer: 第38回日本炎症・再生医学会
• [Presentation] 樹状細胞サブセットに注目したがんペプチドワクチンの開発 (2017)
  • Author(s): 2.水本有紀、勝田将裕、宮澤基樹、北畑裕司、宮本篤、中森幹人、松田健司、尾島敏康 早田啓治、邊見弘明、改正恒康、山上裕機
  • Organizer: 第38回 癌免疫外科研究会
• [Presentation] 粘膜感染防御における腸管特殊上皮M細胞の役割の解明 (2017)
  • Author(s): 中村有孝、國澤純、改正恒康、清野宏、長谷耕二
  • Organizer: 第160回日本獣医学会学術集会
• [Presentation] がん抗原ペプチドの生体内樹状細胞サブセット送達によるワクチン療法の開発 (2017)
  • Author(s): 4.水本有紀、勝田将裕、宮澤基樹、北畑裕司、宮本篤、中森幹人、尾島敏康、松田健司、早田啓治、邊見弘明、改正恒康、山上裕機
  • Organizer: 第30回日本バイオセラピィ学会学術集会総会
• [Presentation] An Ets family member, Ets2 is required for Cholera toxin-induced arginase-1 gene expression. (2017)
  • Author(s): K. Negoro, M. Tane, M. Morinaka, Y. Fukuda, I. Sasaki, T. Kaisho
  • Organizer: 第46回日本免疫学会総会学術集会記録
• [Presentation] Roles of arginine and methionine metabolism in cholera toxin-induced adjuvant effects. (2017)
  • Author(s): I.Sasaki, T. Orimo, H. Hemmi, T. Ozasa, Y. Fukuda, S. Fukuda, T. Kaisho.
  • Organizer: 第46回日本免疫学会総会学術集会記録
• [Presentation] Spi-C inhibits expression of a subset of Toll-like receptor 4-inducible genes in intestinal CX3CR1high macrophages and prevents colonic inflammation. (2017)
  • Author(s): H. Kayama, M. Kohyama, H. Arase, T. Kaisho, K. Takeda.
  • Organizer: 第46回日本免疫学会総会学術集会記録
• [Presentation] Decline of lysyl oxidase protein causes acute aortic dissection in Spi-B knockout mice. (2017)
  • Author(s): A.Taruya, A. Kimura, Y. Ishida, M. Nosaka, K. Yumi, I. Sasaki, T. Kaisho, T. Kondo.
  • Organizer: 第46回日本免疫学会総会学術集会記録
• [Presentation] Spi-B plays a protective role in pressure overload-induced heart failure through attenuation of cardiac inflammation. (2017)
  • Author(s): 1.A. Kimura, Y. Ihida, M. Nosaka, I. Sasaki, H. Yamamoto, Y. Kuninaka, T. Kato, Y. Fukuda, T. Kaisho, T. Kondo.
  • Organizer: 22nd World Congress Heart Disease（国際学会）
• [Remarks] 和歌山県立医科大学 先端医学研究所 生体調節機構研究部
  • URL: http://www.wakayama-med.ac.jp/med/seitai/index.php